DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rdo and TLR6

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	NP_001381482.1	Gene:	TLR6 / 10333	HGNCID:	16711	Length:	796	Species:	Homo sapiens

Alignment Length:	683	Identity:	131/683 - (19%)
Similarity:	244/683 - (35%)	Gaps:	232/683 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 VIIIRGPR------NSITIGPALRQF--------MKLEILRITDSNLPAIGAESFWGLKYLRILD 112
            :|||.|.|      |...:..:.|..        :|.::|.::.:.:..:.......|..|.:|.
Human    18 MIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLR 82

  Fly   113 LSKNNITNITENNFRGQDNLLELDLSKNKVLRMASS---TFRHLTDLRRLNLADNSIVEL-VQRN 173
            ||.|.|..:..:.|:...:|..||||.|::.:::..   :|||      |:|:.|....| :.:.
Human    83 LSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRH------LDLSFNDFKALPICKE 141

  Fly   174 FFMLSRLKYLDLSGNPLQ--DLQPDVFRDVPELKVLKCRNCQLKKINPQMYNLLPLLS------- 229
            |..||:|.:|.||...||  ||.|.....:..: :|..||..:|:...:...:|...:
Human   142 FGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYI-LLDLRNYYIKENETESLQILNAKTLHLVFHP 205

  Fly   230 ------ELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQK-------SLNHLDL 281
                  ::::..|....|         :||.:.|:.:...|.:..|..:.:       :|||::.
Human   206 TSLFAIQVNISVNTLGCL---------QLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIET 261

  Fly   282 SYNRLAKV-----PND-SFLQLTNLTFL------DLSYNKLVRLEPQSIRSLSN----------- 323
            ::..|.:|     |.. .:|.:.|||.:      |.:|:| ..|:..:|..::|
Human   262 TWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSK-TTLKALTIEHITNQVFLFSQTALY 325

  Fly   324 ---------LLTLNISGNVLMDLREMRETFEPLIY-------YFFLTCSKLFFQLIPQLTHLAIA 372
                     :||::.:..:.|.......||:.|.:       ..|..||.|.     :|..|.:.
Human   326 TVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLV-----KLETLILQ 385

  Fly   373 DMG---TMPVGLL---------------------HP-----FKQLRYLNISGNSLNNTALEVIDP 408
            ..|   ...|||:                     |.     .:.:..||:|.|.|.::....:.|
Human   386 KNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPP 450

  Fly   409 CRELEFLDLSRNQLHGI---------------------------------------------SED 428
              .::.|||..|::..:                                             |.|
Human   451 --RIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSAD 513

  Fly   429 TVLRIQGIRNVRLDNNPLICDECHMGKLINVVRQLQ------WKWDTYPICFLPKSLRGAEINNL 487
            .....|.:|:::..:||..| .|.:.:.:..:.|:.      |. |:|. |..|:|.||:.:.:.
Human   514 FFQSCQKMRSIKAGDNPFQC-TCELREFVKNIDQVSSEVLEGWP-DSYK-CDYPESYRGSPLKDF 575

  Fly   488 DINGLHTCLTFITDEEQNAASTSYNFLEHGGLNTLAILGGIIFVLIAVIILSL-----------V 541
            .::.|...:|.:                      :..:|..:.|| ||.:.||           :
Human   576 HMSELSCNITLL----------------------IVTIGATMLVL-AVTVTSLCIYLDLPWYLRM 617

  Fly   542 AC---FSKNRARYYTREDHLNGSESKCLEKNLE 571
            .|   .::.|||....|:         |::||:
Human   618 VCQWTQTRRRARNIPLEE---------LQRNLQ 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	2/22 (9%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_8	131..190	CDD:290566	20/62 (32%)
		leucine-rich repeat	132..155	CDD:275380	9/25 (36%)
		LRR_RI	151..422	CDD:238064	73/361 (20%)
		leucine-rich repeat	156..179	CDD:275380	6/23 (26%)
		LRR_8	178..262	CDD:290566	20/98 (20%)
		leucine-rich repeat	180..203	CDD:275380	9/24 (38%)
		leucine-rich repeat	204..251	CDD:275380	7/59 (12%)
		leucine-rich repeat	252..275	CDD:275380	5/29 (17%)
		LRR_8	274..334	CDD:290566	18/98 (18%)
		leucine-rich repeat	276..299	CDD:275380	7/28 (25%)
		LRR_4	298..342	CDD:289563	12/69 (17%)
		leucine-rich repeat	300..323	CDD:275380	7/28 (25%)
		leucine-rich repeat	388..411	CDD:275380	6/22 (27%)
TLR6	NP_001381482.1	LRR 1	54..77		2/22 (9%)
		LRR 2	78..101		7/22 (32%)
		LRR 3	102..122		6/19 (32%)
		LRR 4	123..147		9/29 (31%)
		LRR 5	148..168		9/19 (47%)
		LRR 6	169..196		5/27 (19%)
		LRR 7	197..219		0/21 (0%)
		LRR 8	220..250		6/38 (16%)
		LRR 9	251..277		6/25 (24%)
		LRR 10	278..303		7/25 (28%)
		LRR 11	304..330		3/25 (12%)
		LRR 12	331..354		3/22 (14%)
		LRR 13	355..378		6/27 (22%)
		LRR 14	379..404		6/24 (25%)
		LRR 15	405..429		1/23 (4%)
		LRR 16	430..450		5/19 (26%)
		LRR 17	451..474		4/22 (18%)
		LRR 18	475..496		0/20 (0%)
		LRR 19	497..520		2/22 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900