DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and cdh23

DIOPT Version :10

Sequence 1:NP_609855.3 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_999974.1 Gene:cdh23 / 407978 ZFINID:ZDB-GENE-040513-7 Length:3366 Species:Danio rerio


Alignment Length:1347 Identity:302/1347 - (22%)
Similarity:460/1347 - (34%) Gaps:524/1347 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LTNSTYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVL-TVNAKDHNESTN--IRYQ 72
            |:.||   |.:||  |.|:||:.|.|....|.||:.|..:....:: ||.|.|.:|..|  |||.
Zfish  1617 LSTST---TVWVR--IIDENDNAPEFPEEEYVTELREGPNTVGAIIATVTAIDPDEGLNGTIRYA 1676

  Fly    73 ITGGNIGNAFAVQNTTGVIYVASPLDYE-TRPRYELRLEATRN------RKNNYTTVVINVRDVN 130
            |:.||:...|.:.:.||.|.|.|.|||| :...|.|.:.||..      |..:.|||::||.|||
Zfish  1677 ISKGNLAQTFQINSVTGQIVVVSALDYEISNGHYVLTVTATDQCPIPLLRLTSSTTVLVNVIDVN 1741

  Fly   131 DNPPVF----------------------------------------------------------- 136
            ||||:|                                                           
Zfish  1742 DNPPIFPRPFEGPFEITEGQPGPRVWTVKATDADSGSNGKVEYSITAGDLKNEFVISSVEGELRV 1806

  Fly   137 ------DRQT---YRTQITEED--------------------DR-----NLPKR----------- 156
                  ||:|   |...||.:|                    |.     |||..           
Zfish  1807 RKDIELDRETIAYYNITITAKDLGTPSLNATVVVGILVLDINDNDPILLNLPANTSVSEGAAVQT 1871

  Fly   157 -ILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRF 220
             |:||.|.|.|..|...:.|.:|....|      ..|.||.|:|.:.|.:||||::.   .::..
Zfish  1872 FIIQVRAQDSDSGRNALLTYSITAGNSD------GAFYINETSGVVQVNRPLDRERV---AEYSL 1927

  Fly   221 TVFAQDEGGEGLVGYAD---IQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSA-VDYDD 281
            |:..:|......:...|   :.|.|.|:|||.|.|.|..|.|.::||...|::|:.::. |..:|
Zfish  1928 TITVKDNPDNPRIARRDSELLTVTLLDVNDNRPIFSQSSYRGEISENSPTGTTVLILNGPVLAED 1992

  Fly   282 PNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKT---AVCCLDRE--RTPDYSIQVVAMDG 341
            .:...||.:.|.:      ..|...||.|:..||::..   ||  ||||  ..|...:.:|::|.
Zfish  1993 KDIGVNAVVSYGL------LGTRVDIFSIDSRTGVVSVRGGAV--LDREAFSVPRVELFLVSVDV 2049

  Fly   342 GGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQYKVVP 406
            |||..:...:|.:.|:||.||.|....:...:.|.:.|.:..|. |:.|..|.......||::  
Zfish  2050 GGLNSSVPLTITILDVNDNPPVFNPSSFTVRLPENSPTGVVVTQ-LSATDADAGSNGWLQYRL-- 2111

  Fly   407 NSGFGADKF--------------------------AMVRNGDGTGSL------------------ 427
            :|| ..|:|                          .::....||.||                  
Zfish  2112 DSG-AQDRFIVDALSGAVLVGNATLDREERSSYRLVVIATDRGTPSLSGTATLTVVLDDVNDSRP 2175

  Fly   428 KIIQP------------------LDYEDP--------------------------LQSSGFRFR- 447
            :.|||                  |..|||                          .||.|..|. 
Zfish  2176 RFIQPVQTISVNESTPPGVVVATLAAEDPDLKPRLEYYIISVEAKDDGNNAVDGLQQSFGIDFHT 2240

  Fly   448 ----------------------------------------------IQVNDKG------------ 454
                                                          :.|||..            
Zfish  2241 GAVFVRNPLNRELVATFEIIVSVHDNASDVIEMSVSVPNAKLTINVLDVNDNAPRFRPFGVANFS 2305

  Fly   455 ---------------------DDGPGGSDKYHV----------------------------AYSW 470
                                 |.||.|...|.:                            ...|
Zfish  2306 ESILEGAVPGTTLLSVTAVDPDKGPNGQIIYQLLNLPRGNYIRLEDPSTGKIVANRTVDFEQVQW 2370

  Fly   471 --------------------VVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQG 515
                                |.:::.|:|||.|.|.:...:.||:||..:|||:...:|||||.|
Zfish  2371 LNFTVRAQDHGSPPRFTELPVYLRIIDVNDNNPVFQQPLYQKSIFEDVALGTIIVSVRATDADSG 2435

  Fly   516 GHSKVAYKIVRSTNRKRQFAIS-DRGAVSIQRPLDRETQDRHHIQILAIDD--GSP--ARTATAT 575
            ..|.:.|.:|   :.:.:|.|: ..|.:.|...|||||:||:.:...|.|:  |||  .|..:..
Zfish  2436 LFSVIEYGLV---DGEGKFGITPTTGDIYILSALDRETKDRYTLTAYARDNPGGSPNNRRENSVQ 2497

