DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btv and Dync2h1

DIOPT Version :9

Sequence 1:	NP_001036369.3	Gene:	btv / 35073	FlyBaseID:	FBgn0023096	Length:	4236	Species:	Drosophila melanogaster
Sequence 2:	NP_075413.2	Gene:	Dync2h1 / 65209	RGDID:	71042	Length:	4306	Species:	Rattus norvegicus

Alignment Length:	4491	Identity:	1453/4491 - (32%)
Similarity:	2372/4491 - (52%)	Gaps:	453/4491 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RTKFIINTSVEYFSARLPGSELDEQTAM-----ILEFLEQEELTVISAVHSRSDGRIRFHHRI-- 61
            |..|:..|:..||..|   .||.:||.:     :..||:.....::..  .|||..:.|.:.|
  Rat     9 RKLFLFTTTQNYFGLR---PELWDQTPLSNCPEVNNFLDDGNQMLLRV--QRSDAGLAFSNTIDF 68

  Fly    62 -PNEELCLLFYKV-PQVGHHRKEDGS--EPLLGILTLEGGMVKSIYNSVSRVFSP--------SA 114
             ..::..|:|:|: |:|    ..||:  ..:|....|| ..:.|:|.:|.:||:|        |.
  Rat    69 DDTKDKVLVFFKLRPEV----ITDGNLHTNILVSSMLE-SPINSLYQAVRQVFAPMLLKDQEWSR 128

  Fly   115 NSARRSEYGPELSGILENLHQNLG-----SSLGLPQ--------SGITSLRNEIKYWQQKLGQKS 166
            |      :.|:|..:|..|...||     |...||:        .||.:..:|.::|.:: ..:.
  Rat   129 N------FDPKLQNLLSELEAGLGVVLRKSDTNLPKLKLKEDDTRGILTPSDEFQFWIEQ-AHRG 186

  Fly   167 SSRLDREAAQVFIGVLENMEKQISTIDGANPSGTIEEFLDHAHTN---LDELWRLPY--NYPQQR 226
            |.::.:|.|..|..:.|.:.::...:|    |.::.|.:|...|.   :|::||...  :||:.|
  Rat   187 SKQISKERASYFKELFETIAREFYNLD----SLSLLEVVDLVETTRDVVDDVWRQTEHDHYPESR 247

  Fly   227 MADLLDIIG---KRLLEVCLTQL-LAEDVWSLNSSHVNNLMSQSIDTVDAWIQLCDSLTRLFWPN 287
            |..|||:||   .|.::..|..| |.||.:.|    |...:...|...:.|:.:|..||...|..
  Rat   248 MLHLLDVIGGSFGRFVQKKLGSLKLWEDPYYL----VKENLKAGISICEQWVIVCSHLTGQVWQR 308

  Fly   288 YVKHPWLGDSHVPKRGQQFKERLSEIRSIKQLYKQIATLLEDTE-----LQEMFQEQAPFTEFNI 347
            ||.|||..:.:.|:...:..:||.|:.:|:.:::::...|..:|     |..:|:   |||..|.
  Rat   309 YVPHPWKSEKYFPETLDRLGKRLEEVLAIRTIHEKLLYFLPASEERIVCLSRVFE---PFTGVNP 370

  Fly   348 FDTSSLGQNKWHKALQHFEQVLQPIDERIAAALKRQLHNHLSNPRQVIFIFSKYETLIQRPAVLE 412
            ...:...:..|..|:..:|:::.|.:::||..||..:.....:|:|::..|.||:.|::||.:.:
  Rat   371 VQYNPYTEPLWKAAVSQYEKIIAPAEQKIAGKLKNYISEIQDSPQQLLQAFLKYKELVKRPTISK 435

  Fly   413 LLTIEREQFLQSLHILLQDLR-------KAMVDSNMEPDTG-HLSVICNECRWLKVVQHQIQEIE 469
            .|.:|||..|..|....:|.|       :.:......|.:| :||.:.|...|::.::.::.:..
  Rat   436 ELMLERETLLARLGDSAKDFRLDFENRCRGIPGDASGPLSGKNLSEVVNNIVWVRQLELKVDDTI 500

