DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and Cdh10

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001303687.1	Gene:	Cdh10 / 320873	MGIID:	107436	Length:	788	Species:	Mus musculus

Alignment Length:	775	Identity:	203/775 - (26%)
Similarity:	331/775 - (42%)	Gaps:	167/775 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 NIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQDEGGEGL---V 233
            ::.|.|:|.|      |.:.|.|:..||||...:.:||::     :..:|:.||......|   .
Mouse    88 SLKYILSGDG------AGTLFIIDEKTGDIHATRRIDREE-----KAFYTLRAQAINRRTLRPVE 141

  Fly   234 GYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNV 298
            ..::..:.:.|||||.|.||:.||..:|.|....|:||:.::|.|.|||:...:|::||||.:
Mouse   142 PESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQ-- 204

  Fly   299 IEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASIRVKDLND 359
                 |.|.|.:|||||:|:||:..::||....|.:.:.|.|    .|||.||.|.:|.:.|:||
Mouse   205 -----GQPYFSVEPETGIIRTALPNMNRENKEQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVND 264

  Fly   360 MPPQFTKDEWVTEVDETN--GTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGD 422
            .||:|.::.....|.|::  ||.:..   :..|..|..:.....|:::  .|.|.|.|.::...|
Mouse   265 NPPRFPQNTIHLRVLESSPVGTAVGS---VKATDADTGKNAEVDYRII--DGDGTDMFDIITEKD 324

  Fly   423 -GTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDD------GPGGSDKYHVAYSWVVVKLRDIND 480
             ..|.:.:.:|||||:   ...:..:::..:...|      ||....      :.|.:.:.|: |
Mouse   325 TQEGIITVKKPLDYEN---RRLYTLKVEAENTHVDPRFYYLGPFKDT------TIVKISIEDV-D 379

  Fly   481 NVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAI-SDRGAVSI 544
            ..|.|.|......::||.:||||:....|.|.|... |.:.:.:.|.|:..|.|.| |..|::..
Mouse   380 EPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSTS-SPIRFTLDRHTDLDRIFNIHSGNGSLYT 443

  Fly   545 QRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENV-SGKKIL 608
            .:|||||....|::.::|.:..:|..|...::.|.:.|||||||.||..|...:.||. .|:.|.
Mouse   444 SKPLDRELSQWHNLTVIAAEINNPKETTRVSVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQ 508

  Fly   609 EVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVA-IISSLRPFDREAQKS 672
            .::|.|.||.|  .|..|.|.|     ..:...|.|:     |||:..| |::....|:|....:
Mouse   509 TISAVDKDDPL--GGQKFFFSL-----AAVNPNFTVQ-----DNEDNTARILTRKNGFNRHEIST 561

  Fly   673 YAIPIEIKDNGAPAMTGTSTLTVTI---------------------------------------- 697
            |.:|:.|.||..|..:.|.|||:.:
Mouse   562 YLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGALIAILLCIIILLV 626

  Fly   698 ---------------------GDVNDNKMQPGSKSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPD 741
                                 .|:.||        ::.||.:|..::         |...:|:..
Mouse   627 IVVLFAALKRQRKKEPLILSKEDIRDN--------IVSYNDEGGGEE---------DTQAFDIGT 674

  Fly   742 KKYYWEVQEHQ-RFKLDTDTGILTMRAGTRRGRYQLRFKVYDR--EHGQE------DIPANLSVT 797
            .:....::|.: |..:..:|..:..|..|......:|..:.:|  ||..:      |..|..:..
Mouse   675 LRNPAAIEEKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINERLKEHDLDPTAPPYDSLATYAYE 739

  Fly   798 VRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAELL---YTDRD 854
            ..|..||::....|.......:.|::|.|.|           || |||||:.   .:|:|
Mouse   740 GNDSVAESLSSLESGTTEGDQNYDYLREWGP-----------RF-NKLAEMYGGGESDKD 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	20/78 (26%)
		Cadherin_repeat	256..359	CDD:206637	41/106 (39%)
		Cadherin_repeat	379..481	CDD:206637	20/108 (19%)
		Cadherin_repeat	489..586	CDD:206637	30/97 (31%)
		Cadherin_repeat	594..703	CDD:206637	34/171 (20%)
		Cadherin_repeat	724..801	CDD:206637	13/85 (15%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Cdh10	NP_001303687.1	CA	80..158	CDD:214520	22/80 (28%)
		Cadherin_repeat	164..265	CDD:206637	42/107 (39%)
		Cadherin_repeat	273..380	CDD:206637	23/121 (19%)
		Cadherin_repeat	388..485	CDD:206637	30/97 (31%)
		Cadherin_repeat	493..587	CDD:206637	33/105 (31%)
		Cadherin_C	643..780	CDD:279398	34/165 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5176
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010