DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and fat3a

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_017206475.1	Gene:	fat3a / 569256	ZFINID:	ZDB-GENE-060929-1254	Length:	4601	Species:	Danio rerio

Alignment Length:	1824	Identity:	422/1824 - (23%)
Similarity:	676/1824 - (37%)	Gaps:	480/1824 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNES---TNIRYQITGGNIGNAFA 83
            :.|.::|.||:.|.|.:..|...:.|:......|..:|.:|::.|   ..:.|.|||||.|..||
Zfish  2958 ITIAVSDSNDNIPQFLQPRYYGSVRESDAPGEVVAVLNTRDNDSSPGNRQVTYHITGGNRGGVFA 3022

  Fly    84 VQNTTG--VIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQIT 146
            :....|  .:||..|||.|.:.||.:.:.||.....:..:|.:.|.|.|||.||.:...|...::
Zfish  3023 LGLVQGEWKLYVKRPLDREEQERYLINVTATDGLYVSTASVDVTVMDTNDNSPVCEPALYSVSVS 3087

  Fly   147 EEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQ 211
            |  |..|.|:||:|.|||.|......|.:.|.|.|.:       .|.|:..||::.....|||::
Zfish  3088 E--DVPLNKQILRVKATDADTGSNAQIQFSLFGSGAE-------DFFIHPHTGELKTAVALDREK 3143

  Fly   212 PNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMT-MS 275
            .:     |:::.|:...|.||...|::.|:|.|:||:.|.|....|..:|.|| ||..:::| :.
Zfish  3144 VS-----RYSLVARATDGGGLWCEAEVVVDLLDVNDSPPMFSMPHYTTSVYEN-TATKALLTRIQ 3202

  Fly   276 AVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMD 340
            |:   ||:...|.|::||:    ::...|  .|.|:..:|:: .....||||....|.|.|.|.|
Zfish  3203 AI---DPDLGVNRKVVYSL----VDSADG--FFSIDKSSGIV-VLERLLDREIQSSYHIVVRASD 3257

  Fly   341 GG---GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQY 402
            .|   .|......:|.|.|:||.||.|.:.:::..:.|       :..:.|..||        .|
Zfish  3258 QGVPVRLSSLANITITVLDINDNPPVFERRDYLATLPE-------DVAVGTEVVQ--------VY 3307

  Fly   403 KVVPNSGFGADKFAMVRNGD---------GTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGP 458
            ....:.|..||.:..:|:|:         .||::.:.:.||:|   ....:...::..|
Zfish  3308 AASKDIGTNADIYYNIRSGNQQGHFTINVNTGAISVSRALDFE---SCKDYFLTVEATD------ 3363

  Fly   459 GGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYK 523
            ||:.... |.:.|.:.|.|:|||.|.|.|:...|||.||..:|..:.:..|.|.|...:..:.|.
Zfish  3364 GGTPPLS-AVTMVNINLTDVNDNAPIFSRDAYSVSISEDANIGDTVVKVMAEDVDSYVNGDILYS 3427

  Fly   524 IVRSTNRKRQFAISD-RGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNA 587
            |: |.:|:.||.|.. .|.:.:.:.|||||...:.:.:.|:|.|:||.::|..:.:.:.|||||.
Zfish  3428 II-SGDRENQFFIEPITGQIKVNKQLDRETMAGYSLSVRALDSGTPAMSSTVLVNIDISDVNDNP 3491

  Fly   588 PTFA--------QDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKV 644
            |||.        |:.||.      |..:|:::..|.|  ...||.||.|.:  |:.:| .|.||:
Zfish  3492 PTFTPANHTAVIQENKPL------GTSVLQLSVIDKD--ASHNGPPFHFHI--LSGNE-GAWFKL 3545

  Fly   645 EYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGS 709
              ||.|       :::|.:.|.|.....|.|.::..|:|.|.::..:::.|.:.:.:.:|.....
Zfish  3546 --DREG-------LLTSNQVFRRSEGTEYVIHVQASDSGRPPLSSVASVLVRVIEESVHKPAASP 3601

