DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and FAT4

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001278232.1 Gene:FAT4 / 79633 HGNCID:23109 Length:4983 Species:Homo sapiens


Alignment Length:2232 Identity:488/2232 - (21%)
Similarity:794/2232 - (35%) Gaps:672/2232 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTNI--RYQITGGNIGNAFAV 84
            |.|.|.|:||:.|.|.: ::...:.||:.|..||..|...|.:...|.  ||.|...::  .|.:
Human  2761 VMINILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASL--PFTI 2822

  Fly    85 QNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYR---TQIT 146
            ..:||.|.::.||:.|...||.:|:.|..:.....|.|.|.|.|:|||.|.|.|.:|.   .::|
Human  2823 NPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELT 2887

  Fly   147 EEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQ 211
            |     :..::.||.|||.|......:.||:..|        :..|.||.|||:||..:.|....
Human  2888 E-----IGSKVTQVFATDPDEGSNGQVFYFIKSQ--------SEYFRINATTGEIFNKQILKYQN 2939

  Fly   212 PNGRP-----QWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSV 271
            ..|..     :..|.|.:.|.|...|:....:.:|:.|.|||||||.:..||..||:|...|:.:
Human  2940 VTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKL 3004

  Fly   272 MTMSAVDYDD----------------------PNE----STNAKLIYSIEKN------------- 297
            :.::|:|..|                      .|:    |..:.||..:.:|             
Human  3005 IRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNP 3069

  Fly   298 -----------VIEEETGAP--------------------------------------------- 306
                       |.||....|                                             
Human  3070 PLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGN 3134

  Fly   307 ---IFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRVK--DLNDMPPQFTK 366
               ||.|...||:: |....||.|....:.:.:.|:|||.:..||..|:.|.  |:||..|.|..
Human  3135 EEGIFAINSSTGIL-TLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLS 3198

  Fly   367 DEWVTEVDET--NGTYIPETPILTVTVQDEDE-TNTFQYKVVPNSGFGADKFAMVRNGDGTGSLK 428
            |::...|.|.  :|     |.::.:...|.|. ||......|.:|  .:|.|.:..|   ||.:.
Human  3199 DDYFPTVLENAPSG-----TTVIHLNATDADSGTNAVIAYTVQSS--DSDLFVIDPN---TGVIT 3253

  Fly   429 IIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVS 493
            ....||:|.. ||    :.:.|  |..:.|   |:...:::.|.::|:..|:.||:|..:.....
Human  3254 TQGFLDFETK-QS----YHLTV--KAFNVP---DEERCSFATVNIQLKGTNEYVPRFVSKLYYFE 3308

  Fly   494 IYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAIS------------DR------- 539
            |.|....|||:.:..|:|.|.|...:|.| ::...:||:.|.|:            ||       
Human  3309 ISEAAPKGTIVGEVFASDRDLGTDGEVHY-LIFGNSRKKGFQINKKTGQIYVSGILDREKEERVS 3372

  Fly   540 ----------------------------------------------------------------- 539
                                                                             
Human  3373 LKVLAKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIP 3437

  Fly   540 ------------------------GAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIV 580
                                    |.:::...|||||...:::.:||:|.|:|:.|.:|:|.|.:
Human  3438 SWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTL 3502

  Fly   581 KDVNDNAPTFAQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVE 645
            :|:|||.|.........:.....|..::.:.:.|||  |..|.||||:.|  |::....:.|.: 
Human  3503 EDINDNGPMLTVSEGEVMENKRPGTLVMTLQSTDPD--LPPNQGPFTYYL--LSTGPATSYFSL- 3562

  Fly   646 YDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSK 710
                    :...::|:.|..|||....:.:.:..||:|.|.|:.|.|:.:|:.|.|||..|  |:
Human  3563 --------STAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDNPSQ--SR 3617

