DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and PCDHA1

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_061723.1	Gene:	PCDHA1 / 56147	HGNCID:	8663	Length:	950	Species:	Homo sapiens

Alignment Length:	694	Identity:	185/694 - (26%)
Similarity:	293/694 - (42%)	Gaps:	122/694 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ENADLQSTVLTVNAKDHNESTNIRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRY----EL 107
            |.|:|...:..|.:|.|.:...:..|               .|:::|.|.:|.|...::    .:
Human    55 ELAELVPRLFRVASKTHRDLLEVNLQ---------------NGILFVNSRIDREELCQWSAECSI 104

  Fly   108 RLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPIN 172
            .||...:|......|.:.|:|:|||||||..:.....|.|  .|.|..|.....|.|.|:.....
Human   105 HLELIADRPLQVFHVEVKVKDINDNPPVFRGREQIIFIPE--SRLLNSRFPIEGAADADIGANAL 167

  Fly   173 IVYFLTGQGIDPDNPANSKFDINRTTGD-------IFVLKPLDRDQPNGRPQWRFTVFAQDEGGE 230
            :.|.|:         .:..|.::....|       :.:.|.|||::   .|:....:.|.|.|..
Human   168 LTYTLS---------PSDYFSLDVEASDELSKSLWLELRKYLDREE---TPELHLLLTATDGGKP 220

  Fly   231 GLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIE 295
            .|.|..::.:.:.|:|||||.|.|.:|..::.|....|:.|.|::|.|.|   |..|.::::|.:
Human   221 ELQGTVELLITVLDVNDNAPLFDQAVYRVHLLETTANGTLVTTLNASDAD---EGVNGEVVFSFD 282

  Fly   296 KNV---IEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRVK-- 355
            ..:   |:|:     |:::..:|.|: .:..||.|.|..|.|||.|:|.|....:....:.||
Human   283 SGISRDIQEK-----FKVDSSSGEIR-LIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVL 341

  Fly   356 DLNDMPPQFTKDEWVTEVDETNGTYIP---ETPILTV----TVQDEDETNTFQY--KVVPNSGFG 411
            |:||..|:..    ||.:      |:|   :.|:.||    ||.|.|.....|.  .::|:.
Human   342 DVNDNAPELA----VTSL------YLPIREDAPLSTVIALITVSDRDSGANGQVTCSLMPHV--- 393

  Fly   412 ADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLR 476
              .|.:|.......||.:...||.|   ..|.:...:...|      |||.... |.:.|.|::.
Human   394 --PFKLVSTFKNYYSLVLDSALDRE---SLSVYELVVTARD------GGSPSLW-ATARVSVEVA 446

  Fly   477 DINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAIS---- 537
            |:|||.|.|.:....|.:.|:...|..:....|.|||...::.|:|.:|.  .|..:.|:|
Human   447 DVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSARDADAQENALVSYSLVE--RRVGERALSNYVS 509

  Fly   538 ---DRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQD------ 593
               :.|.|...:|||.|..:....|:.|.|.|.|...:..||.|.|.|.|||||.....
Human   510 VHAESGKVYALQPLDHEELELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTI 574

  Fly   594 --YKPTLPENV-SGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRG--DNE 653
              ....:|..| :|..:.:|.|.|.|.   |.....::.|.|.|     .|.::.: |.|  ..|
Human   575 GAVSELVPRLVGAGHVVAKVRAVDADS---GYNAWLSYELQPAA-----GGARIPF-RVGLYTGE 630

  Fly   654 NGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI 697
                 ||:.|..|......|.:.:.:||:|.||:|.|:|:.|::
Human   631 -----ISTTRVLDEADLSRYRLLVLVKDHGEPALTATATVLVSL 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	19/88 (22%)
		Cadherin_repeat	140..248	CDD:206637	24/114 (21%)
		Cadherin_repeat	256..359	CDD:206637	30/107 (28%)
		Cadherin_repeat	379..481	CDD:206637	28/110 (25%)
		Cadherin_repeat	489..586	CDD:206637	30/103 (29%)
		Cadherin_repeat	594..703	CDD:206637	29/107 (27%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
PCDHA1	NP_061723.1	Cadherin_2	30..111	CDD:285466	14/70 (20%)
		Cadherin_repeat	137..238	CDD:206637	24/114 (21%)
		Cadherin_repeat	246..346	CDD:206637	31/108 (29%)
		Cadherin_repeat	354..451	CDD:206637	28/117 (24%)
		Cadherin_repeat	459..561	CDD:206637	30/103 (29%)
		Cadherin_repeat	577..670	CDD:206637	29/107 (27%)
		5 X 4 AA repeats of P-X-X-P	734..894
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..808
		Cadherin_tail	799..942	CDD:292596
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	828..856
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	871..890
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	900..950
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000