DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN2 and Fat2

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_075243.1 Gene:Fat2 / 65048 RGDID:620656 Length:4351 Species:Rattus norvegicus


Alignment Length:1758 Identity:391/1758 - (22%)
Similarity:643/1758 - (36%) Gaps:455/1758 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 TNSTYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTN--IRYQIT 74
            |:...||:  |.|.:.|.||:.|.|:...|:..:.||....:||:.|.|.|.:..::  :.|:::
  Rat  2777 TDLVSLVS--VSIQVEDVNDNRPVFEADPYKAFLTENMPGGTTVIQVTANDQDTGSDGQVSYRLS 2839

  Fly    75 ---GGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEATRN----RKNNYTTVVINVRDVNDN 132
               |.||...|||.:.:|.|.....||.||:..|...:.|..:    :.::...|.:::.|.|||
  Rat  2840 VEPGSNIHELFAVDSESGWITTLQELDCETQQTYRFYVVAFDHGQTIQLSSQALVEVSITDENDN 2904

  Fly   133 PPVFDRQTYRTQITEEDDRNLPKRILQVTAT-DGDV-DRPINIVYFLTGQGIDPDNPANSKFDIN 195
            ||.|..:.||..:.|   .|.|..::....| |.|| |:...:..::| :| ||    ..:|.|:
  Rat  2905 PPRFASEDYRGSVVE---NNEPGELVATLKTLDADVSDQNRQVTCYIT-EG-DP----LGQFSIS 2960

  Fly   196 RTTGD---IFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIY 257
            : .||   |...|.|||:.   ..::...|.|.|...:..|   .::|.:.|||||:||..|.:|
  Rat  2961 Q-VGDEWRISSRKTLDREH---IAKYLLRVTASDGKFQASV---PVEVFVVDINDNSPQCSQLLY 3018

  Fly   258 FGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVC 322
            .|.|.|:.|.|..::.:||:|.|   ..|||::.||:      ...||..|:::|.||.: |.:.
  Rat  3019 TGKVREDVTPGHFILKVSAIDVD---MDTNAQITYSL------HGPGAQEFKLDPHTGEL-TTLT 3073

  Fly   323 CLDRERTPDYSIQVVAMDGGGLKGTGTASIRVKDLNDMPPQFTKDEW-VTEVDETNGTYIPETPI 386
            .|||||...|::...|.||||.......::.::|:||..|:|..... |...|.|.    .:||:
  Rat  3074 VLDRERKDVYNLVAKATDGGGQSCQAEVTLHIEDVNDNAPRFFPSHCDVAVFDNTT----VKTPV 3134

  Fly   387 LTVTVQDEDETNTFQYKVVPNSGFGADK---FAMVRNGDGTGSLKIIQ-PLDYEDPLQ---SSGF 444
            ..|..:|.|:              ||:.   :::..:.||..|:.... .:..|.|||   ||..
  Rat  3135 AVVFARDPDQ--------------GANAQVVYSLTDSADGQFSIDATSGVIRLEKPLQVRASSAV 3185

  Fly   445 RFRIQVNDKG-----------------------------------DDGP-------------GGS 461
            ...::.:|.|                                   :|.|             .||
  Rat  3186 ELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPIFLNAEHSTQVPEDAPIDMEVLHLATLTRPGS 3250

  Fly   462 DK--YHVA-----------------------------------------------YSWVVVKLRD 477
            :|  ||:.                                               .:.:|:.:.|
  Rat  3251 EKTGYHITGGNEQGKFRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSSSLSDVTTIVINVTD 3315

  Fly   478 INDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAIS-DRGA 541
            :|::.|:|..:...|.:.|:..||.::....|:|.|...:|.:.|.:| ..|:...|.|: .:|.
  Rat  3316 VNEHHPRFTHDLYTVRVLENAVVGDVILTVSASDDDGPVNSAITYSLV-GGNQLGHFTINPKKGK 3379

  Fly   542 VSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQ-DYKPTLPENVS-G 604
            :.:.:.||.|....:.:::.|.|.|.|.......:.|.|.|||||.|.|.| :|..::.||.. |
  Rat  3380 LQVAKALDWEQTPSYSLRLRATDSGQPPLHEDTEVAVEVVDVNDNPPRFFQLNYSTSVQENSPIG 3444

  Fly   605 KKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREA 669
            .|:|::...|||.  ..||.|:.||:....:..:   |:|..|      ..:...:||   .::|
  Rat  3445 IKVLQLILDDPDS--PQNGPPYFFRITEGNTGSV---FRVTPD------GWLVTAASL---SKKA 3495

