DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and Pcdha2

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_955798.1	Gene:	Pcdha2 / 393086	RGDID:	735182	Length:	948	Species:	Rattus norvegicus

Alignment Length:	732	Identity:	186/732 - (25%)
Similarity:	300/732 - (40%)	Gaps:	134/732 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ENADLQSTVLTVNAKDHNESTNIRYQITGGNIGNAFAVQNTTGVIYVASPLDYE----TRPRYEL 107
            |.|:|...:..|.:||..:...:..|               .|:::|.|.:|.|    ......:
  Rat    55 ELAELVPRLFRVASKDRGDLLEVNLQ---------------NGILFVNSRIDREELCGQSAECSI 104

  Fly   108 RLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEE-----DDRNLPKRILQVTATDGDV 167
            .||...:|......|.:.|||:|||||:|       .:||:     :.|.|..|.....|:|.|:
  Rat   105 HLEVIVDRPLQVFHVEVEVRDINDNPPLF-------PMTEKIIQFFESRVLHSRFPLEGASDADI 162

  Fly   168 DRPINIVYFLTGQGIDPDNPANSKFDINRTTGD-----IFVL--KPLDRDQPNGRPQWRFTVFAQ 225
            .....:.|.|:         .:..|.::..|.|     :|::  |.|||::   ..:.:..:.|.
  Rat   163 GANALLSYKLS---------PSEFFFLDVQTSDELSQSLFLVLGKSLDREE---NAEVKLLLVAT 215

  Fly   226 DEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKL 290
            |.|...|.|...|.:.:.|:|||.|.|||.:|...:.||...|:.|:.::|.|.|   |..|:::
  Rat   216 DGGKPELTGTVQILIKVLDVNDNEPTFPQSVYKVPLLENTANGTLVIKLNASDAD---EGANSEI 277

  Fly   291 IYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGG--GLKGTGTASIR 353
            :||:..:|  ..|....|:|:..:|.|:| ...||.|....|.||::|.|.|  .:.|....|::
  Rat   278 VYSLSSDV--SSTTRTKFQIDANSGEIRT-TGELDYEEKTSYEIQIIASDKGTPSMSGHCKISVK 339

  Fly   354 VKDLNDMPPQFTKDEWVTEVDETNGTYIPETP----ILTVTVQDEDETNTFQYKVVPNSGFGAD- 413
            :.|:||..|:.:.......|.|       ..|    |..::|.|.|            ||....
  Rat   340 LMDINDNTPEVSITSLSLPVQE-------NAPLGAVIALISVSDRD------------SGINGQV 385

  Fly   414 --------KFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSW 470
                    .|.:|.......||.:...||.|...:     :::.|..:    .|||.... |.:.
  Rat   386 TCSLSPHLPFKLVSTFKNYYSLVLDSALDRETTAE-----YKVMVTAR----DGGSPSLQ-ATAT 440

  Fly   471 VVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFA 535
            :.|::.|:|||.|.|.:....|.:.|:...|..:....|.|||...::.|.|.:|.....:|..:
  Rat   441 ISVEVADVNDNAPLFAQPEYTVFVKENNPPGAHIFTVSAVDADAQENALVFYSLVERRMGERLLS 505

  Fly   536 I-----SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTF----- 590
            .     ::.|.|...:|||.|..:....|:.|.|.|.||..:..||.|.|.|.|||||..
  Rat   506 SYVSVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVLDENDNAPMLLPHGA 570

  Fly   591 ---AQDYKPTLPENV-SGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGD 651
               .......:|.:| ||..:.:|.|.|.|.   |.....::.|.|.....|.  |:|
  Rat   571 VGVGGSVSELVPRSVGSGHVVTKVHAVDADS---GYNAWLSYELQPTVGTRIP--FRV------- 623

  Fly   652 NENGV--AIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLV 714
               |:  ..||:.|..|......:.:.:.:||:|.||:|.|:|:.:::   .:|...|.:.|..:
  Rat   624 ---GLYTGEISTTRALDEVDALRHRLLVLVKDHGEPALTATATVLLSL---VENGQAPKTSSRAL 682

  Fly   715 YNYQGQSQDTPIGRVYV 731
            .:..||........||:
  Rat   683 VDAAGQETSLVTVNVYL 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	20/88 (23%)
		Cadherin_repeat	140..248	CDD:206637	26/119 (22%)
		Cadherin_repeat	256..359	CDD:206637	31/104 (30%)
		Cadherin_repeat	379..481	CDD:206637	22/114 (19%)
		Cadherin_repeat	489..586	CDD:206637	29/101 (29%)
		Cadherin_repeat	594..703	CDD:206637	27/111 (24%)
		Cadherin_repeat	724..801	CDD:206637	2/8 (25%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Pcdha2	NP_955798.1	Cadherin_2	30..111	CDD:285466	14/70 (20%)
		Cadherin_repeat	<157..238	CDD:206637	21/92 (23%)
		Cadherin_repeat	246..346	CDD:206637	32/105 (30%)
		Cadherin_repeat	354..451	CDD:206637	24/125 (19%)
		Cadherin_repeat	459..561	CDD:206637	29/101 (29%)
		Cadherin_repeat	581..669	CDD:206637	27/105 (26%)
		Cadherin_tail	797..940	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000