DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and PCDHGA4

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_061740.2	Gene:	PCDHGA4 / 56111	HGNCID:	8702	Length:	962	Species:	Homo sapiens

Alignment Length:	765	Identity:	198/765 - (25%)
Similarity:	310/765 - (40%)	Gaps:	109/765 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITE-EDDRN 152
            ||:..|.|    .||.:...|:...     ...|::.:|.......||:.|...:.:.. ..|..
Human    29 GVVMAAPP----ARPDHTRLLQICL-----LLGVLVEIRAEQILYSVFEEQEEGSVVGNIAKDLG 84

  Fly   153 LPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQ-----P 212
            |..|.|        .:|.:.||          .......|.:|..:|.:.....:||::     |
Human    85 LAPREL--------AERGVRIV----------SRGRTQLFALNPRSGTLVTAGRIDREELCDRSP 131

  Fly   213 NGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAV 277
            |........:       |..|....::|.:.|:|||.|.|........|.||...|:......|.
Human   132 NCVTNLEILL-------EDTVKILRVEVEIIDVNDNPPSFGTEQREIKVAENENPGARFPLPEAF 189

  Fly   278 DYDDPNESTNAKLIYSIEKN---VIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAM 339
               ||:...|:...|.:..|   .::.::||...:. ||..|.:    .||||....:.:.:.|.
Human   190 ---DPDVGVNSLQGYQLNSNGYFSLDVQSGADGIKY-PELVLER----ALDREEEAVHHLVLTAF 246

  Fly   340 DGGGLKGTGTASIRV--KDLNDMPPQFTKDEWVTEVDETNGTYIP-ETPILTVTVQDEDE-TN-- 398
            |||....:|||.|.:  .|.||..|.||:.|:...|.|.    :| .|.:|||...|.|| .|
Human   247 DGGDPVRSGTARILIILVDTNDNAPVFTQPEYHVSVREN----VPVGTRLLTVKATDPDEGANGD 307

  Fly   399 -TFQYKVVPNSGFGADKFA-MVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGS 461
             |:.::.|      .||.: :.:....:|.:.|:..|||||    |||   ..::.:..||||..
Human   308 VTYSFRKV------RDKISQLFQLNSLSGDITILGGLDYED----SGF---YDIDVEAHDGPGLR 359

  Fly   462 DKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVR 526
                 |.|.|:|.:.|.|||.|:.....:..|:.|.:..||::..|...|:|.||:..|...|..
Human   360 -----ARSKVLVTVLDENDNAPEVTVTSLTSSVQESSSPGTVIALFNVHDSDSGGNGLVTCSIPD 419

  Fly   527 STNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFA 591
            :.....:....:...:...|.||||....::|.:.|.|.|:|..:....:::.|.|:|||.|||.
Human   420 NLPFTLEKTYGNYYRLLTHRTLDREEVSEYNITVTATDQGTPPLSTETHISLQVMDINDNPPTFP 484

  Fly   592 Q-DYKPTLPE-NVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNEN 654
            . .|...:|| |..|..||.:.|:|||.   |:....|:   .||.|..:......|.....|
Human   485 HASYSAYIPENNPRGASILSMTAQDPDS---GDNARITY---SLAEDTFQGAPLSSYVSINSN-- 541

  Fly   655 GVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQ--------PGSKS 711
             ..|:.:|..||.|..:...:.:...|:|.|.::...:|::.:.|.|||..:        .||..
Human   542 -TGILYALCSFDYEQFRDLQLLMTASDSGDPPLSSNVSLSLFVLDQNDNVPEILYPTFPTDGSTG 605

  Fly   712 VLVYNYQGQSQDTP--IGRVYVNDPDDWDVPDKKY-YWEVQEHQRFKLDTDTG-ILTMRAGTRRG 772
            |   ....:|.|:.  :.:|...|.|........| ..:..|...|.:...|| :.|.||...|.
Human   606 V---ELAPRSADSGYLVTKVVAVDRDSGQNAWLSYSLLKSSEPGLFAVGLHTGEVRTARALLDRD 667

  Fly   773 RYQLRFKVYDREHGQEDIPA--NLSVTVRDITAEAVQQAGSMRLSHITDE 820
            ..:.|..|..::|||..:.|  .|:|.|.|...:.:...||::.|...|:
Human   668 ALKQRLVVVVQDHGQPPLSATVTLTVAVADSIPDVLADLGSLKPSADPDD 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	9/42 (21%)
		Cadherin_repeat	140..248	CDD:206637	19/113 (17%)
		Cadherin_repeat	256..359	CDD:206637	28/107 (26%)
		Cadherin_repeat	379..481	CDD:206637	33/107 (31%)
		Cadherin_repeat	489..586	CDD:206637	24/96 (25%)
		Cadherin_repeat	594..703	CDD:206637	29/109 (27%)
		Cadherin_repeat	724..801	CDD:206637	21/82 (26%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
PCDHGA4	NP_061740.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Cadherin_2	61..143	CDD:311943	17/106 (16%)
		Cadherin_repeat	170..269	CDD:206637	29/106 (27%)
		Cadherin_repeat	277..374	CDD:206637	36/118 (31%)
		Cadherin_repeat	386..479	CDD:206637	24/92 (26%)
		Cadherin_repeat	487..589	CDD:206637	29/110 (26%)
		Cadherin_repeat	610..697	CDD:206637	23/86 (27%)
		Cadherin_C_2	720..803	CDD:318652
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	832..871
		Cadherin_tail	841..>935	CDD:318236
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..962
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000