  Fly   670 QKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVYNYQGQS--QDTPIGRVYVN 732
            ::.|.:.||:.|:|.|.::.::.:.|.:  ...::..|.:..:.:...:|:.  |...||:::..
  Rat  3496 REWYQLHIEVSDSGLPPLSSSTLVRVQV--TEQSRYPPSTLPLEISITKGEEEFQGGMIGKIHAT 3558

  Fly   733 DPDDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKVYDREHGQEDIPANLSVT 797
            |.|..|........|....:.|.:....|.:....|...|||.....|.|   |.......:.|.
  Rat  3559 DRDPQDTLTYSLEQEGGLDRYFTVGASDGKIIASQGLPHGRYSFNVTVSD---GTFTTTTGVHVH 3620

  Fly   798 VRDITAEAVQQAGSMRLSHITDEDFVRT-WNPVKNQVEPSKLERFRNKLAELLYTDRDNVDVFSV 861
            |..:..|..|||..:....:|.|:.|.. |.         .|:||   |:.||...|.|:.:.|:
  Rat  3621 VWHMEPEVPQQAVWLGFHQLTPEELVSDHWR---------NLQRF---LSNLLDVKRANIHLASL 3673

  Fly   862 QLKEGSPYPLT---DV--HFAARSATQQPYFKAVRLNGVVQMHREEIEKDVGLNI-TMVNINECL 920
            |     |..:|   ||  .|...|.|.   :....|...:.....|||..||:.: :.:.:..| 
  Rat  3674 Q-----PAEVTAGVDVLLVFERHSGTS---YDLQELASAIAHSVREIEHSVGIRMRSALPVVPC- 3729

  Fly   921 HEGKGKCGSNSCTSKVELGKKPYTVSVNRTALVGVRLDISAQCVCRARNFTHQDHNCRTHLCYNG 985
             :|: .|...:|...|.|..:           ||.....:...:...|:  |...||        
  Rat  3730 -QGQ-SCQDQTCQETVSLEPR-----------VGPSYSTARLSILTPRH--HLGRNC-------- 3771

  Fly   986 GRCVETRNGPKCVACPVGYNGPRCQQSTRSFRGNGWAWYPPLQLCQ-ESHLSLEFITRVADGLIL 1049
                                  .|..:|..|.|..:..|.||:... :.|..|:.:...|  |::
  Rat  3772 ----------------------SCNGTTLRFSGQSYVQYRPLEAQNWQIHFYLKTLQPWA--LLM 3812

  Fly  1050 YNGPIVPPKPEETVISDFIALELEQGYPRLLIDFGSGTLELRVKTKKTLDDGVWHRLDIFWDTEN 1114
            :.        .||.   .|:|:|..|:..|......|... .:.::..::||.||.:.:.....:
  Rat  3813 FT--------NETA---SISLKLANGFSHLEYHCPGGFYG-NLSSRYPVNDGQWHSMLLEERDTS 3865

  Fly  1115 VRMVVDFCRTALVSEMEDGTPPEFDDNACQARGQIPPFAESLNLNQPLQLGGLYRQHFDQTLYNW 1179
            |.::||                 ..|||...   ||...:.|...:.|.||||...:....:   
  Rat  3866 VHLLVD-----------------ITDNASLV---IPEECQGLRTERQLLLGGLVPSNPSSNV--- 3907

  Fly  1180 QYAFSSKGFDGCIRNVIHNSEHYDL------------------------------------AFPA 1208
                 |.||:||:..|:.|.|..:|                                    ..||
  Rat  3908 -----SLGFEGCLDAVVVNGERLELLGREKKMEGRLETWALSQCCWPGTACSQSPCLNGGSCSPA 3967

  Fly  1209 LARNSFPACP-----QTDEVCLKTEHTARCWEHGNCVASLVQAKCHCQPGWMGPGCNV------- 1261
            |.......||     :..|:..:...:|.|.|.|.||:|.....|:|...:.|..|.:       
  Rat  3968 LGSGYLCRCPPPFSGRNCELGRENCTSAPCQEGGTCVSSPEGTSCNCPHPYTGDRCEMEARGCSG 4032

  Fly  1262 ------PTIPT-TFKAQSYVKFALSFEPDRFSTQLQLRFRTREQGGELFRVSDQHHREYAI---- 1315
                  |.|.. .:..|.::...::......:|...|.:..|.:..:...:.|......:|    
  Rat  4033 GHCLITPEIKRGDWGQQEFLVITVALPLVIIATVGLLLYCRRRKSHKPVTMEDPDLLARSIGVDT 4097

  Fly  1316 -----LELRRGHLQFRYNLN-------SMRNEEQLLT-----------------LTAIAVNDGQW 1351
                 :||...:.....|||       |:.||  |:|                 |...||:....
  Rat  4098 QASPAIELDPLNTSSCNNLNQPEPSKTSVPNE--LVTFGPSSKQRPMVCSVPPRLPPAAVSSHPG 4160

