DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btv and DYNC2H1

DIOPT Version :9

Sequence 1:	NP_001036369.3	Gene:	btv / 35073	FlyBaseID:	FBgn0023096	Length:	4236	Species:	Drosophila melanogaster
Sequence 2:	NP_001073932.1	Gene:	DYNC2H1 / 79659	HGNCID:	2962	Length:	4314	Species:	Homo sapiens

Alignment Length:	4491	Identity:	1460/4491 - (32%)
Similarity:	2386/4491 - (53%)	Gaps:	445/4491 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RTKFIINTSVEYFSARLPGSELDEQTAM-----ILEFLEQEELTVISAVHSRSDGRIRFHHRI-- 61
            |..||..|:..||...   |||.:|..:     |..||:.....::..  .|||..|.|.:.|
Human     9 RKLFIFTTTQNYFGLM---SELWDQPLLCNCLEINNFLDDGNQMLLRV--QRSDAGISFSNTIEF 68

  Fly    62 -PNEELCLLFYKV-PQVGHHRKEDGSEPLLGILTLEGGMVKSIYNSVSRVFSP--------SANS 116
             ..::..|:|:|: |:|  ...|:..:.:|....|| ..:.|:|.:|.:||:|        |.|
Human    69 GDTKDKVLVFFKLRPEV--ITDENLHDNILVSSMLE-SPISSLYQAVRQVFAPMLLKDQEWSRN- 129

  Fly   117 ARRSEYGPELSGILENLHQNLGSSLGLPQSGITSLR-------------NEIKYWQQKLGQKSSS 168
                 :.|:|..:|..|...||..|....:.:|.|:             :|.::|.:: ..:.:.
Human   130 -----FDPKLQNLLSELEAGLGIVLRRSDTNLTKLKFKEDDTRGILTPSDEFQFWIEQ-AHRGNK 188

  Fly   169 RLDREAAQVFIGVLENMEKQISTIDGANPSGTIEEFLDHAHTN---LDELWRLPY--NYPQQRMA 228
            ::.:|.|..|..:.|.:.::...:|    |.::.|.:|...|.   :|::||...  :||:.||.
Human   189 QISKERANYFKELFETIAREFYNLD----SLSLLEVVDLVETTQDVVDDVWRQTEHDHYPESRML 249

  Fly   229 DLLDIIG---KRLLEVCLTQL-LAEDVWSLNSSHVNNLMSQSIDTVDAWIQLCDSLTRLFWPNYV 289
            .||||||   .|.::..|..| |.||.:.|    |...:...|...:.|:.:|:.||...|..||
Human   250 HLLDIIGGSFGRFVQKKLGTLNLWEDPYYL----VKESLKAGISICEQWVIVCNHLTGQVWQRYV 310

  Fly   290 KHPWLGDSHVPKRGQQFKERLSEIRSIKQLYKQIATLLEDTE-----LQEMFQEQAPFTEFNIFD 349
            .|||..:.:.|:...:..:||.|:.:|:.::::....|..:|     |..:|:   |||..|...
Human   311 PHPWKNEKYFPETLDKLGKRLEEVLAIRTIHEKFLYFLPASEEKIICLTRVFE---PFTGLNPVQ 372

  Fly   350 TSSLGQNKWHKALQHFEQVLQPIDERIAAALKRQLHNHLSNPRQVIFIFSKYETLIQRPAVLELL 414
            .:...:..|..|:..:|:::.|.:::||..||..:.....:|:|::..|.||:.|::||.:.:.|
Human   373 YNPYTEPLWKAAVSQYEKIIAPAEQKIAGKLKNYISEIQDSPQQLLQAFLKYKELVKRPTISKEL 437

  Fly   415 TIEREQFLQSLHILLQDLR-------KAMVDSNMEPDTG-HLSVICNECRWLKVVQHQIQEIEKV 471
            .:|||..|..|...::|.|       :.:......|.:| :||.:.|...|::.::.::.:..|:
Human   438 MLERETLLARLVDSIKDFRLDFENRCRGIPGDASGPLSGKNLSEVVNSIVWVRQLELKVDDTIKI 502

  Fly   472 SH-LISGREGFDKINKAVQEIKEETESLLRTNFEIWSGQCSTAVKSGELRLRDDQAVVKFEKEGR 535
            :. |:|...||...:::.:::.::.:...:..|:.||..    ::||   |.|.::.:..|...|
Human   503 AEALLSDLPGFRCFHQSAKDLLDQLKLYEQEQFDDWSRD----IQSG---LSDSRSGLCIEASSR 560

