DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and DCHS2

DIOPT Version :10

Sequence 1:NP_609855.3 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001345164.1 Gene:DCHS2 / 54798 HGNCID:23111 Length:3371 Species:Homo sapiens


Alignment Length:1397 Identity:308/1397 - (22%)
Similarity:520/1397 - (37%) Gaps:348/1397 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 VDPLKIFWVLTNSTYLVTKFVRIGIADKNDSPPY-FDRFLYETEIDENADLQSTVLTVNAK---D 62
            |.|.....|||           :.|..:..||.: |:..:|:.|:.|:....:.:|...|.   .
Human  1060 VHPQAALLVLT-----------VVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113

  Fly    63 HNESTNIRYQITGGNIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEATRNR----KNNYTTVV 123
            ...::.:||.:........|.::..||.||:....|||:...|..|:.|....    :|..|||:
Human  1114 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVI 1178

  Fly   124 INVRDVNDNPPVFDRQTYRTQITEEDDRNLPKRIL-QVTATDGDVDRPINIVYFLTGQGIDPDNP 187
            :.|.|.|||.|.|.......::.|..   :|:.:: ::||.|.|..:...::|||...|      
Human  1179 VRVWDENDNSPTFLHDVLFLKVEESP---VPQGVIGKITAIDMDSGKNGQLLYFLLSDG------ 1234

  Fly   188 ANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQF 252
              ..|.:|..||::.....|||:.   |.....||...|.|.........:.|::.|||||.|.|
Human  1235 --KFFKMNPNTGELINWVALDREH---RGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFF 1294

  Fly   253 PQGIYFGNVTENGTAGSSV-MTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGL 316
            ||.:....:......|..| |.::.|...||:|..||::.||     :..|..:..|:|:...|.
Human  1295 PQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYS-----VSSEDSSDHFKIDANNGE 1354

  Fly   317 IKTAVCCLDRERTPDYSIQVVAMDGG--GLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGT 379
            |:|.. .|..:..|.|.:.|:|.|.|  .|:|....:|:|..|       :|...:.. ......
Human  1355 IRTTT-ILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPL-------SKGRAIMS-QNIRHL 1410

  Fly   380 YIPE----TPILTVTVQDEDE-----TNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDY 435
            .|||    |.|::: ::..|.     .....:.:|.:     ||.........||.|.:.:.|||
Human  1411 IIPENLKPTKIMSL-IKSSDHLQQHYNGKLHFSIVAD-----DKDGHFEIDSSTGDLFLSKELDY 1469

  Fly   436 EDPLQSSGFRFR-------------------IQVNDKGDDGPGGSDK------------------ 463
            |   .:|.:.||                   |.|.|:.|..|...|:                  
Human  1470 E---TTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYV 1531

  Fly   464 ------------------------------YHVAYSWVVV------------------------- 473
                                          .|.::..:|.                         
Human  1532 FNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNV 1596

  Fly   474 ---KLR---------DINDNVP---KFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYK 523
               :||         |:||:.|   .|...|::    ||..||:::....|.|.|:|.:.||.|.
Human  1597 TDRRLRSLTAQIVILDVNDHNPTFISFPNAHVK----EDVTVGSLVHHITAHDPDEGRNGKVTYS 1657

  Fly   524 IVRSTNRKRQFAISD-RGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNA 587
            |: |.|....|.:.: .|.::...|||.|.:.:|.:.:||:|||:||.:::.||||.|.||||.|
Human  1658 IL-SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEA 1721

  Fly   588 PTFAQD-YKPTLPENVS-GKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRG 650
            |.|.|. |:.::.||.: |:.:..|.|.|.|.   |......|.:.|.||.|:   |::      
Human  1722 PVFKQHLYEASVKENQNPGEFVTRVEALDRDS---GVNSKLQFEIMPGASFEL---FEI------ 1774

  Fly   651 DNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVY 715
            :::.|..:.:::  .|||.|:.:.:.:.::|.|.|:::.|:|:..|:.|.||:     :...:|.
Human  1775 NSDTGEVVTTTI--LDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDH-----APEFIVS 1832

  Fly   716 NYQ---GQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEH-------QRFKLDTDTGIL-TMRAGT 769
            :|.   .::|:..:  ||.....|.|..:.:   .|:.|       :.|.::..:|.| |.||..
Human  1833 SYDIEVLENQEPEV--VYTVLASDMDAGNNR---AVEYHIIDGNTDECFTINEMSGELSTTRALD 1892

  Fly   770 RR--GRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQ 832
            |.  ..:.|.....|..........:|.|.|.|....:.........|.:.::..|.|...|.:.
Human  1893 REQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSA 1957

  Fly   833 VEPSKLERFRNKLAELLYTDRDN----VDVFSVQLKEGSPYPLTDVHFAARSATQQPYFKAVRLN 893
            |:.   :...|...|...||..:    :|..|..||..:...        |.|..|..|.||..:
Human  1958 VDK---DEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLD--------REARSQHTFSAVARD 2011

