DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CadN2 and Dchs1

DIOPT Version :9

Sequence 1:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster
Sequence 2:NP_001101014.2 Gene:Dchs1 / 308912 RGDID:1309878 Length:3291 Species:Rattus norvegicus


Alignment Length:1147 Identity:290/1147 - (25%)
Similarity:470/1147 - (40%) Gaps:198/1147 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 IADKNDSPPYFDRFLYETE-IDENADLQSTVLTVNAKDHNESTN--IRYQITGGNIGNAFAVQNT 87
            :.|.||:.|.|||.||..| :.|.|...|.|:.|.|:|.::.||  :.|.:..|...:.|::..|
  Rat   456 VTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGTHTHWFSIDPT 520

  Fly    88 TGVIYVASPLDYETRPRYELRLEATRNRKN---NYTTVVINVRDVNDNPPVFDRQTYRTQITEED 149
            :|:|..|:.||||..|:.:|.:.||.....   :..||.:.::|||||.|.|.|..|...:.|..
  Rat   521 SGIITTAATLDYELEPQPQLIVVATDGGLPPLVSSATVSVALQDVNDNEPQFQRTFYNASLPEGT 585

  Fly   150 DRNLPKRILQVTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNG 214
            ...  ...|||||||.| ..|..::.:..|.|:...  .:..|.|:..:|::...:.|||||  |
  Rat   586 QPG--TCFLQVTATDAD-SGPFGLLSYSLGAGLGAS--GSPPFRIDAHSGEVCTTRILDRDQ--G 643

  Fly   215 RPQWRFTVFAQDEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDY 279
            ...:.|||.|.|  |.||.....::|.:.|.|||.|||....|..:::...|.|::|:.:.|   
  Rat   644 PSSFDFTVTAID--GGGLKSMVYVKVFVADENDNPPQFYPREYAASLSAQSTPGTAVLRVHA--- 703

  Fly   280 DDPNESTNAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMDGGGL 344
            .||::..:.:|.|.|...     ...|:|.::..:||: |....|.|.......:::.|.|||||
  Rat   704 HDPDQGPHGRLSYHILAG-----NSPPLFALDAHSGLL-TVAWPLGRRANSVVQLEIGAQDGGGL 762

  Fly   345 KGTGTASIRVKDL--NDMPPQFTKDEWVTEVDETNGTYIPETPI--------------LTVTVQD 393
            :....|.:.:..:  ...||.|.:.::|..|.|   ...|.|.:              :|:|:..
  Rat   763 QAEPIARVNISIVPGTPTPPIFEQLQYVFSVPE---DVAPGTSVGVVQAHNPPGRLGPVTLTLSG 824

  Fly   394 EDETNTFQYKVVPNSGFGADKFAMVRNGDGTGSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGP 458
            .|          |...|..|        ..:|.||.::|||.|  |........::.      |.
  Rat   825 GD----------PRGLFSLD--------SASGLLKTLRPLDRE--LLGPVLELEVRA------GS 863

  Fly   459 GGSDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYK 523
            |....:..|.  :.|.|.|:|||.|.|......|.:.::|..||.:...:|.|.|.|.:|:|.:.
  Rat   864 GTPPVFSAAR--IRVLLDDVNDNSPAFPAPEDTVLLPQNTAPGTPVYTLRALDPDSGANSRVTFS 926

  Fly   524 IVRSTNRKRQFAIS-DRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKD--VND 585
            ::...:  ..|.:. ..|.|.:..||.......|.:::.|.|.|||.||:...|.|:::|  ::.
  Rat   927 LLAGGD--GLFTVDPTTGHVRLMGPLGPPGGPPHELEVEAQDGGSPPRTSHFRLRVVIQDLGIHG 989

  Fly   586 NAPTF-AQDYKPTLPE-NVSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDR 648
            .||.| :..|:..||. ..:|.:||:|.|:.||      |.|.|:.   ||:|.....|.:|   
  Rat   990 LAPRFDSPTYRVDLPSGTTTGTQILQVQAQAPD------GSPVTYH---LAADGASNPFGLE--- 1042

  Fly   649 RGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPA----MTGTSTLTVTIGDVNDNKMQPGS 709
               :::|...:.:  ..|||:|:.|.:.: :..:|:.|    .|||:|:.|.|.:.||:..:...
  Rat  1043 ---SQSGWLWVRA--ALDRESQELYTLKV-MAVSGSKAELGQQTGTATVRVVILNQNDHSPRLSE 1101

  Fly   710 KSVLVYNYQGQSQDTPIGRVYVNDPDDWDVPDKKYYWEVQ----EHQRFKLDTDTG-ILTMRAGT 769
            :...:...:.|...|.:|||:..|.|..  |:.:..:.:|    :.:.|::...|| :.|::...
  Rat  1102 EPTFLAVAENQPPGTSVGRVFATDKDSG--PNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLD 1164