  Fly   536 --------QLMRVTFNPKLVTFCQDVREFENLGYNVPLELRAAATHAAKYMCYARRLQQIATFHN 592
                    .|::|.::.:||...::||:...||:.:|.:::..|..|.|:...|..|:|:|.|:|
Human   561 IMELDSNDGLLKVHYSDRLVILLREVRQLSALGFVIPAKIQQVANIAQKFCKQAIILKQVAHFYN 625

  Fly   593 TIGDRMIPCQRPIMLKNALELQRLVQS--------ETVAWQDESSVQRYVDILQAAVSKLSSDNT 649
            :|..:||..|||:||::||..::::::        ..:.|.:...::.|:..||.|..:|:::|.
Human   626 SIDQQMIQSQRPMMLQSALAFEQIIKNSKAGSGGKSQITWDNPKELEGYIQKLQNAAERLATENR 690

  Fly   650 LLVGYHEQAKRSVLKLMSTDLFTQNQIWKDELRHLRELVATLERQGY--THLDAFKLHWDHQLYK 712
            .|..:|......|:.||:.||..|.|.|||.|:.||..:||:|.||:  :.:.|:|.||:|||||
Human   691 KLRKWHTTFCEKVVVLMNIDLLRQQQRWKDGLQELRTGLATVEAQGFQASDMHAWKQHWNHQLYK 755

  Fly   713 VLEYQYILGLLDMNNKLPDIHVKLVLRQRELVFSPPEEEIRELYFSQLRRFIERPCNFHGLSEHS 777
            .||:||.:||..:|..||:|::.|..:|..|.|.||.||||..|:.:::|||..|..|.|:.|..
Human   756 ALEHQYQMGLEALNENLPEINIDLTYKQGRLQFRPPFEEIRAKYYREMKRFIGIPNQFKGVGEAG 820

  Fly   778 QE-LFKSMVTVNRHHFGPLYQRAAELFDKLQDFKTIWLPWIALGCVDVDQLCGIHLNEAGDWDRN 841
            .| :|..|:..|...|..::.:|.:||.:|.........||.:|.||::.|...||....||::|
Human   821 DESIFSIMIDRNASGFLTIFSKAEDLFRRLSAVLHQHKEWIVIGQVDMEALVEKHLFTVHDWEKN 885

  Fly   842 FRSCKHFSQQLAKLQQAEESIDCIVINVLPLRSDIEYISRRYWESLANSLRTAILTDVSLIQEFL 906
            |::.|...:::.:|..|.: :||:.||..|:::.|:.:.::.::.|..||:.:|...:..|..|:
Human   886 FKALKIKGKEVERLPSAVK-VDCLNINCNPVKTVIDDLIQKLFDLLVLSLKKSIQAHLHEIDTFV 949

  Fly   907 QSALQFLQNVPMDEGSISQSGMKYEKIMSKLPQIEKTLEAVRAKDSCL-----GGWCKERVTALS 966
            ..|::.|..:|.....|..:.::|.|:..:.|:|....:....|:..|     ||     :..:|
Human   950 TEAMEVLTIMPQSVEEIGDANLQYSKLQERKPEILPLFQEAEDKNRLLRTVAGGG-----LETIS 1009

  Fly   967 GILLQWEQLQPLLENHAVILQRQVDMIKNQAETQLQNLKNEAEKFLLRWEST---ISELEANEHS 1028
            .:..:|::.:.::|:|.::::.|::::|...:::||....|.|||..||:..   ...:|..:|:
Human  1010 NLKAKWDKFELMMESHQLMIKDQIEVMKGNVKSRLQIYYQELEKFKARWDQLKPGDDVIETGQHN 1074

  Fly  1029 TLD----VFKERRLHWQQLQEKKTQLLEECSKFNMEFPAEMLTPFTEIEEQMEKQSKQWQVYDSF 1089
            |||    :.||:::.:..|:..:.:|:::|..|.:|.|...|.  :.|.:.:|..::.|..|:.|
Human  1075 TLDKSAKLIKEKKIEFDDLEVTRKKLVDDCHHFRLEEPNFSLA--SSISKDIESCAQIWAFYEEF 1137

