DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CadN2 and cdh11

DIOPT Version :9

Sequence 1:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster
Sequence 2:	NP_571289.1	Gene:	cdh11 / 30461	ZFINID:	ZDB-GENE-980526-170	Length:	800	Species:	Danio rerio

Alignment Length:	786	Identity:	208/786 - (26%)
Similarity:	345/786 - (43%)	Gaps:	165/786 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 VTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFA 224
            |.:.||      ||.|.|:|:|      |.:.|.|:..||:|...|.|||::     |.::|:.|
Zfish    89 VDSGDG------NIKYILSGEG------AGTIFVIDDKTGNIHATKTLDREE-----QAQYTLTA 136

  Fly   225 Q---DEGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNEST 286
            |   .:..:.|...::..|.::|||||.|:|..|.|:..|.|....|:||:.::|.|.|||....
Zfish   137 QAVARDTNKPLEPPSEFIVKVQDINDNPPEFLHGPYYARVAEMSNVGTSVIKVTATDADDPTYGN 201

  Fly   287 NAKLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGT 347
            :|:|:|||.:       |.|.|.:||:||:|:||:..:|||...:|.:.:.|.|    .|||.||
Zfish   202 SARLVYSILQ-------GQPYFSVEPQTGIIRTALPNMDREARQEYDVVIQAKDMGGHMGGLSGT 259

  Fly   348 GTASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDED--ETNTFQYKVVPNSGF 410
            ....|.:.|:||.||:|.:..:...|.|..   :|...:..:..:|.|  |.....|:::  .|.
Zfish   260 TQVKITLTDVNDNPPKFAQGVYAMAVSEDK---VPGEEVGRLKARDPDLAENGLVDYRIL--EGD 319

  Fly   411 GADKFAMVRNGDGTGS-LKIIQPLDYEDPLQSSGFRFRIQVNDKGDD------GPGGSDKYHVAY 468
            |.:.|.:.::.:...: :|:.:|:|:|   ....:..:::..:...|      ||      :...
Zfish   320 GMNYFEITKDSETQEAVIKLKKPVDFE---TKRSYTLKVEATNTHVDPRFIAWGP------YKDT 375

  Fly   469 SWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQ 533
            :.|.:.:.|. |..|.|........:.|:...||::.:..|.|.|. .::.:.|.|...|:.:..
Zfish   376 TIVKISVEDA-DEPPTFMAPSYNFEVEENAPAGTLVGRVHAKDTDM-MNNPIRYMIPHYTDLEEF 438

  Fly   534 FAIS-DRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPT 597
            |.|: :.|.:...||||||.|..|:|.:.|.:.|...:.|...:.:.|||||||||.||...:..
Zfish   439 FTINPEDGIIKTTRPLDREAQAWHNISVSATEIGGHHQDAKVRVNIKVKDVNDNAPEFATQNEVL 503

  Fly   598 LPENVSGKKILE-VAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDNENGVAIISS 661
            :.|||:..|::| |:|.|.|:  ..:...|.|.|.|..::......|       ||.:..|.|..
Zfish   504 VCENVNPGKLIETVSATDKDE--MAHRQHFHFSLAPEVANNHSFSLK-------DNRDSTASIFV 559

  Fly   662 LRP-FDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI--GDVND--------------------- 702
            :|. |.|..|..|.:||||.|||.|.|:.|:||.:.:  .|..|
Zfish   560 IRKGFSRMTQDIYHLPIEINDNGVPPMSSTNTLIIRVCSCDSKDTILSCNVEPFILTAGLSTGAL 624

  Fly   703 ----------------------NKMQP--------GSKSVLVYNYQ-GQSQDTPIGRV-YVNDPD 735
                                  .|.:|        ..::::.|:.: |..:||....: .:.:||
Zfish   625 IAILACIVILLAIVVLFVALRRQKKEPLIVFEEEDIRENIITYDDEGGGEEDTEAFDIATLQNPD 689

  Fly   736 DWD--VPDKKYYWEVQEHQR-------FKLDTDTGILTMRAGTRRGRYQLRFKVYDREHGQEDIP 791
            ..:  :|.|....|:|...|       ..:|.|..|.|              ::.|.::.....|
Zfish   690 GANGFLPRKDMKPELQYGMRPGLRPIGNSVDVDDFIKT--------------RISDADNDPTAPP 740

  Fly   792 ANLSVTV-----RDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAELLYT 851
            .: |:.:     |...|.::....|:......|.|::::|.|           ||: |||: ||.
Zfish   741 YD-SIQIYGYEGRGSIAGSLSSLESVTTDSDLDYDYLQSWGP-----------RFK-KLAD-LYG 791

  Fly   852 DRDNVD 857
            .:|:||
Zfish   792 TKDSVD 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	28/90 (31%)
		Cadherin_repeat	256..359	CDD:206637	39/106 (37%)
		Cadherin_repeat	379..481	CDD:206637	17/110 (15%)
		Cadherin_repeat	489..586	CDD:206637	29/97 (30%)
		Cadherin_repeat	594..703	CDD:206637	37/155 (24%)
		Cadherin_repeat	724..801	CDD:206637	16/91 (18%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
cdh11	NP_571289.1	CA	87..165	CDD:214520	30/92 (33%)
		Cadherin_repeat	171..272	CDD:206637	40/107 (37%)
		Cadherin_repeat	280..387	CDD:206637	19/121 (16%)
		Cadherin_repeat	395..492	CDD:206637	29/97 (30%)
		Cadherin_repeat	501..597	CDD:206637	35/104 (34%)
		Cadherin_C	645..793	CDD:307269	34/175 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5001
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010