DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and cdh23

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_999974.1	Gene:	cdh23 / 407978	ZFINID:	ZDB-GENE-040513-7	Length:	3366	Species:	Danio rerio

Alignment Length:	1347	Identity:	302/1347 - (22%)
Similarity:	460/1347 - (34%)	Gaps:	524/1347 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LTNSTYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVL-TVNAKDHNESTN--IRYQ 72
            |:.||   |.:||  |.|:||:.|.|....|.||:.|..:....:: ||.|.|.:|..|  |||.
Zfish  1617 LSTST---TVWVR--IIDENDNAPEFPEEEYVTELREGPNTVGAIIATVTAIDPDEGLNGTIRYA 1676

  Fly    73 ITGGNIGNAFAVQNTTGVIYVASPLDYE-TRPRYELRLEATRN------RKNNYTTVVINVRDVN 130
            |:.||:...|.:.:.||.|.|.|.|||| :...|.|.:.||..      |..:.|||::||.|||
Zfish  1677 ISKGNLAQTFQINSVTGQIVVVSALDYEISNGHYVLTVTATDQCPIPLLRLTSSTTVLVNVIDVN 1741

  Fly   131 DNPPVF----------------------------------------------------------- 136
            ||||:|
Zfish  1742 DNPPIFPRPFEGPFEITEGQPGPRVWTVKATDADSGSNGKVEYSITAGDLKNEFVISSVEGELRV 1806

  Fly   137 ------DRQT---YRTQITEED--------------------DR-----NLPKR----------- 156
                  ||:|   |...||.:|                    |.     |||..
Zfish  1807 RKDIELDRETIAYYNITITAKDLGTPSLNATVVVGILVLDINDNDPILLNLPANTSVSEGAAVQT 1871

  Fly   157 -ILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRF 220
             |:||.|.|.|..|...:.|.:|....|      ..|.||.|:|.:.|.:||||::.   .::..
Zfish  1872 FIIQVRAQDSDSGRNALLTYSITAGNSD------GAFYINETSGVVQVNRPLDRERV---AEYSL 1927

  Fly   221 TVFAQDEGGEGLVGYAD---IQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSA-VDYDD 281
            |:..:|......:...|   :.|.|.|:|||.|.|.|..|.|.::||...|::|:.::. |..:|
Zfish  1928 TITVKDNPDNPRIARRDSELLTVTLLDVNDNRPIFSQSSYRGEISENSPTGTTVLILNGPVLAED 1992

  Fly   282 PNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKT---AVCCLDRE--RTPDYSIQVVAMDG 341
            .:...||.:.|.:      ..|...||.|:..||::..   ||  ||||  ..|...:.:|::|.
Zfish  1993 KDIGVNAVVSYGL------LGTRVDIFSIDSRTGVVSVRGGAV--LDREAFSVPRVELFLVSVDV 2049

  Fly   342 GGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQYKVVP 406
            |||..:...:|.:.|:||.||.|....:...:.|.:.|.:..|. |:.|..|.......||::
Zfish  2050 GGLNSSVPLTITILDVNDNPPVFNPSSFTVRLPENSPTGVVVTQ-LSATDADAGSNGWLQYRL-- 2111

  Fly   407 NSGFGADKF--------------------------AMVRNGDGTGSL------------------ 427
            :|| ..|:|                          .::....||.||
Zfish  2112 DSG-AQDRFIVDALSGAVLVGNATLDREERSSYRLVVIATDRGTPSLSGTATLTVVLDDVNDSRP 2175

  Fly   428 KIIQP------------------LDYEDP--------------------------LQSSGFRFR- 447
            :.|||                  |..|||                          .||.|..|.
Zfish  2176 RFIQPVQTISVNESTPPGVVVATLAAEDPDLKPRLEYYIISVEAKDDGNNAVDGLQQSFGIDFHT 2240

  Fly   448 ----------------------------------------------IQVNDKG------------ 454
                                                          :.|||..
Zfish  2241 GAVFVRNPLNRELVATFEIIVSVHDNASDVIEMSVSVPNAKLTINVLDVNDNAPRFRPFGVANFS 2305

  Fly   455 ---------------------DDGPGGSDKYHV----------------------------AYSW 470
                                 |.||.|...|.:                            ...|
Zfish  2306 ESILEGAVPGTTLLSVTAVDPDKGPNGQIIYQLLNLPRGNYIRLEDPSTGKIVANRTVDFEQVQW 2370

  Fly   471 --------------------VVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQG 515
                                |.:::.|:|||.|.|.:...:.||:||..:|||:...:|||||.|
Zfish  2371 LNFTVRAQDHGSPPRFTELPVYLRIIDVNDNNPVFQQPLYQKSIFEDVALGTIIVSVRATDADSG 2435

  Fly   516 GHSKVAYKIVRSTNRKRQFAIS-DRGAVSIQRPLDRETQDRHHIQILAIDD--GSP--ARTATAT 575
            ..|.:.|.:|   :.:.:|.|: ..|.:.|...|||||:||:.:...|.|:  |||  .|..:..
Zfish  2436 LFSVIEYGLV---DGEGKFGITPTTGDIYILSALDRETKDRYTLTAYARDNPGGSPNNRRENSVQ 2497