  Fly   470 KVSH-LISGREGFDKINKAVQEIKEETESLLRTNFEIWSGQCSTAVKSGELRLRDDQAVVKFEKE 533
            |::. |:|...||...:::.:::.::.:...:..|:.||.:    |:||   |.|.::.:..|..
  Rat   501 KIAEALLSDLSGFRSFHRSAEDLLDQFKLYEQEQFDDWSRE----VQSG---LSDSRSGLCIEAN 558

  Fly   534 GRQL--------MRVTFNPKLVTFCQDVREFENLGYNVPLELRAAATHAAKYMCYARRLQQIATF 590
            .|.:        ::|.::.:||...::||:...||:.:|.:::..|..|.|:...|..|:|:|.|
  Rat   559 SRIMELDPNDGALKVHYSDRLVILLREVRQLSALGFVIPAKIQQVANVAQKFCKQAIILKQVAHF 623

  Fly   591 HNTIGDRMIPCQRPIMLKNALELQRLVQS--------ETVAWQDESSVQRYVDILQAAVSKLSSD 647
            :|:|..:||..|||:||::||..::::::        ..:.|.:...::.|:..||.|..:|:::
  Rat   624 YNSIDQQMIQSQRPMMLQSALAFEQIIKNSKAGSGGKSQITWDNPKELEGYIQKLQNAAERLATE 688

  Fly   648 NTLLVGYHEQAKRSVLKLMSTDLFTQNQIWKDELRHLRELVATLERQGYTHLD--AFKLHWDHQL 710
            |..|..:|......|:.||:.||..|.|.|||.|:.||..:|::..||:...|  |::.||:|||
  Rat   689 NRRLRKWHTTFCEKVVILMNIDLLRQQQRWKDGLQELRTGLASVAAQGFQPSDMRAWRQHWNHQL 753

  Fly   711 YKVLEYQYILGLLDMNNKLPDIHVKLVLRQRELVFSPPEEEIRELYFSQLRRFIERPCNFHGLSE 775
            ||.||:||.:||..:|..||:|:|.|..:|..|.|.||.||||..|:.:::|||..|..|.|:.|
  Rat   754 YKALEHQYQMGLEALNENLPEINVDLTYKQGRLQFRPPFEEIRAKYYREMKRFIGIPNQFKGVGE 818

  Fly   776 HSQE-LFKSMVTVNRHHFGPLYQRAAELFDKLQDFKTIWLPWIALGCVDVDQLCGIHLNEAGDWD 839
            ...| :|..|:..|...|..:|.:|.:||.:|.........|:.:|.||::.|...:|:...||:
  Rat   819 AGDESIFSVMIDRNASGFLTIYSKAEDLFRRLSAVLHQHKEWVVIGQVDMEALVEKNLSTVHDWE 883

  Fly   840 RNFRSCKHFSQQLAKLQQAEESIDCIVINVLPLRSDIEYISRRYWESLANSLRTAILTDVSLIQE 904
            :||::.|...:::.:|..|.: :||:.||..|:::.|:.:.::.::.|..||:.:|.|.:..|..
  Rat   884 KNFKALKIKGKEVERLPSAVK-VDCLNINCSPVKTVIDDLIQKLFDLLVLSLKKSIQTHIHEIDT 947

  Fly   905 FLQSALQFLQNVPMDEGSISQSGMKYEKIMSKLPQIEKTLEAVRAKDSCL-----GGWCKERVTA 964
            |:..|::.|..:|.....|..:.::|..:..:.|:|....:....|:..|     ||     |..
  Rat   948 FVTEAMKVLTVIPQSVEEIGDTNLQYSNLQDRRPEILPLFQEAEDKNRLLRTVAGGG-----VET 1007

  Fly   965 LSGILLQWEQLQPLLENHAVILQRQVDMIKNQAETQLQNLKNEAEKFLLRWEST---ISELEANE 1026
            :|.:..:|::.:.::|:|.::::.|::::|...:::||....|.:||..||:..   ...:|..:
  Rat  1008 VSNLRAKWDKFELMMESHQLMIKDQIEVMKGNVKSRLQIYYQELDKFKARWDQLKPGDDIIETGQ 1072

  Fly  1027 HSTLD----VFKERRLHWQQLQEKKTQLLEECSKFNMEFPAEMLTPFTEIEEQMEKQSKQWQVYD 1087
            .:|:|    ..||:::.:..|:..:.:|:::|..|.:|.|...|.  ..|.:.:|..::.|.:|:
  Rat  1073 QNTMDQSAKSIKEKKIEFDDLEVIRKKLVDDCHHFGLEEPNFSLA--YSISKDIESCAQIWALYE 1135

