DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and pcdh2ab2

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001009592.2 Gene:pcdh2ab2 / 493588 ZFINID:ZDB-GENE-041118-2 Length:944 Species:Danio rerio


Alignment Length:780 Identity:203/780 - (26%)
Similarity:318/780 - (40%) Gaps:197/780 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DPLKIFWV-----LTNSTYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKD 62
            |....:|:     |||..|          ||        .:.:|  .:.|..:..:||..: |||
Zfish    10 DRWSFYWICIVVFLTNWNY----------AD--------GQIVY--SVSEEVNTGTTVGNL-AKD 53

  Fly    63 HNESTNIR------YQITGGNIGNAFAVQNTTGVIYVASPLDYE----TRPRYELRLEATRNRKN 117
            .|  .|::      :||..|.....|.:....|:::|...:|.|    ...:..|.|||..:...
Zfish    54 LN--LNVQDLERRGFQIVSGPNKQYFDLHARNGILFVRERIDREELCGRSSKCALELEAIVSAPM 116

  Fly   118 NYTTVVINVRDVNDNPPVF---------DRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINI 173
            :.....:|:.|||||.|.|         ..|||..|     ...||...        |:|..:|.
Zfish   117 SIYRFEVNILDVNDNAPTFRTSKLFLNISEQTYPGQ-----RFTLPSAF--------DLDAGVNS 168

  Fly   174 V--YFLTGQGIDPDNPANSKFDIN-RTTGD------IFVLKPLDRDQPNGRPQWRFTVFAQDEGG 229
            |  |.|:         ||..|.:: ::.||      :.:.|.|||::   :|..|.|:.|.|.|.
Zfish   169 VKSYKLS---------ANEHFSLDVQSAGDQSVSAELVLQKALDREK---QPVIRLTLTAVDGGK 221

  Fly   230 EGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSI 294
            ..:.|...|.||:.|:|||.|.|.:.:|...:.||...|:||:|:||.|.|   |..|.::|||.
Zfish   222 PPMSGTTQIIVNVVDVNDNIPVFDKPLYKARIAENSAIGASVITVSAKDAD---EGLNGEVIYSF 283

  Fly   295 EKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTAS------IR 353
            ..:  :.|.....|.|.|.||.| |....||.|......|:|.|.|    ||....:      |.
Zfish   284 INH--DNENSINAFLINPNTGEI-TVKGPLDYEENAAIEIRVQAED----KGQNPRASHCKVLIE 341

  Fly   354 VKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDED--ETNTFQYKVVPNSGFGAD--- 413
            :.||||..|:.:....|.||.|.:.   |.|.:..:||:|.|  :....:.::..::.|..:   
Zfish   342 IIDLNDNTPEISIMSLVNEVKEDSA---PGTMVGLITVKDGDAGKNGVVRLQIRDSAQFRLENTY 403

  Fly   414 --KFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLR 476
              :|::|.||          |||.|   .:|.:...|...|:|.. |..|.      |.:.|.:.
Zfish   404 KNRFSLVVNG----------PLDRE---VASEYNVTISAADEGTP-PLSST------SVIAVHVS 448

  Fly   477 DINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISDRGA 541
            |:|||.|:|....|.|.:.|::::|.:|....|.|.|.|.::::.|.::.|         |..|.
Zfish   449 DVNDNAPRFPEPVINVYVKENSQIGAVLHTVSAVDPDVGDNARITYSLLES---------SKSGP 504

  Fly   542 VSIQRPLDRETQDRHHIQ-------------ILAIDDGSPARTATATLTVIVKDVNDNAPTFAQD 593
            |:....::.:|.|.|.:|             :.|.|.|.|..::..|:.|.|.|.|||:|.....
Zfish   505 VTSMININSDTGDLHSLQSFNYEEIKTFEFKVQATDSGVPPLSSNVTVNVFVLDENDNSPAILAP 569

  Fly   594 YK---PTLPENV-----SGKKILEVAAKDPD-----------DRLRGNGGPFTFRLDPLASDEIK 639
            |.   ....||:     :|..:.::.|.|.|           ...:||.   .||:. .:|.||:
Zfish   570 YSELGSVNTENIPYSAEAGYFVAKIRAVDADSGYNALLSYHISEPKGNN---LFRIG-TSSGEIR 630

  Fly   640 AGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI----GDV 700
            .     ..|..||:                .|::.:.|.:.|||.|:::.|.::...:    |||
Zfish   631 T-----KRRMSDND----------------LKTHPLVILVCDNGEPSLSATVSIDAVVVESGGDV 674

  Fly   701  700
            Zfish   675  674

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 25/100 (25%)
Cadherin_repeat 140..248 CDD:206637 32/116 (28%)
Cadherin_repeat 256..359 CDD:206637 36/108 (33%)
Cadherin_repeat 379..481 CDD:206637 25/108 (23%)
Cadherin_repeat 489..586 CDD:206637 27/109 (25%)
Cadherin_repeat 594..703 CDD:206637 27/130 (21%)
Cadherin_repeat 724..801 CDD:206637
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
pcdh2ab2NP_001009592.2 Cadherin_2 32..112 CDD:311943 21/84 (25%)
Cadherin_repeat 141..240 CDD:206637 33/123 (27%)
Cadherin_repeat 249..348 CDD:206637 37/108 (34%)
Cadherin_repeat 360..453 CDD:206637 28/115 (24%)
Cadherin_repeat 461..562 CDD:206637 27/109 (25%)
Cadherin_repeat 580..663 CDD:206637 22/107 (21%)
Cadherin_C_2 690..762 CDD:318652
Cadherin_tail 799..916 CDD:318236
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
00.000

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