DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and PCDHGA2

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_061738.1	Gene:	PCDHGA2 / 56113	HGNCID:	8700	Length:	932	Species:	Homo sapiens

Alignment Length:	727	Identity:	189/727 - (25%)
Similarity:	310/727 - (42%)	Gaps:	120/727 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 RTQITEEDDR-----NLPKRI-LQVTATDGDVDRPINIVYFLTGQGIDPDNPANSK-FDINRTTG 199
            |..:.||.||     |:.|.: |:..|              |..||:...:...|: |.:|..:|
Human    32 RYSVREEIDRGSFVGNIAKDLGLEPLA--------------LAEQGVRIVSRGRSQLFALNPRSG 82

  Fly   200 DIFVLKPLDRDQ--PNGRP-QWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNV 261
            .:.....:||::  ....| ...|.:..:|:    |..|: ::|.:.|||||||:|........:
Human    83 SLVTANRIDREELCAQSAPCLLNFNILLEDK----LTIYS-VEVEITDINDNAPRFGVEELELKI 142

  Fly   262 TENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKN---VIEEETGAPIFEIEPETGLIKTAVCC 323
            :|..|.|..:...:|.|.|   ...||...|::..|   .::...||...:. ||..|.::
Human   143 SETTTPGFRIPLKNAHDAD---VGENALQKYALNPNDHFSLDVRRGADGNKY-PELVLERS---- 199

  Fly   324 LDRERTPDYSIQVVAMDGGG--LKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPI 386
            ||||....:.:.:||.|||.  |.||....::|.|.||..|.||:.|:...:.|..   :..|.|
Human   200 LDREEEAVHHLVLVASDGGDPVLSGTSRICVKVLDANDNAPVFTQPEYRISIPENT---LVGTRI 261

  Fly   387 LTVTVQDEDETNTFQ--YKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQ 449
            ||||..|.||....|  |.:..:.|..::.|.:...   :|.|.||:.|||||    :.|.   :
Human   262 LTVTATDADEGYYAQVVYFLEKSPGETSEVFELKST---SGELTIIKDLDYED----ATFH---E 316

  Fly   450 VNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQ 514
            ::.:..||||     .:..:.|:|.:.|:|||.|:|.......|:.||:..|||:..|...|.|.
Human   317 IDIEAQDGPG-----LLTRAKVIVTVLDVNDNAPEFYMTSATSSVSEDSLPGTIIGLFNVHDRDS 376

  Fly   515 GGHSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVI 579
            |.::.....:......|.:.::.:...:...|.||||....::|.:.|.|.|:|:.:..|.:.:.
Human   377 GQNAFTTCSLPEDLPFKLEKSVDNYYRLVTTRALDREQFSFYNITLTAKDGGNPSLSTDAHILLQ 441

  Fly   580 VKDVNDNAPTFAQ-DYKPTLPE-NVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGF 642
            |.|:|||||.|:: .|...:|| |..|..:..|.|.|||.....: ..::|..|.:....:.:..
Human   442 VADINDNAPAFSRTSYSTYIPENNPRGASVFSVTAHDPDSNDNAH-VTYSFAEDTVQGAPLSSYI 505

  Fly   643 KVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDN---- 703
            .:..|        ..::.:||.||.|..:...:.:..:|:|.|.::...:|::.:.|.|||
Human   506 SINSD--------TGVLYALRSFDYEQLRDLQVWVIARDSGNPPLSSNVSLSLFVLDQNDNAPEI 562

  Fly   704 ------------------KMQPG---SKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYY-W 746
                              ..:||   :|.|.|....||:.              |    ..|: .
Human   563 LYPAFPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNA--------------W----LSYHLL 609

  Fly   747 EVQEHQRFKLDTDTG-ILTMRAGTRRGRYQLRFKVYDREHGQEDIPA--NLSVTVRDITAEAVQQ 808
            :..|...|.:...|| :.|.||...|...:....|..::|||..:.|  .|:|.|.|...:.:..
Human   610 KASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAIQDHGQPPLSATVTLTVAVADRIPDILAD 674

  Fly   809 AGSMRLSHITDE 820
            .||:..|.|.::
Human   675 LGSLEPSAIPND 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	27/115 (23%)
		Cadherin_repeat	256..359	CDD:206637	29/107 (27%)
		Cadherin_repeat	379..481	CDD:206637	31/103 (30%)
		Cadherin_repeat	489..586	CDD:206637	25/96 (26%)
		Cadherin_repeat	594..703	CDD:206637	24/109 (22%)
		Cadherin_repeat	724..801	CDD:206637	18/80 (23%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
PCDHGA2	NP_061738.1	Cadherin_2	30..112	CDD:285466	20/93 (22%)
		Cadherin_repeat	137..238	CDD:206637	30/108 (28%)
		Cadherin_repeat	246..343	CDD:206637	33/114 (29%)
		Cadherin_repeat	355..448	CDD:206637	25/92 (27%)
		Cadherin_repeat	456..558	CDD:206637	24/110 (22%)
		Cadherin_repeat	579..666	CDD:206637	25/104 (24%)
		Cadherin_C_2	688..772	CDD:293101
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..841
		Cadherin_tail	809..>905	CDD:292596
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	902..932
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000