  Fly   711 SVLVY-NYQGQSQDTPI-GRVYVNDPDDWDVPDKKYYWEVQE--HQRFKLDTDTGILTMRAGTRR 771
            :|.:: ||.|......| |.|...|||..|    .::..:..  ...|.:...|..|..:..:..
Human  3618 TVEIFVNYYGNLFPGGILGSVKPQDPDVLD----SFHCSLTSGVTSLFSIPGGTCDLNSQPRSTD 3678

  Fly   772 GRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFV------------- 823
            |.:.|.....|..|  ..:.:|:.|.....:...|..:..:||...|.:||:             
Human  3679 GTFDLTVLSNDGVH--STVTSNIRVFFAGFSNATVDNSILLRLGVPTVKDFLTNHYLHFLRIASS 3741

  Fly   824 -------------------RTW--NPVK---NQ-VEPSKLERFRNKLAELLY---------TDRD 854
                               ||:  ..||   || |.||.:..|...:.|:|.         .|.|
Human  3742 QLTGLGTAVQLYSAYEENNRTFLLAAVKRNHNQYVNPSGVATFFESIKEILLRQSGVKVESVDHD 3806

  Fly   855 N---------------VDVFSVQLKEGSPYPLTDVHFAARSATQQPYFKAVRLNGVVQMHREEIE 904
            :               :.|.|| ||.....|:..|    .:...|| |....|.|......|   
Human  3807 SCVHGPCQNGGSCLRRLAVSSV-LKSRESLPVIIV----ANEPLQP-FLCKCLPGYAGSWCE--- 3862

  Fly   905 KDVGLNITMVNINECL----HEGKGKC----GSNSCTSKVELGKKPYTVSVN-------RTALVG 954
                     ::|:|||    |.| |.|    |..||:.......:.....:|       :...:.
Human  3863 ---------IDIDECLPSPCHSG-GTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAIC 3917

  Fly   955 VRLDISAQCVCRARNFT-----HQDHNCRTHLCYNGGRCVETRNGPKCVACPVGYNGPRCQQSTR 1014
            .....|..|||:. .:|     ...:.|..:.|:|||.|....:...| .||.|..|..|:.::.
Human  3918 QNFPGSFNCVCKT-GYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYC-HCPFGVFGKHCELNSY 3980

  Fly  1015 SFRGNGWAWYPPLQLCQESHLSLEFITRVADGLILYNGPIVPPKPEET-VISDFIALELEQGYPR 1078
            .|....:..:|.|. ...:::.::|.|..:..|:|||      ...:| ..::|:|||:.:...|
Human  3981 GFEELSYMEFPSLD-PNNNYIYVKFATIKSHALLLYN------YDNQTGDRAEFLALEIAEERLR 4038

  Fly  1079 LLIDFGSGTLELRVKTKKTLDDGVWHRL---------DIFWDTENVRMVVDFCRTALVSEMEDGT 1134
            ...:.||||.:|  .|.|.:.||.:|.:         .:..|:.:......:|..:.|:..:|.|
Human  4039 FSYNLGSGTYKL--TTMKKVSDGHFHTVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWT 4101

  Fly  1135 PPEFDDNACQARGQIPPFAESLNLNQP--LQLGGL--------YRQHFDQTLYNWQYAFSSKGFD 1189
                                 |:: ||  :.:||:        .|.|.:           |..|.
Human  4102 ---------------------LDV-QPNRVTVGGIRSLEPILQRRGHVE-----------SHDFV 4133

  Fly  1190 GCIRNVIHNSEHYDLAFPALARNSFPACPQTDEVCLKTEHTARCWEHGNCVASLVQAKCHCQPGW 1254
            |||.....|....:.:....|:.....||:.:..|.::.    |...|.|:......:|||:.|.
Human  4134 GCIMEFAVNGRPLEPSQALAAQGILDQCPRLEGACTRSP----CQHGGTCMDYWSWQQCHCKEGL 4194