  Fly  1088 SFLTELQPVLHEEWAIYRRRPYVLNEFIGKWEGSV-----HASIDLPSKRIRQQVEQLQSALPIL 1147
            .|...||.:..|:|..||.:.|:..||:..|...:     |:.:.:   :::.:|::.:..:|||
  Rat  1136 EFQQGLQEMAKEDWITYRTKIYIFEEFLINWHERLRKVEEHSVMTV---KLQSEVDRYKIIIPIL 1197

  Fly  1148 QQLQSESLSERHWARIFQLLNHKETKPLHSILLQDILQDFDVLQSAAQEISSIVRQASSEQIVRQ 1212
            :.::.|.||..||..:|:||.......|..:|..|:|:..|.:...|.::..:..:|..|..:|:
  Rat  1198 KYVRGEHLSPDHWLDLFRLLGLPRGTSLEKLLFGDLLRVADTIVEKASDLKDLNSRAQGEVTIRE 1262

  Fly  1213 ALIELDQWSVTAQLKLITRTDASGQSVSLIKDYQEVLNKIGDNQSLLQSANNSAAFESFSDQAEL 1277
            ||.|||.|.|.|...||...|:..:::.||||:::::|::|||:.||||..:|..::.|.|:..:
  Rat  1263 ALRELDLWGVGAVFSLIDYEDSQNRTIKLIKDWKDIVNQVGDNRCLLQSLKDSPYYKGFEDKVSI 1327

  Fly  1278 WESRLNTLDALLSSLNHSQRRWVYLEPVFGSGTLQHEQALFKRIDKDFRFVMREIEMDPRVTSLT 1342
            ||.:|..||..|.:|||.||:||||||:||.|.|..||..|.::|:|||.:|.:|..|.|||:||
  Rat  1328 WERKLAQLDEYLQNLNHIQRKWVYLEPIFGRGALPKEQTRFNKVDEDFRSIMMDIRKDSRVTTLT 1392

  Fly  1343 KINNITTIVNALETQLARCQQNLMSYITDKRNSFPRFYFLGDDDLLELLGQASKDAEVIQRHIRK 1407
            ....|...:..:..||.|||::|..::.:||::||||||:|||||||:||| |.:..|||.|::|
  Rat  1393 THAGIRNTLLTILDQLQRCQKSLNEFLEEKRSAFPRFYFIGDDDLLEILGQ-STNPSVIQSHLKK 1456

  Fly  1408 LFPGCHSLSIRQVGPNPATSSDVNQYSITSVHSAEGDELKLSQPVEMKGDIERWLNQLVTVVQDT 1472
            ||.|.:|:..           |.....||::.|.||:.:.....|.:..::|.|||.|...::.|
  Rat  1457 LFAGINSVCF-----------DEESKHITAMRSLEGEVVPFKSKVLLSNNVEAWLNDLALEMKQT 1510

  Fly  1473 LRDQIYECYTGTTGGSDNLDEKILKKYASQVLATARALHFTRQAEQAIGSMSLGKLKQQLKDEIT 1537
            |:..:.||.|........:|..:   :.||:|..|..:.||...|.||...||.:::.||..::.
  Rat  1511 LKQLLKECVTAGRSSQGAIDPSL---FPSQILCLAEQIKFTEDVEDAIRDHSLHQIEAQLAAKLE 1572

  Fly  1538 HLAALKNKSEN-----GTLISLKLRALLLDLVHYSGVTEQLQKHNVVHTSDWHWLCQLRYYLGKK 1597
            ...::...||:     ..::.|||:||:||::|...:.:||.:..|..|.||.|..|:|:|:
  Rat  1573 RYTSVDTSSEDPGNSESGILELKLKALILDIIHNIDIVKQLNQAQVHTTDDWAWKKQVRFYM--- 1634

  Fly  1598 GGTSGEVNANRQVCVRMVYAEFEYAYEFLGQASKLVHTRLTHRCYLILTQAMHMGLGGNPFGPAG 1662
                   .::....|:||.:|.:|.||:.|.|.|||:|.||.:|||.|||||.|||||||:||||
  Rat  1635 -------KSDHTCYVQMVDSELQYTYEYQGNAPKLVYTPLTDKCYLTLTQAMKMGLGGNPYGPAG 1692

