DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and pcdh2ab10

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001009589.2 Gene:pcdh2ab10 / 493598 ZFINID:ZDB-GENE-041118-9 Length:940 Species:Danio rerio


Alignment Length:749 Identity:192/749 - (25%)
Similarity:312/749 - (41%) Gaps:157/749 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 WVLTNSTYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTNIR--- 70
            |:.||.                       :.:|  .|.|.|: ..|.:...|||.|  .|::   
Zfish    22 WIFTNG-----------------------QIVY--SISEEAN-PGTAVGNLAKDFN--LNVQDIE 58

  Fly    71 ---YQITGGNIGNAFAVQNTTGVIYVASPLD----YETRPRYELRLEATRNRKNNYTTVVINVRD 128
               :||...:....|.....|||::|...:|    .|.:.:..|.|||..|...|.....|||.|
Zfish    59 RRGFQIVSESNKRYFDFNFKTGVLHVKERIDREELCEQKIKCSLPLEAIVNSPLNVFRFEINVLD 123

  Fly   129 VNDNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIV--YFLTGQGIDPDNPANSK 191
            :|||||.|  :|.:|.|...:.....::....:|.|.||.  ||.|  |.|:         .|..
Zfish   124 INDNPPKF--RTPKTTINISESALPGEQFALPSAFDADVG--INSVKSYKLS---------PNEH 175

  Fly   192 FDINRTTG-------DIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNA 249
            |.::..:|       ::.:.|.|||::   :|..|.|:.|.|.|.....|...|.|:::|:|||.
Zfish   176 FSLDVQSGGEQSVSAELVLQKALDREK---QPLIRLTLTAVDGGKPLRSGTMQITVHVEDVNDNI 237

  Fly   250 PQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPET 314
            |.|.:.:|...|.||...|:|::|:.|   .||:|..|.:::|::..:  :.:.....|.|.|||
Zfish   238 PVFSKSLYKARVNENAPPGTSIITVQA---SDPDEGVNGQIVYALVNH--DNDRNVESFAINPET 297

  Fly   315 GLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASI--RVKDLNDMPPQFTKDEWVTEVDETN 377
            |.| |....:|.||.....::|.|.|.|.........:  .:.|:||..|:.:....|..|.|  
Zfish   298 GEI-TVKGDVDYERKNAVELRVQAKDKGHKPRAALCKVLLEIIDVNDNVPEISVTSLVNTVKE-- 359

  Fly   378 GTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSS 442
             ..:.:|.:..:||.|.|.....|  |:.|.. |:..|.:..:.....:|.:..|||.|   ::|
Zfish   360 -DALIDTVVGMITVTDNDAGKNGQ--VILNIQ-GSSPFKVQNSYKNYYTLFVNGPLDRE---RAS 417

  Fly   443 GFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQF 507
            .:...|...|:|.. |..|.      |.:.|.:.|:|||.|:|....|.|.:.|::::|.:|...
Zfish   418 EYNVTISAADEGTP-PLSST------SVIAVHVSDVNDNAPRFPEPVINVYVKENSQIGAVLHTV 475

  Fly   508 KATDADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQ------------- 559
            .|.|.|.|.::::.|.::.|         |..|.|:....::.:|.|.|.:|             
Zfish   476 SAVDPDVGDNARITYSLLES---------SKSGPVTSMININSDTGDLHSLQSFNYEEIKTFEFK 531

  Fly   560 ILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYK---PTLPENV-----SGKKILEVAAKDPD 616
            :.|.|.|.|..::..|:.|.|.|.|||:|.....|.   ....||:     :|..:.::.|.|.|
Zfish   532 VQATDSGVPPLSSNVTVNVFVLDENDNSPAILAPYSELGSVNTENIPYSAEAGYFVAKIRAVDAD 596

  Fly   617 -----------DRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQ 670
                       ...:||.   .||:. .:|.||:.     ..|..||:                .
Zfish   597 SGYNALLSYHISEPKGNN---LFRIG-TSSGEIRT-----KRRMSDND----------------L 636

  Fly   671 KSYAIPIEIKDNGAPAMTGTSTLTVTI----GDV 700
            |::.:.:.:.|||.|:::.|.::...:    |||
Zfish   637 KTHPLVVLVCDNGEPSLSATVSIDAVVVESGGDV 670

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 30/100 (30%)
Cadherin_repeat 140..248 CDD:206637 30/116 (26%)
Cadherin_repeat 256..359 CDD:206637 29/104 (28%)
Cadherin_repeat 379..481 CDD:206637 25/101 (25%)
Cadherin_repeat 489..586 CDD:206637 27/109 (25%)
Cadherin_repeat 594..703 CDD:206637 26/130 (20%)
Cadherin_repeat 724..801 CDD:206637
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
pcdh2ab10NP_001009589.2 Cadherin_2 28..109 CDD:311943 23/85 (27%)
Cadherin_repeat 137..236 CDD:206637 28/112 (25%)
Cadherin_repeat 245..344 CDD:206637 30/104 (29%)
Cadherin_repeat 356..449 CDD:206637 27/108 (25%)
Cadherin_repeat 457..558 CDD:206637 27/109 (25%)
Cadherin_repeat 576..659 CDD:206637 21/107 (20%)
Cadherin_C_2 686..758 CDD:318652
Cadherin_tail 795..912 CDD:318236
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
00.000

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