DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and cdh26.1

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_017209214.1	Gene:	cdh26.1 / 571792	ZFINID:	ZDB-GENE-100922-193	Length:	835	Species:	Danio rerio

Alignment Length:	885	Identity:	189/885 - (21%)
Similarity:	319/885 - (36%)	Gaps:	249/885 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 FAVQNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQIT 146
            |.:..|.|.:..:...|..:|.:.:..|..|:.|      .|::..|:.:|.    |..:..::|
Zfish     7 FLLLFTLGELSASYTNDTSSRQKRDAVLIRTKRR------WVLSTIDLEENM----RGPFPLEVT 61

  Fly   147 EE-DDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRD 210
            :. :|:                 :..|:.:.::|:|:  ..|....|.||..||.:||.:.:||:
Zfish    62 QMFNDK-----------------KQENVKFRISGEGV--TTPPIGLFSINENTGSVFVHRAIDRE 107

  Fly   211 QPNGRPQWR--FTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMT 273
            .   .|.:.  |.|..:|.|.. |.......|.:||:|||||.|.......:|.||...|....|
Zfish   108 I---NPIFHVDFDVLDKDTGAP-LDRTLSFNVEIKDLNDNAPLFTPTTIPASVPENALEGPIQAT 168

  Fly   274 MSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIE--PETGLIKTAVC--CLDRERTPDYSI 334
            :.|.| :|..::.|::    ....|:.::...|:|.:.  |:|...|....  |.|.::...|.:
Zfish   169 LQAHD-NDQKDTYNSE----FTMRVVSQDPAVPVFSLRDMPQTNKYKQLAFSGCFDFDKAKTYKV 228

  Fly   335 QVVAMDGG--GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDET 397
            .:.|.|.|  .:..|.|..:.:.|.|...|:|:...:..||.|...    ...||.:.:.|:|..
Zfish   229 LIEAKDKGTPPMSSTATVIVNITDSNTHQPEFSSTTYNAEVMEMES----NKEILRINITDKDTP 289

  Fly   398 NTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSD 462
            ||...:.|         |:::: |:..|..:|:     .||..:.|.
Zfish   290 NTPASRAV---------FSILK-GNEEGYYRIV-----TDPKTNQGV------------------ 321

  Fly   463 KYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRS 527
                   ..|:|    ..|..|.:...:|:::..:.|:      |:..|.
Zfish   322 -------LSVIK----GKNFEKTEITQLEIAVENEEKI------FQCVDG--------------- 354

  Fly   528 TNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQ 592
               ||..|                               .|.:..|..:.|.|.|:|| .|.|
Zfish   355 ---KRTSA-------------------------------PPPKPQTTKVAVKVIDLND-PPVF-- 382

  Fly   593 DYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVA 657
                        ||::|...::.      ||.|......|...||......:.|:...|....|:
Zfish   383 ------------KKVIEKVYRNE------NGKPGDVLFTPDIKDEDSDVNNIRYELVKDPAKWVS 429

  Fly   658 I------ISSLRPFDREA----QKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDN-KMQPGSKS 711
            :      |::::..|||:    ..:|.:.::..|:|.|..|||.|:.|.:||:||| ...|.:|:
Zfish   430 VDPKTGKITTVQTMDRESPFVRNGTYTVVVQAIDDGQPPATGTCTVVVYLGDLNDNAPYLPSNKT 494

  Fly   712 VLVYNYQGQSQDTPIGRVYVNDPDDWDVP-------------DKKYYWEVQEHQRFKLDTDTGI- 762
            |:..|        .:.||.|...|| |.|             :.|..|        |||..||:
Zfish   495 VMCAN--------NMNRVRVFPADD-DAPPFSGPFTFSLGDEEMKKLW--------KLDPTTGLN 542

  Fly   763 --LTMRAGTRRGRYQLRFKVYDREHGQEDIPANLSV-------TVRDI---------TAEAVQQA 809
              |........|.|.:..|:.|::..|.|:...:||       |.|.:         .|..:..|
Zfish   543 SSLISLTSLPYGNYTVPLKIQDQQALQSDVVMFVSVCECSSPHTCRGLLPLSSRLGPAAIGLMIA 607

  Fly   810 GSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAELLYTDRDNVDVF--------SVQLKE- 865
            |.:.|:.:....|:...|....|..|..|:...|:.. :.|.|.....||        ::.:||
Zfish   608 GLLLLALLLLFSFLCDCNSKNFQHIPLSLQDEGNQTL-VKYNDEGGGSVFRPESMLVSNLAMKES 671

  Fly   866 ----GSP---YPLTDVHFAARSAT-QQPYFKAVRLNGVVQ 897
                .:|   |..||....:.:.| :.|.:.....:|..|
Zfish   672 IKVASAPAVDYVATDGFRRSENGTMRSPGYNPQYFSGAFQ 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	10/49 (20%)
		Cadherin_repeat	140..248	CDD:206637	25/110 (23%)
		Cadherin_repeat	256..359	CDD:206637	24/108 (22%)
		Cadherin_repeat	379..481	CDD:206637	16/101 (16%)
		Cadherin_repeat	489..586	CDD:206637	13/96 (14%)
		Cadherin_repeat	594..703	CDD:206637	28/118 (24%)
		Cadherin_repeat	724..801	CDD:206637	25/99 (25%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
cdh26.1	XP_017209214.1	CA	71..145	CDD:214520	25/79 (32%)
		Cadherin_repeat	151..256	CDD:206637	25/109 (23%)
		Cadherin_repeat	264..378	CDD:206637	33/216 (15%)
		Cadherin_repeat	393..485	CDD:206637	25/97 (26%)
		Cadherin_C	<751..820	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100