DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and si:ch211-186j3.6

DIOPT Version :10

Sequence 1:NP_609855.3 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:XP_001920988.3 Gene:si:ch211-186j3.6 / 556807 ZFINID:ZDB-GENE-130530-842 Length:2902 Species:Danio rerio


Alignment Length:1848 Identity:622/1848 - (33%)
Similarity:937/1848 - (50%) Gaps:266/1848 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 TKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTN--IRYQITGGNIGNA 81
            |.:|||.|:|.||:.|.|.:.:||.::||:||:.||||||:|.|.:|..|  :|||||.||:|..
Zfish  1180 TAYVRIFISDVNDNKPVFAQPVYEVDVDEDADVGSTVLTVSANDEDEGANAKLRYQITSGNVGGV 1244

  Fly    82 FAVQNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQIT 146
            |.::...|.|::|.|||||....|:|.:.|:..:..:|.||::.:.:.||..|||....|...:|
Zfish  1245 FDMEPEVGTIFIAQPLDYEQNKLYKLHVLASDGKWEHYATVIVTIVNKNDEAPVFSVNEYYGSVT 1309

  Fly   147 EEDDRNLPKRILQVTATDGDVDRPINIV-YFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRD 210
            ||.|.: |..:|||||:|.|.|.....: |.|.|||      |.|:|.|:..||.|:..:.|||:
Zfish  1310 EELDGS-PVFVLQVTASDPDKDADQEALRYSLHGQG------AESEFIIDEVTGKIYAQRTLDRE 1367

  Fly   211 QPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQF---PQGIYFGNVTENGTAGSSVM 272
            .   |..|||.|.|.|||||||.|:.|:.:|:.|||||||.|   |...: |:|.||...|:|||
Zfish  1368 V---RAVWRFVVLATDEGGEGLTGFTDVIINVWDINDNAPIFACAPDSCH-GDVAENSPPGTSVM 1428

  Fly   273 TMSAVDYDDPNESTNAKLIYSIEKNVI--EEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQ 335
            .|:|.|.||.....||.|.|.|..|..  ....||.:|.|.|.||.:..::..||||:...|.:.
Zfish  1429 EMTATDLDDAAVGQNAMLAYRIVGNAALNGANNGADMFNINPATGTVSVSMSGLDREQIDSYVLV 1493

  Fly   336 VVAMDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDED--ETN 398
            |.|.||||:.|:.||:|.|.|:||..|:|........:.|::.   |.|.::.:..:|.|  |..
Zfish  1494 VEARDGGGMIGSATATIHVTDVNDHIPRFLDRSCFVRIPESSE---PNTAVIELAAEDADAGENG 1555

  Fly   399 TFQYKVVPNSGFGADKFAMV-RNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSD 462
            ...:.||  :|....||.|| ...:..|:|::.:.||||.|.:.. |...|:|.|          
Zfish  1556 QLTFSVV--AGDPEQKFYMVSHRQEQRGTLRLKKRLDYERPGEQR-FNLTIKVED---------- 1607

  Fly   463 KYHVAYSWVV---VKLRDINDNVPKFDREHIEV-SIYEDTKVGTILEQFKATDADQGGHSKVAYK 523
               :.||.::   :::.|.||:||.|....::: :|.||...||.|....|:|.|.|.:.::.|.
Zfish  1608 ---MQYSTLLHCTLEIEDCNDHVPVFIPHFLQLPAIREDVAPGTSLASVAASDLDLGLNREITYT 1669

  Fly   524 IVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAP 588
            |...::....|::...|.|::...||||...:||:.|||.|.|:|..|.|||:.:.:.|||||.|
Zfish  1670 IAAESDPYHLFSVDQSGLVTVASELDREKVAQHHLVILAADHGTPPLTGTATIQMALLDVNDNGP 1734

  Fly   589 TFAQDYKPTLPENVSGKKILE-------VAAKDPDDRLRGNGGPFTFRLDPL----ASDEIKAGF 642
            .|...|.|.:.|||.|.:::.       :.|.|.|.  ..||.||:|.: ||    ::|     |
Zfish  1735 EFEVAYAPVVWENVLGPQVVRLNQTSMLLRAVDRDS--VENGSPFSFFV-PLEYRYSND-----F 1791

  Fly   643 KVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQP 707
            .::     ||.|..|.|::||.||||.||.:.:|:.:.|:|:|..|.|:|||:||||.||:....
Zfish  1792 HLQ-----DNGNDTATITALRAFDRERQKEFLLPVIMTDSGSPPKTVTNTLTITIGDENDHAHTA 1851

  Fly   708 GSKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRG 772
            |.|.|.:..::|:.....:|:||..||||||  :|.|.:|......|.|:..||.|.::.....|
Zfish  1852 GQKKVFINCHRGRMPTNVLGKVYSPDPDDWD--NKTYAFEGHVPNYFILNKRTGFLIIKENAPPG 1914

