DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and PCDHB7

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_061763.1 Gene:PCDHB7 / 56129 HGNCID:8692 Length:793 Species:Homo sapiens


Alignment Length:714 Identity:188/714 - (26%)
Similarity:300/714 - (42%) Gaps:143/714 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 ETEIDENADLQSTVLTVNAKD--------HNESTNIRYQITGGNIGNAFAVQNTTGVIYVASPLD 98
            |||       :.|.||..|||        ....|.|   ::..|: ....:.:.||.:.:...||
Human    38 ETE-------RGTFLTNLAKDLGLGVGELRARGTRI---VSDQNM-QILLLSSLTGDLLLNEKLD 91

  Fly    99 YE--TRPR------YELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEEDDRNLPK 155
            .|  ..||      ::|.||    :........:.|||:||:.|||            .||.:..
Human    92 REELCGPREPCVLPFQLLLE----K
PFQIFRAELWVRDINDHAPVF------------LDREISL 140

  Fly   156 RILQVT----------ATDGDVDRPINIVYFLTGQGIDPDNPANSKFDIN---RTTGDIF---VL 204
            :||:.|          |.|.||.     ...|:...|.|    |:.|.||   ...|:|:   ||
Human   141 KILESTTPGAAFLLESAQDSDVG-----TNSLSNYTISP----NAYFHINVHDSGEGNIYPELVL 196

  Fly   205 -KPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAG 268
             :.|||::   .|::..|:.|.|.|.....|.|.:::.:.|:|||||.|.:.:|...|.||...|
Human   197 NQVLDREE---IPEFSLTLTALDGGSPPRSGTALVRILVLDVNDN
APDFVRSLYKVQVPENSPVG 258

  Fly   269 SSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYS 333
            |.|:::||.|.|   ..:|.::.|:..   ...|.....|:|.|.:|.:... ..||.|....|:
Human   259 SMVVSVSARDLD---TGSNGEIAYAFS---YATERILKTFQINPTSGSLHLK-AQLDYEAIQTYT 316

  Fly   334 IQVVAMDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETN 398
            :.:.|.|||||.|..|..:.|.|:||..|:.......:.:.|.:    |||.:....::|.|..|
Human   317 LTIQAKDGGGLSGKCTVVVDVTDINDN
RPELLLSSLTSPIAENS----PETVVAVFRIRDRDSGN 377

  Fly   399 ------TFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDG 457
                  :.|..|         .|.:..:.:...:|...:|||.|   :::.:...|.|.|.|.  
Human   378 NGKTVCSIQDDV---------PFILKPSVENFYTLVTEKPLDRE---RNTEYNITITVTDLGT-- 428

  Fly   458 PGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAY 522
            |....:::     :.|.:.|:|||.|.|.:....:.:.|:......:....|||.|.|.:::|.|
Human   429 PRLKTEHN-----ITVLVSDVNDN
APAFTQTSYTLFVRENNSPALPIGSVSATDRDSGTNAQVIY 488

  Fly   523 KIVRSTNRKRQFAI-----SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKD 582
            .::.|.:.....|.     :|.|.:...|.||.|.......::.|.|.||||.::.|.:.|:|.|
Human   489 SLLPSQDPHLPLASLVSINADNGHLFALRSLDYEALQAFEFRVGATDRGSPALSSEALVRVLVLD 553

  Fly   583 VNDNAP--------TFAQDYKPTLPENVS-GKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEI 638
            .|||:|        :.|...:| ||.... |..:.:|.|.|.|.   |.....:::|       :
Human   554 ANDN
SPFVLYPLQNSSAPCTEP-LPRAAEPGYLVTKVVAVDGDS---GQNAWLSYQL-------L 607

  Fly   639 KA---GFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGD 699
            ||   |....:...|:... ..::|     :|:|.|...: :.:||||.|..:.|:||.|.:.|
Human   608 KATEPGLFGVWAHNGEVRT-ARLLS-----ERDAAKQRLV-VLVKDNGEPPRSATATLHVLLVD 664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 26/105 (25%)
Cadherin_repeat 140..248 CDD:206637 32/124 (26%)
Cadherin_repeat 256..359 CDD:206637 32/102 (31%)
Cadherin_repeat 379..481 CDD:206637 22/107 (21%)
Cadherin_repeat 489..586 CDD:206637 27/101 (27%)
Cadherin_repeat 594..703 CDD:206637 28/110 (25%)
Cadherin_repeat 724..801 CDD:206637
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
PCDHB7NP_061763.1 Cadherin_2 30..112 CDD:285466 22/88 (25%)
Cadherin_repeat 137..238 CDD:206637 30/112 (27%)
Cadherin_repeat 247..343 CDD:206637 33/102 (32%)
Cadherin_repeat 356..447 CDD:206637 23/113 (20%)
Cadherin_repeat 455..557 CDD:206637 27/101 (27%)
Cadherin_repeat 576..664 CDD:206637 26/104 (25%)
Cadherin_C_2 683..766 CDD:293101
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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