  Fly  1663 TGKTECVKALGAMLGRLVLVFNCDENVDTESMSLILTGLARCGAWGCFDEFNRLQEATLSSISML 1727
            |||||.|||||.:|||.||||||||.:|.:||..|..||.:|||||||||||||:||.||::||.
  Rat  1693 TGKTESVKALGGLLGRQVLVFNCDEGIDVKSMGRIFVGLVKCGAWGCFDEFNRLEEAVLSAVSMQ 1757

  Fly  1728 IQPIQSALKERANSVQIGERQIQLNQHCGIFVTLNPAGAEYGGRQKLPGNIQALFRPIVMQQPEP 1792
            ||.||.|||...:..::..:::::|.:.|||:|:||||..||||||||.|::.||||:.|.:|:.
  Rat  1758 IQTIQDALKNHRSVCELLGKEVEINANSGIFITMNPAGKGYGGRQKLPDNLKQLFRPVAMSRPDN 1822

  Fly  1793 GEIARVMLFVEGFTEASAIASRIVELFELSGKMLSAQRHYDWGLRELKTVLMVCGEGLRDQL--- 1854
            ..||.|:|:.|||.:|..:..::|.:|.||.::|:.|:|||||||.|||||...|..|| ||
  Rat  1823 DLIAEVILYSEGFKDAKELGRKLVAIFNLSRELLTPQQHYDWGLRALKTVLRGSGNLLR-QLKKS 1886

  Fly  1855 -TSEDNNQSSANFEMSVVVRCLRSSTMSKLAPHDVNRFEMLLRNVFPEIGSSPAPETQLHQSLSA 1918
             |.:|.|      |..:||:.||.:||||....|..||:.|:::|||.|........:|..:|..
  Rat  1887 GTKQDVN------ENHIVVQALRLNTMSKFTFADCTRFDALIKDVFPGIDFKEVEYNELSSALKQ 1945

  Fly  1919 AFAQLGLCRSERQIEKALQLHEQLQKRMGVVLVGPPGCGKSTIISLLKQALC--GTQLKVHTISP 1981
            .|.:........|::|||:|:|||::|.|||:|||.|.||||:..:|:.|||  |..:|.:|::|
  Rat  1946 VFEEANYEVIPNQMKKALELYEQLRQRTGVVIVGPSGAGKSTLWRMLRAALCKIGKVVKQYTMNP 2010

  Fly  1982 KSMSRIQLLGRLDADTRQWQDGVLTHTAVAVNQESSQVHSWIVCDGSIDPEWIEALNSVLDDNKL 2046
            |:|.|.||||.:|.|||:|.|||||::|..|.:|...|.|||:|||.|||||||:||||||||:|
  Rat  2011 KAMPRHQLLGHIDMDTREWSDGVLTNSARQVVREPQDVSSWIICDGDIDPEWIESLNSVLDDNRL 2075

  Fly  2047 LTLPSGWRIQFGSNVNFIFETDDVRHASPATISRMGIVNMSYDYYPADGILKHELSKEP--YGDL 2109
            ||:|||.|||||.||||:|||.|:..||||||||||::.:|.:....:.::|..|..:|  |...
  Rat  2076 LTMPSGERIQFGPNVNFVFETHDLSCASPATISRMGMIFLSDEETDLNSLIKSWLRNQPVEYRSN 2140

  Fly  2110 LQSYVDGNFQYAVNW--------IESQLLLTHLPGINRAHLLRSLLLQLHGTQSLEEYGAATLRA 2166
            |::::...|..|:.|        :|:.|:.|.:.|::          .|||.:..:::....:|.
  Rat  2141 LENWIGDYFSKALQWVLKQNDYVVETSLVGTVMNGLS----------HLHGCKYHDQFIINLIRG 2195

  Fly  2167 LFGYMPNDRQREFAQLILKHANLYVANPNYAELTHYESSRNSLEQYAVDAIETPE--------KG 2223
            |.|.:....:.||.:.:...|.....:.:....|:::..|..|..|   .::.||        .|
  Rat  2196 LGGNLNMKSRLEFTKEVFNWARETPPDSHRPMDTYFDCDRGQLASY---VLKKPESLTADDFSSG 2257