  Fly  1255 MGPGCNVPTIPTT---FKAQSYVKFALS-----------------FEPDRFSTQLQLRFRTREQG 1299
            .|..|.....|.|   .:.:..:.:.:|                 .||...:: |:::||||.:.
Human  4195 TGKYCEKSVTPDTALSLEGKGRLDYHMSQNEKREYLLRQSLRGAMLEPFGVNS-LEVKFRTRSEN 4258

  Fly  1300 GELFRVSDQHHREYAILELRRGHLQFRYNLNSMRNEEQLLTLTAIAVNDGQWHVIRISRYGSAAL 1364
            |.|..:  |....|..::::.|.:.|..:.......|:  .:..:.|.||.||...|.:.|:|.:
Human  4259 GVLIHI--QESSNYTTVKIKNGKVYFTSDAGIAGKVER--NIPEVYVADGHWHTFLIGKNGTATV 4319

  Fly  1365 MELDGGESRRYNESF-----HFTGHQWLTIDKQEGVYAGGKAEYTGIKTFEVQSDFQRS----CL 1420
            :.:|    |.||...     .|.|...|||            ...||...:...|.|.:    |:
Human  4320 LSVD----RIYNRDIIHPTQDFGGLDVLTI------------SLGGIPPNQAHRDAQTAGFDGCI 4368

  Fly  1421 DDIRLDGKHLPLPPAMNGTQWGQATMAR------NLERNCPSNRPCSNVICPDPFDCVDLWNEYE 1479
            ..:...|:.||..        |:.::|.      :::..|.....|::..|.....|::.|..|.
Human  4369 ASMWYGGESLPFS--------GKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLCINQWYAYR 4425

  Fly  1480 CTCSEGRIMSSDTKGCVDRNECLDLPCLNGATCINLEPRLR--YRCICPEGYWGENCELV----- 1537
                           ||...:|...||.||.:|   ||.|.  :.|.||:.:.|..||:|     
Human  4426 ---------------CVPPGDCASHPCQNGGSC---EPGLHSGFTCSCPDSHTGRTCEMVVACLG 4472

  Fly  1538 ----------------------QEGQRLKLSMGALGAIF-VCLIIILILALIFVLYS-------- 1571
                                  |..:.:.|.:.|:.||. .|..::.:|.|..:|.:        
Human  4473 VLCPQGKVCKAGSPAGHVCVLSQGPEEISLPLWAVPAIVGSCATVLALLVLSLILCNQCRGKKAK 4537

  Fly  1572 --RKRKTTKKKKRSGPEKDVRETVISYEDEGG----GEDDMTAFDITPLQIPISAQGGP-PDIAA 1629
              ::.|..|:||:.|.|.      ::::|...    | ||||        :....:|.| |||..
Human  4538 NPKEEKKPKEKKKKGSEN------VAFDDPDNIPPYG-DDMT--------VRKQPEGNPKPDIIE 4587

  Fly  1630 CKMPIIYPVMTLLPPGQELNVAYLMEERKQRIDKDNNAPPFDDLRNFTFEGSGSIAESLSSLASG 1694
            .:.|.:....|.:|...|            .|.....|.|..::.::..:.:.|||.|.:.:.  
Human  4588 RENPYLIYDETDIPHNSE------------TIPSAPLASPEQEIEHYDIDNASSIAPSDADII-- 4638

  Fly  1695 TDDENQDFNYLQNWGPRFNALAAMYVHDKAKASSQLPSDGGGGS-------GDG----------- 1741
                 |.:...::..|:|    ::..|.....:.|.|...|..|       |.|           
Human  4639 -----QHYKQFRSHTPKF----SIQRHSPLGFARQSPMPLGASSLTYQPSYGQGLRTSSLSHSAC 4694

  Fly  1742 ----------PGPGASSSS------------PLGGGGT---GGGSGIPGNVLAVVATGSG----- 1776
                      |.|.:.||:            |:..|.|   .|.:..||  :...||..|     
Human  4695 PTPNPLSRHSPAPFSKSSTFYRNSPARELHLPIRDGNTLEMHGDTCQPG--IFNYATRLGRRSKS 4757

