DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and Cdh1

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_112624.1 Gene:Cdh1 / 83502 RGDID:69279 Length:886 Species:Rattus norvegicus


Alignment Length:797 Identity:212/797 - (26%)
Similarity:321/797 - (40%) Gaps:161/797 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 PPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRT 197
            ||:        ...|......|:|::|:.:   :.|:...:.|.:||.|  .|.|....|.|.|.
  Rat   163 PPI--------NCPENQKGEFPQRLVQIKS---NRDKETTVFYSITGPG--ADKPPVGVFIIERE 214

  Fly   198 TGDIFVLKPLDRDQPNGRPQWRFTVF--AQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGN 260
            ||.:.|.:||||:..:     ::.::  |....||.:....:|.|.:.|.|||.|:|.|.::.|:
  Rat   215 TGWLKVTQPLDREAID-----KYLLYSHAVSSNGEAVEDPMEIVVTVTDQNDNRPEFIQEVFEGS 274

  Fly   261 VTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP---IFEIEPETGLIKTAVC 322
            |.|....|:|||.:||.|.||...:.||.:.|:|    :.::...|   :|.:..:||:|.....
  Rat   275 VAEGALPGTSVMQVSATDADDDINTYNAAIAYTI----LSQDPELPHKNMFTVNRDTGVISVVTS 335

  Fly   323 CLDRERTPDYSIQVVAMD--GGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETP 385
            .||||..|.|::.|.|.|  |.||..|..|.|.|||:||..|.|....:..:|.|..    ....
  Rat   336 GLDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPIFNPSTYQGQVLENE----VGAR 396

  Fly   386 ILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGD-----------GTGSLKIIQPLDYEDPL 439
            |.|:.|.|:|..||..:..|         :.:|.:.|           ..|.||..:.||:|...
  Rat   397 IATLKVTDDDAPNTPAWNAV---------YTVVNDPDHQFTVITDPKTNEGILKTAKGLDFEAKQ 452

  Fly   440 QSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTIL 504
            |     :.:.|..:.::...||  ...:.:.|.|.:.|:|: .|.|......|.:.||..||..:
  Rat   453 Q-----YILHVTVENEEPFEGS--LVPSTATVTVDVVDVNE-APIFVPAEKRVEVPEDFGVGLEI 509

  Fly   505 EQFKATDADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQ-------ILA 562
            ..:.|.:.|.....|:.|:|.|.|....:.. .:.|.:|.:..:|||  |..|::       |:|
  Rat   510 ASYTAREPDTFMEQKITYRIWRDTANWLEIN-PETGVISTRAEMDRE--DSEHVKNSTYTALIIA 571

  Fly   563 IDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVS----GKKILEVAAKDPDDRLRGNG 623
            .|||||..|.|.||.:::.|||||||.      |. |.|:.    ..|...:...|||  |..|.
  Rat   572 TDDGSPIATGTGTLLLVLSDVNDNAPI------PE-PRNMQFCQRNPKPHVITILDPD--LPPNT 627

  Fly   624 GPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMT 688
            .|||..|...||    ..:.:||:   |.|....|:...:  |.|..: |.|.:::.||  ....
  Rat   628 SPFTAELTHGAS----VNWTIEYN---DAEQESLILQPRK--DLEIGE-YKINLKLSDN--QNKD 680

  Fly   689 GTSTLTVTI----GDVND----NKMQPGSKSVLVYNYQGQSQDTPI----------GRVYVND-- 733
            ..:||.|.:    |.||:    ..::.|.:...:....|......|          .|..|.:  
  Rat   681 QVTTLEVHVCDCEGTVNNCMKAISLEAGLQVPAILGILGGILALLILILLLLLFLRRRTVVKEPL 745

  Fly   734 --PDDWDVPDKKYYWEV----QEHQRFKLDTDTGILTMR--------AGTRRGRYQLRFKVYDRE 784
              ||| |..|..||::.    :|.|.|.|......|..|        |.|.....|.|.:..:.:
  Rat   746 LPPDD-DTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVIRNDVAPTLMSMPQYRPRPANPD 809

  Fly   785 HGQEDIPANLSVTVRDIT------------------AEAVQQAGSMRLSHITDEDFVRTWNPVKN 831
            .....|..||.....|.|                  |.::....|.......|.|::..|.    
  Rat   810 EIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDQDQDYDYLNEWG---- 870

  Fly   832 QVEPSKLERFRNKLAEL 848
                   .||: |||::
  Rat   871 -------NRFK-KLADM 879

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637
Cadherin_repeat 140..248 CDD:206637 28/109 (26%)
Cadherin_repeat 256..359 CDD:206637 39/107 (36%)
Cadherin_repeat 379..481 CDD:206637 24/112 (21%)
Cadherin_repeat 489..586 CDD:206637 33/103 (32%)
Cadherin_repeat 594..703 CDD:206637 32/120 (27%)
Cadherin_repeat 724..801 CDD:206637 23/102 (23%)
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
Cdh1NP_112624.1 Cadherin_pro 31..120 CDD:285913
CA_like 162..262 CDD:206635 30/116 (26%)
Cadherin_repeat 270..375 CDD:206637 40/108 (37%)
Cadherin_repeat 383..>462 CDD:206637 20/96 (21%)
Cadherin_repeat 496..595 CDD:206637 33/101 (33%)
Cadherin 608..690 CDD:278457 26/95 (27%)
Cadherin_C 745..881 CDD:279398 32/148 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 751..771 6/19 (32%)
Required for binding CTNND1 and PSEN1. /evidence=ECO:0000250 762..773 3/10 (30%)
Required for binding alpha, beta and. /evidence=ECO:0000250 815..886 15/77 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 130 1.000 Domainoid score I5067
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24027
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.010

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