DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and PCDHGB1

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_061745.1	Gene:	PCDHGB1 / 56104	HGNCID:	8708	Length:	927	Species:	Homo sapiens

Alignment Length:	702	Identity:	189/702 - (26%)
Similarity:	302/702 - (43%)	Gaps:	136/702 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 RNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGR 215
            |.||.|.|:|:|.|                          .|:::..:||:.|...:||::..||
Human    57 RELPTRKLRVSAED--------------------------YFNVSLESGDLLVNGRIDREKICGR 95

  Fly   216 P---QWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQF-PQGIYFGNVTENGTAGSSVMTMSA 276
            .   ...|...|     |..:....:.|.::|||||||:| .:||.. .:.|:...|......||
Human    96 KLECALEFETVA-----ENPMNVFHVVVVIQDINDNAPRFVAKGIDL-EICESALPGVKFSLDSA 154

  Fly   277 VDYDDPNESTNAKLIYSIEKN------VIEEETGA--PIFEIEPETGLIKTAVCCLDRERTPDYS 333
            .|.|  .|..:.|| |:|..|      ..|...|:  |:..:|..          ||||....:.
Human   155 QDAD--VEGNSLKL-YTINPNQYFSLSTKESPDGSKYPVLLLEKP----------LDREHQSSHR 206

  Fly   334 IQVVAMDGGG--LKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIP-ETPILTVTVQDED 395
            :.:.|||||.  |.||....|||.|.||..|.|:::.:...:.|.    :| .|.:|.|...|:|
Human   207 LILTAMDGGDPPLSGTTHIWIRVTDANDNAPVFSQEVYRVSLQEN----VPWGTSVLRVMATDQD 267

  Fly   396 E------TNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKG 454
            |      |..|.     ||......|.:..|   ||.:.....||:|   ::|.:...::..|.|
Human   268 EGINAEITYAFL-----NSPISTSLFNLNPN---TGDITTNGTLDFE---ETSRYVLSVEAKDGG 321

  Fly   455 DDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGH-- 517
                     .|.|:..|.:::.|.|||.|:.........|.||:.:||::...|..|.|.|.:
Human   322 ---------VHTAHCNVQIEIVDENDNAPEVTFMSFSNQIPEDSDLGTVIALIKVRDKDSGQNGM 377

  Fly   518 ------SKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATL 576
                  .:|.:|: .||: |..:.:...||      |:||....:::.|:|.|.|.||.::..::
Human   378 VTCYTQEEVPFKL-ESTS-KNYYKLVIAGA------LNREQTADYNVTIIATDKGKPALSSRTSI 434

  Fly   577 TVIVKDVNDNAPTFAQ-DYKPTLPE-NVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASD--- 636
            |:.:.|:|||||.|.| .|...:.| |..|..|.:|:|.|||   .|..|..::.:  ||||
Human   435 TLHISDINDNAPVFHQASYVVHVSENNPPGASIAQVSASDPD---LGPNGRVSYSI--LASDLEP 494

  Fly   637 -EIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDV 700
             |:.:...|      ..::||  :.:.|.||.|..:::.:.::.:|.|:||::...:|.|.:||:
Human   495 RELLSYVSV------SPQSGV--VFAQRAFDHEQLRAFELTLQARDQGSPALSANVSLRVLVGDL 551

  Fly   701 NDN-------KMQPGSKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYY-WEVQEHQRFKLD 757
            |||       .:.|...::.....:.......:.:|...|.|........|: .:..|...|.|.
Human   552 NDNAPRVLYPALGPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASEPGLFSLG 616

  Fly   758 TDTG-ILTMRAGTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQ 808
            ..|| :.|.||...|...:.|..|..|:.||.  |.:.:.|:..|.|:::|:
Human   617 LRTGEVRTARALGDRDAARQRLLVAVRDGGQP--PLSATATLHLIFADSLQE 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	23/99 (23%)
		Cadherin_repeat	256..359	CDD:206637	33/112 (29%)
		Cadherin_repeat	379..481	CDD:206637	26/108 (24%)
		Cadherin_repeat	489..586	CDD:206637	28/104 (27%)
		Cadherin_repeat	594..703	CDD:206637	33/113 (29%)
		Cadherin_repeat	724..801	CDD:206637	20/78 (26%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
PCDHGB1	NP_061745.1	Cadherin_2	30..109	CDD:285466	18/82 (22%)
		Cadherin_repeat	137..235	CDD:206637	33/111 (30%)
		Cadherin_repeat	243..339	CDD:206637	27/119 (23%)
		Cadherin_repeat	351..444	CDD:206637	28/100 (28%)
		Cadherin_repeat	452..554	CDD:206637	33/114 (29%)
		Cadherin_repeat	574..658	CDD:206637	20/85 (24%)
		Cadherin_C_2	683..764	CDD:293101
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	797..836
		Cadherin_tail	804..>900	CDD:292596
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..927
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000