Protein Alignment CadN2 and JAG2

DIOPT Version :10

• Sequence 1: NP_609855.3
• Gene: CadN2 / 35071
• FlyBaseID: FBgn0262018
• Length: 1799
• Species: Drosophila melanogaster
• Sequence 2: NP_002217.3
• Gene: JAG2 / 3714
• HGNCID: 6189
• Length: 1238
• Species: Homo sapiens
• Alignment Length: 653
• Identity: 123/653 - (18%)
• Similarity: 179/653 - (27%)
• Gaps: 265/653 - (40%)

  Fly   908 GLNITMVNINECLHEGKGKC-GSNSCTSKVELGKKPYTVSVNRTALVGVRLDISAQCVC----RA 967
            |:| ..:|:|:|    :|:| ...:|...|.                      ..||||    ..
Human   455 GIN-CHINVNDC----RGQCQHGGTCKDLVN----------------------GYQCVCPRGFGG 492

  Fly   968 RNFTHQDHNCRTHLCYNGGRCVETRNGPKCVACPVGYNGPRCQQSTRSFRGNGWAWYPPLQLCQE 1032
            |:...:...|.:..|::||.|.:..:|..| .||.|::||.|:..              :.||:.
Human   493 RHCELERDECASSPCHSGGLCEDLADGFHC-HCPQGFSGPLCEVD--------------VDLCEP 542

  Fly  1033 SHLSLEFITRVADGLILYNGPIVPPKPEETVISDFIALELEQGY----PRLLIDFGSGTLELRVK 1093
            |        ...:|...||                    ||..|    |.   |||.....:
Human   543 S--------PCRNGARCYN--------------------LEGDYYCACPD---DFGGKNCSV--- 573

  Fly  1094 TKKTLDDGVWHRLDIFWDTENVRMVVDFCRTALVSEMEDGTPPEFDDNACQARGQIPPFAESLNL 1158
            .::....|...             |:|.|.    |:...|.|.......|...|:.        :
Human   574 PREPCPGGACR-------------VIDGCG----SDAGPGMPGTAASGVCGPHGRC--------V 613

  Fly  1159 NQPLQLGGLYRQHFDQTLYNWQYAFSSKGFDGCIRNVIHNSEHYDLAFPALARNSFPACPQTDEV 1223
            :||   ||.:.            .....||.|..                        |.:..:.
Human   614 SQP---GGNFS------------CICDSGFTGTY------------------------CHENIDD 639

  Fly  1224 CLKTEHTARCWEHGNCVASLVQAKCHCQPGWMGPGCNVPTIPTTFKAQSYVKFALSFEPDRFSTQ 1288
            ||...    |...|.|:..:...:|.|..||.|..|:  |.|.                |.....
Human   640 CLGQP----CRNGGTCIDEVDAFRCFCPSGWEGELCD--TNPN----------------DCLPDP 682

  Fly  1289 LQLRFRTREQGGELFRVSDQ-------HHREYAILELRRGHLQFRYNLNSMRNEEQLLTLTAIAV 1346
            ...|.|..:...:.:...|.       |.||:
Human   683 CHSRGRCYDLVNDFYCACDDGWKGKTCHSREF--------------------------------- 714

  Fly  1347 NDGQWHVIRISRYGSAALMELDGGESRRYNESFHFTGHQWLTIDKQEGVYAGGKAEYTGIKTFEV 1411
               |......|..|:.    .|.|::.|.                  ....|.|.....:..
Human   715 ---QCDAYTCSNGGTC----YDSGDTFRC------------------ACPPGWKGSTCAVAK--- 751

  Fly  1412 QSDFQRSCLDDIRLDGKHLPLPPAMNGTQWGQATMARNL------ERNCPSN-RPCSNVICPDPF 1469
                ..||          ||.|....||..|.......:      .|.|..| ..|:.:.|.:..
Human   752 ----NSSC----------LPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGG 802

  Fly  1470 DCVDLWNEYECTCSEGRIMSSDTKGCVDRNECLDLPCLNGATCINLEPRLRYRCICPEGYWGENC 1534
            .|||..|.:.|.|:.| ....|.:  ::.:||...||..||||:  :....|||.||.|..|..|
Human   803 ICVDGVNWFRCECAPG-FAGPDCR--INIDECQSSPCAYGATCV--DEINGYRCSCPPGRAGPRC 862

  Fly  1535 ELV 1537
            :.|
Human   863 QEV 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_609855.3	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637
		Cadherin_repeat	256..359	CDD:206637
		CA	388..483	CDD:214520
		Cadherin_repeat	489..586	CDD:206637
		Cadherin_repeat	594..703	CDD:206637
		EGF_CA	977..1010	CDD:238011	12/32 (38%)
		LamG	1013..1198	CDD:238058	29/188 (15%)
		EGF_2	1233..1259	CDD:400365	8/25 (32%)
		LamG	1265..1426	CDD:238058	18/167 (11%)
		EGF_CA	1497..1535	CDD:238011	15/37 (41%)
		CADH_Y-type_LIR	1662..1719	CDD:460041
JAG2	NP_002217.3	MNNL	28..196	CDD:462222
		DSL	178..240	CDD:128366
		EGF_CA	307..345	CDD:238011
		EGF	351..381	CDD:394967
		EGF_CA	385..421	CDD:238011
		EGF_CA	423..458	CDD:238011	2/3 (67%)
		EGF_CA	461..496	CDD:238011	12/60 (20%)
		EGF_CA	500..534	CDD:238011	12/34 (35%)
		EGF_CA	536..571	CDD:238011	13/79 (16%)
		EGF_CA	636..671	CDD:238011	10/38 (26%)
		EGF_CA	676..709	CDD:238011	4/48 (8%)
		EGF	716..746	CDD:394967	7/51 (14%)
		EGF_CA	757..787	CDD:238011	6/29 (21%)
		EGF_CA	789..824	CDD:238011	10/35 (29%)
		EGF_CA	827..863	CDD:238011	15/37 (41%)
		VWC_out	872..943	CDD:214565
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1114..1139
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1156..1238