DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and Pcdhgb7

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001012215.1	Gene:	Pcdhgb7 / 364844	RGDID:	1588516	Length:	931	Species:	Rattus norvegicus

Alignment Length:	719	Identity:	190/719 - (26%)
Similarity:	317/719 - (44%)	Gaps:	126/719 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 QTYRTQITEEDDR-----NLPK----RILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDI 194
            |..|..|.||.||     ||.|    .:|:|:|      |.:.:            :.....|.:
  Rat    31 QPVRYSIPEELDRGSVVGNLAKDLGLSVLEVSA------RKLRV------------SAEKMHFSV 77

  Fly   195 NRTTGDIFVLKPLDRDQ-PNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYF 258
            :..:||:.|...:||:| ..||.:....:.|..|..   :....:.|.::|:||:|||||:....
  Rat    78 DSESGDLLVKDRIDREQICKGRRRCELQLEAVLENP---LNIFHVVVEIEDVNDHAPQFPKDEIN 139

  Fly   259 GNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKN------VIEEETGAPIFEIEPETGLI 317
            ..::|:.:.|...:..||   .||:...|:...|.:..|      |.:...|....|:|.:.
  Rat   140 LEISESVSPGVRTILESA---KDPDIGMNSLSKYQLSPNDYFLLLVKDNPDGTKYPELELQK--- 198

  Fly   318 KTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTAS--IRVKDLNDMPPQFTKDEWVTEVDETNGTY 380
                 .||||....:::.:.|:|||....:|||.  |||.|.||.||.|:::.:...|.|   ..
  Rat   199 -----MLDRETESTHNLVLTAVDGGDPPRSGTAQLRIRVMDANDNPPVFSQEVYRVRVRE---DL 255

  Fly   381 IPETPILTVTVQDEDE----TNTFQYKVVPNSG---FGADKFAMVRNGDGTGSLKIIQPLDYEDP 438
            .|.|.:|.:...|:||    ..|:.:..|.|..   |..|..        ||.:..:|.||:|:.
  Rat   256 PPGTTVLRLRATDQDEGINAEFTYSFLGVANKAQHEFSLDPV--------TGDIITLQSLDFEEV 312

  Fly   439 LQSSGFRFRIQVNDKGDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTI 503
            .|   :...::..|:|...         :...|::::.|.|||.|:.....:...|.||:..||:
  Rat   313 EQ---YTIDVEAKDRGSLS---------SQCKVIIEVLDENDNRPEIIITSLSDQILEDSPSGTV 365

  Fly   504 LEQFKATDADQGGHSKVA--------YKIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQI 560
            :..||..|.|.|.:::|.        :||..|:|...:. ::|    ||   ||||....:::.|
  Rat   366 VALFKVRDRDSGENAEVTCSLSGNNPFKIHSSSNNYYKL-VTD----SI---LDREQTPGYNVTI 422

  Fly   561 LAIDDGSPARTATATLTVIVKDVNDNAPTFAQD-YKPTLPE-NVSGKKILEVAAKDPDDRLRGNG 623
            .|.|.|.|..:::.|:|:.|.|||||||.|.|. |...:|| |..|..|.:|.|.|||   .|:.
  Rat   423 TATDRGKPPLSSSTTITLNVADVNDNAPVFQQQAYLINVPENNQPGTSITQVRAWDPD---VGSN 484

  Fly   624 GPFTFRLDPLASD---EIKAGF-KVEYDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGA 684
            |..::.:  :|||   ::.:.| .|..|.        .::.:.|.||.|..:|:.:.::.:|.|:
  Rat   485 GLVSYSI--IASDLEPKVLSSFVSVNQDS--------GVVFAQRAFDHEQLRSFQLTLQARDQGS 539

  Fly   685 PAMTGTSTLTVTIGDVNDN-------KMQPGSKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDK 742
            ||::...::.|.:||.|||       .::|...::.....:.......:.:|...|.|.......
  Rat   540 PALSANVSMRVLVGDRNDNAPRVLYPALEPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWL 604

  Fly   743 KYY-WEVQEHQRFKLDTDTG-ILTMRAGTRRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEA 805
            .|: .:..:...|.|...|| :.|.||...:...:.|..|..|:.||.  |.:.:.|:..:.|:.
  Rat   605 SYHVLQASDPGLFSLGLRTGEVRTARALGDKDAARQRLLVAVRDGGQP--PLSATATLLLVFADT 667

  Fly   806 VQQA 809
            :|:|
  Rat   668 LQEA 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	27/117 (23%)
		Cadherin_repeat	256..359	CDD:206637	28/110 (25%)
		Cadherin_repeat	379..481	CDD:206637	23/108 (21%)
		Cadherin_repeat	489..586	CDD:206637	33/104 (32%)
		Cadherin_repeat	594..703	CDD:206637	32/113 (28%)
		Cadherin_repeat	724..801	CDD:206637	18/78 (23%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Pcdhgb7	NP_001012215.1	Cadherin_2	32..112	CDD:285466	23/97 (24%)
		Cadherin_repeat	137..238	CDD:206637	29/111 (26%)
		Cadherin_repeat	246..343	CDD:206637	25/119 (21%)
		Cadherin_repeat	355..448	CDD:206637	33/100 (33%)
		Cadherin_repeat	457..558	CDD:206637	32/113 (28%)
		Cadherin_repeat	578..662	CDD:206637	18/85 (21%)
		Cadherin_C_2	687..768	CDD:293101
		Cadherin_tail	808..>904	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000