DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and pcdh2ab8

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001009595.2	Gene:	pcdh2ab8 / 493594	ZFINID:	ZDB-GENE-041118-7	Length:	937	Species:	Danio rerio

Alignment Length:	1146	Identity:	244/1146 - (21%)
Similarity:	401/1146 - (34%)	Gaps:	348/1146 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 IDENADLQSTVLTVNAKDHN---ESTNIR-YQITGGNIGNAFAVQNTTGVIYVASPLDYE----T 101
            |.|.||..:||..: |||.|   ....:| :|:..|.....|.|...:||:.|...:|.|    .
Zfish    30 ISEEADPGTTVGPI-AKDLNLNLHELQLRGFQLVSGPNKRYFDVNLKSGVLLVKERIDRELLCGR 93

  Fly   102 RPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEEDDRNLPKRILQVTATDGD 166
            ..|..|.:||..|...|...:.:||.|:|||.|:|  ::.:|::...:.....:|.....|.|.|
Zfish    94 SSRCSLEIEAIVNSPLNMYRLEVNVLDINDNGPIF--KSSKTELNIVESAFPGERFTLPDAFDAD 156

  Fly   167 VDRPINIVYFLTGQGIDPDNPANSKFDINRTTG-------DIFVLKPLDRDQPNGRPQWRFTVFA 224
            |.......|.|:         ||..|.::..:|       ::.:.|.|||::   :|..:.|:.|
Zfish   157 VGSNSVKSYKLS---------ANEHFTLDVQSGGEQSVSAELVLQKALDREK---QPVIKLTLTA 209

  Fly   225 QDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAK 289
            .|.|.....|...|.:|::|:|||.|.|...:|...:.||...|:||:|:.|.|.|   |..|.:
Zfish   210 VDGGKPQKSGTTQIIINVEDVNDNIPVFSTSLYKTRIMENAAVGTSVITVQASDAD---EGLNGE 271

  Fly   290 LIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRV 354
            :|||.                                          ::.||
Zfish   272 IIYSF------------------------------------------ISHDG------------- 281

  Fly   355 KDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVR 419
                                                   ::..|.|....|
Zfish   282 ---------------------------------------DNRVNAFTIDSV-------------- 293

  Fly   420 NGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPK 484
                :|.:.:...:|||   .|:....|:|..|||       .|...|:..|::::.|:|||:|:
Zfish   294 ----SGVISVKGNIDYE---TSNAVEIRVQAKDKG-------QKPRAAHCKVLIEIVDVNDNIPE 344

  Fly   485 FDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLD 549
            .....:..::.||...||::......|.|.|.:..|...|..|...:.|....::..:.:...||
Zfish   345 ISVTSLAETVREDAAAGTMVGLITVKDGDAGKNGAVVLNIRGSAPFRIQNTYKNKYYLLVDGQLD 409

  Fly   550 RETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTL----PENVS-GKKILE 609
            |||...:::.|.|.|:|||..::|:.:.|.|.|||||||.|.:   |.:    .||.. |..:..
Zfish   410 RETASEYNVTISAADEGSPPLSSTSVIAVHVSDVNDNAPRFPE---PVINVYVKENSQIGAVLHT 471

  Fly   610 VAAKDPDDRLRGNGGPFTFR-LDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSY 673
            |:|.|||   .|:....|:. |:...|..:.:...:..| .||       :.||:.|:.|..|::
Zfish   472 VSAVDPD---VGDNARITYSLLESSKSGPVTSMININSD-TGD-------LHSLQSFNYEEIKTF 525

  Fly   674 AIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLV-YNYQG--QSQDTP--------IG 727
            ...::..|:|.|.::...|:.|.:.|.|||     |.::|. |:..|  .:::.|        :.
Zfish   526 EFKVQATDSGVPPLSSNVTVNVFVLDENDN-----SPAILAPYSELGSVNTENIPYSAEAGYFVA 585

  Fly   728 RVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKVYDR--------- 783
            ::...|      .|..|...:..|    :....|....|.||..|..:.:.::.|.
Zfish   586 KIRAVD------ADSGYNALLSYH----ISEPKGNNLFRIGTSSGEIRTKRRMSDNDLKTHPLVI 640

  Fly   784 ---EHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKL 845
               ::|:..:.|.:|     |.|..|:..|.::             .|.::  .|.|.|.|.:..
Zfish   641 LVCDNGEPSLSATVS-----IDAVVVESGGDVK-------------TPFRH--APVKEESFSDLN 685

  Fly   846 AELLYTDRDNVDVFSVQLKEGSPYPLTDV----------HFAARSATQQP-----YFKAVRLNGV 895
            ..||........:|.:.|     ..|..|          .::|...|..|     |.|:.:...|
Zfish   686 LYLLIAIVSVSVIFLLSL-----ISLIAVKCHRTDSSLGRYSAPMITTHPDGSWSYSKSTQQYDV 745

  Fly   896 VQMHREEIEKDVGL--------NITMVNINECLHEGKGKCGSNSCTSKVELGKKP---------- 942
            . ...:.::.||.:        :..:::||          |.::.|....|..|.
Zfish   746 C-FSSDTLKSDVVVFPAPFPPADAELISIN----------GGDTFTRTQTLPNKEKPKVPSSDWR 799

  Fly   943 YTVSVNRTALVGVRLDISAQCVCRARNFTHQDHNCRTHLCYNGGRCVETRNGPKCVACPVGYNGP 1007
            |:.|:.......||::.|:                    ...|.:.|..:|.|...:.|....|.
Zfish   800 YSASLRAGMQSSVRMEESS--------------------VMQGAQGVLVQNWPTVSSAPDNEGGE 844

  Fly  1008 RCQQSTRSFRGNGWAW-YPPLQLCQESHLSLEFITRVADGLILYNGPIVPP--KPEETVISDFIA 1069
            ...........|.|.: |.|                         ||..||  ||.|.....||.
Zfish   845 VSPPVGAGVDSNSWHFRYGP-------------------------GPGGPPHLKPGEVPPEAFII 884

  Fly  1070 LELEQGYPRLL--------------IDFGSGTLELRVKTKK 1096
                .|.|.::              |.||......::|.||
Zfish   885 ----PGSPAIISIRQGQDGDDKSDFITFGKKEEAKKLKKKK 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	30/94 (32%)
		Cadherin_repeat	140..248	CDD:206637	26/114 (23%)
		Cadherin_repeat	256..359	CDD:206637	17/102 (17%)
		Cadherin_repeat	379..481	CDD:206637	18/101 (18%)
		Cadherin_repeat	489..586	CDD:206637	28/96 (29%)
		Cadherin_repeat	594..703	CDD:206637	28/114 (25%)
		Cadherin_repeat	724..801	CDD:206637	14/96 (15%)
		EGF_CA	977..1010	CDD:238011	6/32 (19%)
		LamG	1013..1198	CDD:238058	21/101 (21%)
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
pcdh2ab8	NP_001009595.2	Cadherin_2	25..106	CDD:311943	24/76 (32%)
		Cadherin_repeat	134..233	CDD:206637	25/110 (23%)
		Cadherin_repeat	242..341	CDD:206637	35/223 (16%)
		Cadherin_repeat	353..446	CDD:206637	28/92 (30%)
		Cadherin_repeat	454..555	CDD:206637	27/111 (24%)
		Cadherin_repeat	573..656	CDD:206637	14/97 (14%)
		Cadherin_C_2	683..755	CDD:318652	12/77 (16%)
		Cadherin_tail	792..909	CDD:318236	27/165 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000