  Fly   576 LTVIVKDVNDNAPTFAQD-YKPTLPENVS-GKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEI 638
            :.:.|.||||..|.|::. :..::.||.. |..::.:.|.|.|:   |.....|:.|....:|
Zfish  2498 VQLTVLDVNDFRPRFSERVFTTSVFENEPVGTSVITMKATDLDE---GENALLTYSLQGPGAD-- 2557

  Fly   639 KAGFKVEYDRRGDNENGVAIISSLR---PFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDV 700
              .|.::.|        ..:|.|||   .|:|     :.:.:...|.|.|.:.||::|.:|:.||
Zfish  2558 --AFSLDPD--------TGLIRSLRLLQSFER-----FNLTVVATDQGRPPLWGTASLQITVIDV 2607

  Fly   701 NDNK---MQPGSKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYY----------WEVQEHQ 752
            |||:   ::|.:.::: :..:.|.....:..|:..|.|:....:.:|.          ||
Zfish  2608 NDNRPIFVRPANGTIM-HILEEQPPGLVVYEVFATDEDEGVNGEVRYSFLQTGAGNRDWE----- 2666

  Fly   753 RFKLDTDTGILTMRAGTRRGR---YQLRFKVYDREHGQ--------------EDIPAN------- 793
            .|.:|..||::|......|.:   |.|....||.  ||              .||..|
Zfish  2667 NFHIDAVTGVITTAVKLDREKQALYSLVVVAYDL--GQPVPYETMQPLQVALSDIDDNEPVFLKP 2729

  Fly   794 ---------LSV--------TVRDITAE------------------------AVQQAGSMRLSHI 817
                     |||        .|.::|..                        |:..:|.:|:...
Zfish  2730 PRGSLPYQSLSVPEHSSPGTVVGNVTGAVDADEGSNAIVYYFIAGGDTGGNFALSVSGVLRVKKD 2794

  Fly   818 TDEDFV------------RTWNPVKNQVEPSKLERFRNKLAELLYTDRD----NVDVFSVQLKEG 866
            .|.:.:            |.|.|.|.|         |::.|::|...||    .|.:|...:.:.
Zfish  2795 LDREEIPVYSIIVKASSNRNWTPPKGQ---------RSQRAQVLDPSRDPTLQEVRIFLEDINDQ 2850

  Fly   867 SPYPLTDVHFAARSATQQPYFKAVRLNGVV---QMHREEIEKDVGLN 910
            ||           ..|:..|...|..:..|   .:..:.|:.|:|.|
Zfish  2851 SP-----------RFTKLEYTTGVAADAKVGSDLIRVQAIDNDIGNN 2886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	39/100 (39%)
		Cadherin_repeat	140..248	CDD:206637	36/150 (24%)
		Cadherin_repeat	256..359	CDD:206637	31/108 (29%)
		Cadherin_repeat	379..481	CDD:206637	38/317 (12%)
		Cadherin_repeat	489..586	CDD:206637	37/101 (37%)
		Cadherin_repeat	594..703	CDD:206637	28/112 (25%)
		Cadherin_repeat	724..801	CDD:206637	25/127 (20%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
cdh23	NP_999974.1	Cadherin_repeat	48..134	CDD:206637
		Cadherin_repeat	142..237	CDD:206637
		Cadherin_repeat	246..350	CDD:206637
		Cadherin_repeat	358..460	CDD:206637
		Cadherin_repeat	469..561	CDD:206637
		Cadherin_repeat	570..671	CDD:206637
		Cadherin_repeat	679..778	CDD:206637
		Cadherin_repeat	786..890	CDD:206637
		Cadherin_repeat	898..994	CDD:206637
		Cadherin_repeat	1003..1102	CDD:206637
		Cadherin_repeat	1110..1206	CDD:206637
		Cadherin_repeat	1221..1311	CDD:206637
		Cadherin_repeat	1321..1417	CDD:206637
		Cadherin_repeat	1428..1526	CDD:206637
		Cadherin_repeat	1536..1633	CDD:206637	9/20 (45%)
		Cadherin_repeat	1641..1743	CDD:206637	39/101 (39%)
		Cadherin_repeat	1755..1850	CDD:206637	7/94 (7%)
		Cadherin_repeat	1858..1958	CDD:206637	28/108 (26%)
		Cadherin_repeat	1966..2068	CDD:206637	32/109 (29%)
		Cadherin_repeat	2076..2172	CDD:206637	16/99 (16%)
		Cadherin_repeat	2181..2292	CDD:206637	10/110 (9%)
		Cadherin_repeat	2304..2401	CDD:206637	9/96 (9%)
		Cadherin_repeat	2410..2507	CDD:206637	36/99 (36%)
		Cadherin_repeat	2516..2610	CDD:206637	28/113 (25%)
		Cadherin_repeat	2624..2722	CDD:206637	21/104 (20%)
		Cadherin_repeat	2738..2849	CDD:206637	21/119 (18%)
		Cadherin_repeat	2858..2959	CDD:206637	7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9B2
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100175
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.800