  Fly   773 RYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSK 837
            .|:.:.:|.|..  ..|..:::.|.||::..:|:..:.|:||:.|:..:|:.....:|     |:
Zfish  1915 SYEFQVRVSDGV--WPDAVSSVKVNVRELRDDAIYNSASLRLADISATEFMERRGNLK-----SR 1972

  Fly   838 LERFRNKLAELLYTDRDNVDVFS-VQLKEGSPYPLTDVHFAARSATQQPYFKAVRLNGVVQMHRE 901
            .|...:.|:::|....|::::|| :::::.:    .||.|:..|.   |:.:|.|::|.:..|::
Zfish  1973 YELLGDFLSDMLSVGVDDINIFSLMEVRDRT----LDVRFSVHST---PFLRAERVHGYLAAHKQ 2030

  Fly   902 EIEKDVGLNITMVNINECLHEGKGKC-GSNSCTSKVELGKKPYTVSVNRTALVGVRLDISAQCVC 965
            :::..:.:|:|.|:::||:   ...| |...|||.:.:..||..|.....|||.|.::.:|.|.|
Zfish  2031 KLQSFLQVNVTQVHVDECV---DADCRGGGGCTSHLSVTDKPAVVDSGSMALVSVTVEATAVCSC 2092

  Fly   966 RARNFTHQDHNCRTH---LCYNGGRCVETRNGPKCVACPVGYNGPRCQQSTRSFRGNGWAWYPPL 1027
            .||...||  :|..:   .|:|||.||:|::|.:| .||..:.||.|||:..||.|||:||:||:
Zfish  2093 SAREHLHQ--SCSIYPRNPCHNGGVCVDTQSGYRC-QCPAQFEGPECQQTKHSFHGNGYAWFPPI 2154

  Fly  1028 QLCQESHLSLEFITRVADGLILYNGPIVPPKPEETVISDFIALELEQGYPRLLIDFGSGTLELRV 1092
            :.|.||||||||||.|||||:||:||:...:|.|.  .||:|:||..|.|.|.|:.|||||.|::
Zfish  2155 RPCFESHLSLEFITEVADGLLLYSGPLSQLQPWEP--EDFMAIELIDGTPTLKINHGSGTLVLQL 2217

  Fly  1093 KTKKTLDDGVWHRLDIFWDTENVRMVVDFCRTALVSEMED-GTPPEFDDN-ACQARGQIPPFAES 1155
            .....:.|..|||||:..:::.||..:|.|..|.:.|||. |:....:|: :|:..|..|...:.
Zfish  2218 PGNVNVADRRWHRLDVRSNSKEVRFTLDRCAGATIMEMEGVGSWLTTEDHTSCEVTGITPNMDKH 2282

  Fly  1156 LNLNQPLQLGGLYRQHFDQTLYNWQYAF---SSKGFDGCIRNVIHNSEHYDLAFPALARNSFPAC 1217
            ||:.|.|||||:..        |..|.:   ..|.|.|||||:|.:|::|||..||.:..|.|.|
Zfish  2283 LNVTQVLQLGGVNE--------NLPYIYPQLQHKHFTGCIRNLIVDSKYYDLGSPADSSGSAPGC 2339

  Fly  1218 PQTDEVCLKTEHTARCWEHGNCVASLVQAKCHCQPGWMGPGCNVPTIPTTFKAQSYVKFALSFEP 1282
            ..||..|:.....: |...|.|........|.|.||:.|..|.......:|..:|::.|.|:|..
Zfish  2340 VMTDSSCVNMGFPS-CGTRGRCHGEWGSFSCQCIPGYSGHQCEKEVPEYSFDGRSHIHFQLAFTL 2403

  Fly  1283 DRFSTQLQLRFRTREQGGELFRVSDQHHREYAILELRRGHLQFRYNLNSMRNEEQLLTLTAIAVN 1347
            ....||:|:..|||::...:..:..:...||..||:.:|.|...|||.   :.:..||:.:..::
Zfish  2404 PARHTQVQVLVRTRKRSSSILSLLSKEQNEYLRLEIYQGLLSVFYNLG---DGDFNLTMPSYRLD 2465

  Fly  1348 DGQWHVIRISRYGSAALMELDGGESRRYNESFHFTGHQWLTIDKQEGVYAGGKAEYTGI--KTFE 1410
            :|:||.|.:.|:.:...:.||||                           ||:.|.||.  ::.|
Zfish  2466 NGEWHDIHLDRHDNELTLRLDGG---------------------------GGRREVTGSPGRSRE 2503

  Fly  1411 VQSD-----------------FQRSCLDDIRLDGKHLPL-PPAMNGTQWGQATMARNLERNCPSN 1457
            :..|                 || .|:.|:||:|:.:.| ..|.:|.   ....::.:...|.|:
Zfish  2504 IVIDPAVVMLGNSFPSGHNRSFQ-GCMRDLRLNGRFIALDSQARDGV---SVVSSQGVSLGCFSD 2564

