DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and egg-6

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_492348.1	Gene:	egg-6 / 172670	WormBaseID:	WBGene00010621	Length:	961	Species:	Caenorhabditis elegans

Alignment Length:	859	Identity:	187/859 - (21%)
Similarity:	303/859 - (35%)	Gaps:	270/859 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KWL-LFSLCIMPAMFSNTKRKC---PTECQCSMDDLDRYQAICTKGGLNSLLSPNELDVDVKVII 64
            :|| |.::..:.|..|:.:..|   |.:|.|.:          :|..:  :||.|  ..|||.|
Worm     2 RWLTLIAVAHLIAFLSSAEITCPRIPEKCDCKI----------SKSMI--ILSCN--GEDVKTI- 51

  Fly    65 IRGPRNSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRILDLS------------KNN 117
                  :.|:|.:  |..:|.||..||..:.::   .|.||:.:.||:.:            :..
Worm    52 ------AQTVGTS--QIDELHILNGTDVKIESL---PFNGLRTIAILNSTLQSFSPTAWRHVEAT 105

  Fly   118 ITNITENN--------FRGQDNLLELDLSKNKVLRMASSTFRHLTDLRRLNLADNSI-------V 167
            |.:||.|.        |.....|:.::|:.|::..:....|..|:.|.:|.|.:|:|       :
Worm   106 IEHITINGNELKTVPVFGNLSTLMSMNLNSNQISSIPDKAFNGLSALTQLRLENNAICDFPPKSL 170

  Fly   168 ELVQRNFFML------------------SRLKYLDLSGNPLQDLQPDVFRDVPELKVLKCRNCQL 214
            :.|:.:..:|                  :.|.||||..|.:.::......::|.|:.|:.:|..|
Worm   171 DAVKASLVLLDVSGNCLDAIPAQILRNAANLMYLDLGSNNISEINNFELMNLPFLRELRVQNNTL 235

  Fly   215 KKINPQMYNLLPLLSELDLGRNEFKFLDKD----------------------EFRDVKRLTKVLL 257
            ::|:|..:..:|.|..|.|..|....||.:                      ..:|:..|.:|.:
Worm   236 RRIHPMAFMNVPQLQYLYLQDNIISTLDGNRLQGFKNLEVLDVSNNALYALPSLKDLPNLKQVRV 300

  Fly   258 DGNQLSVVVDQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLS 322
            |||.::.:....|....:|..:.:..|.:.::..:||..|..|..|.:..|.|.::|......:.
Worm   301 DGNLITKIETLAFSNNPNLQLISVQNNNIVQISRNSFESLDKLVVLLVGNNSLAKIERGMFDGMK 365

  Fly   323 NLLTLNISGNVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIADMGTMPVGLLHPFKQ 387
            ||..|:|..|                     |.:.|......||.||...|:|       |
Worm   366 NLQQLSIRNN---------------------TLTALDASSFAQLAHLTTLDLG-------H---- 398

  Fly   388 LRYLNISGNSLNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPLICDEC- 451
                    |.:::......|...:|.:||||.|::.|..  |.:..:.|.|:.||.|.|||||.
Worm   399 --------NKIHDIEEGTFDKLSKLFWLDLSNNKISGFK--TSVFKKKISNILLDGNQLICDESF 453

  Fly   452 --HMGKLI-NVVRQ-LQWKWDTYPICFLPKSLRGAEINNLDINGLHTCLT-----FITDEEQNAA 507
              .:..|| |.||. |.::.:.  :|..|:...|..:.:|.:...:..|:     ....:..|..
Worm   454 NEFLTYLIANKVRTFLPFQQEI--MCHGPEKYAGVRLKDLMMKKANETLSEGSRLLGVPQGSNQH 516

  Fly   508 STSYNFLEH-GGLNTLAILGGIIFVLIAVIILSLVACFSKNRARYYTREDHLNGSESKCLEKNLE 571
            |...:||.. |.|.||...||....|
Worm   517 SLLSSFLPSLGPLGTLNGAGGAAIPL--------------------------------------- 542