  Fly  1090 LTELQPVLHEEWAIYRRRPYVLNEFIGKWEGSV-----HASIDLPSKRIRQQVEQLQSALPILQQ 1149
            ....|.:.:|:|..:|.:.|:..||:..|...:     |:.:.:   :::.:|::.:..:|||:.
Human  1138 QQGFQEMANEDWITFRTKTYLFEEFLMNWHDRLRKVEEHSVMTV---KLQSEVDKYKIVIPILKY 1199

  Fly  1150 LQSESLSERHWARIFQLLNHKETKPLHSILLQDILQDFDVLQSAAQEISSIVRQASSEQIVRQAL 1214
            ::.|.||..||..:|:||.......|..:|..|:|:..|.:.:.|.::..:..:|..|..:|:||
Human  1200 VRGEHLSPDHWLDLFRLLGLPRGTSLEKLLFGDLLRVADTIVAKAADLKDLNSRAQGEVTIREAL 1264

  Fly  1215 IELDQWSVTAQLKLITRTDASGQSVSLIKDYQEVLNKIGDNQSLLQSANNSAAFESFSDQAELWE 1279
            .|||.|.|.|...||...|:..:::.||||:::::|::|||:.||||..:|..::.|.|:..:||
Human  1265 RELDLWGVGAVFTLIDYEDSQSRTMKLIKDWKDIVNQVGDNRCLLQSLKDSPYYKGFEDKVSIWE 1329

  Fly  1280 SRLNTLDALLSSLNHSQRRWVYLEPVFGSGTLQHEQALFKRIDKDFRFVMREIEMDPRVTSLTK- 1343
            .:|..||..|.:|||.||:||||||:||.|.|..||..|.|:|:|||.:|.:|:.|.|||:||.
Human  1330 RKLAELDEYLQNLNHIQRKWVYLEPIFGRGALPKEQTRFNRVDEDFRSIMTDIKKDNRVTTLTTH 1394

  Fly  1344 ---INNITTIVNALETQLARCQQNLMSYITDKRNSFPRFYFLGDDDLLELLGQASKDAEVIQRHI 1405
               .|::.||::    ||.|||::|..::.:||::||||||:|||||||:||| |.:..|||.|:
Human  1395 AGIRNSLLTILD----QLQRCQKSLNEFLEEKRSAFPRFYFIGDDDLLEILGQ-STNPSVIQSHL 1454

  Fly  1406 RKLFPGCHSLSIRQVGPNPATSSDVNQYSITSVHSAEGDELKLSQPVEMKGDIERWLNQLVTVVQ 1470
            :|||.|.:|:..           |.....||::.|.||:.:.....|.:..::|.|||.|...::
Human  1455 KKLFAGINSVCF-----------DEKSKHITAMKSLEGEVVPFKNKVPLSNNVETWLNDLALEMK 1508

  Fly  1471 DTLRDQIYECYTGTTGGSDNLDEKILKKYASQVLATARALHFTRQAEQAIGSMSLGKLKQQLKDE 1535
            .||...:.||.|........:|..:   :.||:|..|..:.||...|.||...||.:::.||.::
Human  1509 KTLEQLLKECVTTGRSSQGAVDPSL---FPSQILCLAEQIKFTEDVENAIKDHSLHQIETQLVNK 1570

  Fly  1536 ITHLAALKNKSEN-----GTLISLKLRALLLDLVHYSGVTEQLQKHNVVHTSDWHWLCQLRYYLG 1595
            :.....:...||:     ..::.|||:||:||::|...|.:||.:..|..|.||.|..|||:|:
Human  1571 LEQYTNIDTSSEDPGNTESGILELKLKALILDIIHNIDVVKQLNQIQVHTTEDWAWKKQLRFYM- 1634

  Fly  1596 KKGGTSGEVNANRQVCVRMVYAEFEYAYEFLGQASKLVHTRLTHRCYLILTQAMHMGLGGNPFGP 1660
                     .::...||:||.:||:|.||:.|.|||||:|.||.:|||.|||||.|||||||:||
Human  1635 ---------KSDHTCCVQMVDSEFQYTYEYQGNASKLVYTPLTDKCYLTLTQAMKMGLGGNPYGP 1690