  Fly  1458 RPCSNVICPDPFDCVDLWNEYECTCSEGRIMSSDTKG--CVDRNECLDLPCLNGATCINLEPRLR 1520
             .|...:|..||.|||||..:||.|..|.::..::.|  || ...|...||..| ||:...|. :
Zfish  2565 -SCRKNLCSPPFTCVDLWRVHECRCPTGHMVKVNSTGKFCV-YTMCASRPCHKG-TCVAQSPS-K 2625

  Fly  1521 YRCICPEGYWGENCELVQEGQR--LKLSMGALGAIFVCLIIILILALIFVLYSRKRKTTKKKK-- 1581
            :.|.|||||.|.:||:.....|  :.||..:|.||.:|.:.:|:|.|...||:|.|.....|:  
Zfish  2626 FTCHCPEGYRGRHCEVTLAIYRDDVGLSFSSLFAICICFMALLVLLLGIFLYTRWRSYKGLKEGV 2690

  Fly  1582 ------RSGPEKDVRETVISYEDEGGGEDDMTAFDITPLQIPIS--------------------- 1619
                  ..|.| |:||.|::|::|||||:|..|:|:..||..:.                     
Zfish  2691 YHVSAHHDGWE-DIRENVLNYDEEGGGEEDQNAYDMAELQKSLQPSPAQSVQYSRSRAIHHHPPS 2754

  Fly  1620 -------AQGGPP----------------------DIAACKMPIIYPVMTLLPPGQELN------ 1649
                   .|..||                      |:..|:.|         ..||..|      
Zfish  2755 QQQQQHFCQPDPPSRAGTATTTTSSISSGSATIRRDVPPCRSP---------AQGQTANPSRAAQ 2810

  Fly  1650 -------------VAYLMEERKQRIDKDNNAPPFDDLRNFTFEGSGSIAESLSSLASGTDDENQD 1701
                         ..||.|..:. .|:.....|||.|:.|:.||.||:|.||||.:|...:|...
Zfish  2811 LARKSLSFSSQDLARYLCEIIRD-ADQHPETAPFDSLQVFSTEGGGSLAGSLSSFSSAGLEEGMA 2874

  Fly  1702 FNY--LQNWGPRFNALAAMYVHDKAKAS 1727
            ..:  |:.|||||..|.|:|  ::|:.|
Zfish  2875 AGHECLKEWGPRFEKLKALY--ERAEGS 2900

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_609855.3 Cadherin_repeat 41..132 CDD:206637 40/92 (43%)
Cadherin_repeat 140..248 CDD:206637 48/108 (44%)
Cadherin_repeat 256..359 CDD:206637 43/104 (41%)
CA 388..483 CDD:214520 26/100 (26%)
Cadherin_repeat 489..586 CDD:206637 34/97 (35%)
Cadherin_repeat 594..703 CDD:206637 45/119 (38%)
EGF_CA 977..1010 CDD:238011 14/35 (40%)
LamG 1013..1198 CDD:238058 83/189 (44%)
EGF_2 1233..1259 CDD:400365 8/25 (32%)
LamG 1265..1426 CDD:238058 43/179 (24%)
EGF_CA 1497..1535 CDD:238011 14/37 (38%)
CADH_Y-type_LIR 1662..1719 CDD:460041 25/58 (43%)
si:ch211-186j3.6XP_001920988.3 Cadherin_repeat 26..134 CDD:206637
Cadherin_repeat 145..222 CDD:206637
Cadherin_repeat 257..346 CDD:206637
Cadherin_repeat 365..442 CDD:206637
Cadherin_repeat 455..547 CDD:206637
Cadherin_repeat 562..649 CDD:206637
Cadherin_repeat 658..757 CDD:206637
Cadherin_repeat 771..866 CDD:206637
Cadherin_repeat 875..963 CDD:206637
Cadherin_repeat 975..1078 CDD:206637
Cadherin_repeat 1086..1193 CDD:206637 7/12 (58%)
Cadherin_repeat 1201..1294 CDD:206637 39/92 (42%)
Cadherin_repeat 1303..1402 CDD:206637 48/108 (44%)
Cadherin_repeat 1417..1518 CDD:206637 43/100 (43%)
Cadherin_repeat 1528..1626 CDD:206637 28/116 (24%)
Cadherin_repeat 1640..1732 CDD:206637 34/91 (37%)
Cadherin_repeat 1740..1847 CDD:206637 45/119 (38%)
Cadherin_repeat <1877..1939 CDD:206637 20/65 (31%)
EGF_CA 2102..2137 CDD:238011 14/35 (40%)
LamG 2142..2320 CDD:238058 83/187 (44%)
EGF_CA <2354..2381 CDD:238011 8/26 (31%)
Laminin_G_2 2430..2537 CDD:460494 33/137 (24%)
EGF 2608..2638 CDD:394967 14/31 (45%)
CADH_Y-type_LIR 2834..2894 CDD:460041 25/59 (42%)
Blue background indicates that the domain is not in the aligned region.

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