DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and pcdh15b

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	XP_009304712.1	Gene:	pcdh15b / 503521	ZFINID:	ZDB-GENE-050214-1	Length:	1964	Species:	Danio rerio

Alignment Length:	996	Identity:	235/996 - (23%)
Similarity:	404/996 - (40%)	Gaps:	230/996 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTV---LTVN--AKDHNESTN------IRYQITG 75
            |||.:.|:||:.|.|.:..|...::|...:.:|:   .|.|  |.|.::..|      |:|....
Zfish   140 VRIVVRDRNDNAPRFQQPRYYVAVNELTPVGTTIFSGFTGNNGAVDIDDGPNGQIEYTIQYNPRD 204

  Fly    76 GNIGNAFAVQNT-TGVIYVASPLDYETRPRYELRLEAT------RNRKNNYTTVVINVRDVNDNP 133
            ......|.:..| :|.:.:...|:||...||.:.::|.      ::|....||:.::|.|.:|..
Zfish   205 PTTNRTFDIPLTLSGSVVLRERLNYEEITRYLVIIQANDRAPNPKDRLTATTTLTVDVLDGDDLG 269

  Fly   134 PVF------DRQ------TYRTQITEEDDRNLPKRILQVTAT------DGD------VDRPINIV 174
            |:|      |..      |||..|.|..|   |.|:..|..|      |.|      .||| .|:
Zfish   270 PMFLPCSLVDNTRDCKPLTYRASILELTD---PSRVNPVNVTPPIQAVDQDRNIQPPSDRP-GIL 330

  Fly   175 YFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQ 239
            |.:.   |.........|.:||:|.::.:||.:.|::   ...:...:.|:.:.|..|..:|::.
Zfish   331 YSIL---IGKPETYGEFFWMNRSTAELQLLKAISREK---YQHFDLVIKAEQDNGHPLPAFANLH 389

  Fly   240 VNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETG 304
            :.:.|.|:.||.|....|.|.::|:...|:::.:.:       |.||...:|. ::.::  |||.
Zfish   390 IEVLDENNQAPYFQVATYHGFISESAPLGTTISSSA-------NLSTPLAIIV-LDNDI--EETK 444

  Fly   305 APIFEIEPET----------GLIK--TAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRVKDL 357
            .|:..|..:.          |:::  |.:..:|.|..|.|:..::|.||.......|.:|.|.|.
Zfish   445 DPMVRISLDNYNGIFAVTAGGIVRYLTLLRPVDHEEQPTYAFTMIASDGVQESAPVTINITVIDA 509

  Fly   358 NDMPPQFTKDEWVTEVDETNGTYI---PETPILTVTVQDEDE--TNTFQYKVVPNSGFGADKFAM 417
            ||..|.|....:...|      |.   |..|:|.:|..|.|:  .....||::     ..|:...
Zfish   510 NDNTPTFPNVSYGVSV------YTDMQPGDPVLQLTALDADDGPNGLVSYKIL-----AGDQGHF 563

  Fly   418 VRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNV 482
            ..| |.||.:.::..::.     :.|..:.:.|. ..|:||....:..:...::.| |...|.:.
Zfish   564 TIN-DCTGVITVLPSVNL-----TVGRSYALTVR-ATDNGPTAQRRSSITTVYIEV-LPPNNQSP 620

  Fly   483 PKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISD-RGAVSIQR 546
            |:|.:....:.|.|..:.|..|...:|||.::   ..:.|.|.:. :....|.:|. .|.:.:.:
Zfish   621 PRFHQLVYSLEISEAMRTGATLLNIQATDREK---DPITYSIQKG-DPNNVFEVSQTSGLLLLAK 681

  Fly   547 PLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKK----- 606
            .||||..|.:.:.:.| .||.|..|:|.|:.:.|.|||||.|    ::.|.||.|::.::
Zfish   682 TLDREITDHYTLTVTA-SDGKPDGTSTTTVNIAVTDVNDNDP----EFDPLLPLNLTVQEEEANA 741

  Fly   607 -ILEVAAKDPDDRLRGN------GGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRP 664
             :.:|.|.|.|..:.|.      ..|..||:.|..|                       |.:..|
Zfish   742 FVGQVKATDLDLGINGQVRYRLVSYPDLFRISPNGS-----------------------IFTAMP 783

  Fly   665 FDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNK---MQPGSKSVLVYNYQGQSQDTPI 726
            .|||.:..|.:.::..|........|.||::|:.||:||.   ..|...:.|       .:::|:
Zfish   784 LDREERAQYDLIVQASDGAKDPRRTTITLSITVLDVDDNSPVFSPPAYHATL-------PENSPV 841

  Fly   727 GRVYVN----DPD-DWDVPDKKYYWEVQEHQRFKLDTDTGILTM-----------RAGTRRGRYQ 775
            |.|.:|    ||| |.:|..:....|.:|  .|.:::.||.|.:           .|.|:
Zfish   842 GTVILNISALDPDLDANVTYRIRTKEARE--LFAVNSLTGELKVLRSLDFEKLLPNATTQ----- 899

  Fly   776 LRFKVYDREHGQEDIP---ANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPV--KNQVEP 835
             .|.|...:.|...:|   |:::|||.|:                  .||...::..  :..|.|
Zfish   900 -TFVVEALDGGSGKMPPGLASVTVTVLDM------------------NDFPPVFSQTLYRGMVAP 945

  Fly   836 SKLERFRNKLAELLYTDRDNVDVFSVQLKEGSPYPLT---DVHFAARSATQQPYFKAVRLNGVVQ 897
            :.::               ...|.:|..::..| |.|   .||:.| ...|.||..::
Zfish   946 NAVK---------------GTIVTAVHAEDLDP-PGTAASRVHYKA-DLEQFPYSTSI------- 986

  Fly   898 MHREEIEKDVGLNITMVNINE 918
               .::|::.|...|.||:||
Zfish   987 ---FDVEENSGNIFTRVNLNE 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	24/108 (22%)
		Cadherin_repeat	140..248	CDD:206637	31/119 (26%)
		Cadherin_repeat	256..359	CDD:206637	26/114 (23%)
		Cadherin_repeat	379..481	CDD:206637	22/106 (21%)
		Cadherin_repeat	489..586	CDD:206637	28/97 (29%)
		Cadherin_repeat	594..703	CDD:206637	27/120 (23%)
		Cadherin_repeat	724..801	CDD:206637	25/95 (26%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
pcdh15b	XP_009304712.1	Cadherin_repeat	159..267	CDD:206637	24/107 (22%)
		Cadherin_repeat	288..396	CDD:206637	30/117 (26%)
		Cadherin_repeat	406..512	CDD:206637	27/115 (23%)
		Cadherin_repeat	520..616	CDD:206637	22/114 (19%)
		Cadherin_repeat	627..720	CDD:206637	28/97 (29%)
		Cadherin_repeat	729..822	CDD:206637	25/115 (22%)
		Cadherin_repeat	831..929	CDD:206637	27/130 (21%)
		Cadherin_repeat	939..1035	CDD:206637	20/93 (22%)
		Cadherin_repeat	1047..1148	CDD:206637
		Cadherin_repeat	1161..1240	CDD:206637
		NESP55	<1784..1894	CDD:115071
		SRRM_C	1846..>1893	CDD:291883
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000