Protein Alignment CadN2 and Cdh2

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_112623.2
• Gene: Cdh2 / 83501
• RGDID: 69280
• Length: 906
• Species: Rattus norvegicus
• Alignment Length: 952
• Identity: 236/952 - (24%)
• Similarity: 377/952 - (39%)
• Gaps: 226/952 - (23%)

  Fly    36 FDRFLYETEIDENADLQSTVLTVNAKDHNESTNIRYQITG------GNIGNAFAV-------QNT 87
            |...:|...:.::......:|.|...:.|....::|:.:.      ...|..:||       :..
  Rat    36 FPEAVYSAVLPKDVHEGQPLLNVKFSNCNRKRKVQYESSEPADFKVDEDGTVYAVRSFPLSAEQA 100

  Fly    88 TGVIYVASPLDYETRPRYE----LRLE----------------------------ATRNRKNNYT 120
            ..:||..   |.||:.:::    |.||                            |.:.:|.::.
  Rat   101 KFLIYAQ---DKETQEKWQVAVNLSLEPSLTEEPMKEPHEIEEIVFPRQLAKHSGALQRQKRDWV 162

  Fly   121 TVVINVRDVNDNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPD 185
            ...||:.:.:..|                   .|:.::::.:   |.|:.:::.|.:||.|  .|
  Rat   163 IPPINLPENSRGP-------------------FPQELVRIRS---DRDKNLSLRYSVTGPG--AD 203

  Fly   186 NPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAP 250
            .|....|.||..:|.:.|.|||||:.   ..::.....|.|..|..:....||.:|:.|:|||.|
  Rat   204 QPPTGIFIINPISGQLSVTKPLDREL---IARFHLRAHAVDINGNQVENPIDIVINVIDMNDNRP 265

  Fly   251 QFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP-IFEIEPET 314
            :|...::.|:|.|....|:.|||::|:|.|||| :.|..|.|.|....  ..|.:| :|.|..||
  Rat   266 EFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPN-ALNGMLRYRILSQA--PSTPSPNMFTINNET 327

  Fly   315 GLIKTAVCCLDRERTPDYS--IQVVAMDGG---GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVD 374
            |.|.|....||||:...|:  ||...|:|.   ||..|.||.|.|.|:||.||:||...:..||.
  Rat   328 GDIITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVP 392

  Fly   375 ETNGTYIPETPILTVTVQDEDETNT----FQYKVVPNSGFGADKFAMVRN-GDGTGSLKIIQPLD 434
            |.....|    :..:||.|:|:.:|    ..|::  :.|....:||::.: ....|.:.:::|:|
  Rat   393 ENRVDVI----VANLTVTDKDQPHTPAWNAAYRI--SGGDPTGRFAILTDPNSNDGLVTVVKPID 451

  Fly   435 YEDPLQSSGFRFRIQVND-----KGDDGPGGSDKYHVAYSWVVVKLRDINDNV-----PKFDREH 489
            :|   .:..|...:...:     ||...|..|.      :.|.|.:.|:|:|.     ||..|:.
  Rat   452 FE---TNRMFVLTVAAENQVPLAKGIQHPPQST------ATVSVTVIDVNENPYFAPNPKIIRQE 507

  Fly   490 IEVSIYEDTKVGTILEQFKATDADQGGHSKVAY-KIVRSTNRKRQFAISDRGAVSIQRPLDRET- 552
                  |....||:|....|.|.|:.....:.| |:....|..:...::  |.::....||||:
  Rat   508 ------EGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSDPANWLKIDPVN--GQITTIAVLDRESP 564

  Fly   553 ---QDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPT--LPENVSGKKILEVAA 612
               .:.::...||.|:|.|..:.|.||.:.:.|:|||||........|  .||..|    :.:.|
  Rat   565 NVKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQEAETCETPEPNS----INITA 625

  Fly   613 KDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPI 677
            .|.|  :..|.|||.|.| ||:...||..:.:      ...||.....:|:....|| ..|.:||
  Rat   626 LDYD--IDPNAGPFAFDL-PLSPVTIKRNWTI------TRLNGDFAQLNLKIKFLEA-GIYEVPI 680

  Fly   678 EIKDNGAPAMTGTSTLTVTI------GDVNDNKMQPGS----------------KSVLVYNY--- 717
            .|.|:|.|..:..|.|.|.:      ||..|.....|:                ..:||..:
  Rat   681 VITDSGNPPKSNISILRVKVCQCDSNGDCTDVDRIVGAGLGTGAIIAILLCIIILLILVLMFVVW 745

  Fly   718 -QGQSQDTPIGRVYVNDPDDWDVPDK--KYYWE--VQEHQRFKL------DTDTGILTMRAGTRR 771
             :.:.::....::.: ||:| ||.|.  ||..|  .:|.|.:.|      ||.........|.||
  Rat   746 MKRRDKERQAKQLLI-DPED-DVRDNILKYDEEGGGEEDQDYDLSQLQQPDTVEPDAIKPVGIRR 808

  Fly   772 ---------GRYQLR----------------FKVYDREHGQEDIPANLSVTVRDI-----TAEAV 806
                     .:|.:|                .|..|.:   ...|...|:.|.|.     ||.::
  Rat   809 LDERPIHAEPQYPVRSAAPHPGDIGDFINEGLKAADND---PTAPPYDSLLVFDYEGSGSTAGSL 870

  Fly   807 QQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAEL 848
            ....|.......|.|::..|.|           ||: |||::
  Rat   871 SSLNSSSSGGDQDYDYLNDWGP-----------RFK-KLADM 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	20/135 (15%)
		Cadherin_repeat	140..248	CDD:206637	27/107 (25%)
		Cadherin_repeat	256..359	CDD:206637	43/108 (40%)
		CA	388..483	CDD:214520	23/109 (21%)
		Cadherin_repeat	489..586	CDD:206637	25/101 (25%)
		Cadherin_repeat	594..703	CDD:206637	34/116 (29%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	1233..1259	CDD:400365
		LamG	1265..1426	CDD:238058
		EGF_CA	1497..1535	CDD:238011
		CADH_Y-type_LIR	1662..1719	CDD:460041
Cdh2	NP_112623.2	Cadherin_pro	31..121	CDD:462590	14/87 (16%)
		CA_like	163..263	CDD:481204	30/126 (24%)
		Cadherin_repeat	273..378	CDD:206637	44/107 (41%)
		Cadherin_repeat	386..494	CDD:206637	26/122 (21%)
		Cadherin_repeat	508..601	CDD:206637	25/94 (27%)
		CA_like	608..701	CDD:481204	32/106 (30%)
		CADH_Y-type_LIR	843..902	CDD:460041	17/73 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..883		3/19 (16%)