DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and Pcdh17

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_001100749.1	Gene:	Pcdh17 / 306055	RGDID:	1304753	Length:	1208	Species:	Rattus norvegicus

Alignment Length:	858	Identity:	201/858 - (23%)
Similarity:	332/858 - (38%)	Gaps:	225/858 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 DNPANSKFDINRTTGDIFVLKPLDRD---QPNGRPQWRFTVFAQDEGGEGLVGYADIQVNLKDIN 246
            :|.|....|::..:|.::..:.:||:   :.|.:.|....|||.|:      ....|:|.::|||
  Rat    69 ENSAPHLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDK------EICMIKVEIQDIN 127

  Fly   247 DNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEETGAPIFEIE 311
            ||||.||......:::||...|:.....||   .||:...|....|.:.:    ::.|....:::
  Rat   128 DNAPSFPSDQIEMDISENAAPGTRFPLTSA---HDPDAGENGLRTYLLTR----DDHGLFALDVK 185

  Fly   312 --------PETGLIKTAVCCLDRERTPDYSIQVVAMDGGGLKGTGTASIRVK--DLNDMPPQFTK 366
                    ||..:.|    .||||....:::.:.|:|||....:.|..|.||  |.||..|.|..
  Rat   186 SRGDGTKFPELVIQK----ALDRELQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEA 246

  Fly   367 DEWVTEVDETN--GTYIPETPILTVTVQDEDETNTFQYKVVPNSGFGADKFAMVRNGD-GTGSLK 428
            ..::.|:.|..  ||.:.:   |..|..||.......|..   |.:..|:...:.:.| .||.::
  Rat   247 PSYLVELPENAPLGTVVID---LNATDADEGPNGEVLYSF---SSYVPDRVRELFSIDPKTGLIR 305

  Fly   429 IIQPLDYEDPLQSSGFRFRIQVNDKGDDG-PGGSDKYHVAYSWVVVKLRDINDNVPKFDREHI-E 491
            :...||||   ::......:|..|.|.:. |        |:..|.|||.|.|||.|......: :
  Rat   306 VKGNLDYE---ENGMLEIDVQARDLGPNPIP--------AHCKVTVKLIDRNDNAPSIGFVSVRQ 359

  Fly   492 VSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAISDRGAVSIQ----------- 545
            .::.|....||::...:.||.|.|.:.::..:::..........:...|:|..:
  Rat   360 GALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGGPGSVPFKLEENYDNFYTV 424

  Fly   546 ---RPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQD-YKPTLPE-NVSGK 605
               |||||||||.:::.|:|.|.|||...:|.:..|.:.|.|||.|.|.:. |...:.| |:.|:
  Rat   425 VTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAVKILDENDNPPRFTKGLYVLQVHENNIPGE 489

  Fly   606 KILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISSLRPFDREAQ 670
            .:..|.|:|||   .|..|..::.:.|....::.....|..    :..||.  |.:||.|:.|..
  Rat   490 YLGSVLAQDPD---LGQNGTVSYSILPSHIGDVSIYTYVSV----NPTNGA--IYALRSFNYEQT 545

  Fly   671 KSYAIPIEIKDNGAPA-MTGTSTLTVTIGDVNDNKMQPGSKSVLVYNYQGQSQDTPIGRVYVNDP 734
            |::...:..||:|||| :...:|:.||:.|||||     :..:::...|             ||.
  Rat   546 KAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDN-----APVIVLPTLQ-------------NDT 592

  Fly   735 DDWDVPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKVYDREHGQEDIPANLSVTVR 799
            .:..||.......:....| .||:|.|        ..||  |.:::.|   |.:|
  Rat   593 AELQVPRNAGLGYLVSTVR-ALDSDFG--------ESGR--LTYEIVD---GNDD---------- 633

  Fly   800 DITAEAVQQAGSMRLSHITDED----FVRTWNPVKNQVEPSKLERFRNKLAELL--YTDRDNVDV 858
                            |:.:.|    .:||.:|....|.|         :.||:  .||.....:
  Rat   634 ----------------HLFEIDPSSGEIRTLHPFWEDVTP---------VVELVVKVTDHGKPTL 673

  Fly   859 FSV----------QLKEGSPYPLTDVHFAARSATQQPYFKAVRLNGVVQMHREEIEKDVGLNITM 913
            .:|          .|.||.|                      |:||      |:...|:.|
  Rat   674 SAVAKLIIRSVSGSLPEGVP----------------------RVNG------EQHHWDMSL---- 706

  Fly   914 VNINECLHEGKGKCGSNSCTSKVELGKKPYTVSVNRTALVGVRLDISAQCVCRARNFTHQDHNCR 978
                                        |..|:::..:::.:...|:....|:..|...:.:|||
  Rat   707 ----------------------------PLIVTLSTISIILLAAMITIAVKCKRENKEIRTYNCR 743

  Fly   979 ----THLCYNGGR 987
                :|....||:
  Rat   744 IAEYSHPQLGGGK 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	17/65 (26%)
		Cadherin_repeat	256..359	CDD:206637	26/112 (23%)
		Cadherin_repeat	379..481	CDD:206637	26/103 (25%)
		Cadherin_repeat	489..586	CDD:206637	28/111 (25%)
		Cadherin_repeat	594..703	CDD:206637	33/110 (30%)
		Cadherin_repeat	724..801	CDD:206637	15/76 (20%)
		EGF_CA	977..1010	CDD:238011	5/15 (33%)
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Pcdh17	NP_001100749.1	E_set	21..113	CDD:298831	11/43 (26%)
		Cadherin_repeat	142..240	CDD:206637	27/108 (25%)
		Cadherin_repeat	248..348	CDD:206637	29/116 (25%)
		Cadherin_repeat	362..468	CDD:206637	28/105 (27%)
		Cadherin_repeat	477..579	CDD:206637	33/110 (30%)
		Cadherin_repeat	594..682	CDD:206637	25/136 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000