  Fly  1661 AGTGKTECVKALGAMLGRLVLVFNCDENVDTESMSLILTGLARCGAWGCFDEFNRLQEATLSSIS 1725
            |||||||.|||||.:|||.||||||||.:|.:||..|..||.:|||||||||||||:|:.||::|
Human  1691 AGTGKTESVKALGGLLGRQVLVFNCDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEESVLSAVS 1755

  Fly  1726 MLIQPIQSALKERANSVQIGERQIQLNQHCGIFVTLNPAGAEYGGRQKLPGNIQALFRPIVMQQP 1790
            |.||.||.|||......::..:::::|.:.|||:|:||||..||||||||.|::.||||:.|..|
Human  1756 MQIQTIQDALKNHRTVCELLGKEVEVNSNSGIFITMNPAGKGYGGRQKLPDNLKQLFRPVAMSHP 1820

  Fly  1791 EPGEIARVMLFVEGFTEASAIASRIVELFELSGKMLSAQRHYDWGLRELKTVLMVCGEGLRDQLT 1855
            :...||.|:|:.|||.:|..::.::|.:|.||.::|:.|:|||||||.|||||...|..|| ||.
Human  1821 DNELIAEVILYSEGFKDAKVLSRKLVAIFNLSRELLTPQQHYDWGLRALKTVLRGSGNLLR-QLN 1884

  Fly  1856 SEDNNQSSANFEMSVVVRCLRSSTMSKLAPHDVNRFEMLLRNVFPEIGSSPAPETQLHQSLSAAF 1920
            .....| :|| |..:||:.||.:||||....|..||:.|:::|||.|........:|..:|...|
Human  1885 KSGTTQ-NAN-ESHIVVQALRLNTMSKFTFTDCTRFDALIKDVFPGIELKEVEYDELSAALKQVF 1947

  Fly  1921 AQLGLCRSERQIEKALQLHEQLQKRMGVVLVGPPGCGKSTIISLLKQALC--GTQLKVHTISPKS 1983
            .:........||:|||:|:|||.:|||||:|||.|.||||:..:|:.|||  |..:|.:|::||:
Human  1948 EEANYEIIPNQIKKALELYEQLCQRMGVVIVGPSGAGKSTLWRMLRAALCKTGKVVKQYTMNPKA 2012

  Fly  1984 MSRIQLLGRLDADTRQWQDGVLTHTAVAVNQESSQVHSWIVCDGSIDPEWIEALNSVLDDNKLLT 2048
            |.|.||||.:|.|||:|.|||||::|..|.:|...|.|||:|||.|||||||:||||||||:|||
Human  2013 MPRYQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSWIICDGDIDPEWIESLNSVLDDNRLLT 2077

  Fly  2049 LPSGWRIQFGSNVNFIFETDDVRHASPATISRMGIVNMSYDYYPADGILKHELSKEP--YGDLLQ 2111
            :|||.|||||.||||:|||.|:..||||||||||::.:|.:....:.::|..|..:|  |.:.|:
Human  2078 MPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLSDEETDLNSLIKSWLRNQPAEYRNNLE 2142

  Fly  2112 SYVDGNFQYAVNW--------IESQLLLTHLPGINRAHLLRSLLLQLHGTQSLEEYGAATLRALF 2168
            :::...|:.|:.|        :|:.|:.|.:.|::          .|||.:..:|:....:|.|.
Human  2143 NWIGDYFEKALQWVLKQNDYVVETSLVGTVMNGLS----------HLHGCRDHDEFIINLIRGLG 2197

  Fly  2169 GYMPNDRQREFAQLILKHANLYVANPNYAEL--THYESSRNSLEQYAVDAIETPE--------KG 2223
            |.:....:.||.:.:...|.  .:.|::.:.  |:|:|:|..|..|   .::.||        .|
Human  2198 GNLNMKSRLEFTKEVFHWAR--ESPPDFHKPMDTYYDSTRGRLATY---VLKKPEDLTADDFSNG 2257

  Fly  2224 SQL--IITSYMKSYLDILETLLKTQGTRLPPFMLIGPSGSGKTLLLQRAVLENSGYQLATINCST 2286
            ..|  |.|..|:..||..:..|.:...:  ||:|:||.|.||.:||:.|..:....|:||::||.
Human  2258 LTLPVIQTPDMQRGLDYFKPWLSSDTKQ--PFILVGPEGCGKGMLLRYAFSQLRSTQIATVHCSA 2320

