DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btv and DNHD1

DIOPT Version :9

Sequence 1:	NP_001036369.3	Gene:	btv / 35073	FlyBaseID:	FBgn0023096	Length:	4236	Species:	Drosophila melanogaster
Sequence 2:	NP_653267.2	Gene:	DNHD1 / 144132	HGNCID:	26532	Length:	4753	Species:	Homo sapiens

Alignment Length:	5210	Identity:	1034/5210 - (19%)
Similarity:	1780/5210 - (34%)	Gaps:	1668/5210 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PGSELDEQTAMILEFLEQEELTVISAV-HSRSDGRIRFHHRI-----PNEELCL----------- 68
            |.:|.::.|  :||.|..|..|:.||| ...|....|:.|.:     |..||.:
Human    48 PVTESEQPT--VLELLLAELRTLFSAVLQDSSPAAWRYLHAVLGLLPPYRELLVGHLDLLPFLEQ 110

  Fly    69 LFYKVPQVGHHRKEDGSEPLLGILTLEGGMVKSIYNSVSRVFSPSA---NSARRSEYGPELSGIL 130
            |:...|.|..|...|    |||              ::.:.|.|.:   :||..::..|:    .
Human   111 LYCWAPWVQTHLHLD----LLG--------------AIVQAFPPDSSLLDSASHADCCPQ----K 153

  Fly   131 ENLHQNLGSSLGLPQSGITSLRNEIKYWQQKLGQKSSSRLDREAAQVFIGVLENMEKQISTIDGA 195
            ..||..      .|......::.:   |.:                      :.::::::|
Human   154 RRLHHR------PPCPACPFVQAQ---WSR----------------------QQVKEELAT---- 183

  Fly   196 NPSGTIEEFLDHAHTNLDELWRLPYNYPQ-QRMADLLDIIGKRLLEVCLTQLLAEDVWSLNSSHV 259
                                |..|...|: ||   .|.|:|.::       .|.|.||
Human   184 --------------------WLRPLTLPELQR---CLGIVGAQV-------ALEEAVW------- 211

  Fly   260 NNLMSQSIDTVDAWIQLCDSLTRLFWPNYVKHPWLGDSHVPKRGQQFKERLSEIRSIKQLYKQIA 324
                             .|.|:.|        |....:.:|.|.:......:|:..:.:  |:..
Human   212 -----------------LDGLSLL--------PLALAADIPVRYESSDTDNAEVEPVGR--KETR 249

  Fly   325 TLLEDTELQEMFQEQAPFTEFNIFDTSSLGQNKWHKALQHFEQVLQPIDERIAAALKRQLHNHLS 389
            :.|:    .|:.:|:|       |..||.|          |......:|.::..|||  :..:|
Human   250 SQLD----YEVPREKA-------FQKSSTG----------FSPETSFLDSQVMTALK--MERYL- 290

  Fly   390 NPRQVIFIF-----SKYETLIQRPAVLELL---TIEREQFLQS----LHILLQDLRKAMVDSNME 442
              :::.|::     |:|    .||..|.::   .:..|.::.|    ||:     ........|.
Human   291 --KKIHFLYLNVAPSRY----FRPYSLMVVPPDKVNPEHYIFSPFGILHV-----HPVEGSETMT 344

  Fly   443 PDTGHLSVICNECRWLKVVQHQIQEIEKVSHLISGREGFDKINKAVQEIKEETESLLRTNFEIWS 507
            ..|.|     :.|    |:..|:|.|....:                       .|||.:|..|
Human   345 LGTWH-----HHC----VLWQQLQFIPFFKY-----------------------CLLRKSFTCW- 376

  Fly   508 GQCSTAVKSGELRLRDDQAVVKFEKEGRQLMRVT-FNPKLVTFCQDVREFENLGYNVP------- 564
                    ...:||:....:.|| .|...|:.|. |...|:...:.::|..::.: :|
Human   377 --------KKNVRLQGLHRLQKF-LENHLLLAVPHFGAGLLHISRLLQELHSVSW-LPQELDRCY 431

  Fly   565 --LELRAAAT----------HAAKYMCYA-RRLQQIATFH--NTIGDRMIPCQRPIMLKNALELQ 614
              |:|:.|..          |....:|.: .||....|:|  ..:.:|:..|.|....:.::.||
Human   432 ELLDLQTALAEEKHKALRLLHRCLNLCTSILRLVHEDTYHMQQCLQERVQNCDRIRTGQGSIYLQ 496