  Fly   572 ATTITTLGNGSSPTTTTTLTLATSPAAPNGPKTNGQGLSLSPANGSTPV-HGISDDKGKEIN--- 632
               :.||.|             |.||..:.|   |.|       |:.|| .|.|....|.:|
Worm   543 ---VNTLTN-------------TIPALRSIP---GFG-------GNIPVGTGASSVPNKNLNDAI 581

  Fly   633 --FTFPVDDRVCT--------IDELMPSPP------------------PPPQQH-------PHPN 662
              ||.|: .|..|        |::|:.|.|                  |...|:       |..:
Worm   582 EGFTGPL-VRFATGGQPVASDIEQLIRSIPNMVVNVPGFGDIDLSKMDPTMIQYVLNGGQIPGID 645

  Fly   663 MGSLMYSVSHSPNSATTLAAVAAAATVIPPGAPSHSSMPTPTPTPAEAVVVVLPPPPLP------ 721
            ..:|...|..:.|...|.||...|..   |.......:|.....|:..|..|:...|||
Worm   646 KATLDKIVKQTMNKMHTAAAANLAGN---PVEGQEKVLPPLDKLPSGLVTQVMSGEPLPGLNENQ 707

  Fly   722 ----PQQHHHQMDG 731
                .:.:.|||.|
Worm   708 TKIIMEYYTHQMPG 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	8/22 (36%)
		leucine-rich repeat	108..131	CDD:275380	7/42 (17%)
		LRR_8	131..190	CDD:290566	18/83 (22%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		LRR_RI	151..422	CDD:238064	67/317 (21%)
		leucine-rich repeat	156..179	CDD:275380	7/47 (15%)
		LRR_8	178..262	CDD:290566	26/105 (25%)
		leucine-rich repeat	180..203	CDD:275380	6/22 (27%)
		leucine-rich repeat	204..251	CDD:275380	14/68 (21%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	15/59 (25%)
		leucine-rich repeat	276..299	CDD:275380	5/22 (23%)
		LRR_4	298..342	CDD:289563	10/43 (23%)
		leucine-rich repeat	300..323	CDD:275380	5/22 (23%)
		leucine-rich repeat	388..411	CDD:275380	2/22 (9%)
egg-6	NP_492348.1	LRR_8	107..162	CDD:290566	13/54 (24%)
		leucine-rich repeat	107..127	CDD:275380	4/19 (21%)
		leucine-rich repeat	128..151	CDD:275380	5/22 (23%)
		LRR_RI	<144..281	CDD:238064	29/136 (21%)
		leucine-rich repeat	152..200	CDD:275380	7/47 (15%)
		LRR_8	176..233	CDD:290566	10/56 (18%)
		leucine-rich repeat	201..224	CDD:275380	6/22 (27%)
		LRR_8	225..283	CDD:290566	13/57 (23%)
		leucine-rich repeat	225..248	CDD:275380	6/22 (27%)
		LRR_RI	<240..458	CDD:238064	59/259 (23%)
		leucine-rich repeat	249..272	CDD:275380	6/22 (27%)
		LRR_8	271..329	CDD:290566	9/57 (16%)
		leucine-rich repeat	273..294	CDD:275380	1/20 (5%)
		leucine-rich repeat	295..318	CDD:275380	6/22 (27%)
		LRR_8	317..375	CDD:290566	14/57 (25%)
		leucine-rich repeat	319..342	CDD:275380	5/22 (23%)
		leucine-rich repeat	343..366	CDD:275380	5/22 (23%)
		LRR_8	365..425	CDD:290566	22/99 (22%)
		leucine-rich repeat	367..390	CDD:275380	8/43 (19%)
		leucine-rich repeat	391..414	CDD:275380	6/41 (15%)
		leucine-rich repeat	415..434	CDD:275380	8/20 (40%)
		leucine-rich repeat	437..449	CDD:275378	6/11 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910