Protein Alignment CadN2 and cdh15

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_997771.3
• Gene: cdh15 / 565617
• ZFINID: ZDB-GENE-030131-780
• Length: 792
• Species: Danio rerio
• Alignment Length: 860
• Identity: 205/860 - (23%)
• Similarity: 341/860 - (39%)
• Gaps: 215/860 - (25%)

  Fly   121 TVVINV-----RDVNDNPPVFDRQTYRTQ--------ITEEDDRNLPKRILQVTAT---DGDVDR 169
            |:|..|     :..:.||.|.:...:|.:        ...|:.::||:.::|:.:.   .|:|
Zfish    12 TIVCQVSSSRLKQSDANPAVLNPWRHRVKRDWIIPPIRVLENSKHLPEDLVQIKSDKIFTGEV-- 74

  Fly   170 PINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVG 234
                :|.|.|.|:|.|  ....|:|:..||.|...:||||::   ...::...||....||.|..
Zfish    75 ----IYMLEGPGVDQD--PKGLFEIDEKTGWIKSKEPLDREK---HKSFKLKAFALSPSGERLES 130

  Fly   235 YADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVI 299
            ...|::.:.|.|||.|:|.|..:.|.:.|....|:|||.::|||:|||: :.||.|.|||    |
Zfish   131 PTTIEIYVLDQNDNRPEFTQKEFIGTIPEFSVPGTSVMQVTAVDFDDPS-TDNAALSYSI----I 190

  Fly   300 EEETGAP------IFEIEPETGLIKTAVCCLDRERTPDY--SIQVVAMDGGGLKGTGTASIRVKD 356
            .:|...|      :|.|..:||:|......|||:....:  ::||..|.|.||..:..|.|.:.|
Zfish   191 GQECDPPHGINKTMFGINNKTGVIYIRDVGLDRDVVQSFRLTLQVADMSGMGLTSSSRAIIHISD 255

  Fly   357 LNDMPPQF---------TKDEWVTEVDETNGTYIPETPILTVTVQDEDETN----TFQYKVVPNS 408
            :|:..|:|         .:::.:.||...|.|             |:|:..    ..:|.:|..|
Zfish   256 INNHAPKFQPTTYNMYAMENKLIAEVGRVNAT-------------DKDQRGGDNWRIKYTIVNPS 307

  Fly   409 GFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVV 473
            |..|.:...|.|   .|.:.:::.||||     |...:.:.|  |.::.......|...:| ..|
Zfish   308 GHFAIRTDPVSN---QGIISVVKSLDYE-----SKAEYNLIV--KAENEVKLKSLYEQIHS-ATV 361

  Fly   474 KLRDINDN-VPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVR----------S 527
            .:|.:|:| .|.|.:..|:|::.|....||||....|.|.|   |:|:.::|::          |
Zfish   362 TVRVMNENEAPIFYKNPIKVTVPESVVPGTILVSDIAHDPD---HAKLRFEIIQDPDEWLAIDHS 423

  Fly   528 TNR---KRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPT 589
            |.:   |:.|        .|:.|..|  .:.:...:...|..:...:|||||.|.:.:.||..|.
Zfish   424 TGQIMAKKNF--------KIRSPFVR--NNIYSAVVKVTDQDADGISATATLEVNLWETNDYPPL 478

  Fly   590 FAQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNEN 654
            ..........:....|..|.::|.|.|  :.....||||.   :|...:.|.:.:    ...||.
Zfish   479 LIPQSGTVCSDRDRDKLGLLLSALDED--MSPQADPFTFN---IADQNMAANWTI----ITLNET 534

  Fly   655 GVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI------GDVND-NKMQPGSK-- 710
            . |::..|...:|   ..::||:.:.|:|:|::..::.:.||:      ||... .....|||
Zfish   535 H-AVLQPLVDIER---GEFSIPVVVSDSGSPSLYSSALVNVTVCPCDSFGDCKSITAAIFGSKIG 595

  Fly   711 ----------------------SVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQ---- 749
                                  :|.|.:...|:.... |.:.|...|| |:.|..::::.|
Zfish   596 ISFIALMIIIGCIALLLVLLLLTVAVRSCTSQNIRKG-GGLLVGGSDD-DIRDNVFHYDEQGGGE 658

  Fly   750 -EHQRFKLD----------TDTGILTMRAGTRRGRYQLR--------FKVYDRE----------- 784
             :.:.|.:|          ..........|..||:..||        ...|.|:
Zfish   659 EDEEAFNIDFLRSPSDMLPAPASFFPQDCGLPRGKQPLRKDAPHYLPSPTYPRKPSGDPTDIEDF 723

  Fly   785 --------HGQEDIPANLSVTVRDITAEAVQQAGSMRLSHIT--------DEDFVRTWNPVKNQV 833
                    ....::|...:..:.|...:. ..|||  ||.|.        |.|::..|.|
Zfish   724 INVGLDAADNDPNVPPYDTALIYDYEGDG-SVAGS--LSSIASTGSDGDQDYDYLNDWGP----- 780

  Fly   834 EPSKLERFRNKLAEL 848
                  ||: |||.:
Zfish   781 ------RFK-KLANM 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637	3/15 (20%)
		Cadherin_repeat	140..248	CDD:206637	30/118 (25%)
		Cadherin_repeat	256..359	CDD:206637	38/110 (35%)
		CA	388..483	CDD:214520	23/99 (23%)
		Cadherin_repeat	489..586	CDD:206637	28/109 (26%)
		Cadherin_repeat	594..703	CDD:206637	25/115 (22%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	1233..1259	CDD:400365
		LamG	1265..1426	CDD:238058
		EGF_CA	1497..1535	CDD:238011
		CADH_Y-type_LIR	1662..1719	CDD:460041
cdh15	NP_997771.3	None