DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and Pcdhb14

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_444369.3 Gene:Pcdhb14 / 93885 MGIID:2136749 Length:796 Species:Mus musculus


Alignment Length:706 Identity:189/706 - (26%)
Similarity:295/706 - (41%) Gaps:131/706 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 ENADLQSTVLTVNAKDHNESTNIRYQITGG----NIGN--AFAVQNTTGVIYVASPLDYE----- 100
            |..|..|.|..: |||...|  :|..||.|    :.||  ...::..:|.:.:...||.|     
Mouse    37 EETDRGSLVGNL-AKDLGLS--LRELITRGAQILSKGNKQLLQLEQKSGNLLLKEKLDREELCGS 98

  Fly   101 TRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDG 165
            |.|.. |..:........:....|.::||||:.|.|.......:|.|.   :||..:..:.... 
Mouse    99 TNPCI-LHFQVLLK
SPVQFIQGEIQLQDVNDHAPEFMEDEILLKILES---SLPGAVFPLKIAQ- 158

  Fly   166 DVDRPINIV--YFLTGQGIDPDNPANSKFDI---NRTTG----DIFVLKPLDRDQPNGRPQWRFT 221
            |:|...|.|  |.::         .|:.|.:   |.:.|    ::.:.|.|||::   :.|.|.|
Mouse   159 DLDVGSNTVQNYTIS---------TNAHFHLLTRNHSDGRKYPELVLDKALDREE---QAQIRLT 211

  Fly   222 VFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNEST 286
            :.|.|.|.....|...:.:.:.|||||||:|.||:|...|.||...||.|:|:||.|.|   ..|
Mouse   212 LTAMDSGSPPKTGTTQVVIVVLDINDN
APEFAQGLYEVQVQENSPVGSLVLTVSARDLD---AGT 273

  Fly   287 NAKLIYSI---EKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTG 348
            :.:|.||:   ...|::      .||:..:||.|:... .||.|....|.:::.|.|||||.|..
Mouse   274 HGELSYSLFQSSNQVLQ------AFEVNTDTGEIRVRK-LLDFEEIQSYRMEIEASDGGGLSGKC 331

  Fly   349 TASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGA- 412
            |..|.|.|:||..|:.|....::|:.|.:    |||.:....:.|            |:||... 
Mouse   332 TVVIHVMDVNDN
APELTMSVLISEIPENS----PETIVAIFGISD------------PDSGDNGK 380

  Fly   413 ------DK--FAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYS 469
                  |:  |.:..|.:...:|...:.||.|...:   :...|.|:|.|.  |..:.::     
Mouse   381 MVCSVQDRLPFLLKPNEENFYTLVTERALDRESRAE---YNITITVSDMGT--PRLTTQH----- 435

  Fly   470 WVVVKLRDINDNVPKFDREHIEVSIYEDTK----VGTILEQFKATDADQGGHSKVAYKIVRSTNR 530
            .:.|::.|||||.|.|......:.:.|:..    :|||    .|||:|.|.::.:.|.::  ...
Mouse   436 TITVQVSDINDNAP
AFTHTSYTMFVRENNSPALHIGTI----SATDSDSGSNAHITYSLL--PPH 494

  Fly   531 KRQFAI-------SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAP 588
            ..|.|:       :|.|.:...|.||.|........:.|.|.||||.::.|.:.|:|.|.|||||
Mouse   495 DPQLALNSLISINADNGQLFALRALDYEALQAFEFHVGATDGGSPALSSQALVRVVVLDDNDNAP 559

  Fly   589 TF----------AQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFK 643
            ..          ..:..|...|  .|..:.:|.|.|.|.   |.....:|:|  |.:.|  .|..
Mouse   560 FVLYPMQNASAPCTELLPRAAE--PGYLVTKVVAVDRDS---GQNAWLSFQL--LKTTE--PGLF 615

  Fly   644 VEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGD 699
            ..:...|:       :.:.|.........:.:.:.:||||.|..:.:.||.|.:.|
Mouse   616 SVWAHNGE-------VRTTRLLSERDVPKHRLLLLVKDNGEPPHSASVTLHVLLVD 664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 25/95 (26%)
Cadherin_repeat 140..248 CDD:206637 27/116 (23%)
Cadherin_repeat 256..359 CDD:206637 37/105 (35%)
Cadherin_repeat 379..481 CDD:206637 23/110 (21%)
Cadherin_repeat 489..586 CDD:206637 29/107 (27%)
Cadherin_repeat 594..703 CDD:206637 24/106 (23%)
Cadherin_repeat 724..801 CDD:206637
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
Pcdhb14NP_444369.3 Cadherin_2 30..111 CDD:285466 21/77 (27%)
Cadherin_repeat 140..238 CDD:206637 27/113 (24%)
Cadherin_repeat 247..343 CDD:206637 38/105 (36%)
CA 371..449 CDD:214520 22/99 (22%)
Cadherin_repeat 455..557 CDD:206637 29/107 (27%)
Cadherin_repeat 576..664 CDD:206637 23/103 (22%)
Cadherin_C_2 686..768 CDD:293101
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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