DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and PCDHA11

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_061725.1	Gene:	PCDHA11 / 56138	HGNCID:	8665	Length:	949	Species:	Homo sapiens

Alignment Length:	678	Identity:	177/678 - (26%)
Similarity:	286/678 - (42%)	Gaps:	91/678 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ENADLQSTVLTVNAKDHNESTNIRYQITGGNIGNAFAVQNTTGVIYVASPLDYE----TRPRYEL 107
            |.|:|...:..|.:|.|.:...:..|               .|:::|.|.:|.|    ......:
Human    55 ELAELVQRLFRVASKTHGDLLEVNLQ---------------NGILFVNSRIDREELCGQSAECSI 104

  Fly   108 RLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITE--EDDRNLPKRILQVTATDGDVDRP 170
            .||...:|......|.:.|:|:|||||||..:..:..|.|  :.|...|..    .|:|.|::..
Human   105 HLEVIVDRPLQVFHVNVEVKDINDNPPVFSLREQKLLIAESKQSDSRFPLE----GASDADIEEN 165

  Fly   171 INIVYFLT-GQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVG 234
            ..:.|.|: .:....|:|.|.| .|.|.:  :.:.|.|||::   .|:....:.|.|.|...|.|
Human   166 ALLTYRLSKNEYFSLDSPTNGK-QIKRLS--LILKKSLDREK---TPELNLLLTATDGGKPELTG 224

  Fly   235 YADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVI 299
            ...:.|.:.|:|||.|:|.:..|..::.||....:.|:.::|.|.|   |..|.::.||:   :.
Human   225 TVRLLVQVLDVNDNDPEFDKSEYKVSLMENAAKETLVLKLNATDRD---EGVNGEVTYSL---MS 283

  Fly   300 EEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGG--GLKGTGTASIRVKDLNDMPP 362
            .:..|..:|.::...|.::.. ..||.|....|.|:|.|.|.|  .:.|..|..:.:.|.||..|
Human   284 IKPNGRHLFTLDQNNGEVRVN-GTLDYEENKFYKIEVQATDKGTPPMAGHCTVWVEILDTNDNSP 347

  Fly   363 QFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQY--KVVPNSGFGADKFAMVRNGDGTG 425
            :.........|.|...   |.|.|..::|.|.|.....|.  .:.|:.     .|.:|.......
Human   348 EVAVTSLSLPVREDAQ---PSTVIALISVSDRDSGVNGQVTCSLTPHV-----PFKLVSTFKNYY 404

  Fly   426 SLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHI 490
            ||.:...||.|:.     :.:.:.|..:    .|||.... |.:.|.|::.|:|||.|.|.:...
Human   405 SLVLDSALDRENV-----WAYELVVTAR----DGGSPSLW-ATARVSVEVADVNDNAPAFAQPEY 459

  Fly   491 EVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIV--RSTNRKRQFAIS---DRGAVSIQRPLDR 550
            .|.:.|:...|..:....|.|||...::.|:|.:|  |..:|.....:|   :.|.|...:|||.
Human   460 TVFVKENNPPGCHIFTVSARDADAQENALVSYSLVERRLGDRALSSYVSVHAESGKVYALQPLDH 524

  Fly   551 ETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQD--------YKPTLPENV-SGKK 606
            |..:....|:.|.|.|.|..::..||.|.|.|.|||||.....        ....:|.:| :|..
Human   525 EELELLQFQVSARDAGVPPLSSNVTLQVFVLDENDNAPALLATQAGSAGGAVNKLVPRSVGAGHV 589

  Fly   607 ILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGV--AIISSLRPFDREA 669
            :.:|.|.|.|.   |.....::.|.|.|... :..|:|          |:  ..||:.|..|...
Human   590 VAKVRAVDADS---GYNAWLSYELQPAAGGS-RIPFRV----------GLYTGEISTTRALDEAD 640

  Fly   670 QKSYAIPIEIKDNGAPAMTGTSTLTVTI 697
            ...:.:.:.:||:|.||:|.|:|:.|::
Human   641 SPRHRLLVLVKDHGEPALTATATVLVSL 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	19/88 (22%)
		Cadherin_repeat	140..248	CDD:206637	28/110 (25%)
		Cadherin_repeat	256..359	CDD:206637	26/104 (25%)
		Cadherin_repeat	379..481	CDD:206637	24/103 (23%)
		Cadherin_repeat	489..586	CDD:206637	30/101 (30%)
		Cadherin_repeat	594..703	CDD:206637	27/107 (25%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
PCDHA11	NP_061725.1	Cadherin_2	30..111	CDD:285466	14/70 (20%)
		Cadherin_repeat	142..238	CDD:206637	28/105 (27%)
		Cadherin_repeat	246..345	CDD:206637	27/105 (26%)
		Cadherin_repeat	353..450	CDD:206637	26/114 (23%)
		Cadherin_repeat	458..560	CDD:206637	30/101 (30%)
		Cadherin_repeat	580..669	CDD:206637	27/103 (26%)
		6 X 4 AA repeats of P-X-X-P	733..893
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	753..807
		Cadherin_tail	798..941	CDD:292596
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	826..949
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000