DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN2 and Fat4

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_899044.3 Gene:Fat4 / 329628 MGIID:3045256 Length:4981 Species:Mus musculus


Alignment Length:2230 Identity:487/2230 - (21%)
Similarity:768/2230 - (34%) Gaps:668/2230 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 VRIGIADKNDSPPYFDRFLYETEIDENADLQSTVLTVNAKDHNESTNI--RYQITGGNIGNAFAV 84
            |.|.|.|:||:.|.|.: ::...:.||:.|..||..|...|.:...|.  ||.|...::  .|.:
Mouse  2761 VIISILDENDNAPRFSQ-IFSAYVSENSPLGYTVTRVTTSDEDIGINAISRYSIVDTSL--PFTI 2822

  Fly    85 QNTTGVIYVASPLDYETRPRYELRLEATRNRKNNYTTVVINVRDVNDNPPVFDRQTYRTQITEED 149
            ...||.|.::.||:.|...||.:|:.|..:.....|.|.|.|.|:|||.|.|.|.:|.....|..
Mouse  2823 NPNTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDINDNTPRFSRPSYYLDCPELP 2887

  Fly   150 DRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNG 214
            :  |..|:.||:|||.|......:.||:..|        :..|.||.|||:||..:.|.....:|
Mouse  2888 E--LGSRVTQVSATDPDEGSNGQVFYFIKSQ--------SEYFRINATTGEIFNKQVLKYQNVSG 2942

  Fly   215 RP-----QWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTM 274
            ..     :..|.|.|.|.|...|:....:.:|..|.|||.|||.|..||..||:|...|:.::.:
Mouse  2943 FSNVNINRHSFIVTASDRGNPSLLSETTVTINTVDSNDNPPQFLQNKYFTPVTKNVKVGTKLIKV 3007

  Fly   275 SAVDYDD----------------------PNE----STNAKLIYSIEKN---------------- 297
            :|||..|                      .|:    |..:.|:..:.:|                
Mouse  3008 TAVDDKDFGLNSEVEYFVSDGNHLGKFKLDNDTGWISIASSLVSDLNQNFLIRVTAKDKGNPPLS 3072

  Fly   298 --------VIEEETGAP------------------------------------------------ 306
                    |.||....|                                                
Mouse  3073 SQAVVHITVTEENYHTPEFSQNHISATIPESHSIGSVVRTVSARDRDTAMNGLISYNIISGNEEG 3137

  Fly   307 IFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRVK--DLNDMPPQFTKDEW 369
            ||.|...||:: |....||.|.:..:.:.:.|.|||.:..||..|:.|.  |:||..|.|..||:
Mouse  3138 IFAINSSTGVV-TLAKALDYEMSSKHEMTISATDGGWVARTGYCSLTVSVIDVNDNSPVFVPDEF 3201

  Fly   370 VTEVDET--NGTYI-------------------------------PETPILTV------------ 389
            ...|.|.  :||.:                               |...::|.            
Mouse  3202 FPTVMENAPSGTTVIHLNATDADSGANAVIAYTVQSSDSDLFVIDPNMGVITTQGFLDFETKQSY 3266

  Fly   390 -------TVQDEDE------------TNTF----------------------------------- 400
                   .|.||::            ||.:                                   
Mouse  3267 HLTVKAFNVPDEEKCSFATVDIQLKGTNEYVPRFVSKLYYFEVSEAASRGTAVGEVFASDRDMGA 3331

  Fly   401 ----QYKVVPNS---GFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGP 458
                .|.:..||   ||..:|.        ||.:.:...||.|     ...|..::|..|.....
Mouse  3332 DGEVHYLIFGNSRKKGFQINKM--------TGQIYVSGLLDRE-----KEERVSLKVLAKNFGNI 3383

  Fly   459 GGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQ-GGHSKVAY 522
            .|:|...|.   |.:.:.|.|| .|.|......|.|.|...:||.:....|.|:|. ...|:.:|
Mouse  3384 RGADIDEVT---VNITVLDAND-PPVFSLSTYRVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSY 3444

  Fly   523 KIVRSTNRKRQFAISDR-GAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDN 586
             .:.|.|....|:|:.: |.:::...||||:...:::.:||:|.|:|:.|.:|:|.|.::|:|||
Mouse  3445 -FIGSGNENGAFSINPQTGQITVTSGLDRESLPVYNLTVLAVDSGTPSATGSASLVVTLEDINDN 3508

  Fly   587 APTFAQDYKPTLPENVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGD 651
            .|.........|.....|..::.:.:.|||  |..|.|||.:.|       :..|....|    .
Mouse  3509 GPVLTVSEGEVLENKRPGTLVMTLQSTDPD--LPPNQGPFNYYL-------LSTGPATNY----F 3560

  Fly   652 NENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTIGDVNDNKMQPGSKSVLVYN 716
            :.:...::|:.|..|||....:.:.:..:|:|||.|:.|.|:.:|:.|.|||..|..:..:.|..
Mouse  3561 SLSTAGVLSTTREIDREQIADFYLSVVTRDSGAPQMSSTGTVHITVLDQNDNPSQSRTVEIFVNY 3625

  Fly   717 YQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQEHQRFKLDTDTGI------------LTMRAGT 769
            |........:|.|...|||..|              .|.....:|:            |:.:..:
Mouse  3626 YGNLFPGGTLGSVKPQDPDVLD--------------SFHCSLTSGVTSLFSIPAGSCDLSSQPRS 3676

  Fly   770 RRGRYQLRFKVYDREHGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFV----------- 823
            ..|.:.|.....|..|  ..:..|:.|.....:...:..:..:|:...|.:||:           
Mouse  3677 TDGTFDLTVVSSDGVH--STVTNNIRVFFAGFSNATIDNSILLRVGVPTVKDFLTNHYLHFLRIA 3739

  Fly   824 ---------------------RTW--NPVK---NQ-VEPSKLERFRNKLAELLYTDRDNVDVFSV 861
                                 ||:  ..||   || |.||.:..|...:.|:|.. :..|.|.||
Mouse  3740 SSQLTGLGTAVQLYAAYEENNRTFLLAAVKRNNNQYVNPSGVATFFESIKEILLR-QSGVKVESV 3803

  Fly   862 ------------------QLKEGSPYPLTD---VHFAARSATQQPYFKAVRLNGVVQMHREEIEK 905
                              :|..||...:.:   |...|....|....|.|  .|......|    
Mouse  3804 DHDPCIHGPCQNGGSCLRRLAVGSALKIQESLPVIIVANEPLQPSQCKCV--PGYAGSWCE---- 3862

  Fly   906 DVGLNITMVNINECL----HEGKGKC----GSNSCTSKVELGKKPYTVSVN-------RTALVGV 955
                    |:|:|||    |.| |.|    |..||:.......:.....:|       :...|..
Mouse  3863 --------VDIDECLPAPCHNG-GTCHNLVGGFSCSCPEGFTGRACERDINECLPSPCKHGAVCQ 3918

  Fly   956 RLDISAQCVCRARNFT-----HQDHNCRTHLCYNGGRCVETRNGPKCVACPVGYNGPRCQQSTRS 1015
            .......|||:. .:|     ...:.|..:.|:|||.|........| .||.|..|..|:.::..
Mouse  3919 NFPGGFNCVCKT-GYTGKMCESSVNYCECNPCFNGGSCQSGVESYYC-HCPFGVFGKHCELNSYG 3981

  Fly  1016 FRGNGWAWYPPLQLCQESHLSLEFITRVADGLILYNGPIVPPKPEET-VISDFIALELEQGYPRL 1079
            |....:..:|.|. ...:::.::|.|..:..|:|||      ...:| ..::|:|||:.:...|.
Mouse  3982 FEELSYMEFPSLD-PNNNYIYVKFATIKSHALLLYN------YDNQTGERAEFLALEIAEERLRF 4039

  Fly  1080 LIDFGSGTLELRVKTKKTLDDGVWHRL---------DIFWDTENVRMVVDFCRTALVSEMEDGTP 1135
            ..:.||||.:|  .|.|.:.||.:|.:         .:..|:.:......:|..:.|:..:|.| 
Mouse  4040 SYNLGSGTYKL--TTMKKVSDGQFHTVIARRAGMAASLTVDSCSENQEPGYCTVSNVAVSDDWT- 4101

  Fly  1136 PEFDDNACQARGQIPPFAESLNLNQP--LQLGGL--------YRQHFDQTLYNWQYAFSSKGFDG 1190
                                |:: ||  :.:||:        .|.|.:           |..|.|
Mouse  4102 --------------------LDV-QPNRVTVGGIRSLEPILQRRGHVE-----------SHDFVG 4134

