DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and Cdh19

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001009448.1 Gene:Cdh19 / 360835 RGDID:1307169 Length:770 Species:Rattus norvegicus


Alignment Length:574 Identity:151/574 - (26%)
Similarity:267/574 - (46%) Gaps:64/574 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   145 ITEEDDRNLPKRILQVTATDGDVDRPIN-IVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLD 208
            :.||.|     .|..|.....|:|...| ..|.|.|.|       :..|.|:..|||||.::.||
  Rat    52 VPEEMD-----TIQHVGRLRSDLDNGNNSFQYKLLGTG-------DGSFSIDEKTGDIFAMQKLD 104

  Fly   209 RDQPNGRPQWRFTVFAQ---DEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSS 270
            |::     |..:.:.||   ...|:.:...::..:.:.|:|||.|:|....|...|.|....|:.
  Rat   105 REK-----QSLYILRAQVIDTTIGKAVEPESEFVIRVSDVNDN
EPRFLDEPYEAIVPEMSPEGTF 164

  Fly   271 VMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQ 335
            |:.::|.|.|||....:|:::|::|:       |.|.|.:||.||:|:.: ..:|||....|.:.
  Rat   165 VIKVTANDADDPTSGYHARILYNLEQ-------GQPYFSVEPTTGVIRIS-SKMDRELQDTYCVI 221

  Fly   336 VVAMD----GGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDET--NGTYIPETPILTVTVQDE 394
            :.|.|    .|.|.||.|.||::.|:||..|.|.:..:...:.|:  :||.|.:     :...|:
  Rat   222 IQAKDMLGQPGALSGTTTISIKLSDINDN
KPIFKESFYRFTISESAPSGTTIGK-----IMAYDD 281

  Fly   395 D--ETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDG 457
            |  |.....|.:..:.....|  .::.|....|.:.:.:.:|:|   ..:.:..|::|.:...|.
  Rat   282 DIGENAEMDYSIEDDESQIFD--IVIDNETQEGIVILKKKVDFE---HQNHYGIRVKVKNCHVDE 341

  Fly   458 PGGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAY 522
            .......:.:.:::.|::.| .|..|.|...:....|.|....||::....|.|.|: ..|.:.|
  Rat   342 ELAPAHVNASTTYIKVQVED-EDE
PPTFLLPYYIFEIPEGKPYGTMVGTVSAVDPDR-RQSPMRY 404

  Fly   523 KIVRSTNRKRQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNA 587
            .::.|    :.|.|:..|.:.....||||....:::.:.|.:..:..:.::|.:.|.|.::||:|
  Rat   405 SLIGS----KMFDINGNGTIVTTNLLDREVSAWYNLSVTATETYNVQQISSAHVYVQVLNINDHA 465

  Fly   588 PTFAQDYKPTLPENV-SGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGD 651
            |.|:|.|:..:.||. ||:.|..::|.|.|:.:..:    .|..:....|...:.|.:.     |
  Rat   466 PEFSQLYETYVCENAESGEIIQTISAIDRDESIEDH----HFYFNHSVEDTNNSSFILT-----D 521

  Fly   652 NENGVAIISSLRP-FDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNK 704
            |::..|:|.|.|. |..:.:..:.:.|.|.|||.|.:|.|:|||:.:.|..|::
  Rat   522 NQDNTAVILSNRAGFSLKEETVFYMIILIADNGIPPLTSTNTLTIQVCDCGDSR 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637
Cadherin_repeat 140..248 CDD:206637 28/106 (26%)
Cadherin_repeat 256..359 CDD:206637 35/106 (33%)
Cadherin_repeat 379..481 CDD:206637 16/103 (16%)
Cadherin_repeat 489..586 CDD:206637 22/96 (23%)
Cadherin_repeat 594..703 CDD:206637 31/110 (28%)
Cadherin_repeat 724..801 CDD:206637
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
Cdh19NP_001009448.1 Cadherin_repeat 49..142 CDD:206637 28/106 (26%)
Cadherin_repeat 150..250 CDD:206637 36/107 (34%)
Cadherin_repeat 259..364 CDD:206637 18/115 (16%)
Cadherin_repeat 373..464 CDD:206637 22/95 (23%)
Cadherin_repeat 472..570 CDD:206637 30/106 (28%)
Cadherin_C 617..764 CDD:395833
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 130 1.000 Domainoid score I5067
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24027
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.010

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