DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and CDH26

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_011527271.1	Gene:	CDH26 / 60437	HGNCID:	15902	Length:	895	Species:	Homo sapiens

Alignment Length:	892	Identity:	216/892 - (24%)
Similarity:	348/892 - (39%)	Gaps:	243/892 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 QITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDI-NRTTGDIFVLKPL 207
            ::.|||....||.|.::.   .::...::::|.::|.|:| :.|....|.: :...|.|:|.:|:
Human    64 ELEEEDPGPFPKLIGELF---NNMSYNMSLMYLISGPGVD-EYPEIGLFSLEDHENGRIYVHRPV 124

  Fly   208 DRDQ-PNGRPQWRFTV-FAQDEGGEGLVGYADIQVNLK--DINDNAPQFPQGIYFGNVTENGTAG 268
            ||:. |:      ||| |...|...|.:....:..|::  |:||:|||||:..:...|.||.:||
Human   125 DREMTPS------FTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKEFNITVQENQSAG 183

  Fly   269 SSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYS 333
            ..:..|.|||.|:.|...:..|.:.|.:..:.:|:|   |.::..:|.|:.: .|||.|..|.::
Human   184 QPIFQMLAVDLDEENTPNSQVLYFLISQTPLLKESG---FRVDRLSGEIRLS-GCLDYETAPQFT 244

  Fly   334 IQVVAMDGG--GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDE 396
            :.:.|.|.|  .|..|.|..:.|::.|:..|.||::.:..::.|...:    ..:|.:.|||.|.
Human   245 LLIRARDCGEPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIPEGRAS----QGVLRLLVQDRDS 305

  Fly   397 TNTFQYKVVPNSGFGADKFAMVR-NGDG-----------TGSLKIIQPLDYED-PLQSSGF---- 444
            ..|..::.         ||.::. |.:|           .|.|.:|:|||||. |.||...
Human   306 PFTSAWRA---------KFNILHGNEEGHFDISTDPETNEGILNVIKPLDYETRPAQSLIIVVEN 361

  Fly   445 RFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKA 509
            ..|:...::|...|   .:...|.:.|.|::.|.|| .|.|..:...|:..|..:.||:|..|.|
Human   362 EERLVFCERGKLQP---PRKAAASATVSVQVTDAND-PPAFHPQSFIVNKEEGARPGTLLGTFNA 422

  Fly   510 TDADQGGHSKVAYKIVR------STNRKRQFAISDRGAVSIQRPLDRETQDRHH----IQILAID 564
            .|.|    |::.|::|.      |.::       :.|.|....|:|||:...::    |.|.|:|
Human   423 MDPD----SQIRYELVHDPANWVSVDK-------NSGVVITVEPIDRESPHVNNSFYVIIIHAVD 476

  Fly   565 DGSPARTATATLTVIVKDVNDNAPTF--AQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFT 627
            ||.|.:|||.||.:.:.|:|||.||.  ...|.......|  .:.|.:.|:|||  |.....|||
Human   477 DGFPPQTATGTLMLFLSDINDNVPTLRPRSRYMEVCESAV--HEPLHIEAEDPD--LEPFSDPFT 537

  Fly   628 FRLDPL---ASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNG------ 683
            |.||..   |.|..|.         |.|......:.:||...|   .:|.:|:.|.|..
Human   538 FELDNTWGNAEDTWKL---------GRNWGQSVELLTLRSLPR---GNYLVPLFIGDKQGLSQKQ 590

  Fly   684 ------APAMTGTSTLTVTIGDV-----------------------------------------N 701
                  .|..:|.:.:.:...:|                                         |
Human   591 TVHVRICPCASGLTCVELADAEVGLHVGALFPVCAAFVALAVALLFLLRCYFVLEPKRHGCSVSN 655

  Fly   702 DNKMQPGSKSVLVYNYQ--GQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGILT 764
            |.    |.:::::||.:  |.|..|                     |...|.||..|    .|.|
Human   656 DE----GHQTLVMYNAESKGTSAQT---------------------WSDVEGQRPAL----LICT 691

  Fly   765 MRAGTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNP- 828
            ..||..:|...|           |::|.:           |..|:...|.: :....:.:.:.|
Human   692 AAAGPTQGVKDL-----------EEVPPS-----------AASQSAQARCA-LGSWGYGKPFEPR 733

  Fly   829 -VKN----------QVEPSKLERFRNKLAELLYTDRDNVDVFSVQ-------------------- 862
             |||          .:....|.....::||.|...::. :.||:.
Human   734 SVKNIHSTPAYPDATMHRQLLAPVEGRMAETLNQSKER-NRFSLSRGCIIPQGRATAGRGLPQDI 797

  Fly   863 LKEGSPYPLTDVHFAARSA-TQQPYFKAVRLNGVVQMHREEIEKDVG 908
            .||..|..||........| .:.|.||.     ||..|:|:.|...|
Human   798 YKEMMPRRLTQTGKRKHGALARTPSFKK-----VVYDHKEDEENKAG 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	28/108 (26%)
		Cadherin_repeat	256..359	CDD:206637	30/104 (29%)
		Cadherin_repeat	379..481	CDD:206637	29/118 (25%)
		Cadherin_repeat	489..586	CDD:206637	33/106 (31%)
		Cadherin_repeat	594..703	CDD:206637	30/164 (18%)
		Cadherin_repeat	724..801	CDD:206637	14/76 (18%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
CDH26	XP_011527271.1	Cadherin_repeat	<87..163	CDD:206637	22/82 (27%)
		Cadherin_repeat	171..273	CDD:206637	31/105 (30%)
		Cadherin_repeat	282..394	CDD:206637	29/127 (23%)
		Cadherin_repeat	409..498	CDD:206637	32/99 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010