  Fly  2224 SQL--IITSYMKSYLDILETLLKTQGTRLPPFMLIGPSGSGKTLLLQRAVLENSGYQLATINCST 2286
            ..|  |.|..|:..||..:..|.::..:  ||:|:||.|.||.:||:.|..:....::|||:||.
  Rat  2258 HSLPVIQTPDMQRGLDYFKPWLSSETKQ--PFILVGPEGCGKGMLLRYAFSQLRSTEIATIHCSA 2320

  Fly  2287 QLTPRYILHTLKTHCVTVSGIKGREYRPKQA-RLVLFMKNLDLCQQDSWGACEVVELLFQLAQRG 2350
            |.|.|::|..|...|:.:|...||.||||.. ||||::|:::|.:.|.||...:|..|.|:....
  Rat  2321 QTTSRHLLQKLSQTCMVISTNTGRVYRPKDCERLVLYLKDINLPKLDKWGTSTLVAFLQQVLTYQ 2385

  Fly  2351 GFYAENLEWIGVSGLQLCASI--GGNTG--KIAPRYFAINQFVRVSRPTSQDMLEIVQRRLEPLL 2411
            |||.|||||:|:..:|:.||:  ||..|  |:..|:.:|.:...|..|..:.:..|....||.:|
  Rat  2386 GFYDENLEWVGLENIQIVASMSAGGRLGRHKLTTRFTSIVRLCAVDYPEREQLQTIYGAYLEAVL 2450

  Fly  2412 EEHFRGSENRGRSGVNLQHVSESLMDCFEKLQATFTNVGGRQAHYQFSPKCIMKLLDALVF---- 2472
            .::.:.....|.|. .:..::.|::..:|:::|.||  ....:||.|:| ||:......:|
  Rat  2451 HKNLKNHSIWGSSS-KIYLLAGSMVQVYEQVRAKFT--VDDYSHYFFTP-CILTQWVLGLFRYDL 2511

  Fly  2473 ------YPASDFNEALYCELLGMFRDRLISEEHVQQFEGILKQTMRKYYGKEKV------FFV-- 2523
                  :|.....|.:..|...:|||:::..:.:..|:.||...::..:|.:.:      |:|
  Rat  2512 EGGSSNHPLDYVLEIVAYEARRLFRDKIVGVKELHLFDNILTSVLQGDWGSDILDNMADSFYVTW 2576

  Fly  2524 --------------PKSPKSRGHLHCLTHDEWMEEVQRQVTICNTENYSITAPITEELLSHVARI 2574
                          |..|..: .|..|:..:..:.:::.:.....:|.::...:.:|:|.:::||
  Rat  2577 GAQHISGAKIAPGQPLPPHGK-PLGKLSSADLKDVIKKGLIHYGRDNQNLDILLFQEVLEYMSRI 2640

  Fly  2575 TRVLSRTDAHMLILGQSG-GRH----LDAIFTAATFQEAKVVTLQGGPSYDLTDFYNDLKVAMQT 2634
            .||||.....:|:.|:|| ||.    |.:....|.....|:     ...|:...|..|||..:..
  Rat  2641 DRVLSFPGGSLLLAGRSGVGRRTVTSLVSHMHGAVLFSPKI-----SRGYEPKQFRTDLKHVLHL 2700

  Fly  2635 AALEQQMSYLLIEQCWLSYVPDILKPIEALLEGSEILELFG-DDLETVASTLKQAAQLEGYQESM 2698
            |.:|.|...||:|.....: |..|:.|.:||...|:..|:. ::||.:...||..|..:|:...:
  Rat  2701 AGIEAQQVVLLLEDYQFVH-PTFLEMINSLLSSGEVPGLYTLEELEPLLLPLKDQASQDGFFGPV 2764

  Fly  2699 GTYFLKRARDYLHIIIVLDPNSAKVQDYFN--NFPALHRQMDLLYVRGESRETIAILP------- 2754
            ..||..|.:..|||::::|  ||.:....|  :.||||::..:|::.|.|..::..:|
  Rat  2765 FNYFTYRIQQNLHIVLIMD--SANLNFIINCESNPALHKKCQVLWMEGWSDSSMKKIPEMLFSEA 2827

  Fly  2755 ------------------------KQFIELLNESIAGGGSGRGKVPTCSHFADISDELPSEETSQ 2795
                                    |.|: |::||....|:                      |..
  Rat  2828 DIEEKYEKKRKDEKKKSSVDPDFIKSFL-LIHESCKAYGA----------------------TPS 2869