  Fly   770 R--RGRYQLRFKVYDREHGQEDIPANLSVTVRDIT------AEAVQQAGSMRLSHITDEDFVRTW 826
            |  :..:||..:|.|...........:.|.|.|:.      .:|...||......:.|.....|.
  Rat  1165 REQQSSFQLLVQVQDAGSPPRSATGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTL 1229

  Fly   827 NPVKNQVEPSKLERFRNKLAELLYT-DRDNVDVFSVQLKEGSPYPLTDVHFAAR-SATQQPYF-- 887
            .......:|.:.|.     ..:||| .....::||:....|      ::|.||. ...::|::  
  Rat  1230 VTTLQAKDPDEGEN-----GTILYTLTGSGSELFSLHPHTG------ELHTAASLIRAERPHYVL 1283

  Fly   888 -----------KAVRLNGVVQM--------HREEIEKDVGLNITM---VNINECLHEGKGKCGSN 930
                       ::..|..:||:        ..:.:|.|....:.:   |...|.|..| ...||.
  Rat  1284 TLSAHDQGSPPRSASLQLLVQVLPSTRMVESPDLVEADSAATVPVVLTVTAAEGLRPG-SLLGSV 1347

  Fly   931 SCTSKVELGKKPYTVSVNRTALVGVRLDISAQCVCRARNFTHQDHNCRTHLCYNGGRCVETRNGP 995
            :......:|...||       ||| ..|...       .|.....:.|.:|    .|.::..:||
  Rat  1348 APQEPASMGVLTYT-------LVG-GADPEG-------TFALDSASGRLYL----ARVLDFESGP 1393

  Fly   996 KCVACPVGYNGP--------RCQQSTRSFRGNGWAW-YPPLQLC----QESHLSL-EFITRVADG 1046
            ...|..|...||        |.|...:....:..|: ..||.|.    .|...:| .|....|||
  Rat  1394 AWRALTVRAEGPGGAGARLMRVQVRVQDENEHAPAFARDPLALALPENPEPGATLYTFRASDADG 1458

  Fly  1047 LILYNGPIVPPKPEETVISDFIALELEQGYPRLLIDFGSGTL 1088
                      |.|...|  .:..|..|...|.|.:|..:|.|
  Rat  1459 ----------PGPNSDV--RYRLLRQEPPVPALRLDARTGAL 1488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637 31/96 (32%)
Cadherin_repeat 140..248 CDD:206637 33/107 (31%)
Cadherin_repeat 256..359 CDD:206637 24/104 (23%)
Cadherin_repeat 379..481 CDD:206637 23/115 (20%)
Cadherin_repeat 489..586 CDD:206637 26/99 (26%)
Cadherin_repeat 594..703 CDD:206637 33/113 (29%)
Cadherin_repeat 724..801 CDD:206637 19/83 (23%)
EGF_CA 977..1010 CDD:238011 10/40 (25%)
LamG 1013..1198 CDD:238058 20/82 (24%)
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
Dchs1NP_001101014.2 Cadherin_repeat 43..133 CDD:206637
Cadherin_repeat 144..245 CDD:206637
Cadherin_repeat 254..352 CDD:206637
Cadherin_repeat 368..462 CDD:206637 2/5 (40%)
Cadherin_repeat 476..568 CDD:206637 29/91 (32%)
Cadherin_repeat 577..675 CDD:206637 33/106 (31%)
Cadherin_repeat 683..775 CDD:206637 24/100 (24%)
Cadherin_repeat 788..884 CDD:206637 26/126 (21%)
Cadherin_repeat 894..984 CDD:206637 25/91 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 951..971 5/19 (26%)
Cadherin_repeat 998..1095 CDD:206637 33/114 (29%)
Cadherin_repeat 1108..1201 CDD:206637 21/94 (22%)
Cadherin_repeat 1218..1306 CDD:206637 17/98 (17%)
CA 1356..1427 CDD:214520 19/89 (21%)
Cadherin_repeat 1438..1535 CDD:206637 16/63 (25%)
Cadherin_repeat 1544..1637 CDD:206637
Cadherin_repeat 1646..1740 CDD:206637
Cadherin_repeat 1750..1844 CDD:206637
Cadherin_repeat 1852..1949 CDD:206637
Cadherin_repeat 1976..2052 CDD:206637
Cadherin_repeat 2067..2160 CDD:206637
Cadherin_repeat 2168..2266 CDD:206637
Cadherin_repeat 2275..2365 CDD:206637
Cadherin_repeat 2374..2471 CDD:206637
Cadherin_repeat 2479..2591 CDD:206637
Cadherin_repeat 2599..2695 CDD:206637
Cadherin_repeat 2705..2801 CDD:206637
Cadherin_repeat 2810..2916 CDD:206637
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2978..3033
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3051..3080
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3226..3291
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3B9B2
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

Return to query results.
Submit another query.