DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and PCDH10

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_011530452.1	Gene:	PCDH10 / 57575	HGNCID:	13404	Length:	1057	Species:	Homo sapiens

Alignment Length:	719	Identity:	186/719 - (25%)
Similarity:	291/719 - (40%)	Gaps:	147/719 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 DLQSTVLTVNAKDHNESTNIRYQITGGNIGNAFAVQNTTGVIYVASPLDYE----TRPRYELRLE 110
            ||...:..::|:......|.|......|:        .|||:||...:|.|    ..|...|.||
Human    40 DLGLDITKLSARGFQTVPNSRTPYLDLNL--------ETGVLYVNEKIDREQICKQSPSCVLHLE 96

  Fly   111 ATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVY 175
            ...........|.|.|.|:|||||.|.......:|:|             :||.|        ..
Human    97 VFLENPLELFQVEIEVLDINDNPPSFPEPDLTVEISE-------------SATPG--------TR 140

  Fly   176 FLTGQGIDPDNPANSKFDINRTTGDIFVL-----------------KPLDRDQPNGRPQWRFTVF 223
            |......|||...||..|...|....|.|                 |||||:|   :...|:.:.
Human   141 FPLESAFDPDVGTNSLRDYEITPNSYFSLDVQTQGDGNRFAELVLEKPLDREQ---QAVHRYVLT 202

  Fly   224 AQDEGGEGLV-------------------GYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGS 269
            |.|.||.|.|                   |.|.:.:.:.|.|||.|.|.|.:|..::.||...|:
Human   203 AVDGGGGGGVGEGGGGGGGAGLPPQQQRTGTALLTIRVLDSNDNVPAFDQPVYTVSLPENSPPGT 267

  Fly   270 SVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSI 334
            .|:.::|.   ||:|..|.:::||...::  ......:|.:.|.||.::.: ..||.|.:|.|.:
Human   268 LVIQLNAT---DPDEGQNGEVVYSFSSHI--SPRARELFGLSPRTGRLEVS-GELDYEESPVYQV 326

  Fly   335 QVVAMDGG--GLKGTGTASIRVKDLNDMPPQF---TKDEWVTEVDETNGTYIPETPILTVTVQDE 394
            .|.|.|.|  .:.......:||.|.||..|:.   |..|.|:| ....||.:   .:.:||.:|.
Human   327 YVQAKDLGPNAVPAHCKVLVRVLDANDNAPEISFSTVKEAVSE-GAAPGTVV---ALFSVTDRDS 387

  Fly   395 DETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPG 459
            :|....|.:::     |...|.:..:.....::....|||.|   ....:...:...|:|:....
Human   388 EENGQVQCELL-----GDVPFRLKSSFKNYYTIVTEAPLDRE---AGDSYTLTVVARDRGEPALS 444

  Fly   460 GSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKI 524
            .|..       :.|::.|:|||.|:|.:...:|.:.|:...|..:....|||.|:|.::::||.|
Human   445 TSKS-------IQVQVSDVNDNAPRFSQPVYDVYVTENNVPGAYIYAVSATDRDEGANAQLAYSI 502

  Fly   525 VR------------STNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSP-ARTATATL 576
            :.            |.|       |:.|.:...|..|.|.......|:.|.|.||| |....||:
Human   503 LECQIQGMSVFTYVSIN-------SENGYLYALRSFDYEQLKDFSFQVEARDAGSPQALAGNATV 560

  Fly   577 TVIVKDVNDNAP-----------TFAQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRL 630
            .:::.|.|||||           |.|::..|...|  .|..:..|||.|.||   |.....|:.:
Human   561 NILIVDQNDNAPAIVAPLPGRNGTPAREVLPRSAE--PGYLLTRVAAVDADD---GENARLTYSI 620

  Fly   631 DPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTV 695
              :..:|:.. |:::: |.|:......:     |..|:.|:.|.:.||::|:|.|.::.|:||.|
Human   621 --VRGNEMNL-FRMDW-RTGELRTARRV-----PAKRDPQRPYELVIEVRDHGQPPLSSTATLVV 676

  Fly   696 TIGD 699
            .:.|
Human   677 QLVD 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	22/85 (26%)
		Cadherin_repeat	140..248	CDD:206637	32/143 (22%)
		Cadherin_repeat	256..359	CDD:206637	28/104 (27%)
		Cadherin_repeat	379..481	CDD:206637	18/101 (18%)
		Cadherin_repeat	489..586	CDD:206637	29/109 (27%)
		Cadherin_repeat	594..703	CDD:206637	29/106 (27%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
PCDH10	XP_011530452.1	Cadherin_2	19..101	CDD:285466	17/68 (25%)
		Cadherin_repeat	128..246	CDD:206637	32/141 (23%)
		Cadherin_repeat	254..354	CDD:206637	29/105 (28%)
		Cadherin_repeat	367..459	CDD:206637	21/110 (19%)
		Cadherin_repeat	467..570	CDD:206637	29/109 (27%)
		Cadherin_repeat	590..680	CDD:206637	28/103 (27%)
		Cadherin_C_2	713..838	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000