  Fly  2287 QLTPRYILHTLKTHCVTVSGIKGREYRPKQA-RLVLFMKNLDLCQQDSWGACEVVELLFQLAQRG 2350
            |.|.|::|..|...|:.:|...||.||||.. ||||::|:::|.:.|.||...:|..|.|:....
Human  2321 QTTSRHLLQKLSQTCMVISTNTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTLVAFLQQVLTYQ 2385

  Fly  2351 GFYAENLEWIGVSGLQLCASI--GGNTG--KIAPRYFAINQFVRVSRPTSQDMLEIVQRRLEPLL 2411
            |||.|||||:|:..:|:.||:  ||..|  |:..|:.:|.:...:..|..:.:..|....|||:|
Human  2386 GFYDENLEWVGLENIQIVASMSAGGRLGRHKLTTRFTSIVRLCSIDYPEREQLQTIYGAYLEPVL 2450

  Fly  2412 EEHFRGSENRGRSGVNLQHVSESLMDCFEKLQATFTNVGGRQAHYQFSPKCIMKLLDALVF---- 2472
            .::.:.....|.|. .:..::.|::..:|:::|.||  ....:||.|:| ||:......:|
Human  2451 HKNLKNHSIWGSSS-KIYLLAGSMVQVYEQVRAKFT--VDDYSHYFFTP-CILTQWVLGLFRYDL 2511

  Fly  2473 ------YPASDFNEALYCELLGMFRDRLISEEHVQQFEGILKQTMRKYYGKEKV------FFV-- 2523
                  :|.....|.:..|...:|||:::..:.:..|:.||....:..:|.:.:      |:|
Human  2512 EGGSSNHPLDYVLEIVAYEARRLFRDKIVGAKELHLFDIILTSVFQGDWGSDILDNMSDSFYVTW 2576

  Fly  2524 --------------PKSPKSRGHLHCLTHDEWMEEVQRQVTICNTENYSITAPITEELLSHVARI 2574
                          |..|..: .|..|...:..:.:::.:.....:|.::...:..|:|.:::||
Human  2577 GARHNSGARAAPGQPLPPHGK-PLGKLNSTDLKDVIKKGLIHYGRDNQNLDILLFHEVLEYMSRI 2640

  Fly  2575 TRVLSRTDAHMLILGQSG-GRH----LDAIFTAATFQEAKVVTLQGGPSYDLTDFYNDLKVAMQT 2634
            .||||.....:|:.|:|| ||.    |.:....|.....|:     ...|:|..|.||||..:|.
Human  2641 DRVLSFPGGSLLLAGRSGVGRRTITSLVSHMHGAVLFSPKI-----SRGYELKQFKNDLKHVLQL 2700

  Fly  2635 AALEQQMSYLLIEQCWLSYVPDILKPIEALLEGSEILELFG-DDLETVASTLKQAAQLEGYQESM 2698
            |.:|.|...||:|.....: |..|:.|.:||...|:..|:. ::||.:...||..|..:|:...:
Human  2701 AGIEAQQVVLLLEDYQFVH-PTFLEMINSLLSSGEVPGLYTLEELEPLLLPLKDQASQDGFFGPV 2764

  Fly  2699 GTYFLKRARDYLHIIIVLDPNSAKVQDYFNNFPALHRQMDLLYVRGESRETIAILPKQFIELLNE 2763
            ..||..|.:..|||::::|..::.......:.||||::..:|::.|.|..::..:|:.   |.:|
Human  2765 FNYFTYRIQQNLHIVLIMDSANSNFMINCESNPALHKKCQVLWMEGWSNSSMKKIPEM---LFSE 2826

  Fly  2764 SIAGGGSGRGKVPTCSHFADISDELPSEE--------------------------TSQRYYQLIR 2802
            :  |||.            ..:|:...||                          |..||...:.
Human  2827 T--GGGE------------KYNDKKRKEEKKKNSVDPDFLKSFLLIHESCKAYGATPSRYMTFLH 2877

  Fly  2803 TYFHMYNNAANEIDQRLGKLQMGVDKLASAHALVDTLKSNAAAQEQALGEKRQLANEALEMISFT 2867
            .|..:.::...|:.:|...||.||.||..|.||||.|...|..|...|..|:..|:.||:||:.:
Human  2878 VYSAISSSKKKELLKRQSHLQAGVSKLNEAKALVDELNRKAGEQSVLLKTKQDEADAALQMITVS 2942