  Fly  2796 RYYQLIRTYFHMYNNAANEIDQRLGKLQMGVDKLASAHALVDTLKSNAAAQEQALGEKRQLANEA 2860
            ||...:|.|..:.::...|:.:|...||.||.||..|.||||.|...|..|...|..|:..|:.|
  Rat  2870 RYMTFLRVYSAISSSKRKELLKRQSHLQAGVSKLNEAKALVDELNRKAGEQSILLRIKQDEADSA 2934

  Fly  2861 LEMISFTMRNANEQKSSMLELKQQTQKSSEQLKIRQKEIQQELAEVEPILAEASNAVGQIKSEAL 2925
            |:.|:.:|::|:|||:.:..||.:..:...:::.|:.:|..||.||:|::.||..|||.|:.|:|
  Rat  2935 LQEITVSMQDASEQKTELERLKHRIAEEVVKIEERKSKIDDELKEVQPLVNEAKLAVGNIRPESL 2999

  Fly  2926 SEIRSLRAPPEAVRDILEGVLRLMGIRDTSWNSMKTFLAKRGVKEDIRSLDPARISPENCEAVER 2990
            |||||||.||:.:|||||||||||||.||||.|||:|||||||:|||.:.|...|..|..|:||.
  Rat  3000 SEIRSLRMPPDVIRDILEGVLRLMGIFDTSWVSMKSFLAKRGVREDIATFDARNIPKEIRESVEE 3064

  Fly  2991 LLLAKGDSYEAKNAKRASAAAAPLAAWVQASVRYSRVIQSIKPLEREQNELQKNLNAAEDEMQEL 3055
            ||.....|::.|||||||.|||||||||:|:|:||.|::.|:|||.||:.|:.||...||..::|
  Rat  3065 LLFKNKASFDPKNAKRASTAAAPLAAWVKANVQYSHVLERIQPLETEQSGLELNLKKTEDRKRKL 3129

  Fly  3056 ASGLDDVDKRVKQLSAKLQTYTQEAAVLELKLQEASGTLQAAELLVEKLSAEYTTWSLQLTELKK 3120
            ...|:.|.::|.:|..|.|:.|.|||.||.::.:|..|::|||:|:.:|..|:..|:.|:.|:.:
  Rat  3130 EDLLNSVGQKVSELKEKFQSRTSEAAKLEAEVSKAQETIKAAEVLISQLDREHRRWNAQVAEIAE 3194

  Fly  3121 AHKTLDAKTLLIAIAINY--CAGLGLEQRCSSLKRLAADFHLPSDFDLRGSLLTEQQQIIWESQG 3183
            ...||..:..|.|..|.|  .|..||.:.|......||..   ..||||..|.||.:|:||:|:|
  Rat  3195 ELATLPKRAQLAAAFITYLSAAPEGLRKNCLEEWTKAAGL---EKFDLRRFLCTESEQLIWKSEG 3256

  Fly  3184 LARDAQIIESAALLREMLSLPYGACPIPLLLDPTQTAAAWLMAHLKGSGRPCELTTHGNDRLPYQ 3248
            |..|...||:|.::     |....|  |.|:||:..|..||..|||.|  ..|:....:......
  Rat  3257 LPSDDLSIENALVI-----LQSRVC--PFLIDPSSQATEWLKTHLKDS--HLEVINQQDSNFITA 3312

  Fly  3249 LELAVRFGKTLLVTDCEQLRPPVLQLLQGHVFVRFNKRQLAIGSKLVDLHESFQLVLISKSHRLD 3313
            |||||||||||::.:.:.:.|.:..||:..:..:..:..:.||.|::|.:|.|:|.|.:::....
  Rat  3313 LELAVRFGKTLIIQEMDGVEPVLYPLLRRDLVAQGPRYVVQIGDKIIDYNEDFRLFLSTRNPNPF 3377

  Fly  3314 LPEEQRSQLNVLKFTVTAAGLADQLMSKAIVLKNGELEQQRIELLQKEGHLLKQRMEMQDKLLEQ 3378
            :|.:..|.:..:.||.|.:||..||::..|..:..:||:|:.:|||:|.....|...:::.|||.
  Rat  3378 IPPDAASIVTEVNFTTTRSGLRGQLLALTIQHEKPDLEEQKTKLLQQEEDKKIQLARLEESLLET 3442

