DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rdo and si:dkey-182i3.11

DIOPT Version :9

Sequence 1:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster
Sequence 2:	XP_021322095.1	Gene:	si:dkey-182i3.11 / 100334238	ZFINID:	ZDB-GENE-121214-258	Length:	710	Species:	Danio rerio

Alignment Length:	589	Identity:	144/589 - (24%)
Similarity:	237/589 - (40%)	Gaps:	120/589 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LNSLLSPNELDVDVKVIIIRGPRNSITIGPALRQFMKLEILRITDSNLPAIGAESFWGLKYLRIL 111
            |..|::...|::::..|:      |::.| .|...:.|..|::.|:.:..|....|....||..|
Zfish   171 LYGLINLQTLNLNINQIL------SLSYG-VLEGPLALTDLQLRDNMIDMIEMNVFENCTYLAKL 228

  Fly   112 DLSKNNITNITENNFRG------------------------QDNLLELDLSKNKVLRMASSTFRH 152
            .||||.:.::...:|:|                        ..||..|.|.||.:..:..:.|..
Zfish   229 YLSKNKLKSVGNGSFKGATGLNHLDLGLNGLAGIPTIVLQETSNLTSLYLQKNDITSIPDNVFSE 293

  Fly   153 LTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPDVFRDVPELKVLKCRNCQLKKI 217
            :..|:.|:|:.|.:|.:...:|..||:|.|||||.|.||.|...||.|:.:|:.|...:.:|..:
Zfish   294 ILSLKHLDLSYNGLVSISNGSFRSLSQLVYLDLSFNQLQTLTQHVFEDLGKLENLNLYHNKLTSL 358

  Fly   218 NPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVVDQLFRMQKSLNHLDLS 282
            ...|:..|.:|.||.|..|....:..|.|..:..|..:.||.|.:|.:....|:..:.|..||:|
Zfish   359 PNNMFKNLTMLKELQLDSNNISVIPPDLFHPLSALKDLQLDNNHISKLHSHTFKKLRQLKQLDIS 423

  Fly   283 YNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMDLREMRETFEPL 347
            .|.|.|:||..|.:  ||..|:|..|.:..:...|.::|..|.:|.:|.|.|
Zfish   424 SNDLTKIPNHLFHK--NLKELNLENNHISFISKFSFKNLHRLQSLKLSHNNL------------- 473

  Fly   348 IYYFFLTCSKLFFQLIPQLTHLAIA-----DMGTMPVGLLHPFKQLRYLNISGNSLNNTALEVID 407
                    |||:.:|:..||.|...     .:.|:|||.....:.||.|::|.|.::....:..:
Zfish   474 --------SKLYRELLTNLTRLRELLLNENQIETIPVGFFKGLENLRVLDLSNNKMHFILPDAFN 530

  Fly   408 PCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPLI------------CDECHMGKLINVV 460
            ....|:.||||.|.||.:.||....::.:..:.|.||.|.            .:|.|:.:  |.:
Zfish   531 DLSALKDLDLSFNFLHNLPEDIFASLRNLTKLHLQNNKLRYLPSRLFSALVGLEELHLDR--NYI 593

  Fly   461 RQLQWKWDTYPICFLPKSLRG-AEINNLDINGLHTCLTFITDEEQNAASTSYNFLEHGGLNTL-- 522
            :::.           |....| .:::.||:.                 |.....:|.|.|..|
Zfish   594 QRIH-----------PTQFEGLVKLHELDMK-----------------SNQLRSMEDGTLMPLRK 630

  Fly   523 ---AILGGIIFVLIAVIILSLVACFSKNRARYYTREDHLNGS-------------ESKCLEKNLE 571
               ..|.|..:....|:||.:...|:.|.....|.....:|.             .|.|...|::
Zfish   631 LKRIHLDGNPWDCSTVVILYISQWFNNNTQLVKTTPMCSSGQNLSNPALFPSSLLNSACFSANIK 695

  Fly   572 ATTI 575
            ..|:
Zfish   696 QLTV 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	5/22 (23%)
		leucine-rich repeat	108..131	CDD:275380	8/46 (17%)
		LRR_8	131..190	CDD:290566	22/58 (38%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		LRR_RI	151..422	CDD:238064	83/275 (30%)
		leucine-rich repeat	156..179	CDD:275380	7/22 (32%)
		LRR_8	178..262	CDD:290566	30/83 (36%)
		leucine-rich repeat	180..203	CDD:275380	13/22 (59%)
		leucine-rich repeat	204..251	CDD:275380	12/46 (26%)
		leucine-rich repeat	252..275	CDD:275380	6/22 (27%)
		LRR_8	274..334	CDD:290566	21/59 (36%)
		leucine-rich repeat	276..299	CDD:275380	10/22 (45%)
		LRR_4	298..342	CDD:289563	12/43 (28%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
si:dkey-182i3.11	XP_021322095.1	PLN00113	97..>617	CDD:331614	127/505 (25%)
		leucine-rich repeat	129..152	CDD:275380
		leucine-rich repeat	153..176	CDD:275380	2/4 (50%)
		leucine-rich repeat	177..200	CDD:275380	5/29 (17%)
		leucine-rich repeat	201..224	CDD:275380	5/22 (23%)
		leucine-rich repeat	225..248	CDD:275380	8/22 (36%)
		leucine-rich repeat	249..272	CDD:275380	0/22 (0%)
		leucine-rich repeat	273..296	CDD:275380	6/22 (27%)
		leucine-rich repeat	297..320	CDD:275380	7/22 (32%)
		leucine-rich repeat	321..344	CDD:275380	13/22 (59%)
		leucine-rich repeat	345..368	CDD:275380	5/22 (23%)
		leucine-rich repeat	369..392	CDD:275380	7/22 (32%)
		leucine-rich repeat	393..438	CDD:275380	16/46 (35%)
		leucine-rich repeat	417..436	CDD:275380	9/18 (50%)
		leucine-rich repeat	439..462	CDD:275380	6/22 (27%)
		leucine-rich repeat	463..486	CDD:275380	10/43 (23%)
		leucine-rich repeat	487..510	CDD:275380	5/22 (23%)
		leucine-rich repeat	511..534	CDD:275380	5/22 (23%)
		leucine-rich repeat	535..558	CDD:275380	10/22 (45%)
		leucine-rich repeat	559..582	CDD:275380	4/22 (18%)
		leucine-rich repeat	583..606	CDD:275380	5/35 (14%)
		leucine-rich repeat	607..628	CDD:275380	6/37 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.870