  Fly  1191 CIRNVIHNSEHYDLAFPALARNSFPACPQTDEVCLKTEHTARCWEHGNCVASLVQAKCHCQPGWM 1255
            |:.....|....:.:....|:.....||:.:..|.:..    |...|.||......:|.|..|..
Mouse  4135 CVMEFAVNGRPLEPSQALAAQGILDQCPRLEGTCARNP----CQHGGTCVDFWSWQQCQCMEGLT 4195

  Fly  1256 GPGCNVPTIPTT------------FKAQSYVKFALSFEPDRFST-------QLQLRFRTREQGGE 1301
            |..|.....|.|            ..:||..:..|..:..|.:|       .|:::||||.:.|.
Mouse  4196 GKYCEKSVTPDTALSLEGKGRLDYHMSQSEKREYLLTQSIRDTTLEPFGVNSLEVKFRTRSENGI 4260

  Fly  1302 LFRVSDQHHREYAILELRRGHLQFRYNLNSMRNEEQLLTLTAIAVNDGQWHVIRISRYGSAALME 1366
            |..:  |....|..::::.|.:.|..:.......|:::....||  ||.||..|||:.||..::.
Mouse  4261 LIHI--QESSNYTTVKIKNGKVHFTSDAGVAGKVERIIPEAYIA--DGHWHTFRISKNGSITVLS 4321

  Fly  1367 LDGGESRRYNESF-----HFTGHQWLTIDKQEGVYAGGKAEYTGIKTFEVQSDFQ---RSCLDDI 1423
            :|    |.:|...     .|.|.:.|::            ...||...:...|.|   ..|:..:
Mouse  4322 VD----RIHNRDIVHPTQDFGGIEVLSM------------SLGGIPPNQAHRDTQTGFNGCIASV 4370

  Fly  1424 RLDGKHLPLPPAMNGTQWGQATMAR------NLERNCPSNRPCSNVICPDPFDCVDLWNEYECTC 1482
            ...|:.||..        |:.::|.      :::..|.....|::..|.....|::.|..|:   
Mouse  4371 LYGGESLPFS--------GKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLCINQWYAYK--- 4424

  Fly  1483 SEGRIMSSDTKGCVDRNECLDLPCLNGATCINLEPRL--RYRCICPEGYWGENCELV-------- 1537
                        ||...:|...||.||.:|   ||.|  .|.|.|||.:.|..||.|        
Mouse  4425 ------------CVPPGDCASHPCQNGGSC---EPGLLSGYTCSCPESHTGRTCETVVACLGVLC 4474

  Fly  1538 -------------------QEGQRLKLSMGALGAIF-VCLIIILILALIFVLYS----------R 1572
                               |....:.|.:.|:.||. .|...:.:|.|..:|.:          :
Mouse  4475 PQGKVCKAGSPGGHVCVQSQGPDEISLPLWAVPAIVGSCATALALLVLSLILCNQCRGKMPKNPK 4539

  Fly  1573 KRKTTKKKKRSGPEKDVRETVISYEDEGG----GEDDMTAFDITPLQIPISAQGGP-PDIAACKM 1632
            :.|..|:||:.|.|.      ::::|...    |:|         |.:....:|.| |||...:.
Mouse  4540 EEKKPKEKKKKGSEN------VAFDDPDNIPPYGDD---------LAVRKQPEGNPKPDIIEREN 4589

  Fly  1633 PIIYPVMTLLPPGQELNVAYLMEERKQRIDKDNNAPPFDDLRNFTFEGSGSIAESLSSLASGTDD 1697
            |.:....|.:|...|            .|.....|.|..::.::..:.:.|||.|.:.:.     
Mouse  4590 PYLIFDETDIPHNSE------------TIPSAPLASPEQEIEHYDIDNASSIAPSDADII----- 4637

  Fly  1698 ENQDFNYLQNWGPRFNALAAMYVHDKAKASSQLPSDGGGGS--------GDG------------- 1741
              |.:...::..|:|    ::..|.....:.|.|...|..|        |.|             
Mouse  4638 --QHYKQFRSHTPKF----SIQRHSPLGFARQSPMPLGASSLTYQPSSYGQGLRTSSLSHSACPT 4696

