DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and PCDHB13

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_061756.1	Gene:	PCDHB13 / 56123	HGNCID:	8684	Length:	798	Species:	Homo sapiens

Alignment Length:	726	Identity:	184/726 - (25%)
Similarity:	307/726 - (42%)	Gaps:	126/726 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKD----HNESTNIRYQITGGNIGNA 81
            |:.:|::....:.|.....:.|||       .|:.:|..|||    ..|.:....::.  :.||.
Human    18 FLLLGLSLAGAAEPRSYSVVEETE-------GSSFVTNLAKDLGLEQREFSRRGVRVV--SRGNK 73

  Fly    82 FAVQ--NTTGVIYVASPLDYE-----TRP---RYELRLEATRNRKNNYTTVVINVRDVNDNPPVF 136
            ..:|  ..|..:.:...||.|     |.|   |:::.||:    ...:....:.|.|:||:.|||
Human    74 LHLQLNQETADLLLNEKLDREDLCGHTEPCVLRFQVLLES----PFEFFQAELQVIDINDHSPVF 134

  Fly   137 -DRQTYRTQITEEDDRNLPKRILQV-TATDGDVDRPINIVYFLTGQGIDPDNPANSKFDI---NR 196
             |:|    .:.:..:.:.|.....: .|.|.||.:. ||..::    |.|    ||.|.:   .|
Human   135 LDKQ----MLVKVSESSPPGTTFPLKNAEDLDVGQN-NIENYI----ISP----NSYFRVLTRKR 186

  Fly   197 TTG----DIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIY 257
            :.|    ::.:.|.|||::   ..:.|.|:.|.|.|.....|.|.:.:.:.|:|||||:|.|..|
Human   187 SDGRKYPELVLDKALDREE---EAELRLTLTALDGGSPPRSGTAQVYIEVLDVNDNAPEFEQPFY 248

  Fly   258 FGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVC 322
            ...::|:...|..|:.:||.|.|   ...|.::.||:.:  ..||.| ..|:|.|.||.|:...
Human   249 RVQISEDSPVGFLVVKVSATDVD---TGVNGEISYSLFQ--ASEEIG-KTFKINPLTGEIELKK- 306

  Fly   323 CLDRERTPDYSIQVVAMDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPIL 387
            .||.|:...|.:.:.|.|.|...|..|..|:|.|:||..|:.|...:.:.:.|.    .|||.:.
Human   307 QLDFEKLQSYEVNIEARDAGTFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPEN----APETVVA 367

  Fly   388 TVTVQDED--ETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQV 450
            ..:|.|.|  |.......:..:..|      ::::.:...:|...:|||.|...:   :...|.|
Human   368 LFSVSDLDSGENGKISCSIQEDLPF------LLKSAENFYTLLTERPLDRESRAE---YNITITV 423

  Fly   451 NDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQG 515
            .|.|       ....:....:.|.:.|:|||.|.|.:....:.:.|:......:....|||.|.|
Human   424 TDLG-------TPMLITQLNMTVLIADVNDNAPAFTQTSYTLFVRENNSPALHIRSVSATDRDSG 481

  Fly   516 GHSKVAYKIVR------------STNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSP 568
            .:::|.|.::.            |.|       :|.|.:...|.||.|.......::.|.|.|||
Human   482 TNAQVTYSLLPPQDPHLPLTSLVSIN-------ADNGHLFALRSLDYEALQGFQFRVGASDHGSP 539

  Fly   569 ARTATATLTVIVKDVNDNAPTF----------AQDYKPTLPENVSGKKILEVAAKDPDDRLRGNG 623
            |.::.|.:.|:|.|.|||:|..          ..:..|...|  .|..:.:|.|.|.|.   |..
Human   540 ALSSEALVRVVVLDANDNSPFVLYPLQNGSAPCTELVPRAAE--PGYLVTKVVAVDGDS---GQN 599

  Fly   624 GPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMT 688
            ...:::|  |.:.|:  |....:...|:... ..::|     :|:|.| :.:.:.:||||.|..:
Human   600 AWLSYQL--LKATEL--GLFGVWAHNGEVRT-ARLLS-----ERDAAK-HRLVVLVKDNGEPPRS 653

  Fly   689 GTSTLTVTIGD 699
            .|:||.|.:.|
Human   654 ATATLHVLLVD 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	24/104 (23%)
		Cadherin_repeat	140..248	CDD:206637	27/115 (23%)
		Cadherin_repeat	256..359	CDD:206637	32/102 (31%)
		Cadherin_repeat	379..481	CDD:206637	20/103 (19%)
		Cadherin_repeat	489..586	CDD:206637	27/108 (25%)
		Cadherin_repeat	594..703	CDD:206637	27/106 (25%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
PCDHB13	NP_061756.1	Cadherin_2	31..112	CDD:285466	20/89 (22%)
		Cadherin_repeat	141..239	CDD:206637	27/109 (25%)
		Cadherin_repeat	248..344	CDD:206637	33/102 (32%)
		Cadherin_repeat	357..447	CDD:206637	21/109 (19%)
		Cadherin_repeat	455..557	CDD:206637	27/108 (25%)
		Cadherin_repeat	576..664	CDD:206637	26/103 (25%)
		Cadherin_C_2	686..768	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000