  Fly  1777 ----AGPGGGGGSSGLMPLPEV 1794
                |..|...||....|:.::
Human  4758 PQAMASHGSRPGSRLKQPIGQI 4779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 28/92 (30%)
Cadherin_repeat 140..248 CDD:206637 30/115 (26%)
Cadherin_repeat 256..359 CDD:206637 36/202 (18%)
Cadherin_repeat 379..481 CDD:206637 24/102 (24%)
Cadherin_repeat 489..586 CDD:206637 34/204 (17%)
Cadherin_repeat 594..703 CDD:206637 28/108 (26%)
Cadherin_repeat 724..801 CDD:206637 16/79 (20%)
EGF_CA 977..1010 CDD:238011 11/32 (34%)
LamG 1013..1198 CDD:238058 42/204 (21%)
EGF_2 <1233..1259 CDD:285248 8/25 (32%)
Laminin_G_2 1293..1428 CDD:280389 33/143 (23%)
EGF_CA 1497..1535 CDD:238011 13/39 (33%)
Cadherin_C 1583..1719 CDD:279398 27/140 (19%)
FAT4NP_001278232.1 Cadherin_repeat 48..131 CDD:206637
Cadherin_repeat 139..246 CDD:206637
Cadherin_repeat 254..349 CDD:206637
Cadherin_repeat 364..471 CDD:206637
Cadherin_repeat 479..577 CDD:206637
Cadherin_repeat 588..685 CDD:206637
Cadherin_repeat 693..789 CDD:206637
Cadherin_repeat 798..889 CDD:206637
Cadherin_repeat 899..992 CDD:206637
Cadherin_repeat 1000..1096 CDD:206637
Cadherin_repeat 1105..1206 CDD:206637
Cadherin_repeat 1215..1311 CDD:206637
Cadherin_repeat 1321..1416 CDD:206637
Cadherin_repeat 1428..1525 CDD:206637
Cadherin_repeat 1540..1622 CDD:206637
Cadherin_repeat 1634..1736 CDD:206637
Cadherin_repeat 1747..1837 CDD:206637
Cadherin_repeat 1845..1940 CDD:206637
Cadherin_repeat 1948..2047 CDD:206637
Cadherin_repeat 2057..2150 CDD:206637
Cadherin_repeat 2159..2254 CDD:206637
Cadherin_repeat 2263..2360 CDD:206637
Cadherin_repeat 2369..2464 CDD:206637
Cadherin_repeat 2472..2559 CDD:206637
Cadherin_repeat 2573..2667 CDD:206637
Cadherin_repeat 2675..2771 CDD:206637 5/9 (56%)
Cadherin_repeat 2778..2870 CDD:206637 28/93 (30%)
Cadherin_repeat 2878..2981 CDD:206637 30/115 (26%)
Cadherin_repeat 2990..3085 CDD:206637 16/94 (17%)
Cadherin_repeat 3095..3192 CDD:206637 19/97 (20%)
Cadherin_repeat 3201..3295 CDD:206637 26/113 (23%)
Cadherin_repeat 3305..3402 CDD:206637 17/97 (18%)
Cadherin_repeat 3410..3508 CDD:206637 17/97 (18%)
Cadherin_repeat 3516..3612 CDD:206637 28/108 (26%)
EGF_CA 3864..3900 CDD:238011 11/36 (31%)
EGF_CA 3902..3938 CDD:238011 6/36 (17%)
EGF_CA 3941..3976 CDD:238011 11/35 (31%)
LamG 3979..4142 CDD:238058 42/204 (21%)
EGF 4168..4198 CDD:278437 9/33 (27%)
LamG 4247..4368 CDD:238058 33/141 (23%)
EGF_CA 4431..4465 CDD:238011 13/36 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3B9B2
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.710

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