  Fly  1742 --------PGPGASSSS------------PLGGGGT---GGGSGIPGNVLAVVATGSG------- 1776
                    |.|.:..|:            ||..|||   .|....||  :...||..|       
Mouse  4697 PNPLSRHSPAPFSKPSAFYRNSPARELHLPLRDGGTLEMHGDPCQPG--MFNYATRLGRRSKSPQ 4759

  Fly  1777 --AGPGGGGGSSGLMPLPEV 1794
              |..|...||....|:.::
Mouse  4760 AMASHGSRPGSRLKQPIAQI 4779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 28/92 (30%)
Cadherin_repeat 140..248 CDD:206637 32/112 (29%)
Cadherin_repeat 256..359 CDD:206637 36/202 (18%)
Cadherin_repeat 379..481 CDD:206637 28/205 (14%)
Cadherin_repeat 489..586 CDD:206637 30/98 (31%)
Cadherin_repeat 594..703 CDD:206637 28/108 (26%)
Cadherin_repeat 724..801 CDD:206637 15/88 (17%)
EGF_CA 977..1010 CDD:238011 11/32 (34%)
LamG 1013..1198 CDD:238058 41/204 (20%)
EGF_2 <1233..1259 CDD:285248 8/25 (32%)
Laminin_G_2 1293..1428 CDD:280389 33/142 (23%)
EGF_CA 1497..1535 CDD:238011 15/39 (38%)
Cadherin_C 1583..1719 CDD:279398 25/140 (18%)
Fat4NP_899044.3 Cadherin_repeat 48..131 CDD:206637
Cadherin_repeat 139..246 CDD:206637
Cadherin_repeat 254..349 CDD:206637
Cadherin_repeat 364..471 CDD:206637
Cadherin_repeat 479..577 CDD:206637
Cadherin_repeat 588..685 CDD:206637
Cadherin_repeat 693..789 CDD:206637
Cadherin_repeat 798..889 CDD:206637
Cadherin_repeat 904..992 CDD:206637
Cadherin_repeat 1000..1096 CDD:206637
Cadherin_repeat 1105..1206 CDD:206637
Cadherin_repeat 1215..1311 CDD:206637
Cadherin_repeat 1321..1416 CDD:206637
Cadherin_repeat 1428..1525 CDD:206637
Cadherin_repeat 1540..1622 CDD:206637
Cadherin_repeat 1634..1736 CDD:206637
Cadherin_repeat 1747..1837 CDD:206637
Cadherin_repeat 1845..1940 CDD:206637
Cadherin_repeat 1948..2047 CDD:206637
Cadherin_repeat 2057..2150 CDD:206637
Cadherin_repeat 2159..2254 CDD:206637
Cadherin_repeat 2263..2360 CDD:206637
Cadherin_repeat 2369..2464 CDD:206637
Cadherin_repeat 2472..2559 CDD:206637
Cadherin_repeat 2573..2667 CDD:206637
Cadherin_repeat 2675..2771 CDD:206637 5/9 (56%)
Cadherin_repeat 2778..2870 CDD:206637 28/93 (30%)
Cadherin_repeat 2878..2981 CDD:206637 32/112 (29%)
Cadherin_repeat 2990..3085 CDD:206637 16/94 (17%)
Cadherin_repeat 3095..3192 CDD:206637 19/97 (20%)
Cadherin_repeat 3200..3295 CDD:206637 11/94 (12%)
Cadherin_repeat 3305..3402 CDD:206637 19/112 (17%)
Cadherin_repeat 3410..3508 CDD:206637 30/98 (31%)
Cadherin_repeat 3516..3612 CDD:206637 28/108 (26%)
EGF_CA 3804..3862 CDD:238011 9/59 (15%)
EGF_CA 3864..3900 CDD:238011 11/36 (31%)
EGF_CA 3902..3938 CDD:238011 6/36 (17%)
EGF_CA 3941..3976 CDD:238011 11/35 (31%)
LamG 3979..4142 CDD:238058 41/204 (20%)
EGF_CA 4168..4200 CDD:238011 9/35 (26%)
Laminin_G_2 4252..4372 CDD:366983 33/139 (24%)
EGF_CA 4430..4464 CDD:238011 15/36 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4535..4585 14/64 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4677..4713 4/35 (11%)
Necessary and sufficient for interaction with MPDZ. /evidence=ECO:0000269|PubMed:19506035 4708..4797 17/74 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4753..4773 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4796..4911
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4957..4981
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3B9B2
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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