DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CadN2 and CadN

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001027277.1	Gene:	CadN / 35070	FlyBaseID:	FBgn0015609	Length:	3101	Species:	Drosophila melanogaster

Alignment Length:	1710	Identity:	1283/1710 - (75%)
Similarity:	1478/1710 - (86%)	Gaps:	18/1710 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TNSTYLVTKFVRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTNIRYQITGG 76
            :|....||||:|||||||||:|||||:.|||.|:|||.|:|.|||||.||||:||:.|||:||.|
  Fly  1394 SNGPNSVTKFIRIGIADKNDNPPYFDKSLYEAEVDENEDIQHTVLTVTAKDHDESSRIRYEITSG 1458

  Fly    77 NIGNAFAVQNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTY 141
            |||.||||:|.||.||||..||||||.||||||.|:.|.|.|||||:|:|:|||||||||:|.||
  Fly  1459 NIGGAFAVKNMTGAIYVAGALDYETRRRYELRLAASDNLKENYTTVIIHVKDVNDNPPVFERPTY 1523

  Fly   142 RTQITEEDDRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKP 206
            |||||||||||||||:|||||||||.|||.||||||||||||||||||||||||||||:||||||
  Fly  1524 RTQITEEDDRNLPKRVLQVTATDGDKDRPQNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKP 1588

  Fly   207 LDRDQPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSV 271
            |||||||||||||||||||||||||||||||:||||||||||||.||||:||||||||||||..|
  Fly  1589 LDRDQPNGRPQWRFTVFAQDEGGEGLVGYADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVV 1653

  Fly   272 MTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQV 336
            |||:|||||||||.:||:|:|||||||||||||:|||||||:||:||||||||||||||||||||
  Fly  1654 MTMTAVDYDDPNEGSNARLVYSIEKNVIEEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQV 1718

  Fly   337 VAMDGGGLKGTGTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDEDETNTFQ 401
            ||||||||||||||||||||:||||||||||||.||||||:||.:||.|||||||.||||||.||
  Fly  1719 VAMDGGGLKGTGTASIRVKDINDMPPQFTKDEWFTEVDETDGTALPEMPILTVTVHDEDETNKFQ 1783

  Fly   402 YKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGSDKYHV 466
            |||:.|||:|||||.||||.||||||||:|||||||.|||:||||||||||||:|  ..:|||||
  Fly  1784 YKVIDNSGYGADKFTMVRNNDGTGSLKIVQPLDYEDQLQSNGFRFRIQVNDKGED--NDNDKYHV 1846

  Fly   467 AYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRK 531
            |||||||||||||||.|.|:|.::|||::|||||||.||:|||||.||||.|||:|.|.||::|:
  Fly  1847 AYSWVVVKLRDINDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQ 1911

  Fly   532 RQFAISDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKP 596
            |||||:..|:|:|||.||||...||.::|||||||||.:||||||||||:|:|||||.|.:||:|
  Fly  1912 RQFAINQNGSVTIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRP 1976

  Fly   597 TLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISS 661
            .|||:|..:|::|:.|.|.|||.:.||.||.|||||.|.|.|:|.||||.|::|.|.:|:|:|||
  Fly  1977 VLPEHVPPRKVVEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISS 2041

  Fly   662 LRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVYNYQGQSQDTPI 726
            ||.||||.||.|.|||.|||:|:|||||||||||.||||||||||||||.:.||||||||.||||
  Fly  2042 LRSFDREQQKEYMIPIVIKDHGSPAMTGTSTLTVIIGDVNDNKMQPGSKDIFVYNYQGQSPDTPI 2106

  Fly   727 GRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKVYDREHGQEDIP 791
            |||||.|.||||:||||:|||..||.|||||.|:|::|||||||.|||.||||||||:|.|.|||
  Fly  2107 GRVYVYDLDDWDLPDKKFYWEAMEHPRFKLDEDSGMVTMRAGTREGRYHLRFKVYDRKHTQTDIP 2171

  Fly   792 ANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAELLYTDRDNV 856
            ||::||||:|..|||..:||:|||.|:||||:|.||.....:..||::|||:|||:||.|:|:||
  Fly  2172 ANVTVTVREIPHEAVVNSGSVRLSGISDEDFIRVWNYRTQSMSRSKMDRFRDKLADLLNTERENV 2236

