DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and shg

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster


Alignment Length:1789 Identity:476/1789 - (26%)
Similarity:719/1789 - (40%) Gaps:532/1789 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 TYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTN--IRYQITGGN 77
            |:.||      |.|.||:.|.|::..|:..:.|||...:.|:|::|.|.::..|  :.|:|....
  Fly   180 TFNVT------IEDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDDGNNSLVEYEILRER 238

  Fly    78 IGNAFAVQNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTV---------VINVRDVNDN- 132
            ....|.:...:|:||:..|:|......|.:.:.|       |..|         .:.:|.|..: 
  Fly   239 DFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRA-------YNVVPDPPQDAQIEVRIRVVESSI 296

  Fly   133 -PPVF----DRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSK- 191
             ||.|    |...|    .:|:.:|....|..:.|.....|:|..|....||:    ....||| 
  Fly   297 KPPSFVNPIDTPIY----LKENLKNFTHPIATLRAVSNMPDKPEVIFELNTGR----TEQTNSKN 353

  Fly   192 -FDINRTTGDIFVL--KPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFP 253
             |..|:...::.:.  |.||.:   ....:..|:..::....|......|||  :|:|||.|.:.
  Fly   354 TFVFNQIGNEVTISLGKTLDYE---AITDYTLTMIVRNTHELGTEHQIKIQV--EDVNDNIPYYT 413

  Fly   254 QGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIK 318
            : :..|.:.||...|:.||.:.|.|.|    .|:|..|.|.|.....|     .|.|:|.||.| 
  Fly   414 E-VKSGTILENEPPGTPVMQVRAFDMD----GTSANNIVSFELADNRE-----YFTIDPNTGNI- 467

  Fly   319 TAVCCLDRERTPDYSIQVVAMD---------GGGLKGTGTASIRVKDLNDMPPQFTKDEWVTE-- 372
            ||:...|||....|:::|:|.|         |...:|.....|.:.|.||..|.|.:|:::.|  
  Fly   468 TALTTFDREERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERL 532

  Fly   373 VDETNGTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYED 437
            :::.|    ..|.::.|..:|||..:...|.:  .||...|.|.:   |..||.:.:.|.||||.
  Fly   533 LEDAN----TNTEVIEVKAEDEDNASQILYSI--ESGNVGDAFKI---GLKTGKITVNQKLDYET 588

  Fly   438 PLQSSGFRFRIQVNDKG--DDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKV 500
            ..:   :..:::..| |  ||           |:.||:|:.|:|||.|.|.::: .|:|.|:|..
  Fly   589 ITE---YELKVRAFD-GIYDD-----------YTTVVIKIEDVNDNPPVFKQDY-SVTILEETTY 637

  Fly   501 GTILEQFKATD---ADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRH---HIQ 559
            ...:...:|.|   .|:.....:.|.|  ..|...::.|.:.|.:.:.:.|||:..:.|   .:.
  Fly   638 DDCILTVEAYDPDIKDRNADQHIVYSI--HQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVL 700

  Fly   560 ILAIDDGSPARTATAT--LTVIVKDVNDNAPTFAQDYKPTLPENVSGKKILEVAAKDPDDRLRGN 622
            |.|.|:.....|.:..  :||.:||:|||||....:......||.:...::::.|.|.||  ...
  Fly   701 IKANDEDGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDD--TPG 763

  Fly   623 GGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAM 687
            .|.|||.:|..|:.:||..|.::.|....|..          |||||||.|.|||.|.|:|.|..
  Fly   764 AGNFTFGIDSEATPDIKTKFSMDGDYLHANVQ----------FDREAQKEYFIPIRISDSGVPRQ 818

  Fly   688 TGTSTLTVTIGDVNDNKMQPGSKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQ 752
            :..|.|.:.|||||||.|..||..:.:|||:|::.:|.||||:|:|.||||:.||.:.|:...|.
  Fly   819 SAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHD 883

  Fly   753 RFKLDTDTGILTMRAGTRRGRYQLRFKVYDREH--GQEDIPANLSVTVRDITAEAVQQAGSMRLS 815
            :|:|:..||::||...|..|.|.|.|.|.:...  .:..:.|.::|.||::..|||.::||:|..
  Fly   884 QFRLNPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFI 948

  Fly   816 HITDEDFVRTWNPVKNQVEPSKLERFRNKLAELLYTDRDNVDVFSVQLKEGSPYPLTDVHFAARS 880
            ::|.|:|:......::....|..:|.:..||:|..|...|||||:|...|..   ..||.|:|..
  Fly   949 NVTKEEFISVPRDFQSPDALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENH---TLDVRFSAHG 1010

  Fly   881 ATQQPYFKAVRLNGVVQMHREEIEKDVGLNITMVNINECLHEGKGKCGSNSCTSKVELGKKPYTV 945
            :   ||:...:|||:|..:::.:|.::.|.:.||||:|||.| |.|| ..|||:::.....||.:
  Fly  1011 S---PYYAPEKLNGIVAQNQQRLENELDLQMLMVNIDECLIE-KFKC-EESCTNELHKSSVPYMI 1070

  Fly   946 SVNRTALVGVRLDISAQCVCRARNFTHQDHNCRTHLCYNGGRCVETRNGPKCVA-CPVGYNGPRC 1009
            ..|.|:.|||...:.|||||.|.....         |.|||   ..|.|...|. |..|:.||.|
  Fly  1071 YSNTTSFVGVNAFVQAQCVCEAPLMRR---------CLNGG---SPRYGENDVCDCIDGFTGPHC 1123