  Fly  3379 LSKSEGDILKNEQLLESLNEIKQGSTQIDEALKQSGQIRDTLLAQFGSLRELSSRAATFY----- 3438
            |:.|:|:||:|:.|:||||:.|..|..|.::||:|.:::.:|..:..:...|:..|:..|
  Rat  3443 LATSQGNILENKDLIESLNQTKASSALIQDSLKESYKLQISLDQERDAYLPLAESASKMYFIISD 3507

  Fly  3439 -AGLIQGYELSPLVYIELFLGALSKSQRDES--KVYDCLVRS----VYMNLARATSRDSQLSLSL 3496
             :.:...|..|...::.||..||...|..||  :...|||.|    ||..:.|...:..||..:|
  Rat  3508 LSKINNMYRFSLASFLRLFQRALQNKQDSESTEQRIQCLVNSLKHMVYEYICRCLFKADQLMFAL 3572

  Fly  3497 WVCHQAYPDRLNPKEWELF----VNNFMGSSDGSMVLSQLGKLPDCMPKEAQLKLAMLLQLFPDL 3557
            ......:|:.....||:.|    |.:.:..:|....:..  :||..:.:|....:|.|....|.|
  Rat  3573 HFVRGMHPEFFQENEWDTFTGVVVGDMLRKADSQQRIRD--QLPSWIDQERSWAVATLKISLPGL 3635

  Fly  3558 RSKLQLEKDYIWRGF-----IEAQADDVLPALGSSFQRVLIAQIFRPDLMLHQLRKVSSDLLGIS 3617
            ...|..|...:||.:     .|.:...:|....|.||:||:.|..|||.:...:...:...||:.
  Rat  3636 YQTLCFEDGTLWRTYYHHSMCEQEFPSILAKKVSLFQQVLVVQALRPDRLQSAMALFACKALGLK 3700

  Fly  3618 PDASTQPSVEQLLQQSSCDRPILMVSHAENDPTTELRKWANQK-----YREMAIGKGVEKRVLSE 3677
            ..:....::::|.:::....|||::.....||:.||::.||.:     |.::|:|:|.....:..
  Rat  3701 ELSPLPLNLKRLYKETLEIEPILIIISPGADPSQELQELANAERSSECYHQVAMGQGQADLAIQM 3765

  Fly  3678 MRQAAIDGHWLCVKNVHLVPEFLTQMERELSEIQKSKDFRLWLLCESTEGFSEAAIYKCLKVRYE 3742
            :::.|.:|.|||:||:|||..:|..:|:||:.:|..:.|||||..|....|:...:...||:.||
  Rat  3766 LKECARNGDWLCLKNLHLVVSWLPVLEKELNTLQPKESFRLWLTAEVHPNFTPILLQSSLKITYE 3830

  Fly  3743 QPKGLKQIVMRLLQNFAAEQDQKLKNQPKSLKM-RLVYFVLTAVLQQRRQFIPQGWSKYYEFGEA 3806
            .|.|||:.:||..:::..||..|..|..::..: .|.:|  .|..|:||.||||||:|:|||..:
  Rat  3831 SPPGLKKNLMRTYESWTPEQISKKDNIHRAHALFSLAWF--HAACQERRNFIPQGWTKFYEFSLS 3893

  Fly  3807 DLKAALGIL-RMMDQQLNSGKCDWLLMQRLSEALAYGGRVNNQRDLEILTTYLNQFCSA---DVL 3867
            ||:|...:: |:.|   .|....|..:..|.|...||||::|..||.:|.:||.||.::   |||
  Rat  3894 DLRAGYHVIDRLFD---GSKDVQWEFVHGLLENSIYGGRIDNYFDLRVLQSYLKQFFNSSIIDVL 3955

  Fly  3868 S--NRWSPLGLSLSIPTSGQLQDYYAALEKLPDTDEPSMYGL-ANQAQQQREIEQAKRVIKELRG 3929
            :  |:.|....|:|:|.|..:.||.|.:||||:.|:||.:|| ||.|:..:.: .:.:||.:||.
  Rat  3956 NQRNKKSIFPYSISLPNSCSILDYRAVIEKLPEDDKPSFFGLPANIARSSQRM-TSSQVISQLRI 4019