  Fly   615 R---------LVQSETVAWQDESSVQRYVD--ILQAAVSKLSSDNTLLVGYHEQAKRSVLKLMST 668
            |         |.|:| ..|.......|.||  |.|:.:|.|....|..|....||.|....|.|.
Human   497 RVQHKQLEQKLKQAE-AWWLQLGKFARLVDYMICQSLISVLEEQITSFVANILQAPRQKPFLSSQ 560

  Fly   669 DLFTQNQIWKDELRH---LRELVATLERQGYTHLDAFKLHWDHQLYKVLEYQYILGLLDMNNKLP 730
            .:|..:    .:|.|   :..::.||..                           ||..:.....
Human   561 LVFDDH----GQLSHVPCVENMIQTLTG---------------------------GLQSVKTSAL 594

  Fly   731 DIHVKLVLR-QRELVFSPPEEEIRELYFSQLRRFIERPCNFHGLSEHSQELFKSMVTVNRHHFGP 794
            .:.....|: ..:.::|..|:|..:    ....|: .| .|.|....:..:|          .||
Human   595 QVVQSADLKTSSDSLYSEEEDEEED----SKDEFL-MP-KFQGQPSDAVSIF----------CGP 643

  Fly   795 LYQRAAELFDKLQDFKTIWLPWIALGCVDVDQLCGIHLNEAGDW-DRNFRSCKHFSQQLAKLQQA 858
                         :...:| ||.:.....:.::.|..|.  |.: ..|::..:.......|:|||
Human   644 -------------NVGLVW-PWKSHPIAGILEVRGCRLR--GQYFPHNYKQLEEDLDNNPKIQQA 692

  Fly   859 EESIDCIVINVL----------------------------------PLRSDIEYISR-RYW---- 884
            ......::..||                                  |:::.:..:|| ..|
Human   693 LNIQQVLLEGVLCKVQEFCREHHWITGIYEFLQSWGPQKLEDMRGGPIKNYVTLVSRLNVWQARV 757

  Fly   885 -------------------------ESLANSLRTAILTDV-----SLIQEFLQSALQFL---QNV 916
                                     ||..||:|..||..|     :|.|:.:.....|:   :.:
Human   758 SSMPIELLTKGGLLLLSCHDVQAEMESKLNSIRKDILAHVQNECWNLSQQLMTELTDFMHIFRTI 822

  Fly   917 PMDEGSISQSGMKYEKIMSKLPQIEKTLEAVRAKDSCLGGWCKERVTALSGILLQWEQLQPLLEN 981
            ..|..:|:|...|..:...:..::|:.:|.|||                         |..|:.|
Human   823 NSDIHAIAQCTQKLNEANEQYVELEERMEYVRA-------------------------LHELIRN 862

  Fly   982 HAVILQRQVDMIKNQAETQ----------------LQNLKNEAEKFLLRWESTISELEANEHSTL 1030
            |..:...:.:.:......|                |.:....|.:.|..||:  .:.|.::.|..
Human   863 HFSLFSAENEALDISVRRQFGESPIPPCPPPPQPHLLHCPLLAPQLLDMWEA--FQFEKSQASEF 925

  Fly  1031 DVFKERRLHWQQLQEKKTQLLEECSKFNMEFPAEMLT-PFTE-------IEEQMEKQSKQWQVYD 1087
             :..:|.....:||:.....|.|..    ...|:.|: ||.:       .|.|:....:|:|...
Human   926 -LLSKRHAIMPKLQQLMAAALAELE----GLLAKALSGPFMDPTQDQRSTEHQLVSLERQFQNTV 985

  Fly  1088 SFLTEL---------------------QPVLHEE--WAIYRRRPYVLNEFIGKW----------- 1118
            |.|:||                     :|::.::  |.:||    |::|.|.:|
Human   986 SDLSELHHAYAIFTEDETPVPLPICGTRPIVQQQRIWHLYR----VISENISEWKCMAFAKFSPA 1046

  Fly  1119 ------EG------------SVHASIDLPSKRIRQQVEQLQSALPILQQLQS---ESLSERHWAR 1162
                  ||            .:|:.:.....||   :.:.:|.||:|.:|.|   :||:.:...|
Human  1047 MAQEKTEGWLTEAARMSTTLELHSPVLQHCMRI---LGEFRSYLPLLTKLGSLHPQSLNCQCLLR 1108

