DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and Cdh15

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_997496.1	Gene:	Cdh15 / 361432	RGDID:	1303000	Length:	784	Species:	Rattus norvegicus

Alignment Length:	748	Identity:	197/748 - (26%)
Similarity:	315/748 - (42%)	Gaps:	154/748 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PPVFDRQTYRTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRT 197
            ||:         ...|:.:.||..::|:.:   |..:..:::|.:.|.|:| :.|.| .|.|::.
  Rat    49 PPI---------SVSENHKRLPYPLVQIKS---DKQQLGSVIYSIQGPGVD-EEPRN-VFSIDKF 99

  Fly   198 TGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVT 262
            ||.:::...|||::.:   ::|...||.|.||..|....|:::.:.|.|||.|.|.|.::.|.:.
  Rat   100 TGRVYLNATLDREKTD---RFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPVFLQDVFRGRIL 161

  Fly   263 ENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAP-IFEIEPETGLIKTAVCCLDR 326
            |....|:.|....|.|.||| |:.||.|.:||      .|.|:| :|.|:..||.|:|....|||
  Rat   162 EGAIPGTFVTRAEATDADDP-ETDNAALRFSI------LEQGSPELFSIDEHTGEIRTVQVGLDR 219

  Fly   327 ERTPDY--SIQVVAMDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTV 389
            |....|  ::||..|.|.||..|.:|.|.|.|:||..|:|||||:..|..|.    :....:..:
  Rat   220 EVVAVYNLTLQVADMSGDGLTATASAIISVDDVNDNAPEFTKDEFFMEAAEA----VSGVDVGRL 280

  Fly   390 TVQDEDETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKI-------------IQPLDYEDPLQS 441
            .|:|:|         :|.|.....:|.:: .||..|..||             ::|||||...|
  Rat   281 EVEDKD---------LPGSPNWVARFTIL-EGDPDGQFKIYTDPKTNEGVLSVVKPLDYESREQ- 334

  Fly   442 SGFRFRIQVNDK------GDDGPGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKV 500
              :..|:.|.::      ......|..:..|   ||    :|.|: .|.|....:..||.|....
  Rat   335 --YELRVSVQNEAPLQTAAPRAQRGQTRVSV---WV----QDTNE-APVFPENPLRTSIAEGAPP 389

  Fly   501 GTILEQFKATDADQGGHSKVAY----------KIVRSTNRKRQFAISDRGAVSIQRPLDRETQDR 555
            ||.:..|.|.|.|.....:::|          ::.|:|.|     |..:..:|...|..::  ..
  Rat   390 GTSVATFSARDPDTEQLQRISYSKDYDPEDWLQVDRATGR-----IQTQRVLSPASPFLKD--GW 447

  Fly   556 HHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTL---PENVSGKKILEVAAKDPDD 617
            :...|||:|:..|..|||.||::.:.:|||:||..|.....:|   |:...|   |.:.|.|.|
  Rat   448 YRAIILALDNAMPPSTATGTLSIEILEVNDHAPALAPPLSGSLCSEPDQGPG---LLLGATDED- 508

  Fly   618 RLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISS---LRPFDREAQKSYAIPIEI 679
             |..:|.||.|:|:|...|            .|.|.:...|..|   ||...:.::..:.:.:.:
  Rat   509 -LPPHGAPFHFQLNPRVPD------------LGRNWSLSQINVSHARLRLRHQVSEGLHRLSLLL 560

  Fly   680 KDNGAPAMTGTSTLTVTIGDVN-DNKMQPGSKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKK 743
            :|:|.|......||.||:.... |....||:.::     ||......:|.:.:
  Rat   561 QDSGEPPQQREQTLNVTVCRCGLDGTCLPGAAAL-----QGGGVGVGLGALVI------------ 608

  Fly   744 YYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKVYDREHG-QEDIPANLSVTVRDITAEAVQ 807
                      ....|...::.:.....|.|::.:.:.....|| |||:        ||......:
  Rat   609 ----------VLASTVVLLVLILLAALRTRFRGQSRSKSLLHGLQEDL--------RDNILNYDE 655

  Fly   808 QAGSMRLSHITDEDFVRTWNPVKNQVEPSKLER 840
            |.|...     |:| ....|.:::.|||....|
  Rat   656 QGGGEE-----DQD-AYDINQLRHPVEPKATSR 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	28/107 (26%)
		Cadherin_repeat	256..359	CDD:206637	40/105 (38%)
		Cadherin_repeat	379..481	CDD:206637	25/120 (21%)
		Cadherin_repeat	489..586	CDD:206637	28/106 (26%)
		Cadherin_repeat	594..703	CDD:206637	28/115 (24%)
		Cadherin_repeat	724..801	CDD:206637	10/77 (13%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Cdh15	NP_997496.1	Cadherin_repeat	51..147	CDD:206637	28/112 (25%)
		Cadherin_repeat	155..255	CDD:206637	41/106 (39%)
		Cadherin	270..366	CDD:278457	24/119 (20%)
		Cadherin_repeat	378..478	CDD:206637	28/106 (26%)
		Cadherin	487..579	CDD:278457	28/108 (26%)
		Cadherin_C	639..782	CDD:279398	16/58 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11139
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010