DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment elfless and Cop1

DIOPT Version :9

Sequence 1:	NP_001163003.1	Gene:	elfless / 35076	FlyBaseID:	FBgn0032660	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_036061.1	Gene:	Cop1 / 26374	MGIID:	1347046	Length:	733	Species:	Mus musculus

Alignment Length:	194	Identity:	47/194 - (24%)
Similarity:	73/194 - (37%)	Gaps:	60/194 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 SGSSERNPNEYYGDSDSSSSSRSIDRTPFLLEYSSDSESSSS----------------------- 119
            |||:..:|......|.:|:|| |:..:|     |..|.::|:
Mouse     9 SGSAGTSPGSSAASSVTSASS-SLSSSP-----SPPSVAASAATLVSGGVAPAAGSGGLGGPGRP 67

  Fly   120 -------SDSESSSTSISFDSSMSSTESSTPMGHTESSDSNEDSPPNKR----------IKSDDE 167
                   |.|.|:..::|...|..|. ::.|......|.|:..|...||          :.|.::
Mouse    68 VLVAAAVSGSASAGGAVSAGQSRLSC-AARPSAGVGGSSSSLGSSSRKRPLLVPLCNGLLNSYED 131

  Fly   168 ESKKSVLPYNCPVCLEDVREKLPVSTNCGHVFCKACIKRAVDTGRVCPLCG--VDE-----PEF 224
            :|...|    ||:|.:.:.|  ...|.|||.||..||.::::....||.|.  ||.     |.|
Mouse   132 KSNDFV----CPICFDMIEE--AYMTKCGHSFCYKCIHQSLEDNNRCPKCNYVVDNIDHLYPNF 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elfless	NP_001163003.1	RING	178..217	CDD:214546	14/38 (37%)
Cop1	NP_036061.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		12/39 (31%)
		Nuclear localization signal 1	111..115		0/3 (0%)
		zf-C3HC4	138..175	CDD:278524	14/38 (37%)
		Nuclear localization signal 2	197..208
		Nuclear export signal	237..247
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..327
		WD 1	421..460
		WD40	423..729	CDD:238121
		WD 2	470..510
		WD40 repeat	475..512	CDD:293791
		WD 3	513..553
		WD40 repeat	519..555	CDD:293791
		WD 4	555..595
		WD40 repeat	560..598	CDD:293791
		WD 5	599..637
		WD40 repeat	604..643	CDD:293791
		WD 6	640..679
		Interaction with TRIB1. /evidence=ECO:0000250\|UniProtKB:Q8NHY2	645..647
		WD40 repeat	647..669	CDD:293791
		WD 7	695..731
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910