  Fly   857 DVFSVQLKEGSPYPLTDVHFAARSATQQPYFKAVRLNGVVQMHREEIEKDVGLNITMVNINECLH 921
            |:||||||...| |||||.|:|..:   ||:|.|||||:|.|||||||||||:|||||.|:|||:
  Fly  2237 DIFSVQLKRKHP-PLTDVRFSAHGS---PYYKPVRLNGIVLMHREEIEKDVGINITMVGIDECLY 2297

  Fly   922 EGKGKCGSNSCTSKVELGKKPYTVSVNRTALVGVRLDISAQCVCRARNFTHQDHNCRTHLCYNGG 986
            |.: .| ..|||:.:|:...||.|:.|:|||||||:|..|.|.|.||||| :..:|||..|:|||
  Fly  2298 ENQ-MC-EGSCTNSLEISPLPYMVNANKTALVGVRVDTIADCTCGARNFT-KPESCRTTPCHNGG 2359

  Fly   987 RCVETRNGPKCVACPVGYNGPRCQQSTRSFRGNGWAWYPPLQLCQESHLSLEFITRVADGLILYN 1051
            |||:||.||.| :|||||.||||||:|||||||||||||||::|.|||||||||||..||||:||
  Fly  2360 RCVDTRFGPHC-SCPVGYTGPRCQQTTRSFRGNGWAWYPPLEMCDESHLSLEFITRKPDGLIIYN 2423

  Fly  1052 GPIVPPKPEETVISDFIALELEQGYPRLLIDFGSGTLELRVKTKKTLDDGVWHRLDIFWDTENVR 1116
            ||||||:.:||:||||||||||:|||||||||||||||||||||||||||.|||:|:|||||::|
  Fly  2424 GPIVPPERDETLISDFIALELERGYPRLLIDFGSGTLELRVKTKKTLDDGEWHRIDLFWDTESIR 2488

  Fly  1117 MVVDFCRTALVSEMEDGTPPEFDDNACQARGQIPPFAESLNLNQPLQLGGLYRQHFDQTLYNWQY 1181
            ||||||::|.::||||||||||||.:||||||||||.|.||:|.|||:|||||:.|||:||.|.|
  Fly  2489 MVVDFCKSAEIAEMEDGTPPEFDDMSCQARGQIPPFNEYLNVNAPLQVGGLYREQFDQSLYFWHY 2553

  Fly  1182 AFSSKGFDGCIRNVIHNSEHYDLAFPALARNSFPACPQTDEVCLKTEHTARCWEHGNCVASLVQA 1246
            ..::|||||||||::|||:.||||.|.|:|||...||||:|||.:||.|||||||||||.||.:|
  Fly  2554 MPTAKGFDGCIRNLVHNSKLYDLAHPGLSRNSVAGCPQTEEVCAQTETTARCWEHGNCVGSLSEA 2618

  Fly  1247 KCHCQPGWMGPGCNVPTIPTTFKAQSYVKFALSFEPDRFSTQLQLRFRTREQGGELFRVSDQHHR 1311
            :|||:|||.||.||:||||||||||||||:||||||||||||:||||||||:.||||||||||:|
  Fly  2619 RCHCRPGWTGPACNIPTIPTTFKAQSYVKYALSFEPDRFSTQVQLRFRTREEYGELFRVSDQHNR 2683

  Fly  1312 EYAILELRRGHLQFRYNLNSMRNEEQLLTLTAIAVNDGQWHVIRISRYGSAALMELDGGESRRYN 1376
            ||.|||::.|||.|||||||:|.||:.|.|.||.||||||||::::||||||.:||||||.||||
  Fly  2684 EYGILEIKDGHLHFRYNLNSLRTEEKDLWLNAIVVNDGQWHVVKVNRYGSAATLELDGGEGRRYN 2748

  Fly  1377 ESFHFTGHQWLTIDKQEGVYAGGKAEYTGIKTFEVQSDFQRSCLDDIRLDGKHLPLPPAMNGTQW 1441
            |:|.|.|||||.:||||||||||||||||::||||.:|:|:||||||||:|||||||||||||||
  Fly  2749 ETFEFVGHQWLLVDKQEGVYAGGKAEYTGVRTFEVYADYQKSCLDDIRLEGKHLPLPPAMNGTQW 2813

  Fly  1442 GQATMARNLERNCPSNRPCSNVICPDPFDCVDLWNEYECTCSEGRIMSSDTKGCVDRNECLDLPC 1506
            ||||||||||:.||||:|||||||||||:||||||.|||||.||||||.|:|||:|||||||:||
  Fly  2814 GQATMARNLEKGCPSNKPCSNVICPDPFECVDLWNVYECTCGEGRIMSPDSKGCMDRNECLDMPC 2878