  Fly  1163 IFQL--LNHKETKPLHSILLQDILQDFDVLQSAAQEISSIVRQASSEQIVRQALI-ELDQWSVTA 1224
            ...|  |...|...|..:|...:|:..|.:..        |.|..:|:|..|..| .|.::....
Human  1109 ALGLGSLQTIELLTLGQLLTYPLLEFADRINQ--------VWQNENERIHAQETIRRLQRYWEAR 1165

  Fly  1225 QLKLIT-------RTDASGQS------------------VSLIKDYQEVLNKIGDNQSLLQSANN 1264
            ||:|:.       ...||.:|                  ..::.||..:.:.|   |..||..:.
Human  1166 QLRLLNFILHVPYEPPASERSKRQVLRSPQWEVVDKDSGTFILSDYSNLQDSI---QESLQVLSK 1227

  Fly  1265 SAAFESFSDQAEL---WESRLNTLDALLSSLNHSQRRWVYLEPVFGSGTLQHEQA----LFKRID 1322
            ..|.|...|..::   |.:.::.|.|||......|::|::|..|.....:|...|    .||.:|
Human  1228 ILAIEKSGDLNKIALEWVAIMHGLGALLEVWLTFQQKWIFLNKVLHEMKIQFPNADLNSRFKVMD 1292

  Fly  1323 KDFRFVMREIEMDPRVTSLT----------KINNITTIVNALETQLARCQQNLMSYITDKRNSFP 1377
            ..:|.:||....||.|.||.          :...:..::.|...:|.....:|.|.:......||
Human  1293 DQYRTLMRISVADPMVLSLVVPSAERSPYFQGQQLQQLLQAGSVELEGIIMSLESVLYGVCAHFP 1357

  Fly  1378 RFYFLGDDDLLELLGQASKDAEVIQRHIRKLFPGCHSLSIR------------QVGPNPATSSDV 1430
            |.:||.|.:|:.||....:..|. |..:|:.||..|::|.|            :..||..|
Human  1358 RLFFLSDSELVALLAARLESCEA-QLWVRRCFPHVHAVSFRSCPTGEKNTDDWESSPNTQT---- 1417

  Fly  1431 NQYSITSVHSAEGDELKLSQPVEMKGDIERWLNQLVTVVQDTLRDQIYECYTGTTGGSDNLDEKI 1495
             |....:|..|.|:|:||..|:.:..|:.:||..|...::..|...:..|.........:|.|.:
Human  1418 -QVEALAVLGAGGEEVKLQGPLPLHPDLPKWLASLEKCLRLALVHMLQGCVAARLARGPSLGEAL 1481

  Fly  1496 ----------LKKYAS-----------QVLATARALHFTRQAEQAI---GSMSLGKLKQQLKDEI 1536
                      |:.|..           |.:..|..:.:..:.|:|:   |::::..:..:..:.:
Human  1482 KQLPKQNKLYLQLYVQHWIDLVQAFPWQCVLVAEEVVWRAEMEEALLEWGTLAMVSMHMRKLEVL 1546

  Fly  1537 THLAALKNKSENG-TLISLK----LRALLLDLVHYSGVTEQLQKHNVVHTSDWHWLCQLRYYLGK 1596
            .:....:..|:.| :|.|::    |.|||:..|.:..:.:.|::|.|...:|:||:.||:|:||.
Human  1547 VNFMRAQRASQGGQSLPSVRQTSLLSALLVMAVTHRDIAQLLEQHQVSDLTDFHWVRQLKYHLGS 1611

  Fly  1597 ------------KGGTSGEVNANRQVC-VRMVYAEFEYAYEFLGQASKLVHTRLTHRCYLILTQA 1648
                        |...|.|.:.:...| :.::...|.|.||:||.....:.:.|..|..|:|..|
Human  1612 PHIIPKSPLQSLKTIASSEPSLSPAACWIDVLGRSFLYNYEYLGPRLGPLPSLLPERPALVLLLA 1676

  Fly  1649 MHMGLGGNPFGPAGTGKTECVKALGAMLGRLVLVFNCDENVDTESMSLILTGLARCGAWGCFDEF 1713
            :.....|...||.|.||...|.:|...|||.:::..|...::.:.:|..|.|..:.|||...::.
Human  1677 LEEVACGTVLGPNGVGKRAIVNSLAQALGRQLVMLPCSPQIEAQCLSNYLNGALQGGAWLLLEKV 1741