  Fly  1010 QQSTRSFRGNGWAWYPPLQLCQESHLSLEFITRVADGLILYNGPI-VPPKPEETVISDFIALELE 1073
            :..:.:|.|:|:|:|.|:..|..:.:|||...::..|||:|.||: ..|.   ..||||:||||:
  Fly  1124 ELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPL---LAISDFLALELD 1185

  Fly  1074 QGYPRLLIDFGSGTLELRVKTKKTLDDGVWHRLDIFWDTENVRMVVDFCRTALVSEMEDGTPPEF 1138
            .|||.|.:|:|||.:.:|.:..|.:.|.. ::|||.....::.|.||.||.              
  Fly  1186 NGYPVLTVDYGSGAIRIRHQHIKMVADRT-YQLDIILQRTSIEMTVDNCRL-------------- 1235

  Fly  1139 DDNACQARG-QIPPFAESLNLNQPLQLGG-------LYRQHFDQTLYNWQYAFSSKGFDGCIRNV 1195
              :.||..| .|.| .|.||:|.||||||       |.||      .||.:..:.|||.|||||:
  Fly  1236 --STCQTLGAPIGP-NEFLNVNAPLQLGGTPVDLEQLGRQ------LNWTHVPNQKGFFGCIRNL 1291

  Fly  1196 IHNSEHYDLAFPALARNSFPACPQTDEVCLKTEHTARCWEHGNCVASLVQAKCHCQPGWMGPGCN 1260
            ..|.:.|:|..|::.||....|.|:                                        
  Fly  1292 TINEQTYNLGMPSVFRNIDSGCQQS---------------------------------------- 1316

  Fly  1261 VPTIPTTFKAQSYVKFALSFEPDRFSTQLQLRFRTREQGGELFRVSDQHHREYAILELRRGHLQF 1325
                                                                             
  Fly  1317 ----------------------------------------------------------------- 1316

  Fly  1326 RYNLNSMRNEEQLLTLTAIAVNDGQWHVIRISRYGSAALMELDGGESRRYNESFHFTGHQWLTID 1390
                            .|:|.:.|                                         
  Fly  1317 ----------------VAVAFSFG----------------------------------------- 1324

  Fly  1391 KQEGVYAGGKAEYTGIKTFEVQSDFQRSCLDDIRLDGKHLPLPPAMNGTQWGQATMARNLERNCP 1455
                                                                             
  Fly  1325 ----------------------------------------------------------------- 1324

  Fly  1456 SNRPCSNVICPDPFDCVDLWNEYECTCSEGRIMSSDTKGCVDRNECLDLPCLNGATCINLEPRLR 1520
                                                    :|||..:                  
  Fly  1325 ----------------------------------------IDRNFII------------------ 1331

  Fly  1521 YRCICPEGYWGENCELVQEGQRLKLSMGALGAIFVCLIIILILALIFVLYSRKRKTTKKKKRSGP 1585
                                           ||.|||.::||:.|..|:       .||:|....
  Fly  1332 -------------------------------AIIVCLALLLIILLAVVV-------QKKQKNGWH 1358

  Fly  1586 EK---DVRETVISYEDEGGGEDDMTAFDITPLQI-----------PISAQGGPPDIAACKMPIIY 1636
            ||   |:|||:|:||||||||.| |.:|:..|:.           |.:.||...|          
  Fly  1359 EKDIDDIRETIINYEDEGGGERD-TDYDLNVLRTQPFYEEKLYKDPHALQGNMRD---------- 1412

  Fly  1637 PVMTLLPPGQELNVAYLMEERKQRIDKDNNAPPFDDLRNFTFEGSGSIAESLSSLASGTDDENQD 1701
                   |....::|..:.::|:..|:|..|...||:|::.:||.|:...|||||||.|||.:.:
  Fly  1413 -------PNDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLN 1470

  Fly  1702 FNYLQNWGPRFNALAAMYVHDKAKASSQLPSDGG 1735
            |:||.|:||||..||.||..:.:...|.:..|.|
  Fly  1471 FDYLSNFGPRFRKLADMYGEEPSDTDSNVDDDQG 1504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 23/101 (23%)
Cadherin_repeat 140..248 CDD:206637 25/111 (23%)
Cadherin_repeat 256..359 CDD:206637 34/111 (31%)
Cadherin_repeat 379..481 CDD:206637 28/103 (27%)
Cadherin_repeat 489..586 CDD:206637 25/104 (24%)
Cadherin_repeat 594..703 CDD:206637 39/108 (36%)
Cadherin_repeat 724..801 CDD:206637 31/78 (40%)
EGF_CA 977..1010 CDD:238011 11/33 (33%)
LamG 1013..1198 CDD:238058 72/193 (37%)
EGF_2 <1233..1259 CDD:285248 0/25 (0%)
Laminin_G_2 1293..1428 CDD:280389 3/134 (2%)
EGF_CA 1497..1535 CDD:238011 3/37 (8%)
Cadherin_C 1583..1719 CDD:279398 55/149 (37%)
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637 6/16 (38%)
Cadherin_repeat 200..292 CDD:206637 22/98 (22%)
CA 332..410 CDD:214520 22/86 (26%)
Cadherin_repeat 417..518 CDD:206637 35/110 (32%)
Cadherin_repeat 531..619 CDD:206637 29/111 (26%)
Cadherin_repeat 627..729 CDD:206637 25/104 (24%)
Cadherin_repeat 736..834 CDD:206637 39/109 (36%)
LamG 1127..1294 CDD:238058 72/193 (37%)
Cadherin_C 1358..1489 CDD:279398 56/148 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45464700
Domainoid 1 1.000 70 1.000 Domainoid score I6225
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D3586at50557
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.850

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