  Fly  2868 MRNANEQKSSMLELKQQTQKSSEQLKIRQKEIQQELAEVEPILAEASNAVGQIKSEALSEIRSLR 2932
            |::|:|||:.:..||.:..:...:::.|:.:|..||.||:|::.||..|||.||.|:||||||||
Human  2943 MQDASEQKTELERLKHRIAEEVVKIEERKNKIDDELKEVQPLVNEAKLAVGNIKPESLSEIRSLR 3007

  Fly  2933 APPEAVRDILEGVLRLMGIRDTSWNSMKTFLAKRGVKEDIRSLDPARISPENCEAVERLLLAKGD 2997
            .||:.:|||||||||||||.||||.|||:|||||||:|||.:.|...||.|..|:||.||.....
Human  3008 MPPDVIRDILEGVLRLMGIFDTSWVSMKSFLAKRGVREDIATFDARNISKEIRESVEELLFKNKG 3072

  Fly  2998 SYEAKNAKRASAAAAPLAAWVQASVRYSRVIQSIKPLEREQNELQKNLNAAEDEMQELASGLDDV 3062
            |::.|||||||.|||||||||:|:::||.|::.|.|||.||..|:.||...||..::|...|:.|
Human  3073 SFDPKNAKRASTAAAPLAAWVKANIQYSHVLERIHPLETEQAGLESNLKKTEDRKRKLEELLNSV 3137

  Fly  3063 DKRVKQLSAKLQTYTQEAAVLELKLQEASGTLQAAELLVEKLSAEYTTWSLQLTELKKAHKTLDA 3127
            .::|.:|..|.|:.|.|||.||.::.:|..|::|||:|:.:|..|:..|:.|:.|:.:...||..
Human  3138 GQKVSELKEKFQSRTSEAAKLEAEVSKAQETIKAAEVLINQLDREHKRWNAQVVEITEELATLPK 3202

  Fly  3128 KTLLIAIAINYCAGLGLEQRCSSLKRLAADFHLPSDFDLRGSLLTEQQQIIWESQGLARDAQIIE 3192
            :..|.|..|.|.:......|.:.|:.......| ..||||..|.||.:|:||:|:||..|...||
Human  3203 RAQLAAAFITYLSAAPESLRKTCLEEWTKSAGL-EKFDLRRFLCTESEQLIWKSEGLPSDDLSIE 3266

  Fly  3193 SAALLREMLSLPYGACPIPLLLDPTQTAAAWLMAHLKGSGRPCELTTHGNDRLPYQLELAVRFGK 3257
            :|.::.:::.|...:...|.|:||:..|..||..|||.|  ..|:....:......|||||||||
Human  3267 NALVILQIIGLKSWSRVCPFLIDPSSQATEWLKTHLKDS--RLEVINQQDSNFITALELAVRFGK 3329

  Fly  3258 TLLVTDCEQLRPPVLQLLQGHVFVRFNKRQLAIGSKLVDLHESFQLVLISKSHRLDLPEEQRSQL 3322
            ||::.:.:.:.|.:..||:..:..:..:..:.||.|::|.:|.|:|.|.:::....:|.:..|.:
Human  3330 TLIIQEMDGVEPVLYPLLRRDLVAQGPRYVVQIGDKIIDYNEEFRLFLSTRNPNPFIPPDAASIV 3394

  Fly  3323 NVLKFTVTAAGLADQLMSKAIVLKNGELEQQRIELLQKEGHLLKQRMEMQDKLLEQLSKSEGDIL 3387
            ..:.||.|.:||..||::..|..:..:||:|:.:|||:|.....|..::::.|||.|:.|:|:||
Human  3395 TEVNFTTTRSGLRGQLLALTIQHEKPDLEEQKTKLLQQEEDKKIQLAKLEESLLETLATSQGNIL 3459

  Fly  3388 KNEQLLESLNEIKQGSTQIDEALKQSGQIRDTLLAQFGSLRELSSRAATFY------AGLIQGYE 3446
            :|:.|:||||:.|..|..|.|:||:|.:::.:|..:..:...|:..|:..|      :.:...|.
Human  3460 ENKDLIESLNQTKASSALIQESLKESYKLQISLDQERDAYLPLAESASKMYFIISDLSKINNMYR 3524