  Fly  1714 NRLQEATLSSISM-------LIQPIQSALKERANSVQIGERQ-------------IQLNQHCGIF 1758
            ::|....||::..       |..|:........:::...:.|             ::|...|.:.
Human  1742 HQLPPGLLSALGQRLGELHHLYAPLYQEASRNTSTIDPTQPQLLGSSFFEKHHVSVRLGYGCLLV 1806

  Fly  1759 V-TLNPAGAEYGGRQKLPGNIQALFRPIVMQQPEPGEIARVMLFVEGFTEASAIASRIVELFELS 1822
            : .|:.|         :|.|:..|.||:.:..|:..::|.:.|...|..:|..:|:|:.:.|.|.
Human  1807 LRALSSA---------VPANLHLLLRPVALALPDLRQVAELTLLGAGMRDAFQMATRLSKFFSLE 1862

  Fly  1823 GKMLSAQRHYDWGLRELKTVLMVCGEGLRD-----QLTSED----NNQSSANFEMSVVVRCLRSS 1878
            .:::|.         .|...|.:..:.|.|     .:|.|:    ..:|.|..|.:.::|....|
Human  1863 RELVSG---------PLPCRLPLLKQILEDTIRTLNVTKEEPKCQKPRSLAAIEEAALLRSPLFS 1918

  Fly  1879 TMSKLAPHDVNRFEMLLRNVFP---EIGSSPAPETQLHQSLSAAFAQLGLCRSERQIEKALQLHE 1940
            .::.|..|::..   ||..:||   ::.:.|.....:...:.....|:||..|...:....||.:
Human  1919 ILNGLHLHNLRG---LLCALFPSASQVLAEPMTYKLMKPLVVEELQQVGLDPSPDILGSLEQLSQ 1980

  Fly  1941 QLQKRMGVVLVGPPGCGKST-----------IISLLKQALCGTQ-LKVHTISPKSMSRIQLLGRL 1993
            .|.:..|::|:||.|.||:|           :.::...:..|.| :::..:.|..:|..:.||.|
Human  1981 ALSRASGILLLGPAGSGKTTCWHSLFKIQNRLAAMEDTSTQGCQPVEITHLYPSGLSPQEFLGWL 2045

  Fly  1994 DADTRQWQDGVLTHTAVAVNQ-----------ESSQVHSWIVCDGSIDPEWIEALNSVLDDNKLL 2047
            :...  |..|:......|..|           ||..:..||:|||:.:..|::::..:|.:...|
Human  2046 EGSC--WHHGIFPKVLRAAGQCNNMGQKRQTEESIGIQHWIICDGASNGAWLDSITCLLSELPQL 2108

  Fly  2048 TLPSGWRIQFGSNVNFIFETDDVRHASPATISRMGIV-----------------NMSYDYYPADG 2095
            :||||.:|........:.|..|....||..:....:|                 ::.|:|.
Human  2109 SLPSGQQIARPPGTFLLMEVADTTGISPTVVGCCALVWCGGEQTWQCILSALMASLPYEYR---- 2169

  Fly  2096 ILKHELSKEPYGDLLQSYVDGNFQYAVNWIESQLLLTHLPGINRAHLLR-------SLLLQLHGT 2153
             |:|....|                          |.|:..:.....||       |.|||:||.
Human  2170 -LQHRTVAE--------------------------LNHMAEVLVPATLRFLTCQGVSSLLQVHGQ 2207

  Fly  2154 QSLEEYGAATLRALFGYMPNDRQREFAQLILKHANLYVAN-PNYAELTH-------YESSRNS-L 2209
            |::.. |.|.:.::        .|....|:..|..|.... |...:|::       :.||::| |
Human  2208 QAVCA-GVAEVTSM--------ARILHSLLDLHLRLKEEKAPGPEDLSYSDPVAQSFRSSKSSFL 2263

  Fly  2210 EQYAVDAIETPEKGSQ--LIITSYM------------KSYLDILETLLK---------------- 2244
            .:..||:.:.|:|..:  |.::|::            ..:..|.:|.::
Human  2264 NRSQVDSDDVPDKCREHLLAVSSFLFALIWGFGAHLPSRFWPIFDTFIRDSISRLSNYPEPPPSA 2328