  Fly  1507 LNGATCINLEPRLRYRCICPEGYWGENCELVQEGQRLKLSMGALGAIFVCLIIILILALIFVLYS 1571
            :|||||||||||||||||||:|:||||||||||||.||||||||.||.|||:|||||.|:||:|:
  Fly  2879 MNGATCINLEPRLRYRCICPDGFWGENCELVQEGQTLKLSMGALAAILVCLLIILILVLVFVVYN 2943

  Fly  1572 RKRKTTKKKKRSGPEKDVRETVISYEDEGGGEDDMTAFDITPLQIPISAQGG--PPDIAACKMPI 1634
            |:|:.  ..|..||:.||||.:|:|:|||||||||||||||||||||   ||  ||::|..||||
  Fly  2944 RRREA--HIKYPGPDDDVRENIINYDDEGGGEDDMTAFDITPLQIPI---GGPMPPELAPMKMPI 3003

  Fly  1635 IYPVMTLLPPGQELNVAYLMEERKQRIDKDNNAPPFDDLRNFTFEGSGSIAESLSSLASGTDDEN 1699
            :||||||: ||||.||...:||.|:|.|.|.||||||||||:.:||.||.|.||||||||||||.
  Fly  3004 MYPVMTLM-PGQEPNVGMFIEEHKKRADGDPNAPPFDDLRNYAYEGGGSTAGSLSSLASGTDDEQ 3067

  Fly  1700 QDFNYLQNWGPRFNALAAMY 1719
            |:::||..|||||:.||.||
  Fly  3068 QEYDYLGAWGPRFDKLANMY 3087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637	64/90 (71%)
		Cadherin_repeat	140..248	CDD:206637	102/107 (95%)
		Cadherin_repeat	256..359	CDD:206637	90/102 (88%)
		Cadherin_repeat	379..481	CDD:206637	82/101 (81%)
		Cadherin_repeat	489..586	CDD:206637	66/96 (69%)
		Cadherin_repeat	594..703	CDD:206637	70/108 (65%)
		Cadherin_repeat	724..801	CDD:206637	58/76 (76%)
		EGF_CA	977..1010	CDD:238011	23/32 (72%)
		LamG	1013..1198	CDD:238058	145/184 (79%)
		EGF_2	<1233..1259	CDD:285248	19/25 (76%)
		Laminin_G_2	1293..1428	CDD:280389	100/134 (75%)
		EGF_CA	1497..1535	CDD:238011	33/37 (89%)
		Cadherin_C	1583..1719	CDD:279398	93/137 (68%)
CadN	NP_001027277.1	Cadherin_repeat	178..301	CDD:206637
		Cadherin_repeat	337..396	CDD:206637
		E_set	449..541	CDD:298831
		Cadherin_repeat	549..>625	CDD:206637
		Cadherin_repeat	655..752	CDD:206637
		Cadherin_repeat	765..853	CDD:206637
		Cadherin_repeat	862..964	CDD:206637
		Cadherin_repeat	973..1074	CDD:206637
		Cadherin_repeat	1083..1166	CDD:206637
		Cadherin_repeat	<1219..1298	CDD:206637
		Cadherin_repeat	1310..1414	CDD:206637	13/19 (68%)
		Cadherin_repeat	1423..1514	CDD:206637	64/90 (71%)
		Cadherin_repeat	1522..1630	CDD:206637	102/107 (95%)
		Cadherin_repeat	1638..1741	CDD:206637	90/102 (88%)
		Cadherin_repeat	1762..1861	CDD:206637	81/100 (81%)
		Cadherin_repeat	1871..1966	CDD:206637	66/94 (70%)
		Cadherin_repeat	1974..2083	CDD:206637	70/108 (65%)
		EGF	2350..2380	CDD:278437	21/30 (70%)
		LamG	2385..2570	CDD:238058	145/184 (79%)
		EGF_2	<2605..2631	CDD:285248	19/25 (76%)
		Laminin_G_2	2665..2800	CDD:280389	100/134 (75%)
		EGF_CA	2869..2907	CDD:238011	33/37 (89%)
		Cadherin_C	2952..3088	CDD:279398	95/140 (68%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448945
Domainoid	1	1.000	133	1.000	Domainoid score	I5001
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1505	1.000	Inparanoid score	I101
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D272at7147
OrthoFinder	1	1.000	-	-		FOG0001479
OrthoInspector	1	1.000	-	-		mtm6342
orthoMCL	1	0.900	-	-		OOG6_100175
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2878
	9	8.800