  Fly  3447 LSPLVYIELFLGALSKSQRDES------KVYDCLVRSVYMNLARATSRDSQLSLSLWVCHQAYPD 3505
            .|...::.||..||...|..|:      .:...|...||..:.|...:..||..:|......:|:
Human  3525 FSLAAFLRLFQRALQNKQDSENTEQRIQSLISSLQHMVYEYICRCLFKADQLMFALHFVRGMHPE 3589

  Fly  3506 RLNPKEWELF----VNNFMGSSDGSMVLSQLGKLPDCMPKEAQLKLAMLLQLFPDLRSKLQLEKD 3566
            .....||:.|    |.:.:..:|....:..  :||..:.:|....:|.|....|.|...|..|..
Human  3590 LFQENEWDTFTGVVVGDMLRKADSQQKIRD--QLPSWIDQERSWAVATLKIALPSLYQTLCFEDA 3652

  Fly  3567 YIWRGF-----IEAQADDVLPALGSSFQRVLIAQIFRPDLMLHQLRKVSSDLLGISPDASTQPSV 3626
            .:||.:     .|.:...:|....|.||::|:.|..|||.:...:...:...||:...:....::
Human  3653 ALWRTYYNNSMCEQEFPSILAKKVSLFQQILVVQALRPDRLQSAMALFACKTLGLKEVSPLPLNL 3717

  Fly  3627 EQLLQQSSCDRPILMVSHAENDPTTELRKWANQK-----YREMAIGKGVEKRVLSEMRQAAIDGH 3686
            ::|.:::....|||::.....||:.||::.||.:     |.::|:|:|.....:..:::.|.:|.
Human  3718 KRLYKETLEIEPILIIISPGADPSQELQELANAERSGECYHQVAMGQGQADLAIQMLKECARNGD 3782

  Fly  3687 WLCVKNVHLVPEFLTQMERELSEIQKSKDFRLWLLCESTEGFSEAAIYKCLKVRYEQPKGLKQIV 3751
            |||:||:|||..:|..:|:||:.:|....|||||..|....|:...:...||:.||.|.|||:.:
Human  3783 WLCLKNLHLVVSWLPVLEKELNTLQPKDTFRLWLTAEVHPNFTPILLQSSLKITYESPPGLKKNL 3847

  Fly  3752 MRLLQNFAAEQDQKLKNQPKSLKM-RLVYFVLTAVLQQRRQFIPQGWSKYYEFGEADLKAALGIL 3815
            ||..:::..||..|..|..::..: .|.:|  .|..|:||.:|||||:|:|||..:||:|...|:
Human  3848 MRTYESWTPEQISKKDNTHRAHALFSLAWF--HAACQERRNYIPQGWTKFYEFSLSDLRAGYNII 3910

  Fly  3816 -RMMDQQLNSGKCDWLLMQRLSEALAYGGRVNNQRDLEILTTYLNQFCSADVLS-----NRWSPL 3874
             |:.|   .:....|..:..|.|...||||::|..||.:|.:||.||.::.|:.     |:.|..
Human  3911 DRLFD---GAKDVQWEFVHGLLENAIYGGRIDNYFDLRVLQSYLKQFFNSSVIDVFNQRNKKSIF 3972

  Fly  3875 GLSLSIPTSGQLQDYYAALEKLPDTDEPSMYGL-ANQAQ-QQREIEQAKRVIKELRGLHYGRGLA 3937
            ..|:|:|.|..:.||.|.:||:|:.|:||.:|| ||.|: .||.|  :.:||.:||.|  ||.:.
Human  3973 PYSVSLPQSCSILDYRAVIEKIPEDDKPSFFGLPANIARSSQRMI--SSQVISQLRIL--GRSIT 4033

  Fly  3938 KDSGGAGESKGNDQLTGRQKLEQQIKPLLNLWRKLAASCTIIQTMKEAKTDVGESPWALFVLAEL 4002
                 || ||.:     |:....::.|:||||:||..:..:|........|...||...|::.|.
Human  4034 -----AG-SKFD-----REIWSNELSPVLNLWKKLNQNSNLIHQKVPPPNDRQGSPILSFIILEQ 4087