  Fly  2245 ---------TQGTRLP--------------------------------------PFMLIGPSGSG 2262
                     ..||.:|                                      |.:|.|.:.:|
Human  2329 LVFDLHVSPEDGTLVPFTGQYLSSHIKGTLGTFHPSIQTERLLYVVDLLLSGGQPVLLAGEAATG 2393

  Fly  2263 KTLLLQRAVLENSGYQLATINCSTQLTPRYILHTLKTHCVTVSGIKGR--------EYRPKQARL 2319
            |:..::..|..:..|..:.|:      |.:....|:  .:...||:|:        .::..:..|
Human  2394 KSAFVEVLVEPHHPYIYSPIH------PAFSSSHLR--LLLSRGIQGQTQASPQPGHHQDSKPSL 2450

  Fly  2320 VLFMKNLDLCQQDSWGACE-VVELLFQLAQRGGFYAEN-------------LEWIGVSGL---QL 2367
            :..:::|.|...|...:|: |:|.|.| |..|..||.:             |..:.|.|.   .|
Human  2451 LFLLEDLHLATSDPEKSCQPVLETLRQ-AMDGTVYAHSTLELQTLQPTVNFLATVTVPGYCERPL 2514

  Fly  2368 CASIGGNTGKIAPRYFAINQFVRVSRPTSQDMLE----IVQRRLE--PLLEEHFRGSENRGRSGV 2426
            |           ||.|.:...:.:...|...:||    |:|..||  |.:|.....:....|:.|
Human  2515 C-----------PRLFRLFTVLALESMTQATLLERHVPIIQAWLERFPSVERERALARGLVRASV 2568

  Fly  2427 NLQHVSESLMDCFEKLQATFTNVGGRQAHYQFSPKCIMKLLDALVFYPASDFNEALYCELLGMFR 2491
               ...|::.:||..        .....||.||...:..||.:|...|....:..        |.
Human  2569 ---EAWEAVCNCFMP--------SPLHPHYHFSLHSVSHLLSSLQLLPNRTGSRG--------FV 2614

  Fly  2492 DRLISEEHVQQFEGI---------------------LKQTM---------RKYYGK------EKV 2520
            |....:||:::..|:                     .::|.         |.|..|      :.|
Human  2615 DYPNHQEHLRRVSGLRGTCLTVMMATRNVVRLWLHEAQRTFCDRLDSPRERSYCAKLLLVVAQSV 2679

  Fly  2521 FFVPKSPKSRGHLHCLTHDEWME----EVQRQVTICNTENYSITAPITEE--------------- 2566
            |.....|:..|..|..:.:|..|    ||:.:..:...|::|.:...|||
Human  2680 FCCGPGPQHLGKDHQESEEEEEEERVPEVESEGELAQWEDFSNSNSETEEEEEPYGLQVARVSNS 2744

  Fly  2567 ----LLSHVARITRVLSRTDAHMLILGQSGGR----HLDAIFTAATFQEAKVVTLQGGPSYDLTD 2623
                |...:..::|.:..:.:|. |..:.|.|    .|....:..|:.:.|       |..||
Human  2745 RDPSLTPSIGPVSRGMKESISHK-IRQEKGTRASNYRLQVRRSFKTWWQKK-------PQMDL-- 2799

  Fly  2624 FYNDLKVAMQTAALEQQMSYLLIEQCWLSYVPDILKPIEALLEGSEILELFGDDLETVASTLKQA 2688
             .:.|.:.:.....:::.|.|:..| .|...|:...|...|....|.||   :.|.|.|:.||.:
Human  2800 -ISPLLLPVLLLHPQEKPSDLVFSQ-ELILGPNSETPNLYLERQWEKLE---EQLATSAAQLKLS 2859

  Fly  2689 AQLEGYQESMGTY------FLKRARDY-----------LHIIIVLDPNSAKVQDYFNNFPA---- 2732
            ..| ....||..:      .|.|.|.:           .|..|.|  .|:..|.:|.:.|:
Human  2860 PHL-ARCHSMAQHVARLVRVLARPRQHGLLLSGALGTGRHTAITL--ASSICQAHFFHLPSGSEE 2921

  Fly  2733 --LHRQMDLLYVRGESRETIAILPKQFIELLN----ESIAGGGSGRGKVPTCSHFADISDELPSE 2791
              |....|..:..|...:.:|:|....::|..    .::|..||..|:. |.:....|.:.||.|
Human  2922 AILQCLRDASWHAGMLSQPVALLVPSGVDLTTLHRLLALATSGSFPGQY-TEADLDRIGEHLPRE 2985