  Fly   576 LTVIVKDVNDNAPTFAQD-YKPTLPENVS-GKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEI 638
            :.:.|.||||..|.|::. :..::.||.. |..::.:.|.|.|:   |.....|:.|....:|  
Zfish  2498 VQLTVLDVNDFRPRFSERVFTTSVFENEPVGTSVITMKATDLDE---GENALLTYSLQGPGAD-- 2557

  Fly   639 KAGFKVEYDRRGDNENGVAIISSLR---PFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDV 700
              .|.::.|        ..:|.|||   .|:|     :.:.:...|.|.|.:.||::|.:|:.||
Zfish  2558 --AFSLDPD--------TGLIRSLRLLQSFER-----FNLTVVATDQGRPPLWGTASLQITVIDV 2607

  Fly   701 NDNK---MQPGSKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYY----------WEVQEHQ 752
            |||:   ::|.:.::: :..:.|.....:..|:..|.|:....:.:|.          ||     
Zfish  2608 NDNRPIFVRPANGTIM-HILEEQPPGLVVYEVFATDEDEGVNGEVRYSFLQTGAGNRDWE----- 2666

  Fly   753 RFKLDTDTGILTMRAGTRRGR---YQLRFKVYDREHGQ--------------EDIPAN------- 793
            .|.:|..||::|......|.:   |.|....||.  ||              .||..|       
Zfish  2667 NFHIDAVTGVITTAVKLDREKQALYSLVVVAYDL--GQPVPYETMQPLQVALSDIDDNEPVFLKP 2729

  Fly   794 ---------LSV--------TVRDITAE------------------------AVQQAGSMRLSHI 817
                     |||        .|.::|..                        |:..:|.:|:...
Zfish  2730 PRGSLPYQSLSVPEHSSPGTVVGNVTGAVDADEGSNAIVYYFIAGGDTGGNFALSVSGVLRVKKD 2794

  Fly   818 TDEDFV------------RTWNPVKNQVEPSKLERFRNKLAELLYTDRD----NVDVFSVQLKEG 866
            .|.:.:            |.|.|.|.|         |::.|::|...||    .|.:|...:.:.
Zfish  2795 LDREEIPVYSIIVKASSNRNWTPPKGQ---------RSQRAQVLDPSRDPTLQEVRIFLEDINDQ 2850

  Fly   867 SPYPLTDVHFAARSATQQPYFKAVRLNGVV---QMHREEIEKDVGLN 910
            ||           ..|:..|...|..:..|   .:..:.|:.|:|.|
Zfish  2851 SP-----------RFTKLEYTTGVAADAKVGSDLIRVQAIDNDIGNN 2886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_609855.3 Cadherin_repeat 41..132 CDD:206637 39/100 (39%)
Cadherin_repeat 140..248 CDD:206637 36/150 (24%)
Cadherin_repeat 256..359 CDD:206637 31/108 (29%)
CA 388..483 CDD:214520 37/310 (12%)
Cadherin_repeat 489..586 CDD:206637 37/101 (37%)
Cadherin_repeat 594..703 CDD:206637 28/112 (25%)
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 1233..1259 CDD:400365
LamG 1265..1426 CDD:238058
EGF_CA 1497..1535 CDD:238011
CADH_Y-type_LIR 1662..1719 CDD:460041
cdh23NP_999974.1 Cadherin_repeat 48..134 CDD:206637
Cadherin_repeat 142..237 CDD:206637
Cadherin_repeat 246..350 CDD:206637
Cadherin_repeat 358..460 CDD:206637
Cadherin_repeat 469..561 CDD:206637
Cadherin_repeat 570..671 CDD:206637
Cadherin_repeat 679..778 CDD:206637
Cadherin_repeat 786..890 CDD:206637
Cadherin_repeat 898..994 CDD:206637
Cadherin_repeat 1003..1102 CDD:206637
Cadherin_repeat 1110..1206 CDD:206637
Cadherin_repeat 1221..1311 CDD:206637
Cadherin_repeat 1321..1417 CDD:206637
Cadherin_repeat 1428..1526 CDD:206637
Cadherin_repeat 1536..1633 CDD:206637 9/20 (45%)
Cadherin_repeat 1641..1743 CDD:206637 39/101 (39%)
Cadherin_repeat 1755..1850 CDD:206637 7/94 (7%)
Cadherin_repeat 1858..1958 CDD:206637 28/108 (26%)
Cadherin_repeat 1966..2068 CDD:206637 32/109 (29%)
Cadherin_repeat 2076..2172 CDD:206637 16/99 (16%)
Cadherin_repeat 2181..2292 CDD:206637 10/110 (9%)
Cadherin_repeat 2304..2401 CDD:206637 9/96 (9%)
Cadherin_repeat 2410..2507 CDD:206637 36/99 (36%)
Cadherin_repeat 2516..2610 CDD:206637 28/113 (25%)
Cadherin_repeat 2624..2722 CDD:206637 21/104 (20%)
Cadherin_repeat 2738..2849 CDD:206637 21/119 (18%)
Cadherin_repeat 2858..2959 CDD:206637 7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

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