DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and cdh5

DIOPT Version :10

Sequence 1:NP_609855.3 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001003983.1 Gene:cdh5 / 445471 ZFINID:ZDB-GENE-040816-1 Length:767 Species:Danio rerio


Alignment Length:772 Identity:187/772 - (24%)
Similarity:292/772 - (37%) Gaps:183/772 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 YFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFA---QDEGGEGLVGYA 236
            |.|.|.|      |..||.:. ..|||.||..|||:     .|..:.:.|   ....||.:....
Zfish    87 YILKGDG------AKDKFGVT-DNGDIVVLAKLDRE-----TQSVYNLSASLLNIHTGELVDKDE 139

  Fly   237 DIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEE 301
            ...:.:.|||||.|.|... ..|:::|:..||:::|.:.|.|.|| :.:.|.::.:.:       
Zfish   140 SFVIVVLDINDNIPVFDSD-QSGSISESSRAGTTIMKVKATDADD-SSTENGRIDFKL------- 195

  Fly   302 ETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDG----GGLKGTGTASIRVKDLNDMPP 362
            ..|..:|:|:|...|| .....||||:...|.|.|.|.|.    .|...|...:|.:||:||...
Zfish   196 LNGTDLFKIKPNGDLI-ALKSDLDREKQSQYLIAVQAKDMPEHLTGNSATTVVTINIKDINDNIA 259

  Fly   363 QFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGDGTGSL 427
            .|.|:.:...|.|   ...|.:.|..:.|:|:||...........|.|. |.|.:.|..:..|.|
Zfish   260 TFKKERYQFTVKE---DLKPGSEIGLLEVEDKDEIQNKDPTFALQSKFN-DVFDIKRTKEKDGML 320

  Fly   428 KIIQPLDYEDPLQSSGFRFRIQVND----KGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDRE 488
            .:..|||||   :....:|.:.|.:    :..|..|     .:..:.|::.:.|: |..|.|::.
Zfish   321 SLKVPLDYE---KEKTHKFIVIVEEHTVSRTPDNKG-----LLKRTEVIIDVTDV-DEPPIFNQT 376

  Fly   489 HIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISD----------RGAVS 543
            ....|::|......::....|.|.|     ..:|||        ::.|.|          .|.:|
Zfish   377 EYTFSVFEGPFKNPVIGAVSAKDPD-----SASYKI--------RYTIEDANCPVDVDPVNGYLS 428

  Fly   544 IQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVSGKKIL 608
            ::|.||||.:..:..|:.|.:|......::..:::.|.|:|||||.........:.||.....|:
Zfish   429 LKRTLDREQESLYTFQVTAHEDVLNGLKSSTMVSLKVLDINDNAPELTNGSYVYVCENDKPNTII 493

  Fly   609 -EVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKS 672
             .:.|.|.|:    |.|.|.|.|...:|:     |.: ||   :.:|...|:.....|..|..:.
Zfish   494 GTIGASDKDE----NSGRFRFTLARKSSN-----FSL-YD---NQDNTATIVLKQGGFSTENSEE 545

  Fly   673 YAIPIEIKDNGAP---------------------------AMTGTST-------------LTVTI 697
            |.:.|||.|.|.|                           |.||.|.             |.:.|
Zfish   546 YVLEIEIADGGTPEQKSVNLLQIKVCTCQSGRRVEYCMSYARTGMSVSALLAILLCIITILVIVI 610

  Fly   698 GDVNDNKMQPGSKSVLVYNYQGQSQDTPI-------GRVYVNDPDDWDVP-------DKKY---- 744
            ..|...:.|   |.|||....|:..:..:       |.:   |.:.:||.       |..:    
Zfish   611 LIVLRRRYQ---KEVLVTKASGEIHEQLVRYDEEGGGEM---DTNGYDVSILSSACHDSSFRPSV 669

  Fly   745 ----YWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKVYDREH-----GQEDIPANLSVTVRD 800
                |..|::....|.|....|...:....|.|..:   .||..|     |.|.:..:||     
Zfish   670 GPALYAMVKKPPACKGDMAMMIEVKKDEADRDRDGI---PYDTLHIYGYEGTESLAGSLS----- 726

  Fly   801 ITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAELLYTDRDNVD 857
             :.::.....::      |.||:..|.|           |||. ||:|...|..:.|
Zfish   727 -SLDSSSSGSNL------DYDFIHEWGP-----------RFRT-LAQLYGVDGSDSD 764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_609855.3 Cadherin_repeat 41..132 CDD:206637
Cadherin_repeat 140..248 CDD:206637 22/75 (29%)
Cadherin_repeat 256..359 CDD:206637 30/106 (28%)
CA 388..483 CDD:214520 23/98 (23%)
Cadherin_repeat 489..586 CDD:206637 23/106 (22%)
Cadherin_repeat 594..703 CDD:206637 33/149 (22%)
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 1233..1259 CDD:400365
LamG 1265..1426 CDD:238058
EGF_CA 1497..1535 CDD:238011
CADH_Y-type_LIR 1662..1719 CDD:460041
cdh5NP_001003983.1 CA 86..153 CDD:214520 24/77 (31%)
Cadherin_repeat 160..257 CDD:206637 31/105 (30%)
Cadherin_repeat 266..369 CDD:206637 26/115 (23%)
Cadherin_repeat 377..471 CDD:206637 23/106 (22%)
Cadherin_repeat 480..571 CDD:206637 26/103 (25%)
CADH_Y-type_LIR 698..757 CDD:460041 20/85 (24%)
Blue background indicates that the domain is not in the aligned region.

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