  Fly  2792 ETS-----------QRYYQLIRTYFHMY---------------------NNAANEIDQ------- 2817
            ...           ||::|.:.::.|::                     ..|...||:
Human  2986 NLGVKQNIKKEMVLQRFHQQVCSHLHLFFLIGDKQAHKQLPSTLFLRLLQLATASIDRYEPWDQA 3050

  Fly  2818 RLGK-----------------------LQMGVDKLASAHALV----------------------- 2836
            .|.|                       ||..:..:|.|.||:
Human  3051 ALAKVAQHHLEGAQSVPLDDGSWKYPDLQASIPSVAKAMALIHLSATHYHEHLCPALPLVTPKTF 3115

  Fly  2837 -DTLKSNAAAQEQA---LGEKRQLANEALEMISFTMRNANEQKSSMLELKQQTQKSSEQLKIRQK 2897
             |.|.:....|:|.   :..|.|....|||.:...::......:.:.:|:||.:.|.:.|.:.|:
Human  3116 LDFLDTFLMLQQQTILKIKNKAQRVQNALENLRMLIKEHGTHANLIFDLEQQLKDSGKSLSMFQQ 3180

  Fly  2898 EIQQE----------------------------LAEVEPILAEASNA----VGQIKSEALSEIRS 2930
            :::|.                            .|:.|..|.:.|.|    :.|::.....||||
Human  3181 QLEQSKLLYKQQLEECRHQENLIENLARQRDALQAQREAFLEQMSKAFLEPLSQLQVADFEEIRS 3245

  Fly  2931 LRAPPEAVRDILEGVLRLMGIRDTSWNSMKTFLAKRGVKEDIRSLDPARISPENCEAVERLLLAK 2995
            .|||||:|..:.:.:..|.. .:|.|.|.|..|......:::......:|:  :.|.::..|:.|
Human  3246 YRAPPESVVRVTDAMCDLFH-HETGWASAKQLLCTEDFYQELVFFPKEKIT--DSELIKLHLILK 3307

  Fly  2996 GDSYEAKNAKRASAAAAPLAAWVQASVRY----------SRVIQSIK-PLEREQNELQKNLNAAE 3049
            ....:....:..|..||.||||:.|.:.|          ..::|.:: .|.|||..|......|:
Human  3308 APGMDDAALRAVSRPAASLAAWLWAVLHYGLAHCRGLPTDLLLQQVEATLTREQARLGYYQFQAQ 3372

  Fly  3050 DEMQE---LASGLDD-------VDKRVKQLS-AKLQTYTQEAAVLELKLQEASGTLQAAELLVEK 3103
            :.::.   ||..::|       |.|.:.|.. .:...:..:||:|
Human  3373 ETLEHNLALAKMVEDAQASHNCVAKTLSQAQCGQYHKWPMKAALL-------------------- 3417

  Fly  3104 LSAEYTTWSLQLTELKKAHKTLDAKTLLIAIAINY-------------------CAG----LGLE 3145
              .....|:.||.:||....|:...|||.:.||.|                   |.|    ||.:
Human  3418 --TPMRAWTTQLQKLKGRCMTVFGDTLLCSAAIIYLGPFPPLRRQELLDEWLALCRGFQEALGPD 3480

  Fly  3146 QRCSSLKRLAADFHLP---------SDFDLRGSLLTEQQQIIWESQGLARDAQIIESAALLREML 3201
            ....:|||......:|         |.|.:...|.:|.:|..|:. .|...|:....|.||   |
Human  3481 DVAQALKRKQKSVSIPPKNPLLATHSPFSILSLLSSESEQYQWDG-NLKPQAKSAHLAGLL---L 3541

  Fly  3202 SLP--YGACPIPLLLDPTQTAAAWL------------MAHLKGSGR------------------- 3233
            ..|  |.:|..||||||:..|..||            .|..:|.|:
Human  3542 RSPTHYSSCRWPLLLDPSNEALIWLDPLPLEENRSFAPALTEGRGKGLMRNQKRESKTDMKEEDD 3606

  Fly  3234 PCELTTHGNDR-------------------------------------------LPY-------- 3247
            ..|.:....|:                                           |||
Human  3607 ESEESNEAEDQTKEQKAEERKNEQEKEQEENEEKEEEKTESQGSKPAYETQLPSLPYLSVLSGAD 3671

