DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and cdh12a

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001153302.1	Gene:	cdh12a / 568508	ZFINID:	ZDB-GENE-070912-673	Length:	800	Species:	Danio rerio

Alignment Length:	835	Identity:	210/835 - (25%)
Similarity:	341/835 - (40%)	Gaps:	192/835 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 DVDRPINIV-YFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDE-G 228
            |:|:..::| |.|:|:|:      .|.|.|..:||||..|:.|||::   :|.:.....|.|. .
Zfish    82 DMDKGDSMVKYTLSGEGV------GSIFTIEPSTGDIHALRSLDREE---KPYYTLRAQAVDMLT 137

  Fly   229 GEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYS 293
            |..|...::..:.::|||||.|:|.:|.|..:|.|....|:.|..::|.|.|||....:|:::||
Zfish   138 GRPLEPESEFIIKVQDINDNEPRFLEGPYSASVPEMSPVGTYVTQITATDADDPTYGNSARIVYS 202

  Fly   294 IEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDG----GGLKGTGTASIRV 354
            |..       |.|.|.::|:||:|:.|:..:|||....|.:.:.|.|.    |||.||.|.:|.:
Zfish   203 ILH-------GQPYFSVDPKTGVIRVALPNMDREVKETYQVVIQAKDMGGQLGGLAGTTTINITL 260

  Fly   355 KDLNDMPPQFTKDEWVTEVDETN--GTYIPETPILTVTVQDED--ETNTFQYKVVPNSGFGADKF 415
            :|:||.||:|:|..:...|.|::  |:.:..     |...|.|  :....:|.::|  |.|...|
Zfish   261 RDVNDNPPRFSKSIFHLRVPESSPVGSSVGR-----VKAHDLDTGKNAEVEYSILP--GDGGSMF 318

  Fly   416 AMVRNGD---GTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDD------GPGGSDKYHVAYSWV 471
            .:..|.|   ||..||  :.||:|   ....:.|:::.::...|      ||....      :.|
Zfish   319 DIYSNKDTQEGTVILK--KRLDFE---TRKAYTFKVEASNAVLDHRFLHLGPFKDT------AMV 372

  Fly   472 VVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAI 536
            .|.:.|: :..|.|.|.:..:..||||.||.|:....|.|.|. .:|.|.|.:....:.:..|||
Zfish   373 KVNVLDV-EEPPVFSRLYYNMETYEDTPVGIIVGAVNAEDLDV-SNSPVRYSVEWRKDAENHFAI 435

  Fly   537 SD-RGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPE 600
            .. .|.:||...||||....|::.::|....:|..::..|:|:.|.|||:..|..|..|:..:.|
Zfish   436 DPVEGTLSISEALDRERNAEHNVTVVATKVNNPQLSSKVTVTIKVLDVNEFPPELAFVYETFVCE 500

  Fly   601 NVSGKKILEV-AAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRR--------GDNENGV 656
            |....::::: :|.|.|                :.:.|.:..||....|.        |:|..||
Zfish   501 NAKAGQVIQILSATDKD----------------VPAVEHRFYFKSSQTRNRNFTIRDYGNNTAGV 549

  Fly   657 AIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI--GDVNDNKMQPGSKSVLVYNYQG 719
              ::....|.|..|..|.:|:.::|.|.|..:.|.|::|.:  .|.:.:.:...:::|.
Zfish   550 --VTRRGGFRRLEQSMYLVPVVVEDGGYPIRSSTGTVSVRVCSCDADGSLLSCNAEAVF------ 606

  Fly   720 QSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGIL--------------TMRAGTR 770
                                              |.:...||.|              .:..|.|
Zfish   607 ----------------------------------FPMGLSTGALMAILLCIVILLVMVVLYMGLR 637

  Fly   771 RGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEP 835
            |             |.::|...:....|||.......:.|....:...|...:|  || |...|.
Zfish   638 R-------------HKKKDTLMSSKEDVRDNVIHYDDEGGGEEDTQAFDIGTLR--NP-KGIKET 686

  Fly   836 SKLERFRNKLAELLYTDRDNVDVFSVQLKEGSPYPLTDVHFAARSATQQPYFKAVRL----NGVV 896
            ..|::.|::         |..|..|.  .|.|......:|.....::..||...|..    :|.|
Zfish   687 GPLQKIRSE---------DKADQASA--AEDSEDIRAYIHHCLLESSTPPYDSLVTYAYEGDGSV 740

  Fly   897 QMHREEIE------KDVGLNI--------TMVNINECLHEGKGKCGSNSCTSKVE 937
            ......||      |:...|:        |:..|.: .||||.|       .|||
Zfish   741 AESLSSIESWVLEPKEDYRNLCDWGPRFKTLAGIFK-EHEGKEK-------EKVE 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	26/83 (31%)
		Cadherin_repeat	256..359	CDD:206637	36/106 (34%)
		Cadherin_repeat	379..481	CDD:206637	24/112 (21%)
		Cadherin_repeat	489..586	CDD:206637	32/97 (33%)
		Cadherin_repeat	594..703	CDD:206637	26/119 (22%)
		Cadherin_repeat	724..801	CDD:206637	11/90 (12%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
cdh12a	NP_001153302.1	CA	81..159	CDD:214520	28/85 (33%)
		Cadherin_repeat	165..266	CDD:206637	37/107 (35%)
		Cadherin_repeat	274..379	CDD:206637	26/122 (21%)
		Cadherin_repeat	390..485	CDD:206637	31/95 (33%)
		Cadherin_repeat	493..589	CDD:206637	25/113 (22%)
		Cadherin_C	645..775	CDD:279398	28/143 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010