  Fly  3930 LHYGRGLAKDSGGAGESKGNDQLTGRQKLEQQIKPLLNLWRKLAASCTIIQTMKEAKTDVGESPW 3994
            |  ||.:.     ||..      ..|:....::.|:||||:||..:..:|........|...||.
  Rat  4020 L--GRSVT-----AGCK------FDREIWSNELSPVLNLWKKLNQNSNLIHQKVSPPNDRQGSPI 4071

  Fly  3995 ALFVLAELKLGADLYGIVHQTLSQMHAWLKESQEVDGSTL---------RTLAEQQIPASWLKLW 4050
            ..|::.|......|...|||:|:.:      |:.:.|:||         ..|..|:.|.:|...|
  Rat  4072 LSFIILEQFNAIRLVQSVHQSLAAL------SKVIRGTTLLSSEVQKLASALLNQKCPLTWQSKW 4130

  Fly  4051 PGPGSNSAVDFLRALIVRAQAAE--LRFREQMHLDFVEDINFVQVFNCENLLSCLKLLQSRKLAV 4113
            .||  ...:.:||.|:.|..|.:  :...|:..| ..:.::..::|:.:..|:.|:...:|....
  Rat  4131 EGP--EDPLQYLRGLVARTLAIQNWVEKAEKQAL-LADTLDLSELFHPDTFLNALRQETARATGC 4192

  Fly  4114 STERLELQTCGSSNLESDSSDIILKLAPLKIDGAQ---SGMGKSN----------PFYIKYKIKD 4165
            |.:.|:........|:  .:.:.:|::.|.::|..   |.:.::.          |.|:.:
  Rat  4193 SVDSLKFVASWKGRLQ--EAKLQIKISGLLLEGCSFDGSRLSENQHDSPSVSSVLPCYMGW---- 4251

  Fly  4166 EVQNVSHTTTSSSKYGKNSLYSTQNAESKPKLPLYSRSSRDKLICHLNVDI-VTGTAEQILLAGT 4229
                     |....||.   ||.....|   ||:|:.:.||.::  .|:|: ..|..:|.:..|.
  Rat  4252 ---------TPQGSYGP---YSPDECIS---LPVYTSAERDCVV--TNIDVPCGGNQDQWIQCGA 4299

  Fly  4230 ALIVED 4235
            ||.:::
  Rat  4300 ALFLKN 4305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btv	NP_001036369.3	DHC_N1	200..618	CDD:285571	119/448 (27%)
		DHC_N2	1072..1481	CDD:285579	149/413 (36%)
		P-loop_NTPase	1621..1847	CDD:304359	133/225 (59%)
		P-loop_NTPase	1919..>1967	CDD:304359	22/47 (47%)
		P-loop_NTPase	1947..2081	CDD:304359	87/135 (64%)
		P-loop_NTPase	2565..>2733	CDD:304359	52/175 (30%)
		MT	2821..3138	CDD:289543	151/316 (48%)
		AAA_9	3179..3401	CDD:289547	76/221 (34%)
		Dynein_heavy	3536..>4051	CDD:281078	170/541 (31%)
Dync2h1	NP_075413.2	Stem. /evidence=ECO:0000250	1..1650		499/1711 (29%)
		DYN1	<1361..4015	CDD:227570	984/2756 (36%)
		AAA 1. /evidence=ECO:0000250	1651..1875		133/223 (60%)
		AAA 2. /evidence=ECO:0000250	1941..2161		110/219 (50%)
		AAA 3. /evidence=ECO:0000250	2249..2505		86/261 (33%)
		AAA 4. /evidence=ECO:0000250	2617..2862		65/253 (26%)
		Stalk. /evidence=ECO:0000250	2880..3168		138/287 (48%)
		AAA 5. /evidence=ECO:0000250	3243..3472		84/237 (35%)
		AAA 6. /evidence=ECO:0000250	3689..3904		71/216 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337248
Domainoid	1	1.000	351	1.000	Domainoid score	I985
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2131	1.000	Inparanoid score	I37
OMA	1	1.010	-	-		QHG56373
OrthoDB	1	1.010	-	-		D26380at2759
OrthoFinder	1	1.000	-	-		FOG0006067
OrthoInspector	1	1.000	-	-		oto97587
orthoMCL	1	0.900	-	-		OOG6_100025
Panther	1	1.100	-	-	LDO	PTHR10676
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4363
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810