  Fly  3248 -----QLELAVRFGKTLLVTD------C---------EQLRPPVLQ------------------- 3273
                 ||:.|...|..:|:|:      |         |||.||.:|
Human  3672 PELGSQLQEAAACGLPVLLTNVELGLGCEELQWLLQREQLSPPQVQPGFCLYLSTTLSLCAMEKV 3736

  Fly  3274 ----LLQGHVFVRFNKRQLAIGSKLVD---LHESFQLVLISKSHRLDLPE-EQRSQ-LNVLKF-T 3328
                ||:|     .|...|.:..::::   |||     ::.:.:    || |.|.| |.:... |
Human  3737 LGCELLKG-----LNVLDLGLNMEILEEQMLHE-----ILCREY----PELETRWQDLKIRALDT 3787

  Fly  3329 VTAAGLADQLMSKAIVLKN-----------------GELEQQRIELLQKEGHLLKQR-------- 3368
            ..|...|::.:...::.:|                 |:|.|.|....:.||..|::.
Human  3788 CKAVEAAEERLLTMLLFQNPKRQKPAKFLRNIVRAQGKLCQLRAHCEELEGQKLQEMVLWAPYRP 3852

  Fly  3369 -----MEMQDKLLEQLS--------KSEGDILKNEQLLESL--NEIKQGSTQIDEALKQSGQIRD 3418
                 |.|. |.|.||.        ..|..:...:|.|:|:  .||..|.......|    |:|.
Human  3853 VVWHGMAMV-KALSQLQNLLPLFCMSPENWLAVTKQALDSMKPREINHGEDLASHLL----QLRA 3912

  Fly  3419 TLLAQFGSLRELSSRAATFYAGLIQGYELSPLVYIELFLGALSKSQRDESKVYDCLVRSVYMNLA 3483
            .|..|.     |.|.....  ||.|    .|||..   ||||:                    |.
Human  3913 HLTRQL-----LGSTVTAL--GLTQ----VPLVGA---LGALA--------------------LL 3943

  Fly  3484 RATSRDSQLS-LSLW--------------VCHQAYPDRLNPKEWELFVNNFMGSSDGSMVLSQLG 3533
            :||.:.|:|. |:||              |...|.|..|.||.|.
Human  3944 QATGKASELERLALWPGLAASPSTVHSKPVSDVARPAWLGPKAWH-------------------- 3988

  Fly  3534 KLPDCMPKEAQLKLAMLLQLFPDLRSKLQLEKDYIWRGFIEAQADDVLPALG------SSFQRVL 3592
               :|       ::..||..|..|.:.|..... .|:.::...:..:.||.|      |..|:::
Human  3989 ---EC-------EMLELLPPFVGLCASLAGHSS-AWQAYLSLSSTVLGPAPGPGPEPLSLLQKLI 4042

  Fly  3593 IAQIFRPDLMLHQLRKVSSDLLGISPDAST-QPSVEQLLQQSSCDRPILMV----SH--AENDPT 3650
            :.::.||:.:...|...::.|||...|.:| .|::.  .:.|...:|:|::    .|  |...|.
Human  4043 LWRVLRPECLAGALADFTTSLLGRPLDENTYAPTMP--FKHSQATQPMLILLPPPGHPSATLHPL 4105

  Fly  3651 TELRKWANQKYRE-----MAIGKGVE-----KRVLSEMRQAAIDGHWLCVKNVHLVP-------- 3697
            |.::|.| .||::     ..|..|.|     ..|:|.:.||..:||||.:.|.||:|
Human  4106 TVIQKLA-AKYQQGQKQLQVIALGSEAWDPVSVVVSTLSQAMYEGHWLVLDNCHLMPHWPKELLQ 4169

  Fly  3698 ------------------EFLTQME-RELSEIQKSKDFRLWLL--CESTEGFSEAAIYKCLKVRY 3741
                              :.|.|.| |.:|.:.  :||||||:  .||:...........:.|.:
Human  4170 LLLELLGRAKVVADLESEQLLDQPESRNVSTVH--RDFRLWLIVPAESSASLPAVLTQHSMPVFW 4232

