DRSC/TRiP Functional Genomics Resources

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Protein Alignment CadN2 and Cdh18

DIOPT Version :10

Sequence 1:NP_609855.3 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001101126.2 Gene:Cdh18 / 310174 RGDID:1305430 Length:790 Species:Rattus norvegicus


Alignment Length:572 Identity:169/572 - (29%)
Similarity:266/572 - (46%) Gaps:106/572 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 DGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQ--- 225
            ||.|.      |.|||:|      |.:.|.|:.|||||...|.|||:|     :..:.:.||   
  Rat    85 DGSVK------YILTGEG------AGTIFIIDDTTGDIHSTKSLDREQ-----KTHYVLHAQAID 132

  Fly   226 DEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKL 290
            ....:.|...::..:.::|||||||:|..|.|...|.|....|:||:.::|.|.|||....:|::
  Rat   133 RRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARV 197

  Fly   291 IYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTAS 351
            :|||.:       |.|.|.::|:||:|:||:..:|||....||:.:.|.|    .|||.|:.|.:
  Rat   198 VYSILQ-------GQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVN 255

  Fly   352 IRVKDLNDMPPQFTKDEWVTEVDETNGTYIPE-----TPILTVTVQDEDETNTFQYKVVPNSGFG 411
            |.:.|:||.||:|.:..:        ..|:||     :.:..:...|.|            :|..
  Rat   256 ITLTDVNDNPPRFPQKHY--------QLYVPESAQVGSAVGKIKANDAD------------TGSN 300

  Fly   412 ADKFAMVRNGDGTG---------------SLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGS 461
            ||....:.||||.|               |||  :||:||   :...:...|:         |.:
  Rat   301 ADMTYSITNGDGIGVFSISTDKDTREGILSLK--KPLNYE---KKKSYTLNIE---------GAN 351

  Fly   462 DKYHVAYS---------WVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGH 517
            ......:|         .:.:.:.|: |..|.|......:.:||:.|:|||:....|.|.| ..:
  Rat   352 THLDFRFSHLGPFKDATMLKIIVGDV-DEPPLFSMPSYVMEVYENAKIGTIVGTVLAQDPD-SAN 414

  Fly   518 SKVAYKIVRSTNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVK 581
            |.|.|.|..||..:|.|.| ::.|.:...:.||||....::|.:.|.::.:|...:..::.:.|.
  Rat   415 SLVRYFINHSTEEERFFNIDANTGTIKTSKVLDREETPWYNITVTASENDNPDLLSHVSVGIRVL 479

  Fly   582 DVNDNAPTFAQDYKPTLPENVS-GKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVE 645
            |||||.|..|::|...:.||.. |:.|..:.|.|.||  ..||..|.|.||.      :......
  Rat   480 DVNDNPPELAREYDIVVCENSKPGQVIHTITATDKDD--FANGPRFNFFLDE------RLPMNPN 536

  Fly   646 YDRRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI 697
            :..:.:.:|..:|::..|.|.|..|..|.:||.|.|.|.|:::.:||||:.:
  Rat   537 FTLKDNEDNTASILTRRRRFSRTMQDVYYLPIMISDGGIPSLSSSSTLTIRV 588

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_609855.3 Cadherin_repeat 41..132 CDD:206637
Cadherin_repeat 140..248 CDD:206637 27/86 (31%)
Cadherin_repeat 256..359 CDD:206637 38/106 (36%)
CA 388..483 CDD:214520 22/118 (19%)
Cadherin_repeat 489..586 CDD:206637 30/97 (31%)
Cadherin_repeat 594..703 CDD:206637 32/105 (30%)
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 1233..1259 CDD:400365
LamG 1265..1426 CDD:238058
EGF_CA 1497..1535 CDD:238011
CADH_Y-type_LIR 1662..1719 CDD:460041
Cdh18NP_001101126.2 CA 79..157 CDD:214520 29/88 (33%)
Cadherin_repeat 163..264 CDD:206637 39/107 (36%)
Cadherin_repeat 272..379 CDD:206637 24/141 (17%)
Cadherin_repeat 387..484 CDD:206637 30/97 (31%)
Cadherin_repeat 491..589 CDD:206637 32/106 (30%)
CADH_Y-type_LIR 723..782 CDD:460041
Blue background indicates that the domain is not in the aligned region.

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