  Fly   710 KSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGRY 774
            ..|.:...:.:.....||:::..|.|.:|:  ..|....|:...||:....|.:...:|...|||
Zfish  3602 LHVHIVTMEDEFPGGVIGQIHATDQDAFDI--LTYGHTHQQSSLFKVSPRDGRIIALSGLDAGRY 3664

  Fly   775 QLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLE 839
            .|...|.|   |:..:...:||.|...:.|.:..|.::|...::..||:           ...|.
Zfish  3665 TLNATVTD---GRFTVSVPVSVHVEQASVEMLHDAVTVRFDRVSPHDFI-----------SRHLP 3715

  Fly   840 RFRNKLAELLYTDR-DNVDVFSVQLKEGSPYPLTDVHFAARSATQQPYFKAVRLNGVVQMHREEI 903
            ..|..|:.::.|.| |.:.|.|||..|.:..  .|:..|..||....::||..:...:...|.::
Zfish  3716 SVRRVLSSVMSTSRPDALHVLSVQPVEATGQ--LDLLVAVESAEGGGFYKAALVTQKLSSARRQL 3778

  Fly   904 EKDVGLNITMVNINECLHEGKG-KCGSNSCTSKVELGKKP-YTVSVNRTALVGVRLDISAQCVCR 966
              |..|.::.|....|    .| .|....|...:.|.... .|.|..:|:.|..:...:.:|||.
Zfish  3779 --DQVLRVSAVLDKNC----SGLDCREAQCEQTITLDSHSLLTYSSTKTSFVSPKFHRNTRCVCS 3837

  Fly   967 ARNFTHQDHNCRTHLCYNGGRCV--ETRNGPKCVACPVGYNGPRCQQSTRSFRGNGWAWYPPL-- 1027
            ..:.:.....|....|....:||  ::..||....||.|..|.....::.||.||.:..|...
Zfish  3838 DGSCSAASEVCADMRCPGDMQCVGTDSSRGPYACQCPPGKLGECAGHTSLSFSGNSYIKYRVTDG 3902

  Fly  1028 QLCQESHLSLEFITRVADGLILYNGPIVPPKPEETVISDFIALELEQGYPRLLIDFGSGTLELRV 1092
            :...|..|:|...|..:.|:|:|           |.......|::|:|.....:|.|:....:.:
Zfish  3903 ERSGEMKLALRIRTLQSKGIIMY-----------TRADPCSVLKIEEGKLWFQLDCGNSPRSIGI 3956

  Fly  1093 KTKKTLDDGVWHR--LDIFWDTENVRMVVDFCRTALVSEMEDGTPPEFDDNACQARGQIPPFAES 1155
             :.:.::||.||.  |::..:..::.:...:....|.:  ....|.|.|.:.......:||.|.|
Zfish  3957 -SGRLVNDGNWHHVVLELRGNYSSLSLDDMYVERRLTT--AKFRPLEADLSIYFGAQVLPPDARS 4018

  Fly  1156 LNLNQPLQLGGLYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHNSEHYDLAFPALARNSFPACPQT 1220
            |...:..::                    :.||.||:.:|:.|    |...|...:.|    |..
Zfish  4019 LTEMKGPRV--------------------TNGFQGCLDSVVLN----DNELPLQNKRS----PYA 4055

  Fly  1221 DEVCLKTEHTARCWEHGNCVASLVQAKCHCQPGWMGPGCNVPTIPTTFKAQSYVKFALSFEPDRF 1285
            :.|.| |:....|        .|....|..||...|..|                  :|.....|
Zfish  4056 EVVGL-TDLKLGC--------VLYPDACVAQPCLNGATC------------------ISLPSGGF 4093