  Fly  1352 HVIRISRYGSAALMELDGGES---RRYNESFHFTGHQWLTIDKQEGVYAGGKAEYTGIKTFEVQS 1413
            |...|.|..|...:....|.:   ..|:...|:   ::...:..:|........:.|.......:
  Rat  4161 HEPIIKRTWSGEELVYPSGAAVWPPTYSRKKHW---EYPHPETMQGTLPPSPRRHVGPAVMPDPT 4222

  Fly  1414 DFQRSCLDDIRLDGKHLPLPPAMNGTQWGQATMARNLERNCPSNRPCSNVICPDPFDCVDLWNEY 1478
            .........:.|:.|..||||..:.         :|||...|. ||      |.|          
  Rat  4223 GLYGGFPFPLELENKRAPLPPRYSN---------QNLEDLMPP-RP------PSP---------- 4261

  Fly  1479 ECTCSEGRIMSSDTKGCVDRNECLDLPCLNGATCINLEPRLRYR------CICPEGYWGENCELV 1537
                                .|.|..||||..|.|:.. ..::|      |:...||.|.:..|.
  Rat  4262 --------------------REHLLAPCLNEYTAISYY-HSQFRQGGGGPCLAEGGYKGVSMRLS 4305

  Fly  1538 QEG 1540
            :.|
  Rat  4306 RAG 4308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 26/99 (26%)
Cadherin_repeat 140..248 CDD:206637 31/112 (28%)
Cadherin_repeat 256..359 CDD:206637 34/102 (33%)
Cadherin_repeat 379..481 CDD:206637 28/205 (14%)
Cadherin_repeat 489..586 CDD:206637 26/97 (27%)
Cadherin_repeat 594..703 CDD:206637 27/109 (25%)
Cadherin_repeat 724..801 CDD:206637 17/76 (22%)
EGF_CA 977..1010 CDD:238011 1/32 (3%)
LamG 1013..1198 CDD:238058 42/185 (23%)
EGF_2 <1233..1259 CDD:285248 9/25 (36%)
Laminin_G_2 1293..1428 CDD:280389 26/170 (15%)
EGF_CA 1497..1535 CDD:238011 13/43 (30%)
Cadherin_C 1583..1719 CDD:279398
Fat2NP_075243.1 Cadherin_repeat 38..143 CDD:206637
Cadherin_repeat 152..249 CDD:206637
Cadherin_repeat 366..454 CDD:206637
Cadherin_repeat 462..560 CDD:206637
Cadherin_repeat 570..661 CDD:206637
Cadherin_repeat 719..816 CDD:206637
Cadherin_repeat 825..921 CDD:206637
Cadherin_repeat 931..1026 CDD:206637
Cadherin_repeat 1036..1133 CDD:206637
Cadherin_repeat 1141..1238 CDD:206637
Cadherin_repeat 1247..1335 CDD:206637
Cadherin_repeat 1354..1444 CDD:206637
Cadherin_repeat 1452..1551 CDD:206637
Cadherin_repeat 1560..1650 CDD:206637
Cadherin_repeat 1664..1754 CDD:206637
Cadherin_repeat 1766..1867 CDD:206637
E_set 1877..1959 CDD:298831
Cadherin_repeat 1972..2066 CDD:206637
Cadherin_repeat 2074..2163 CDD:206637
Cadherin_repeat 2176..2268 CDD:206637
Cadherin_repeat 2276..2375 CDD:206637
Cadherin_repeat 2383..2475 CDD:206637
Cadherin_repeat 2485..2581 CDD:206637
Cadherin_repeat 2590..2683 CDD:206637
Cadherin_repeat 2697..2795 CDD:206637 7/19 (37%)
Cadherin_repeat 2803..2904 CDD:206637 26/100 (26%)
Cadherin_repeat 2913..3009 CDD:206637 31/111 (28%)
Cadherin_repeat 3018..3111 CDD:206637 35/102 (34%)
Cadherin_repeat 3122..3211 CDD:206637 21/106 (20%)
Cadherin_repeat 3226..3319 CDD:206637 10/92 (11%)
Cadherin_repeat 3328..3424 CDD:206637 26/96 (27%)
Cadherin 3433..3524 CDD:278457 27/106 (25%)
Cadherin_repeat 3535..3621 CDD:206637 18/88 (20%)
Laminin_G_2 3802..3923 CDD:280389 36/162 (22%)
EGF_CA 3953..3986 CDD:238011 5/32 (16%)
EGF 3992..4022 CDD:278437 10/29 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4316..4340
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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