  Fly   894 GVVQMHREEIEKDVGLNITMVNINECLHEGKGKCGSNSCTSKVELGKKPYTV------SVNRTAL 952
            ..:|..| .....:.:.:|.||.|:.:                 |.:.|:.|      ..|:|.:
Human  2012 CSIQGSR-STTVIIKVYVTDVNDNDPV-----------------LEQNPFDVFLSPESPTNQTTV 2058

  Fly   953 VGVRLD--------------ISAQCVCRARNFTHQDHNCRTHLCYNGGRCVETRNGPKCVACPVG 1003
            : ||.|              ...|.:.....:|.:               ::.:..|.....|:.
Human  2059 I-VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGE---------------IQFQQNPSSEYFPIW 2107

  Fly  1004 YNGPRCQQSTRSFRGNGWAWYPPLQLCQESH-LSLEFITRVADGLILYN----GPIVPPK---PE 1060
            .......|...:....|.     |.:..|.. :.:.|...:..||:..|    ..||..|   |:
Human  2108 LQLKVTDQGIPARTTTGL-----LVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPD 2167

  Fly  1061 ETVISDFIALELEQGYPRLLIDFGSGTLELRVKTKKTLDDGVWHRLDIFWDTENVRMVV------ 1119
            .  |.|.:...:..|....::...|.:.:|.||..|.||         |.....|:::|      
Human  2168 S--IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLD---------FEVRNEVQLIVLAESSG 2221

  Fly  1120 --DFCRTALVSEMEDGTPPEFDDNACQARGQIPPFAESLNLNQPLQLGGLYRQHFDQTLYNWQYA 1182
              .:|:.|::.:.|:...|.|:.:..||         |::.:|      ||..|..|       .
Human  2222 HRAYCKVAVLIQDENDNSPCFEQSIYQA---------SVSESQ------LYNAHVIQ-------V 2264

  Fly  1183 FSS---KGFDGCIR-NVIHNSEHYDLAFPALA 1210
            |::   .|.:|.|. :::..::.......||:
Human  2265 FATDLDSGLNGLIEYSILSGNQEEAFQIDALS 2296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_609855.3 Cadherin_repeat 41..132 CDD:206637 25/97 (26%)
Cadherin_repeat 140..248 CDD:206637 26/108 (24%)
Cadherin_repeat 256..359 CDD:206637 29/105 (28%)
CA 388..483 CDD:214520 27/203 (13%)
Cadherin_repeat 489..586 CDD:206637 37/97 (38%)
Cadherin_repeat 594..703 CDD:206637 28/109 (26%)
EGF_CA 977..1010 CDD:238011 2/32 (6%)
LamG 1013..1198 CDD:238058 41/204 (20%)
EGF_2 1233..1259 CDD:400365
LamG 1265..1426 CDD:238058
EGF_CA 1497..1535 CDD:238011
CADH_Y-type_LIR 1662..1719 CDD:460041
DCHS2NP_001345164.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40
Cadherin_repeat 70..163 CDD:206637
Cadherin_repeat 176..292 CDD:206637
Cadherin_repeat 300..409 CDD:206637
Cadherin_repeat 423..534 CDD:206637
Cadherin_repeat 543..659 CDD:206637
Cadherin_repeat 667..767 CDD:206637
Cadherin_repeat 775..866 CDD:206637
Cadherin_repeat 881..975 CDD:206637
Cadherin_repeat 985..1074 CDD:206637 5/24 (21%)
Cadherin_repeat 1088..1187 CDD:206637 25/98 (26%)
Cadherin_repeat 1195..1290 CDD:206637 26/108 (24%)
Cadherin_repeat 1302..1394 CDD:206637 27/97 (28%)
Cadherin_repeat 1412..1506 CDD:206637 22/102 (22%)
Cadherin_repeat 1515..1616 CDD:206637 6/100 (6%)
Cadherin_repeat 1625..1719 CDD:206637 36/98 (37%)
Cadherin_repeat 1729..1825 CDD:206637 28/109 (26%)
Cadherin_repeat 1833..1929 CDD:206637 21/100 (21%)
Cadherin_repeat 1938..2034 CDD:206637 24/107 (22%)
Cadherin_repeat 2042..2129 CDD:206637 14/107 (13%)
CA 2162..2240 CDD:214520 18/88 (20%)
Cadherin_repeat 2246..2343 CDD:206637 14/73 (19%)
Cadherin_repeat 2353..2443 CDD:206637
Cadherin_repeat 2452..2543 CDD:206637
Cadherin_repeat 2553..2661 CDD:206637
Cadherin_repeat 2669..2765 CDD:206637
Cadherin_repeat 2778..2868 CDD:206637
Cadherin_repeat 2884..2978 CDD:206637
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3117..3141
Blue background indicates that the domain is not in the aligned region.

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