  Fly  1286 STQLQLRFRTREQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSMRNEEQLLTLTAIAVNDGQ 1350
            |...
Zfish  4094 SCSC------------------------------------------------------------- 4097

  Fly  1351 WHVIRISRYGSAALMELDGGESRRYNESFHFTGHQWLTIDKQEGVYAGGKAEYTGIKTFEVQSDF 1415
                                                      ..::.||:.| |.|..
Zfish  4098 ------------------------------------------SALHTGGRCE-TEISV------- 4112

  Fly  1416 QRSCLDDIRLDGKHLPLPPAMNGTQWGQATMARNLERNCPSNRPCSN--VICPDPFDCVDLWNEY 1478
                                                  |..| ||.|  |       |..:.|.:
Zfish  4113 --------------------------------------CMPN-PCQNGGV-------CKPIGNAF 4131

  Fly  1479 ECTCSEGRIMSSDTKGCVDRNECLDLPCLNGATCINLEPRLRYRCICPEGYWGENCE----LVQE 1539
            .|:|..|...::..:   |.|||....|.||..|||...  .:.|.|..|:.|..|.    ||.:
Zfish  4132 ICSCKRGYTGATCEE---DVNECERELCENGGICINTFG--SFYCNCTPGFVGSACSVRPVLVPD 4191

  Fly  1540 GQRLKLSMG--ALGAIFVCLIIILILALIFVLYSRKRKTTKKKKRSGPE--KDVRETVISYEDEG 1600
            .|.....:|  .|..|.|.|.:||.|.|:|:.: ||:...|...|:...  :|.....:.::..|
Zfish  4192 MQAGHAYVGKEELIGIAVVLFLILTLILLFIAF-RKKVFQKSYSRNNLSLVQDPATAALLHKANG 4255

  Fly  1601 GGEDDMTAFDITPLQI----PIS--AQG---GPPDIAACKMPIIYPVMTLLPPGQELNVAYLMEE 1656
            |        ...||:.    |||  .:|   |||.:..  .|:.|   |...||.....   :|:
Zfish  4256 G--------HYPPLRCAIGEPISLYTEGGITGPPQVPV--RPMAY---TPCFPGDARGT---LEK 4304

  Fly  1657 RKQR------------------IDKDN-----------NAPPF-------DDLRNFTFE------ 1679
            |..|                  :...|           |.||.       |.||...:|
Zfish  4305 RDGRGSELTEMSTFHPSESPRILGGTNRRGVVVCSVAPNLPPVSPCRSDCDSLRKSPWEEDGKVD 4369

  Fly  1680 -------------GSGSIAESLSSLASGTDDEN---------------------------QDFNY 1704
                         ||.|..:||||..|.:.|:|                           |:||.
Zfish  4370 LLEEVTCFSGSNKGSNSEVQSLSSFQSDSCDDNASIVTVIRLVNDAVDTIENEVSVMDQGQNFNR 4434

  Fly  1705 LQNW 1708
            ..:|
Zfish  4435 AYHW 4438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	30/95 (32%)
		Cadherin_repeat	140..248	CDD:206637	33/107 (31%)
		Cadherin_repeat	256..359	CDD:206637	32/106 (30%)
		Cadherin_repeat	379..481	CDD:206637	22/110 (20%)
		Cadherin_repeat	489..586	CDD:206637	31/97 (32%)
		Cadherin_repeat	594..703	CDD:206637	28/108 (26%)
		Cadherin_repeat	724..801	CDD:206637	21/76 (28%)
		EGF_CA	977..1010	CDD:238011	10/34 (29%)
		LamG	1013..1198	CDD:238058	37/188 (20%)
		EGF_2	<1233..1259	CDD:285248	6/25 (24%)
		Laminin_G_2	1293..1428	CDD:280389	5/134 (4%)
		EGF_CA	1497..1535	CDD:238011	14/37 (38%)
		Cadherin_C	1583..1719	CDD:279398	42/219 (19%)
fat3a	XP_017206475.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100175
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810