DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and pcdh2ab7

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001009594.1	Gene:	pcdh2ab7 / 493593	ZFINID:	ZDB-GENE-041118-6	Length:	939	Species:	Danio rerio

Alignment Length:	697	Identity:	187/697 - (26%)
Similarity:	298/697 - (42%)	Gaps:	156/697 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 YQITGGNIGNAFAVQNTTGVIYVASPLDYE----TRPRYELRLEATRNRKNNYTTVVINVRDVND 131
            :||.|.| ...|.|...||::.|...||.|    ...:..|.|||..|...|.....:||.|:||
Zfish    62 FQIVGPN-KRYFDVNMKTGILQVKDKLDREEICGQSLKCALELEAIVNSPLNMYRFEVNVLDIND 125

  Fly   132 NPPVFDRQTYRTQITEE----DDRNLPKRILQVTATDGDVDRPINIV--YFLTGQGIDPDNPANS 190
            |.|.|...:.:..::|.    :..:||      :|.|.||.  ||.|  |.|:         ||.
Zfish   126 NSPTFHSSSLQLNVSEAAFIGERYSLP------SADDADVG--INSVKSYKLS---------ANE 173

  Fly   191 KFDINRTTG-------DIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDN 248
            .|.::..:|       ::.:.|.|||::   :|..|.|:.|.|.|.....|..:|.|.:.|.|||
Zfish   174 HFSLDVQSGGEQSVSAELVLQKALDREK---QPVIRLTLTAVDGGKPARSGTVNIIVKIIDANDN 235

  Fly   249 APQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKN----VIEEETGAPIFE 309
            .|.|.:.:|...:.||...|:|::|::|.|.|   |..|.::.||..|:    :||.      |.
Zfish   236 IPVFTKSLYKARIPENAPVGTSIITVNARDAD---EGLNGEIEYSFIKHKNDRIIES------FA 291

  Fly   310 IEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTAS--IRVKDLNDMPPQFTKDEWVTE 372
            |...:|.| |.:..||.|......|:|.|.|.|.|.......  |.:.|:||..|:.:....|..
Zfish   292 INEVSGEI-TVLGKLDHESNNAVEIRVQARDKGSLPRAAHCKVLIEIMDVNDNIPEISVTSLVNV 355

  Fly   373 VDETNGTYIPE-TPILTVTVQDED--ETNTFQYKVVPNSGFG-----ADKFAMVRNGDGTGSLKI 429
            |:|.:    |: |.:..|||:|:|  |..:.:.|::.:..|.     .:|:::|.:|
Zfish   356 VNEDS----PKGTMVGLVTVKDDDSGENGSVKLKILDSLPFALQNTYKNKYSLVVDG-------- 408

  Fly   430 IQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSI 494
              |||.|   ::|.:...|...|:|.. |..|.      |.:.|.:.|:|||.|:|....|.|.:
Zfish   409 --PLDRE---RASEYNVTISAADEGSP-PLSST------SVIAVHVSDVNDNAPRFPEPVINVYV 461

  Fly   495 YEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQ 559
            .|::::|.:|....|.|.|.|.::::.|.::.|         |..|.|:....::.:|.|.|.:|
Zfish   462 KENSQIGAVLHTVSAVDPDVGDNARITYSLLES---------SKSGPVTSMININSDTGDLHSLQ 517

  Fly   560 -------------ILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYK---PTLPENV-----S 603
                         :.|.|.|.|..::..|:.|.|.|.|||:|.....|.   ....||:     :
Zfish   518 SFNYEEIKTFEFKVQATDSGVPPLSSNVTVNVFVLDENDNSPAILAPYSELGSVNTENIPYSAEA 582

  Fly   604 GKKILEVAAKDPD-----------DRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVA 657
            |..:.::.|.|.|           ...:||.   .||:. .:|.||:.     ..|..||:
Zfish   583 GYFVAKIRAVDADSGYNALLSYHISEPKGNN---LFRIG-TSSGEIRT-----KRRMSDND---- 634

  Fly   658 IISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI----GDV 700
                        .|::.:.|.:.|||.|:::.|.::...:    |||
Zfish   635 ------------LKTHPLVILVCDNGEPSLSATVSIDAVVVESGGDV 669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	22/64 (34%)
		Cadherin_repeat	140..248	CDD:206637	31/120 (26%)
		Cadherin_repeat	256..359	CDD:206637	32/108 (30%)
		Cadherin_repeat	379..481	CDD:206637	27/109 (25%)
		Cadherin_repeat	489..586	CDD:206637	27/109 (25%)
		Cadherin_repeat	594..703	CDD:206637	27/130 (21%)
		Cadherin_repeat	724..801	CDD:206637
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
pcdh2ab7	NP_001009594.1	Cadherin_2	28..108	CDD:285466	16/46 (35%)
		Cadherin_repeat	134..235	CDD:206637	31/120 (26%)
		Cadherin_repeat	244..343	CDD:206637	33/108 (31%)
		Cadherin_repeat	356..448	CDD:206637	29/115 (25%)
		Cadherin_repeat	456..557	CDD:206637	27/109 (25%)
		Cadherin_repeat	575..658	CDD:206637	22/107 (21%)
		Cadherin_C_2	685..757	CDD:293101
		Cadherin_tail	793..911	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000