  Fly  3742 EQPKGLKQIVMRLLQNFAAEQDQKLKNQPKSLKMRLVYFVLTAVLQQRRQFIPQGWSKYYEFGEA 3806
            .|...|..:   |:.:....| |.|..||.:..:.|:  :|..:|..|:.:   |.......|..
Human  4233 NQSLELGHV---LIDSVELAQ-QVLYMQPPTQALPLL--LLHGLLLHRQLY---GTRLQAHRGRW 4288

  Fly  3807 DLKAALGILRMMDQQLNSGKCDWLLMQRLSEALAYGGRVNNQRDLEILTTYLNQFCSADVLSNRW 3871
            .......:|:..||...|.......||.|:.::.|||.:.:..|.|.|.: |.|.|.:. .|..|
Human  4289 SQVTLTQVLQTQDQLWASLSNPRAAMQELAASVFYGGPLGDTEDREALIS-LTQACLSP-SSGSW 4351

  Fly  3872 -------SPLGLSLSIPTSGQLQ---DYYAALEKLPDTDEPSMYGLANQAQQQREIEQAKRVIKE 3926
                   |.|...:.:|...:|.   :..|.:..||...||.:.||:...|......|::.::..
Human  4352 VQPHTPQSLLATLMPLPELRELDAMAECKAQMHLLPSPPEPRLCGLSEGPQAWLLRRQSRALLSA 4416

  Fly  3927 LRGLHYGRGLAKDSGGAGESKGNDQLTGRQKLEQQIKPLLNLWRKLAASCTIIQTMKEAKTDVGE 3991
            |:        ........||:...||..| :|.|:   |:.:.|:|.:...::..:  .:.|..:
Human  4417 LQ--------RSSPVWVPESRRGAQLAER-RLRQR---LVQVNRRLESLQDLLTHV--IRQDESD 4467

  Fly  3992 SPWALFVLAELKLGAD----LYGIVHQ---TLSQMHAWLKES-----QEVDG----------STL 4034
            :||::       ||.:    |.|::..   .|||:...|:..     |::.|          :..
Human  4468 APWSV-------LGPNARRPLEGVLETEALELSQLVGTLQRDLDCLLQQLKGAPPCPSRRCAAVA 4525

  Fly  4035 RTLAEQQIPASWLKLWPGPGSNSAVDFLRALIVRAQAAELRFREQMHLDFVEDINFVQVFNCENL 4099
            ..|...::|..|....|. |......:||.|..|.|.. :|:. .:..|...|:. .:||:
Human  4526 HALWTGRLPLPWRPHAPA-GPQPPWHWLRQLSRRGQLL-VRYL-GVGADASSDVP-ERVFH---- 4582

  Fly  4100 LSCLKLLQSRKLAVSTERLELQTCGSSNLESDSSDIILKLAPLKIDGAQSGMGKSNPFYIKYKIK 4164
            ||..:..:...||:..|....|...|||.......:..:|...:::      ..|||.:.:
Human  4583 LSAFRHPRRLLLALRGEAALDQNVPSSNFPGSRGSVSSQLQYKRLE------MNSNPLHFR---- 4637

  Fly  4165 DEVQNVSHTT 4174
              |:|..:.|
Human  4638 --VENGPNPT 4645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btv	NP_001036369.3	DHC_N1	200..618	CDD:285571	84/462 (18%)
		DHC_N2	1072..1481	CDD:285579	118/520 (23%)
		P-loop_NTPase	1621..1847	CDD:304359	55/246 (22%)
		P-loop_NTPase	1919..>1967	CDD:304359	15/58 (26%)
		P-loop_NTPase	1947..2081	CDD:304359	38/156 (24%)
		P-loop_NTPase	2565..>2733	CDD:304359	43/213 (20%)
		MT	2821..3138	CDD:289543	85/420 (20%)
		AAA_9	3179..3401	CDD:289547	77/394 (20%)
		Dynein_heavy	3536..>4051	CDD:281078	133/598 (22%)
DNHD1	NP_653267.2	DHC_N2	1019..1467	CDD:285579	109/471 (23%)
		P-loop_NTPase	1649..1867	CDD:304359	52/226 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2688..2766		13/77 (17%)
		P-loop_NTPase	2870..3119	CDD:304359	41/251 (16%)
		MT	<3193..3467	CDD:289543	63/298 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3580..3657		5/76 (7%)
		AAA_9	<3664..3802	CDD:289547	30/151 (20%)
		Dynein_heavy	3979..4741	CDD:281078	166/755 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4669..4697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5245
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900