  Fly  4003 KLGADLYGIVHQTLSQMHAWLKESQEVDGSTL---------RTLAEQQIPASWLKLWPGPGSNSA 4058
            .....|...|||:|:.:      |:.:.|:||         ..|..|:.|.:|...|.||  ...
Human  4088 FNAIRLVQSVHQSLAAL------SKVIRGTTLLSSEVQKLASALLNQKCPLAWQSKWEGP--EDP 4144

  Fly  4059 VDFLRALIVRAQAAEL---RFREQMHLDFVEDINFVQVFNCENLLSCLKLLQSRKLAVSTERLEL 4120
            :.:||.|:.||.|.:.   :..:|..|.  |.::..::|:.:..|:.|:...:|.:..|.:.|:.
Human  4145 LQYLRGLVARALAIQNWVDKAEKQALLS--ETLDLSELFHPDTFLNALRQETARAVGRSVDSLKF 4207

  Fly  4121 QTCGSSNLESDSSDIILKLAPLKIDGAQSGMGKSNPFYIKYKIKDEVQNVSHTTTSSSKYGKNSL 4185
            .......|:  .:.:.:|::.|.::|.                          :...::..:|.|
Human  4208 VASWKGRLQ--EAKLQIKISGLLLEGC--------------------------SFDGNQLSENQL 4244

  Fly  4186 YSTQNAESKP--------------------KLPLYSRSSRDKLICHLNVDI-VTGTAEQILLAGT 4229
            .|...:...|                    .||:|:.:.||:::  .|:|: ..|..:|.:..|.
Human  4245 DSPSVSSVLPCFMGWIPQDACGPYSPDECISLPVYTSAERDRVV--TNIDVPCGGNQDQWIQCGA 4307

  Fly  4230 ALIVED 4235
            ||.:::
Human  4308 ALFLKN 4313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btv	NP_001036369.3	DHC_N1	200..618	CDD:285571	120/448 (27%)
		DHC_N2	1072..1481	CDD:285579	150/417 (36%)
		P-loop_NTPase	1621..1847	CDD:304359	133/225 (59%)
		P-loop_NTPase	1919..>1967	CDD:304359	24/47 (51%)
		P-loop_NTPase	1947..2081	CDD:304359	87/135 (64%)
		P-loop_NTPase	2565..>2733	CDD:304359	52/173 (30%)
		MT	2821..3138	CDD:289543	153/316 (48%)
		AAA_9	3179..3401	CDD:289547	75/221 (34%)
		Dynein_heavy	3536..>4051	CDD:281078	170/542 (31%)
DYNC2H1	NP_001073932.1	Stem. /evidence=ECO:0000250	1..1650		506/1713 (30%)
		DHC_N1	162..639	CDD:285571	124/495 (25%)
		DHC_N2	1120..1519	CDD:285579	150/417 (36%)
		P-loop_NTPase	1651..1881	CDD:304359	134/229 (59%)
		AAA 1. /evidence=ECO:0000250	1651..1875		133/223 (60%)
		P-loop_NTPase	<1937..>1988	CDD:304359	24/50 (48%)
		AAA 2. /evidence=ECO:0000250	1938..2161		113/222 (51%)
		AAA_5	1974..2110	CDD:285029	87/135 (64%)
		AAA 3. /evidence=ECO:0000250	2251..2505		86/259 (33%)
		P-loop_NTPase	2285..2494	CDD:304359	74/213 (35%)
		AAA 4. /evidence=ECO:0000250	2617..2863		68/268 (25%)
		P-loop_NTPase	2618..>2829	CDD:304359	62/221 (28%)
		Stalk. /evidence=ECO:0000250	2881..3169		140/287 (49%)
		MT	2897..3229	CDD:289543	156/331 (47%)
		AAA_9	3253..3474	CDD:289547	76/222 (34%)
		Dynein_heavy	3622..4303	CDD:281078	205/740 (28%)
		AAA 6. /evidence=ECO:0000250	3697..3912		71/216 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143505
Domainoid	1	1.000	354	1.000	Domainoid score	I1005
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2204	1.000	Inparanoid score	I42
Isobase	1	0.950	-	0	Normalized mean entropy	S4368
OMA	1	1.010	-	-		QHG56373
OrthoDB	1	1.010	-	-		D26380at2759
OrthoFinder	1	1.000	-	-		FOG0006067
OrthoInspector	1	1.000	-	-		oto90478
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	1	1.100	-	-	LDO	PTHR10676
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2498
SonicParanoid	1	1.000	-	-		X4363
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.890