DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and CDH23

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_071407.4	Gene:	CDH23 / 64072	HGNCID:	13733	Length:	3354	Species:	Homo sapiens

Alignment Length:	1265	Identity:	313/1265 - (24%)
Similarity:	478/1265 - (37%)	Gaps:	287/1265 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTNIRYQITGGNIGNAFAVQN 86
            |:|.:.::||:.|.|.:.||...:.||..:.::||||.|.|::..|.........:..:.|::..
Human   446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDK 510

  Fly    87 TTGVIYVASPLDYETRPRYELRLEATRNRKNNYTT--VVINVRDVNDNPPVFDRQTYRTQITEED 149
            .||:|.:.:.||||...|:.|.:.| |:.....||  |.|||.|||||.|.|.:..|...:.|
Human   511 DTGLIMLIARLDYELIQRFTLTIIA-RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRE-- 572

  Fly   150 DRNLPK--RILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDIN--RTTGDIFVLKPLDRD 210
              |.|.  :::::.|||.|......|.|.:...     :...|.|||:  ...|.|.|.:|||.:
Human   573 --NEPSVTQLVRLRATDEDSPPNNQITYSIVSA-----SAFGSYFDISLYEGYGVISVSRPLDYE 630

  Fly   211 Q-PNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTM 274
            | .||...  .||.|.|.|...|.....:.:.:.|.|||.|.|.:..||.:|.||..||::|:.:
Human   631 QISNGLIY--LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFL 693

  Fly   275 SAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAM 339
            :|.|.|...|.....:|||:|        |:..|.|...:|.| |....||||...:|.:.|.|:
Human   694 NATDLDRSREYGQESIIYSLE--------GSTQFRINARSGEI-TTTSLLDRETKSEYILIVRAV 749

  Fly   340 DGG----GLKGTGTASIRVKDLNDMPPQFTKDE--WVTEVDETNGTYIPETPILTVTVQDED--E 396
            |||    ...|..|.:|.:.|:||..|.: ||.  ::..|:.|.    |::.:.||...|.|  |
Human   750 DGGVGHNQKTGIATVNITLLDINDNHPTW-KDAPYYINLVEMTP----PDSDVTTVVAVDPDLGE 809

  Fly   397 TNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQP-LDYEDPLQSSGFRFR---IQVNDKGDDG 457
            ..|..|.:.|     .:||..:.:  .||.::.... ||.|:|........|   :.|.|.|...
Human   810 NGTLVYSIQP-----PNKFYSLNS--TTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867

  Fly   458 PGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAY 522
            ...:..     :.|.|.|.|:|||.|.|........:.|....|..:.|..|.|.|:|.:..|:|
Human   868 LKATSS-----ATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927

  Fly   523 KIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNA 587
            ::.....|......|..|.|.....||||....:.::::|.|.|:|.:::|:|||:.|.||||..
Human   928 RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDET 992

  Fly   588 PT-FAQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVE--YDRR 649
            || |...|..::.|:|                      |..||:..|...:...|...|  |...
Human   993 PTFFPAVYNVSVSEDV----------------------PREFRVVWLNCTDNDVGLNAELSYFIT 1035

  Fly   650 GDNENGV-------AIISSLRPFDREAQKSYAIPIEIKDNG--APAMTGTSTLTVTIGDVNDNKM 705
            |.|.:|.       |::.::...|||...:|.:.:|..|||  ....|||:|:.||:.|||||:
Human  1036 GGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNR- 1099

  Fly   706 QPGSKSVLVYNYQGQ-SQDTPIG----RVYVNDPDDWDVPDKKYYWEVQEH-QRFKLDTDTGILT 764
                ...|..:|:.. .:|.|.|    ::...|.|:.:.....|......| ..|::....|:|
Human  1100 ----PIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLL- 1159

  Fly   765 MRA-----GTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVR 824
            ||.     ..|...:.|..:.|:.:.|.......:.|.|.||..||
Human  1160 MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEA------------------- 1205

  Fly   825 TWNPVKNQVEPSKL-----ERFRNKLAELLYTDRDNVDVFSVQLKEGSPYPLTDVHFAARSATQQ 884
               ||..|.:.|:|     ......:..:..||||:.|        |..     |::...|..:.
Human  1206 ---PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGD--------GGL-----VNYRILSGAEG 1254

