DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elfless and COP1

DIOPT Version :9

Sequence 1:	NP_001163003.1	Gene:	elfless / 35076	FlyBaseID:	FBgn0032660	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	XP_016857548.1	Gene:	COP1 / 64326	HGNCID:	17440	Length:	775	Species:	Homo sapiens

Alignment Length:	186	Identity:	48/186 - (25%)
Similarity:	71/186 - (38%)	Gaps:	46/186 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 SGSSERNPNEYYGDS-DSSSSSRSIDRTPFLLEYSSDSESS------------------------ 117
            |||:..:|......| .|:|||.|...:|..:..|:.:..|
Human     9 SGSAGTSPGSSAASSVTSASSSLSSSPSPPSVAVSAAALVSGGVAQAAGSGGLGGPVRPVLVAPA 73

  Fly   118 -SSSDSESSSTSISFDSSMSSTESSTPMGHTESSDSNEDSPP------NKRIKSDDEESKKSVLP 175
             |.|...:.||.:| ..|.::..|:...|.:.|..|.....|      |..|.|.:::|...|
Human    74 VSGSGGGAVSTGLS-RHSCAARPSAGVGGSSSSLGSGSRKRPLLAPLCNGLINSYEDKSNDFV-- 135

  Fly   176 YNCPVCLEDVREKLPVSTNCGHVFCKACIKRAVDTGRVCPLCG--VDE-----PEF 224
              ||:|.:.:.|  ...|.|||.||..||.::::....||.|.  ||.     |.|
Human   136 --CPICFDMIEE--AYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNIDHLYPNF 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elfless	NP_001163003.1	RING	178..217	CDD:214546	14/38 (37%)
COP1	XP_016857548.1	RING-HC_COP1	132..177	CDD:319418	16/50 (32%)
		PLN00181	<240..725	CDD:177776
		WD40 repeat	491..528	CDD:293791
		WD40 repeat	535..571	CDD:293791
		WD40 repeat	576..614	CDD:293791
		WD40 repeat	620..659	CDD:293791
		WD40 repeat	663..685	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910