DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and PCDHA5

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_061731.1	Gene:	PCDHA5 / 56143	HGNCID:	8671	Length:	936	Species:	Homo sapiens

Alignment Length:	667	Identity:	181/667 - (27%)
Similarity:	281/667 - (42%)	Gaps:	101/667 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 YQITGGNIGNAFAVQNTTGVIYVASPLDYE----TRPRYELRLEATRNRKNNYTTVVINVRDVND 131
            :::.....|:...|....|:::|.|.:|.|    .|....:.||...:|......|.:.|:|:||
Human    63 FRVASKGRGDLLEVNLQNGILFVNSRIDREELCRRRAECSIHLEVIVDRPLQVFHVEVAVKDIND 127

  Fly   132 NPPVFDRQTYRTQITEE--DDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDI 194
            |||.|.||..|..|.|.  .|...|..    .|:|.|:.....:.|.|        || |..||:
Human   128 NPPRFSRQEQRLFILESRMPDSRFPLE----GASDLDIGANAQLRYRL--------NP-NEYFDL 179

  Fly   195 NRTTG-------DIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQF 252
            :..|.       ::.:.|.|||::..   :.|..|.|.|.|...|.|...:.:|:.|.|||||:|
Human   180 DVKTNEEETNFLELVLRKSLDREETQ---EHRLLVIATDGGKPELTGTVQLLINVLDANDNAPEF 241

  Fly   253 PQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLI 317
            .:.||...:.||..:|:.|:.::|.|.|   |..|.:::|.....|:::....  |.|...||.|
Human   242 DKSIYNVRLLENAPSGTLVIKLNASDAD---EGINKEIVYFFSNLVLDDVKSK--FIINSNTGEI 301

  Fly   318 KTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRVK--DLNDMPPQFTKDEWVTEVDETNGTY 380
            |.. ..||.|....|.|.:.|||......:|...:.||  |:||..|:..    :|.:      :
Human   302 KVN-GELDYEDYNSYEINIDAMDKSTFPLSGHCKVVVKLLDVNDNTPEMA----ITTL------F 355

  Fly   381 IP---ETPILTV----TVQDEDETNTFQY--KVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYE 436
            :|   :.|:.||    :|.|.|.....|.  .::|:.     .|.:|.......||.:...||.|
Human   356 LPVKEDAPLSTVIALISVSDRDSGANGQVTCSLMPHV-----PFKLVSTFKNYYSLVLDSALDRE 415

  Fly   437 DPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVG 501
               ..|.:...:...|      |||.......| |.|::.|:|||.|.|.:....|.:.|:...|
Human   416 ---SVSVYELVVTARD------GGSPSLWATAS-VSVEVADVNDNAPAFAQPQYTVFVKENNPPG 470

  Fly   502 TILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAI-----SDRGAVSIQRPLDRETQDRHHIQIL 561
            ..:....|.|||...::.|:|.:|.....:|..:.     ::.|.|...:|||.|..:....|:.
Human   471 CHIFTVSARDADAQENALVSYSLVERRVGERPLSSYVSVHAESGKVYALQPLDHEEVELLQFQVS 535

  Fly   562 AIDDGSPARTATATLTVIVKDVNDNAPTF--------AQDYKPTLPENV-SGKKILEVAAKDPDD 617
            |.|.|.|...:..||.|.|.|.|||||..        .......:|.:| :|..:.:|.|.|||.
Human   536 ARDAGVPPLGSNVTLQVFVLDENDNAPALLVPRVGGTGGAVSELVPRSVGAGHVVAKVRAVDPDS 600

  Fly   618 RLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGV--AIISSLRPFDREAQKSYAIPIEIK 680
               |.....::.|.| |....:..|:|          |:  ..||:.|..|......:.:.:.:|
Human   601 ---GYNAWLSYELQP-APGSARIPFRV----------GLYTGEISTTRSLDETEAPRHRLLVLVK 651

  Fly   681 DNGAPAMTGTSTLTVTI 697
            |:|.|.:|.|:|:.|::
Human   652 DHGEPPLTATATVLVSL 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	15/64 (23%)
		Cadherin_repeat	140..248	CDD:206637	30/116 (26%)
		Cadherin_repeat	256..359	CDD:206637	31/104 (30%)
		Cadherin_repeat	379..481	CDD:206637	26/110 (24%)
		Cadherin_repeat	489..586	CDD:206637	28/101 (28%)
		Cadherin_repeat	594..703	CDD:206637	27/107 (25%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
PCDHA5	NP_061731.1	Cadherin_2	29..110	CDD:285466	10/46 (22%)
		Cadherin_repeat	136..237	CDD:206637	30/116 (26%)
		Cadherin_repeat	245..345	CDD:206637	32/105 (30%)
		Cadherin_repeat	358..450	CDD:206637	25/106 (24%)
		Cadherin_repeat	458..560	CDD:206637	28/101 (28%)
		Cadherin_repeat	580..669	CDD:206637	27/103 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	759..793
		5 X 4 AA repeats of P-X-X-P	773..890
		Cadherin_tail	785..928	CDD:292596
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	816..936
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000