  Fly   885 PYFKAVRLNGVVQMHREEIEKDVGLNIT------------MVNI---NECLHEGKGKCG-----S 929
            .:               ||::..||.||            |:|:   ::.....:|.|.     .
Human  1255 KF---------------EIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLL 1304

  Fly   930 NSCTSKVELGKKPYTVSVNRTALVGVRL-DISAQCVCRARNFTHQDHNCRTHLCYNGGRCVETRN 993
            |.....|:.....|..::.....:|..: .:.|..:......|::
Human  1305 NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYR-------------------- 1349

  Fly   994 GPKCVACPVGYNGPRCQQSTRSFRGNGWAWYPPLQLCQESHLSLEFITRV--ADGLI------LY 1050
                      :|.....|:...|:                   ::.||.|  ..||:      .|
Human  1350 ----------FNAYTSTQAKALFK-------------------IDAITGVITVQGLVDREKGDFY 1385

  Fly  1051 NGPIVP----PKPEETVISDFIALELEQGYPRLLIDFGSGT---------LELRVKTKKTLDDGV 1102
            ...:|.    ||.:.||......|:.....||  .||.|.:         :..||.|.|..|...
Human  1386 TLTVVADDGGPKVDSTVKVYITVLDENDNSPR--FDFTSDSAVSIPEDCPVGQRVATVKAWDPDA 1448

  Fly  1103 WHRLDIFWD-------------TENVRMVVDFCRTALVSEMED-----------GTPPEFDDNAC 1143
            .....:.:.             |.|..:...|....|..|..|           ||||...|:..
Human  1449 GSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513

  Fly  1144 QAR----GQIPPFAES---LNLNQPLQLGG 1166
            |..    ...||..||   .|::....:||
Human  1514 QVTILDINDNPPVIESPFGYNVSVNENVGG 1543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	31/92 (34%)
		Cadherin_repeat	140..248	CDD:206637	31/112 (28%)
		Cadherin_repeat	256..359	CDD:206637	36/106 (34%)
		Cadherin_repeat	379..481	CDD:206637	26/107 (24%)
		Cadherin_repeat	489..586	CDD:206637	29/96 (30%)
		Cadherin_repeat	594..703	CDD:206637	31/119 (26%)
		Cadherin_repeat	724..801	CDD:206637	17/86 (20%)
		EGF_CA	977..1010	CDD:238011	1/32 (3%)
		LamG	1013..1198	CDD:238058	42/206 (20%)
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
CDH23	NP_071407.4	Cadherin_repeat	42..128	CDD:206637
		Cadherin_repeat	136..231	CDD:206637
		Cadherin_repeat	240..344	CDD:206637
		Cadherin_repeat	352..456	CDD:206637	3/9 (33%)
		Cadherin_repeat	465..557	CDD:206637	31/92 (34%)
		Cadherin_repeat	566..667	CDD:206637	31/111 (28%)
		Cadherin_repeat	676..774	CDD:206637	37/106 (35%)
		Cadherin_repeat	782..886	CDD:206637	28/119 (24%)
		Cadherin_repeat	894..990	CDD:206637	28/95 (29%)
		Cadherin_repeat	999..1098	CDD:206637	31/120 (26%)
		Cadherin_repeat	1106..1203	CDD:206637	21/97 (22%)
		Cadherin_repeat	1218..1308	CDD:206637	19/117 (16%)
		Cadherin_repeat	1317..1414	CDD:206637	19/145 (13%)
		Cadherin_repeat	1426..1523	CDD:206637	17/96 (18%)
		Cadherin_repeat	1533..1630	CDD:206637	3/11 (27%)
		Cadherin_repeat	1638..1740	CDD:206637
		Cadherin_repeat	1752..1847	CDD:206637
		Cadherin_repeat	1855..1955	CDD:206637
		Cadherin_repeat	1963..2065	CDD:206637
		Cadherin_repeat	2075..2169	CDD:206637
		Cadherin_repeat	2180..2289	CDD:206637
		Cadherin_repeat	2301..2398	CDD:206637
		Cadherin_repeat	2406..2504	CDD:206637
		Cadherin_repeat	2513..2607	CDD:206637
		Cadherin_repeat	2620..2718	CDD:206637
		Cadherin_repeat	2735..2841	CDD:206637
		Cadherin_repeat	2850..2951	CDD:206637
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9B2
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100175
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.800